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Biomolecular and Health Science Journal

BHSJ
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Published by Universitas Airlangga

ISSN : - EISSN : 26208636 DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

Bimolecular and Health Science Journal (BHSJ) is a scientific peer-reviewed medical doctor which relevant to a medical doctor and other health-related professions by the Faculty of Medicine Universitas Airlangga, Indonesia. BHSJ provides a forum for original article, review article, editorial, case report(s), letter(s) to the editor, short communication and it will be published two times a year. Studies that focus on evaluating and understanding the complex medical importance are welcomed in BHSJ.

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Articles 140 Documents

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Demographic Profile, Clinical and Analysis of Osteoarthritis Patients in Surabaya Ilham Wildan Ahmad; Lita Diah Rahmawati; Teddy Heri Wardhana
Biomolecular and Health Science Journal Vol. 1 No. 1 (2018): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: Osteoarthritis is a degenerative joint disease which affects joint cartilage. As many as 80% patients movement are limited and 25% of them can not even perform daily activities. Osteoarthritis is one of the ten most disabling diseases in developed countries. Due to its chronic and progressive nature, socio-economic impacts in many developed and developing countries are enormous. The purpose of this study is to determine the profile of patients with osteoarthritis in the Orthopedic Department of RSUD Dr. Soetomo Surabaya (Dr. Soetomo General Hospital)Method: This is descriptive observasional research. Questionnaires data were obtained from all patients in the Department of Trauma and Orthopedic of RSUD Dr. Soetomo Surabaya during September 1, 2016 until October 31, 2016. Thirty five subjects with osteoarthritis were analyzed for the study. The variables observed in the patient profile include sex, age, body mass index, type of osteoarthritis, Kellgren-Lawrence scoring system, and knee osteoarthritis severity index.Result: The result shows that 43% of the samples were aged 60-69 years, 83% of the samples were female, 37% of the samples had an I BMI obesity, 60% of samples had bilateral osteoarthritis, and 77% of samples from primary osteoarthritis. A total of 15 of 53 knee samples had class III, and 15 of 53 knee samples also had class I, and as many as 21 of the 35 samples had a "very severe" clinical gradation. These results may be due to patients who have low grade gradation clinics and have received medical attention at the level I health facility or II.Conclusion: From the results of this study, it can be concluded that age, sex, BMI, Kellgren-Lawrence assessment system, index severity of patients Lequesne osteoarthritis in RSUD Dr. Soetomo Surabaya is in conformity with research that has been done in many places and theories that exist.Keywords: Knee osteoarthritis, age, gender, Kellgren-Lawrnce scoring system, knee osteoarthritis severity index

LDL Level in Ischaemic Stroke Patients at Dr. Soetomo General Hospital Surabaya Mayori Rachmawati; Paulus Sugianto; Rr. Indrayuni Lukitra Wardhani
Biomolecular and Health Science Journal Vol. 2 No. 1 (2019): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: Stroke is one of the top killers amongst the non-infectious diseases. Ischemic stroke dominates the rate by 87.0% amongst all type of strokes. One of the risk factors for stroke ischemic stroke is atherosclerosis which caused by lipid build-up in the arteries.Methods: This research is a retrospective study on secondary data. Admitted Ischaemic stroke patients. Lipid profile, and Barthel Index were collected from medical record and presented descriptively.Results: Of the 248 patients, 144 (58.1%) were men, mean age was 59.33. 61.7% ischemic stroke patients have their LDL level elevated, 59.7% HDL decreased, 39.1% total cholesterol elevated, and 33.9% TG elevated. This study also observe the dependency based on Barthel Index of the admitted stroke patients. 75% percents amongst subjects were categorized as “total dependece” are having their LDL level elevated.Conclusion: Most of stroke patients have elevated LDL and HDL while the TG and total cholesterol are mostly optimized. Stroke patients whose admitted with “total dependence” most likely to have elevated LDL in this study.

Correlation Between Nutritional Status of Pregnant Women Based on Upper Arm Circumference and Preeclampsia/Eclampsia Severity Degree at Jagir Public Health Center During January 2014 - March 2014 Dian Nirmala Aprilia; Budi Prasetyo; Sulistiawati Sulistiawati
Biomolecular and Health Science Journal Vol. 1 No. 2 (2018): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: Preeclampsia/eclampsia is one of the causes of maternal mortality besides bleeding and infection. The exact etiology of this condition is still unknown. Nutritional status of pregnant women who are overweight can increase the risk. This study aims to determine the correlation between obesity and the severity of preeclampsia/eclampsia through upper arm circumference (UAC) measurement.Methods: This study is a cross-sectional analytic study. Data on preeclampsia/eclampsia and UAC obtained from patient medical records in Jagir Public Health Center Surabaya. Data were analyzed using Chi-square test.Results: Prevalence of mild preeclampsia was greater than severe preeclampsia (87.5% and 12.5%). The majority of patients with mild preeclampsia have normal UAC size (91.3%). Severe preeclampsia found higher in obesity group than normal nutritional status group (22.2% and 9.1%). From Chi-square test analysis, found that p = 0.557.Conclusion: There was no significant correlation between the nutritional status of pregnant women based on UAC measurement of and the severity of preeclampsia/eclampsia.

The Relationship Between Galen’s Personality Type Theory and Emotional Intelligence Level Olyvia Sita Aldisa Thadea; Suhartono Taat Putra; I Gusti Ngurah Gunadi Sindhu Putra
Biomolecular and Health Science Journal Vol. 1 No. 2 (2018): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: Personality is a behavior and mindset pattern that is typical for each person in responding to every event or stimulus in his environment. Galen's theory has classified personality types into four types they are Sanguinis, Choleric, Melancholy, and Plegmatis. The level of emotional intelligence shows a person's ability to deal with demands and pressures to achieve their best in thinking and behaving appropriately. This study aims to prove the relationship between personality types based on Galen's theory with emotional intelligence level in preclinical medical students.Methods: This study is a comparative study using an online questionnaire instrument on emotional intelligence and personality type tests compiled by Florence Littauer. This research variables are the emotional intelligence level and personality type. This study used data from 100 respondents, then data was analyzed using Chi Square test.Results: From 100 respondents, dominant personality type is Sanguinis 35%, followed by Choleric 13%, Melancholy 27%, and Plegmatis 25%. There were no respondent who showed a low level of emotional intelligence in this study. 64% of respondents have a high level of emotional intelligence, while the remaining 36% have a moderate level. Chi Square test shows p value is 0.032.Conclusion: There is a relationship between personality types based on Galen's theory with emotional intelligence level on medical students in Faculty of Medicine, Universitas Airlangga.

The Effect of Antenatal Corticosteroid Therapy to Respiratory Distress Syndrome Event on Preterm Infants in Surabaya Devy Putri Zenita; Martono Tri Utomo; Ernawati Darmawan
Biomolecular and Health Science Journal Vol. 1 No. 1 (2018): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

ABSTARCTIntroductions: One of the most common cause of morbidity and mortality in premature infants is respiratory distress syndrome (RDS). Several studies have shown that a single dose administration of antenatal corticosteroid therapy in women who are at high risk for premature delivery was associated with decreased incidence of RDS. The study aims to determine the effect of antenatal corticosteroid therapy on the incidence of RDS in prematurity in the Department of Child Health Hospital Dr. Soetomo.Methods: Analytic observational case-control design study was used for this research. Samples were taken from the medical records of RDS patients in premature baby and non-RDS with 36 samples in each group.Results: Antenatal corticosteroid therapy has effect in RDS incidence (p = 0.016). While the results of the odds ratio was 0.298 (with 95% CI 0.110 to 0.810), it means that premature infants with antenatal corticosteroid therapy has 0.298 times lower risk than those who were not given antenatal corticosteroid therapy.Conclusion: Antenatal corticosteroid therapy did not provide a direct relathionship to the incidence of respiratory distress syndrome in premature infants, but it a protective factor that can reduce the incidence of RDS in prematurity.

Combination Effect of The Extract of Avocado Leaf and Seed (Persea americana) on Level of Total Cholesterol, LDL, and HDL in Mice (Mus musculus) with Hypercholesterolemia Muhammad Rafif Alfian Dita; Indri Safitri Mukono; Maftuchah Rochmanti
Biomolecular and Health Science Journal Vol. 2 No. 1 (2019): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: Traditional and herbal medicine are two of the primary treatments in a developing country. Both avocado leaf extract and avocado seed extract (Persea americana) have been proven to have an antihyperlipidemic effect in experimental animals. This study was conducted to analyze the effect of avocado leaf and seed extract in a combination form on total cholesterol, LDL, and HDL of hypercholesterolemia mice induced by high fat diet and duck egg yolk.Methods: The sample unit of this study consisted of 25 mice (Mus musculus) and divided into 5 groups: KO1 (control), KO2 (hypercholesterolemia group), KO3 (1st treatment group), KO4 (2nd treatment group), and KO5 (3rd treatment group). The induction phase was done for 35 days, whilst the treatment phase was done for 28 days. All data were analyzed using t test and one-way ANOVA.Results: Administration of the combination including avocado leaf and seed extract (CALSE) in all treatment group proved to decrease total cholesterol and LDL level in mice although it was not statistically significant (p=0,420; p=0,882). Meanwhile, CALSE had a different effect on HDL KO3 level with HDL KO4 and KO5 level, in which HDL KO3 level tended to decrease and HDL KO4 and KO5 level tended to increase.Conclusion: In conclusion, CALSE has the potential to act as an antihyperlipidemic agent which derive from flavonoid and saponin. The potential efficacy might be achieved in a combination rather than in an individual form.

Frequency of Metabolic Syndrome on Diabetes Mellitus Patients in Surabaya Dyah Peni Puspitasari; Budi Widodo; Jongky Hendro Prayitno
Biomolecular and Health Science Journal Vol. 1 No. 1 (2018): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: Metabolic syndrome is a syndrome characterized by central obesity, high blood glucose or impaired glucose tolerance, dyslipidemia, and high blood pressure. Nearly 70% to 80% of Diabetes melitus (DM) population was diagnosed with metabolic syndrome. We aimed to present the data of frequency of metabolic syndrome in patients with DM for a basis of future research.Methods: This is a descriptive study design on DM patients based on NCEP ATP III criteria. The data was collected from direct measurements and laboratory results of all DM patients: waist circumference, weight, height, and blood pressure of the subjects, triglyceride status (TG), high-density lipoprotein cholesterol (HDL-C) status, and fasting blood glucose status.Results: From 77 DM patients, results were obtained in this study were 69 (89.61%) patients with DM-metabolic syndrome (DM-MetS) and 8 (10.39%) patients with DM-non-metabolic syndrome. From 69 patients with DM-MetS, 52 (75.36%) were female and 17 (24.64%) were male.Conclusion: A total of 69 (89.61%) patients with T2DM were diagnosed as metabolic syndrome.

Correlation Between Children’s Temperament and Risk Factor of Attention Deficit/Hyperactivity Disodrer in Elementary School Cheifia Krissanti Sasono; Yunias Setiawati; Irwanto Irwanto
Biomolecular and Health Science Journal Vol. 2 No. 1 (2019): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: The main symptoms of Attention-Deficit/Hyperactivity Disorder (ADHD) are hyperactivity, impulsivity, and inattention. While temperament in children with ADHD is described as high in negative reactivity, low task persistence, high activity, low attentional focusing, high impulsivity and low inhibitory control. This study aims to analyze the correlation between children’s temperament and risk factor of ADHD.Methods: This study used cross-sectional design with Abbreviated Conners’ Rating Scale and Temperament in Middle Childhood questionnaire for instrument. All data are analyzed using Pearson correlation.Results: Prevalence of children with risks of ADHD from total subject was 21/114 students (18,4%, consisted of 18 males (81%) and 3 females (19%) with average age was 10 years old. The majority of participants were in the sixth grade (28.6%). There was a positive and weak correlation between surgency and ADHD symptoms (3,05 ± 0,75, p=0,045; r=0,44).Conclusion: There was no significant correlation between the negative affect and effortful control dimensions of temperament with severity of ADHD, however this study found a positive and weak correlation between surgency and risk factor of ADHD.

Profile of Cerebral Palsy Patients in Dr. Soetomo General Hospital Surabaya, Indonesia Qorina Nadya Salfi; Darto Saharso; Atika Atika
Biomolecular and Health Science Journal Vol. 2 No. 1 (2019): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: Limited profile data of Cerebral Palsy (CP) patients in Indonesia leads CP to be a less-known disease. The aim of this study is to describe CP patient’s characteristics, including demographic aspect, gestation and birth history, and CP related condition in Dr. Soetomo General Hospital Surabaya, Indonesia.Methods: Cross-sectional study using medical records of CP patients in Dr. Soetomo General Hospital (Surabaya, Indonesia) Outpatient Installation for Pediatric Neurology from January 2016 to June 2018. Data processed descriptively.Results: From total 107 patients, 50 subjects met inclusion criteria. Mean age was 6.16 years old, with domination of male (3:2), live in Surabaya (56%), malnourished (24%), normal birth weight (80.9%), term age of birth (66.7%), spontaneous labor (60%), and also prenatal events as causes of Cerebral Palsy (69.5%). Pneumonia was found to be most among postnatal events leading to Cerebral Palsy (30%). Most of the type was spastic (9:1) with quadriplegic as the dominating one (64%). Congenital malformation was rarely found (38%), but co-morbidities were found in almost all sample (92%).Conclusion: Gestation and birth history of CP patients are mostly ranged normal. Prenatal etiology is found dominating as the cause of CP, therefore emendation in antenatal care (ANC) shall be considered. Analytical study about CP in Indonesia also must be improved because it is still hardly found.

Association between Serum Magnesium Level with Acute Coronary Syndrome (ACS) in Diabetes Mellitus (DM) Patients Ratih Wulansari; Soebagijo Adi Soelistijo; Achmad Lefi
Biomolecular and Health Science Journal Vol. 2 No. 2 (2019): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: Until now, cardiovascular complications are still the highest cause of death and disability in DM patients. Hypomagnesemia in DM accelerate atherosclerosis and can cause instability and plaque rupture which can lead to acute coronary syndrome.Methods: Design of this study was observational analytic using a "case control" study involved 76 samples of DM patients, consisting of 38 samples with SKA (+) and 38 samples with SKA (-). Subjects of this study were all DM patients in the period July-December 2018 in the Emergency Room (ER) and Outpatient Installation of Endocrine at the RSUD Dr. Soetomo Surabaya, which fulfills the criteria for inclusion and exclusion. Demographic data and clinical characteristics are presented descriptively. If data is normally distributed then an unpaired t test is carried out and if the data is not normally, distributed with Mann Whitney test is performed. The statistical test was stated to be significant if p <0.05. The association between hypomagnesemia and the incidence of ACS a multivariate logistic regression test was performed, the risk number was in the form of odds ratios (OR). Results: This study involved 76 subjects with diabetes mellitus with SKA and non SKA 38 subjects. The mean serum magnesium level in the ACS group was lower than non ACS (1.9 mg / dL vs. 2.1 mg / dL), hypomagnesemia cut-off of <2.08 mg / dL. In this study hypomagnesemia as a risk factor for the incidence of ACS in DM patients with OR 2.8 (CI 1.1-7.6; p = 0.039).Conclusion: Magnesium levels in the ACS group were lower than the non ACS group. Hypomagnesemia Increase The Incidence of Acute Coronary Syndrome in Diabetes Mellitus Patients.

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Contact Name Muhammad Miftahussurur

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Muhammad Miftahussurur

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bhsj@journal.unair.ac.id

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Journal Mail Official
bhsj@journal.unair.ac.id

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Location
Kota surabaya,

Jawa timur

INDONESIA