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INDONESIA
ISM (Intisari Sains Medis) : Jurnal Kedokteran
Published by Universitas Udayana
ISSN : 25033638     EISSN : -     DOI : -
Core Subject : Health, Science,
Intisari Sains Medis is published by Medical Scientific Community, Indonesia. Intisari Sains Medis is an international, multidisciplinary, peer-reviewed, open access journal accepts papers for publication in all aspects of Science Digest, Medical Research Development, Research Medical Field and Theory. We also publish cases from third world country, that is considered very rare and special cases.
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Articles 68 Documents
Search results for , issue "Vol. 12 No. 3 (2021): (Available online: 1 December 2021)" : 68 Documents clear
Clinical characteristic of dengue fever and dengue hemorrhagic fever among patients at Sanglah Hospital, Denpasar, Bali Shabrina Inderjit; I Made Sudarmaja; I Kadek Swastika
Intisari Sains Medis Vol. 12 No. 3 (2021): (Available online: 1 December 2021)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (367.249 KB) | DOI: 10.15562/ism.v12i3.550

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Background: Mosquito-borne diseases are one of the most significant public health risks globally, and dengue fever seems to be one of the most important arboviral diseases in humans. In humans, dengue viruses are the supreme agents that cause dengue fever (DF) and dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). Following that, the virus's presence, sufficient numbers of susceptible populations, and mosquito vectors are required to transmit dengue infection. This study aimed to identify the clinical characteristics of dengue fever and dengue hemorrhagic fever among patients at Sanglah Hospital, Denpasar, BaliMethod: The study is a descriptive retrospective study design. The data was collected from the medical records of patients diagnosed with dengue and dengue hemorrhagic fever in Sanglah Hospital, Denpasar, Bali, from June 2015- June 2016. We took 50 patients according to sample size calculation by randomized sampling technic. Data were analyzed descriptively.Result: The study found the age range from 5 to 53 years old. The mean age for DF and DHF were 11 and 31, respectively. Secondly, the proportion of gender in this research was male by 21 (42%) and 29 (58%) female. Further to this, Denpasar showed the maximum number of cases between all the nine regencies. Both DF and DHF cases recorded the highest total cases in April 2016.Conclusion: Expected clinical characteristics prior knowledge and prognosticators of DF and DHF development will be able to provide data to detect persons who are higher risk category and provide adequate time to clinicians to lessen dengue related morbidity and mortality
Incidence report of traumatic brain injury in Mimika Public Hospital Papua Kevin Kristian Putra; Putu Ayu Indra Shanti Wardani; I Wayan Niryana
Intisari Sains Medis Vol. 12 No. 3 (2021): (Available online: 1 December 2021)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (278.774 KB) | DOI: 10.15562/ism.v12i3.853

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Introduction: Traumatic brain injury is a functional brain disorder caused by an external force, which giving persistent consequences, progressive, long-term care, and rehabilitation might be needed. It is also called a “silent epidemic” due to the increased global incidence rate, socio-economic burden, and quality of life. The major cause of TBI was road traffic injury, fall, and blunt trauma.Methods: This research was conducted with a descriptive research design using a prospective cross-sectional design. The research sampling was using medical records in accordance with inclusion and exclusion criteria from 2018 to 2019.Result: The collected sample was 393 cases. There were 66.16% and 67.18% cases occurred to man and productive age with incidence rate 178.89 in 100.000 people. The major cause of TBI was road traffic injury and intentional injury with 58.52% and 24.17% consecutively. The involvement of alcohol in TBI cases was found in 24.42% of cases. The usage of the helmet was not found in 96.6% of cases of RTI.Conclusion: The majority of TBI patients at Mimika Public Hospital in 2018-2019 occurred in men and in the productive age, which was majorly caused by road traffic injury and intentional injury.
Case report of acute epiglottitis in a 44-year-old man: a rare case I Gusti Ayu Putu Wahyu Widiantari; Nyoman Dian Permatasari; Ida Bagus Semara Putra
Intisari Sains Medis Vol. 12 No. 3 (2021): (Available online: 1 December 2021)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (437.303 KB) | DOI: 10.15562/ism.v12i3.954

Abstract

Background: Acute epiglottitis, also known as supraglottitis or supraglottic laryngitis, is an acute inflammation of the supraglottic area of the larynx. The diagnosis can be made based on clinical signs and symptoms as well as several investigations.Case Description: We reported a case of a 44-year-old man who presented to our emergency department and whose condition was ultimately diagnosed as epiglottitis. Indirect laryngoscopy and lateral soft tissue neck radiograph had an important role in determining the diagnosis. The patient was treated conservatively by giving a high dosed antibiotic, anti-inflammatory, and analgesic drugs.Conclusion: Acute epiglottitis can be a life-threatening condition because it can cause sudden upper airway obstruction. Therefore, management must be given quickly and precisely so as not to fall into a life-threatening condition.
Predictors of Mortality for Critically Ill COVID-19 Patients: Systematic Review Lya Lusyana; Randika Rea Ariady; Gede Benny Setia Wirawan
Intisari Sains Medis Vol. 12 No. 3 (2021): (Available online: 1 December 2021)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (393.193 KB) | DOI: 10.15562/ism.v12i3.989

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Objective: To identify mortality predictors of critically ill COVID-19 patients in ICU based on current available literatures.Methods: Systematic literature search was conducted in open-access databases. Data extraction was conducted for publication date, methodology employed, sample size, and results of multivariate analysis. Eligibility criteria for analysis was observational analytic design, sample size of 100 or more, and availability of multivariate results. Primary measures assessed was risk ratio, presented as odds ratio or hazard ratio. Data was analyzed qualitatively for themes that emerged for mortality predictors.Results: Several mortality predictors were identified, which included demographic, clinical history, laboratory results, and oxygenation profile at ICU admission. Several of the most consistently reported mortality predictors was older age, one or more comorbidities that constitute metabolic syndrome, chronic pulmonary disorder, low lymphocyte and platelet count, elevated d-dimer, and low PaO2/FiO2 ratio.Conclusions: Mortality predictors identified in this review were similar to previously known mortality and severity predictors of COVID-19 patients in general. This consistency may point to the potential of developing a scoring system to predict COVID-19 severity and mortality for clinical practice use. 
Facial Skin Injury Related to Personal Protective Equipment Among Healthcare Workers: Single Center Cross-Sectional Study I Gusti Ayu Agung Bella Jayaningrum; Gede Benny Setia Wirawan; Anak Agung Ngurah Krisna Dwipayana; Anak Agung Ngurah Bagus Surya Darma; Lya Lusyana; Sang Nyoman Suriana
Intisari Sains Medis Vol. 12 No. 3 (2021): (Available online: 1 December 2021)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (295.485 KB) | DOI: 10.15562/ism.v12i3.990

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Objective: Our study aimed to learn the phenomenon of facial skin injuries related to PPE use, their characteristics, as well as risk and protective factors.Methods: We conducted a single-center cross-sectional study. Samples was collected consecutively by disseminating self-filled questionnaire to all departments in Sanjiwani General Hospital, Gianyar, Bali, Indonesia. Variables studied included demographic, characteristics of PPE usage, characteristics of facial skin injuries suffered, and preventive measures practiced by healthcare workers. We conducted multivariate analysis for independent determinants of more severe skin injuries and any injuries located on the nasal bridge, cheekbones, and behind the ears.Results: Final analysis included 161 respondents. Male make up 26.7% of respondents, mean age was 35.00 (± 8.91). The majority was nurses (78.3%). Prevalence of skin injury was 90.7%, 39.1% of them being partial or full thickness skin injuries. Only 27.4% respondents practiced preventive measures, including application of polyester tape layering and emollient. The most frequently reported location of skin injury was nasal bridge (77%), followed by behind the ears (57.1%), and on the cheekbones (47.2%). Multivariate analyses discovered that KN95 respirator poses less risk for more severe injuries compared to N95. Protective measures were found effective to prevent skin injuries in all locations, including for more severe injuries.Conclusions: We found high prevalence of facial skin injuries among healthcare workers accompanied by inadequate practice of preventive behaviors. These preventive behaviors have been found effective in other study as well and existing evidence support its promotion for more widespread practice. 
Herniasi nukleus pulposus lumbal multipel disertai kanal stenosis dengan drop foot syndrome dan atrofi otot unilateral: sebuah laporan kasus Anak Agung Ngurah Agung Harawikrama Adityawarma; I Nyoman Gede Wahyudana
Intisari Sains Medis Vol. 12 No. 3 (2021): (Available online: 1 December 2021)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (274.039 KB) | DOI: 10.15562/ism.v12i3.993

Abstract

Background: Low back pain is a fairly common health problem, with a worldwide prevalence of 1.4-20% and an annual incidence of 0.024-7% per year. One of the causes of lower back pain is a herniated nucleus pulposus. The prevalence of nucleus pulposus herniation in Indonesia is not well documented. One of the complications caused by HNP is drop foot syndrome. Drop Foot Syndrome is the inability to perform flexion dorsum movement of the ankle or big toe. The prevalence of drop foot syndrome is quite rare, with around 8.1% of patients suffering from HN.Case Illustration: A 71-year-old male patient presented with complaints of lower back pain radiating to the left rear thigh since two months ago. The pain was getting worse, and the legs were getting weaker, so that he had to drag his legs. The patient was also often experiencing back pain since five years ago. The patient has a history as a truck driver with the Bali-Java-Sumatra route for 30 years. On physical examination, there ware significant atrophy in the left calf. Motor examination found that the left foot could not lift against the gravity force, and when walking, the big toe touched the floor first. There was no interference with defecation or bowel movements. Lumbar MRI examination was performed with the results of the disc herniation of L1-L2, L2-L3, L4-L5, L5-S1, multiple canal stenosis, and lumbar spondylosis. Discectomy laminectomy and posterior vertebral fusion were performed.Conclusion: HNP is one of the most frequent causes of lower back pain. The lack of knowledge about HNP makes people underestimate this problem, and this is one of the causes of complications in the form of drop foot to muscle atrophy due to the delayed treatment. Latar belakang: Nyeri punggung bawah merupakan permasalahan kesehatan yang cukup umum dengan prevalensi di seluruh dunia sebesar 1,4-20% dan insiden setiap tahunnya 0,024-7%. Salah satu penyebab nyeri punggung bawah adalah herniasi nukleus pulposus. Herniasi nukleus pulposus didefinisikan sebagai rupturnya anulus fibrosus sehingga nukleus pulposus menonjol dan menekan ke arah kanalis spinalis. Salah satu komplikasi yang disebabkan oleh HNP adalah drop foot syndrome. Prevalensi terjadinya drop foot syndrome cukup jarang yakni 8,1% dari pasien yang menderita HNP.Ilustrasi Kasus: Pasien laki-laki berusia 71 tahun datang dengan keluhan nyeri punggung bawah menjalar hingga paha kiri belakang sejak 2 bulan yang lalu. Pasien baru memeriksakan diri ke dokter karena nyeri semakin berat dan kaki semakin lemas sehingga harus menyeret kaki serta mengalami nyeri punggung belakang sejak 5 tahun yang lalu. Pasien memiliki riwayat sebagai pengemudi truk Bali-Jawa-Sumatra selama 30 tahun. Pada pemeriksaan fisik ditemukan atrofi signifikan pada betis kiri, pemeriksaan motorik didapatkan punggung kaki kiri tidak mampu mengangkat melawan gaya gravitasi dan ketika berjalan bagian jempol kaki menyentuh lantai terlebih dahulu serta tidak didapatkan adanya gangguan pada BAB ataupun BAK. Pemeriksaan MRI lumbalis dilakukan dengan hasil herniasi diskus L1-L2, L2-L3, L4-L5, L5-S1, stenosis kanal multipel dan spondilosis lumbalis. Dilakukan laminektomi disektomi dan fusi vertebra posterior.Simpulan: HNP merupakan salah satu penyebab nyeri punggung bawah yang paling sering. HNP menjadi salah satu penyebab terjadinya komplikasi berupa drop foot hingga terjadinya atropi otot karena tidak ditangani lebih awal. 
Karakteristik metastasis tulang belakang di Rumah Sakit Umum Pusat Sanglah P. Gde Daniswara Raditya Rahman; Ni Putu Witari; Anak Agung Ayu Putri Laksmidewi; I Made Oka Adnyana
Intisari Sains Medis Vol. 12 No. 3 (2021): (Available online: 1 December 2021)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (298.139 KB) | DOI: 10.15562/ism.v12i3.1002

Abstract

Introduction: Spinal metastases constitute 90% of spine tumors. Primary tumors  originate from a variety of malignancies. However, there are no data on the characteristics of spinal metastases in the local population. This study collected data from one of the Tertiary hospitals in Bali to be used as a reference for the initial description regarding the characteristics of spinal metastases.Methods: A cross-sectional descriptive study was conducted by collecting medical record data of patients with spinal metastases at the Sanglah General Hospital for a year (January–December 2019) by total sampling.Results: This study obtained 39 samples. Most primary cancers that metastasize to the spine were lung cancers (30.77%), followed by multiple myeloma (10.26%), prostate cancer (7.69%), and colorectal cancer (5.13%). There were also contributions from breast, cervix, bladder, thyroid, lymphoma, nasal cavity, acute myeloid leukemia, and plasmacytoma. There were 25.64% cases where the primary cancer was unknown. Most of the metastases were in the thoracic segment (35.90%), followed by the lumbar region (28.21%) and the cervical region (12.82%). There were still many lesions that were less visible or unclear (38.46%). Patients generally experienced sensory (94.87%) and motor (92.31%) deficit. Sensory disturbances include paresthesia, hypesthesia and pain. Meanwhile, motor deficit include parapharesis, paraplegia, and tetrapharesis depending on the location of the lesion. Other disorders were related to the autonomic nerves (56.41%) such as defecation and urination problem.Conclusion: Most of the patients aged ?60 years and male. Spinal metastases frequently found in lung cancer patient. There was a high percentage cases with unknown primary origin. In general, the lesions were found in the thoracic and lumbar segments. There were many lesions which unclear or less visible in location. Almost all patients had sensory and motor deficit and only about half of patients had autonomic disorders.  Pendahuluan: Metastasis tulang belakang merupakan 90% kasus tumor pada tulang belakang. Tumor primer dapat berasal dari berbagai keganasan. Akan tetap, belum ada data karakteristik metastasis tulang belakang di populasi lokal. Penelitian ini mengumpulkan data dari salah satu rumah sakit Tersier di Bali untuk dapat menjadi acuan gambaran awal terkait karakteristik metastasis tulang belakang.Metode: Penelitian deskriptif potong lintang dilakukan dengan mengumpulkan data rekam medis pasien dengan metastasis tulang belakang di Rumah Sakit Umum Pusat Sanglah selama satu tahun (bulan Januari - Desember 2019) secara total sampling.Hasil: Penelitian ini mendapatkan 39 sampel. Kanker primer terbanyak yang bermetastasis ke tulang belakang adalah kanker paru (30,77%), lalu disusul dengan multiple myeloma (10,26%), kanker prostat (7,69%), dan kanker kolorektal (5,13%). Terdapat pula kontribusi dari kanker payudara, serviks, buli, tiroid, limfoma, cavum nasi, leukemia myeloid akut, dan plasmasitoma. Terdapat 25,64% kasus tidak ditemukan lokasi kanker primernya. Lokasi metastasis paling banyak pada segmen thorakal (35,90%) kemudian regio lumbal (28,21%) dan regio servikal (12,82%). Masih banyak lesi yang kurang terlihat atau tidak jelas (38,46%). Pasien secara umum mengalami gangguan sensorik (94,87%) dan motorik (92,31%). Gangguan sensorik termasuk parestesia, hipestesia, dan rasa nyeri. Sedangkan gangguan motorik termasuk paraparesis, paraplegia, dan tetraparesis tergantung dari letak lesi. Gangguan lainnya yaitu gangguan pada saraf otonom (56,41%) dengan kelainan seperti gangguan buang air besar dan berkemih.Simpulan: Sebagian besar pada pasien usia ?60 tahun dan berjenis kelamin laki-laki. Metastasis tulang belakang cenderung lebih sering pada penderita kanker paru. Selain lokasi primer tersebut, terdapat persentase tinggi dimana tidak ditemukannya dari lokasi kanker primer. Pada umumnya hasil lesi terdapat pada segmen thorakal dan segmen lumbal. Masih banyak pula lesi ini masih kurang terlihat atau tidak jelas lokasinya. Pada umumnya pasien memiliki gangguan sensorik dan motorik serta hanya sekitar setengah pasien mengalami gangguan otonom.
Dietary management in colorectal cancer prevention: a review Yudi Kristanto; Angeline Rosa Hartono
Intisari Sains Medis Vol. 12 No. 3 (2021): (Available online: 1 December 2021)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (307.794 KB) | DOI: 10.15562/ism.v12i3.1020

Abstract

Colorectal cancer (CRC) is still a health problem with a high incidence worldwide. Genetic factors and environmental factors are the etiology of colorectal cancer. Eating habits are one of the environmental factors that can be regulated so as to prevent colorectal cancer. Diet food in the development of colorectal cancer has an important role. Several studies in the last decade have shown an association between the consumption of several foods and nutrients and the risk of colorectal cancer in epidemiological and experimental studies.
Satu Kasus Langka: Harlequin Ichthyosis I Gusti Ayu Sattwika Pramita; Ni Luh Putu Ratih Vibriyanti Karna
Intisari Sains Medis Vol. 12 No. 3 (2021): (Available online: 1 December 2021)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (378.641 KB) | DOI: 10.15562/ism.v12i3.1024

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Introduction: Harlequin ichthyosis is a genetic skin disease due to mutations in the ABCA12 gene inherited in an autosomal recessive manner. It is a severe form of ichthyosis characterized by a distinct clinical appearance of a thick stratum corneum. Harlequin ichthyosis is rarely found, and patients generally die a few days after birth.Case description: We reported a baby girl aged one day with thick and cracked skin since birth. Physical examination revealed eclabium, ectropion, microtia, hyperflexion of the arms and legs, and hypoplasia of the fingers and toes. Dermatological examination showed thick yellowish-white scales separated by deep and erythematous fissures. The patient was placed in an incubator and was given supportive care, including nutrition and fluid through an orogastric tube, oleum olivarum as a moisturizer, gentamicin cream 0.1%, and gentamicin eye ointment 0.3%. The patient died after 21 days of treatment.Conclusion: Harlequin ichthyosis has a poor prognosis and a high mortality rate due to impaired skin barrier functions that lead to dehydration, impaired thermoregulation, respiratory problems, and infections. Management of harlequin ichthyosis needs a multidisciplinary team and supportive care, consisting of fluid, electrolyte, and nutrition management, maintaining skin hydration, eye care, and preventing respiratory failure or sepsis.  Pendahuluan: Harlequin ichthyosis adalah penyakit kulit genetik yang diturunkan secara resesif autosomal dan merupakan bentuk berat dari iktiosis akibat adanya mutasi pada gen ABCA12. Penyakit ini ditandai dengan adanya gambaran klinis yang khas berupa penebalan stratum korneum. Harlequin ichthyosis jarang ditemukan dan umumnya pasien meninggal beberapa hari setelah kelahiran.Kasus: Dilaporkan seorang bayi perempuan berumur 1 hari dengan keluhan kulit tebal dan pecah-pecah sejak lahir. Pada pemeriksaan fisik ditemukan eklabium, ektropion, mikrotia, hiperfleksi lengan dan kaki, serta hipoplasia jari-jari tangan dan kaki. Berdasarkan pemeriksaan status dermatologikus didapatkan skuama tebal berwarna putih kekuningan yang dipisahkan fisura. Pasien diberikan perawatan suportif berupa perawatan dalam inkubator, pemberian nutrisi melalui OGT, pelembab topikal oleum olivarum, antibiotik topikal gentamisin krim 0,1 %, dan salep mata gentamisin 0,3%.  Pasien meninggal setelah perawatan selama 21 hari. Simpulan: Harlequin ichthyosis memiliki prognosis yang buruk dan angka kematian yang tinggi akibat gangguan dari barier kulit yang menyebabkan dehidrasi, gangguan termoregulasi, gangguan nafas dan infeksi. Penatalaksanaan pasien harlequin ichthyosis adalah multidisiplin dan bersifat suportif, terdiri atas manajemen cairan dan elektrolit, perawatan secara intensif dalam inkubator, pemberian nutrisi, menjaga hidrasi kulit, perawatan mata, dan pencegahan terjadinya gangguan napas, atau sepsis. 
Kelainan elektrolit berulang pada pasien dengan kecurigaan Sindrom Gitelman Beny Surya Wijaya; Kadek Wisnu Segara Karya
Intisari Sains Medis Vol. 12 No. 3 (2021): (Available online: 1 December 2021)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (387.639 KB) | DOI: 10.15562/ism.v12i3.1082

Abstract

Pendahuluan: Sindrom Gitelman merupakan tubulopati yang terjadi akibat mutasi pada gen Solute Carrier Family 12 Member 3 (SLC12A3), yang mengkode thiazide-sensitive natrium chloride co-transporter (NCCT) pada membran apikal sel tubulus distal. Sindrom ini bersifat autosomal resesif yang ditandai dengan hipokalemia, alkalosis metabolik, hipomagnesemia, dan hipokalsiuria. Gejala yang sering muncul adalah kram dan kelemahan mulai dari keterbatasan aktivitas ringan hingga berat.Laporan kasus: Laki-laki usia 19 tahun datang dengan keluhan lemas disertai kaku otot seluruh anggota gerak dan leher, mual, muntah, nyeri kepala, dan nyeri ulu hati. Pasien memiliki riwayat rawat inap tiga kali dengan keluhan serupa. Pada pemeriksaan fisik ditemukan tanda vital dalam batas normal, serta adanya tanda Chvostek. Pemeriksaan darah lengkap dalam batas normal. Pemeriksaan elektrolit menunjukan kadar natrium 118 mmol/L, kalium 2,16 mmol/L, dan klorida 74 mmol/L. Pasien sudah berulang kali melakukan pemeriksaan elektrolit dengan hasil hipokalemia. Delapan bulan sebelumnya, pasien dirawat akibat penurunan kesadaran dengan gambaran alkalosis metabolik, hipokalemia (2,59 mmol/L), hipomagnesemia (0,76 mg/dL) dan hipokalsemia (8,2 mg/dL). Pemeriksaan fungsi ginjal, urinalisis, dan elektrokardiografi dalam batas normal. Berdasarkan keluhan, riwayat penyakit, dan pemeriksaan penunjang berupa hipokalemia berulang, alkalosis metabolik, dan hipomagnesemia, maka dicurigai suatu Sindrom Gitelman. Pasien diterapi dengan kalium klorida (KCl) intravena 50 mEq dalam natrium klorida (NaCl) 0,9% 500 cc dengan laju 20 tetes per menit, tablet KCl 600 mg tiap 8 jam, kapsul garam dapur 500 mg tiap 12 jam, omeprazole serta ondansetron intravena sesuai keluhan. Pasien dirawat inap satu hari dan dipulangkan setelah kadar kalium terkoreksi (3,1 mmol/L) dan keadaan klinis membaik. Pemeriksaan analisis DNA untuk penegakan diagnosis tidak dilakukan karena keterbatasan fasilitas dan biaya.Kesimpulan: Sindrom Gitelman merupakan tubulopati yang bersifat autosomal resesif ditandai dengan hipokalemia, alkalosis metabolik, hipomagnesemia, dan hipokalsiuria. Tatalaksana sindrom ini tergantung pada klinis dan gangguan laboratorium. Suplemen natrium, kalium, dan magnesium merupakan terapi yang paling sering dibutuhkan. Introduction: Gitelman syndrome is a tubulopathy that occurs due to mutations in the Solute Carrier Family 12 Member 3 (SLC12A3) gene, which encodes thiazide-sensitive sodium chloride co-transporter (NCCT) in the apical membrane of distal tubule cells. This autosomal recessive syndrome characterized by hypokalemia, metabolic alkalosis, hypomagnesemia, and hypocalsiuria. Common symptoms are cramps and weakness ranging from mild to severe limitation of activity.Case Report: a 19 years-old-man present a general weakness accompanied by muscle stiffness throughout the limbs and neck, nausea, vomiting, headache, and heartburn. The patient had a history of hospitalization three times with similar complaints. Normal vital signs and Chvostek's sign were found on physical examination. Complete blood count was within normal limits. Electrolyte examination showed sodium 118 mmol/L, potassium 2.16 mmol/L, and chloride 74 mmol/L. The patient had repeated episode of hypokalemia. In the previous eight months, he was admitted due to decreased of consciousness with metabolic alkalosis, hypokalemia (2.59 mmol/L), hypomagnesemia (0.76 mg/dL) and hypocalcemia (8.2 mg/dL). Kidney function, urinalysis, and electrocardiography within normal limits. Based on complaints, medical history, and the results of investigations a Gitelman syndrome was suspected. The patient was treated with 50 mEq intravenous KCL in 500cc NaCl 0,9% at a rate of 20 drops per minute, 600 mg KCl tablets every 8 hours, 500 mg table salt capsules every 12 hours, intravenous omeprazole and ondansetron as needed. The patient discharged after the potassium level was corrected (3.1 mmol/L) and improved clinical condition. Follow-up examination in the form of DNA analysis was not carried out due to limited facilities and funding.Conclusion: Gitelman syndrome is an autosomal recessive tubulopathy characterized by hypokalemia, metabolic alkalosis, hypomagnesemia, and hypocalciuria. Management of this syndrome in accordance with clinical and laboratory abnormalities that occur. The most frequently needed therapy are sodium, potassium, and magnesium supplement.