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Biomolecular and Health Science Journal
Published by Universitas Airlangga
ISSN : -     EISSN : 26208636     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
Bimolecular and Health Science Journal (BHSJ) is a scientific peer-reviewed medical doctor which relevant to a medical doctor and other health-related professions by the Faculty of Medicine Universitas Airlangga, Indonesia. BHSJ provides a forum for original article, review article, editorial, case report(s), letter(s) to the editor, short communication and it will be published two times a year. Studies that focus on evaluating and understanding the complex medical importance are welcomed in BHSJ.
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Articles 16 Documents
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Search results for , issue "Vol. 3 No. 1 (2020): Biomolecular and Health Science Journal" : 16 Documents clear
Correlation between Allergic Rhinitis and Rhinosinusitis in ENT Outpatient Clinic Patients Felicia Alvita Tjahjono; Irwan Kristyono; Ari Baskoro
Biomolecular and Health Science Journal Vol. 3 No. 1 (2020): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v3i1.19127

Abstract

Introduction: Rhinosinusitis and allergic rhinitis are common health problems. Allergic rhinitis patients tend to have edema on their nasal mucosa, disrupted cilia, and excessive secrete production that clogged paranasal sinuses’ ostiums and lead to inflammation and infection of the paranasal sinuses. There is still a contradiction of allergic rhinitis as predisposing factor of rhinosinusitis. Those correlation is not yet clear, thus we aim to analyze the correlation between allergic rhinitis and rhinosinusitis.Methods: This study was a cross-sectional design. The samples were obtained by consecutive sampling. Adult patients above 19 years old with nasal discharge were examined by the doctors on duty and interviewed. Medical data obtained was recorded and analyzed using chi square test.Results: From 98 patients, 17 patients (17.35%) had both rhinosinusitis and allergic rhinitis, 48 patients (48.98%) only had rhinosinusitis, and 13 patients (13.26%) only had allergic rhinitis. Patients who had neither rhinosinusitis nor allergic rhinitis reported to be 20 patients (20.41%). Chi square test showed that allergic rhinitis had no significant correlation with rhinosinusitis (p=0.266).Conclusion: There is no significant correlation between allergic rhinitis and rhinosinusitis. Rhinosinusitis is a multifactorial disease.
Characteristics and Histopathological Grading of Malignant Spiculated Mass in regards to Histopathological Grading of Breast Cancer Based on The Nottingham Grading System Andi Syarti; Ulinta Pasaribu; Dyah Fauziah; Lies Mardiyana; Tri Wulanhandarini
Biomolecular and Health Science Journal Vol. 3 No. 1 (2020): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v3i1.19134

Abstract

Introduction: Spiculation in mammography is a typical finding for invading breast cancer and is an important criterion in diagnosis and in predicting prognostic and plays an important role in management. The purpose of this research is to determine the characteristics of malignant spiculating mass in mammography in regards to histopathological grading using The Nottingham Grading System.Methods: Patients whom had spiculation in mammography was reviewed using medical record data by two breast imaging consultants and then combined with The Nottingham Grading System criteria obtained from histopathological examination results of core biopsy and surgery specimen. There was 29 cases that met the inclusion criteria.Results: Of the 29 patients that met the inclusion, the spiculated masses grade I, II has mitotic index of 0-12, grade III has mitotic index of 13-25. Histopathologic grade II, III has the most tubular formation of <10%, grade I has 10-75%. Grade I, II has moderate nuclear pleomorphism, grade III has severe nuclear pleomorphism. Most were grade III (44.8%), followed by grade II (37.9%), and minimally grade I (17.2%). Most patients are in stage 3 breast cancer.Conclusion: Malignant spiculated mass with grade I, II has low proliferation index (mitotic index 0-12), histopathological grade II, III had worse cellular differentiation (tubular formation <10%), histopathological grade II, III has moderate to severe nuclear pleomorphism.
Pre-Operative Enhanced Recovery After Surgery (ERAS) Protocol Compliance Towards Major Surgery Patients at Dr. Soetomo General Hospital, Surabaya Ahmad Sabili Rifa'i; Vicky Sumarki Budipramana; Gadis Meinar Sari
Biomolecular and Health Science Journal Vol. 3 No. 1 (2020): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v3i1.19064

Abstract

Introduction: The implementation of ERAS protocol can optimize patients after surgery, which in turn can reduce burdens both for patient and hospital. The purpose of this study is to describe the compliance and consistency of ERAS in the pre-operative period of surgery patients in Dr. Soetomo General Hospital Surabaya. Methods: We conducted consecutive observation of major surgical patients for 4 weeks. The type of surgery observed was digestive, thoracic and cardiovascular, and gynecological surgery. The pre-operative period will be calculated for compliance based on the ERAS international protocol. All data of compliance presented descriptively.s.Results: A total of 36 major surgery patients of which 7 (19,4%) were digestive surgeries, 14 (38,9%) were thoracic and cardiovascular surgeries, and 15 (41,7%) were gynecological surgeries. Overall compliance of the ERAS protocol in the pre-operative period of major surgery patients was 91%. The compliance of ERAS protocol in the pre-operative period of digestive surgery patients was 80%, in thoracic and cardiovascular surgery patients was 93,4% and gynecologic surgery patients was 84.3%. Major surgery patients with ≥90% compliance was 25%. Digestive surgery patients with ≥90% compliance was 0%. Thoracic and cardiovascular surgery patients with ≥90% compliance was 64,3%. Gynecologic surgery patients with ≥90% compliance was 0%.Conclusion: : Pre-operative elements of ERAS protocol in major surgery including digestive, thoracic and cardiovascular, and gynecologic surgery in Dr. Soetomo General Hospital, Surabaya needs to be improved.
Combination of Red Coconut Coir (Cocos nucifera L. var rubescens) and Linezolid on Methicillin-Resistant Staphylococcus aureus in vitro Growth Trisnawati Trisnawati; Wiwin Retnowati; Danti Nur Indiastuti
Biomolecular and Health Science Journal Vol. 3 No. 1 (2020): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v3i1.19128

Abstract

Introduction: Methicillin-Resistant Staphylococcus aureus (MRSA) bacterial infections may cause poor manifestations and even increase patients’ morbidity and mortality. The use of antibiotics in the management of infections remains the main therapy. However, ever-increasing antibacterial resistance has prompted researchers to find the solution. This study aimed to determine the effect of a combination of red coconut coir (Cocos nucifera L. var rubescens) in various concentrations and linezolid 10 µ/ml on the growth of MRSA bacteria in vitro.Methods: The antibacterial activity test method was well-diffusion test. Bacteria was plated in mueller hinton agar for 24 hours at 37oC. The treatment groups were red coconut coir extract and its combination with linezolid 10 µg/ml.  The well-diffusion test results were statistically analyzed with the One-Way ANOVA and Tukey HSD post-hoc tests.Results: Mean inhibitory zone diameter formed in the C. nucifera L. var rubescens extract test in various concentrations was 12.5 ± 0.36 - 16.2 ± 0.79 mm, while its combination with 10 µg/ml linezolid produced mean inhibitory zone of 15.1 ± 1.31-18.4 ± 0.46 mm. There was a significant difference between groups (p<0.05).Conclusion: Increasing concentration of C. nucifera L. var rubescens extract was in line with the increase of mean diameter of the inhibitory zone. Extract and antibiotic combination tests showed higher mean diameter zones than the single test of materials. The combination of extract and linezolid has the potential to synergistically prevent antibacterial resistance.
Pattern of Perioperative Antibiotic Use in Otorhinolaryngology-Head and Neck Surgery at Third Referral Hospital In Surabaya Nabilah Puspa Utami; Dyah Fauziah; Muhtarum Yusuf
Biomolecular and Health Science Journal Vol. 3 No. 1 (2020): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v3i1.19196

Abstract

Introduction: Surgical site infection (SSI) often occurs in operation. SSI frequently only affects the superficial tissues, but some more serious infections can affect the deeper tissues or other parts of the body. The majority of SSIs become apparent within 30 days of an operative procedure, when a prosthetic implant is used, SSI may occur several months after the operation. To minimize surgical site infection occurrence, prophylaxis antibiotic is often used. The aim of the study is to evaluate the use of perioperative antibiotics for otorhinolaryngology surgery in third referral hospital in Surabaya.Methods: This study was a retrospective cross-sectional method through the medical record of patients cases from December 2017 to January 2018. All data about sex, age, diagnosis, wound classification, surgical intervention including ICD 9 CM codes, and antibiotics regiments are presented descriptively.Results: Of total 68 patients, 42 (61.8%) were male and 46 (61.8%) were aged 18-65 years old. The most common type of operation was clean surgery 52 (76.5%). The most common prophylactic antibiotic was cefazoline 25 (96.6%). Conclusion: Most of the performed surgery was clean surgery. The use of perioperative antibiotics in most performed operations was in accordance with existing literature. The most widely used prophylactic and therapeutic antibiotic was cefazoline and ceftriaxone, respectively. Further research about risk factor of SSI, the use of prophylaxis antibiotic, and bacterial profile with more samples is needed for more accurate results.
Fauna of Culex Mosquitoes In Salamwates Village Dongko Subdistrict, Trenggalek City Mardliyana Shalihah; Budi Utomo; Subagyo Yotopranoto; Heny Arwati
Biomolecular and Health Science Journal Vol. 3 No. 1 (2020): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v3i1.19089

Abstract

Introduction: Mosquito-borne diseases are still a burden worldwide, including in Indonesia. Some of those diseases, such as filariasis and Japanese encephalitis, are transmitted by some species of Culex mosquitoes. We aimed to describe the fauna of Culex mosquitoes in Salamwates village, Dongko subdistrict, Trenggalek district. Methods: Female Culex mosquitoes were collected in Salamwates village at night using the methods of indoor human-baited double bed-net trap and outdoor cow-baited double bed-net trap. The spesies of collected Culex mosquitoes were identified based on identification guide published by Ministry of Health of Republic Indonesia. Results: There were 67 identifiable female mosquitoes collected using cow-baited methods and no female mosquitoes collected using human-baited methods. Those mosquitoes consisted of nine species. Culex tritaeniorhynchus (29.85%), C. gelidus (23.88%), C. vishnui (13.43%), C. pseudovishnui (11.94%) were the dominant species. The peaks of biting activities were at 18.45-19.00 and 23.45-24.00.  Conclusion: Nine species of Culex mosquitoes collected using cow-baited methods. C. tritaeniorhynchus was the dominant species. Those mosquitoes were zoophilic and exophagic. The peaks of biting activities of the Culex mosquitoes were at dusk and midnight.

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