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Biomolecular and Health Science Journal

BHSJ
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Published by Universitas Airlangga

ISSN : - EISSN : 26208636 DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

Bimolecular and Health Science Journal (BHSJ) is a scientific peer-reviewed medical doctor which relevant to a medical doctor and other health-related professions by the Faculty of Medicine Universitas Airlangga, Indonesia. BHSJ provides a forum for original article, review article, editorial, case report(s), letter(s) to the editor, short communication and it will be published two times a year. Studies that focus on evaluating and understanding the complex medical importance are welcomed in BHSJ.

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Articles 140 Documents

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The Effect of Antioxidant Vitamin C and E Administration on Spermatozoa Quality of White Rat (Rattus Norvegicus) Strain Wistar Male Against Allethrin Exposure Faisal Yusuf Ashari; Rina Yudiwati; R.Haryanto Aswin
Biomolecular and Health Science Journal Vol. 1 No. 2 (2018): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: Allethrin is an active ingredient used in anti-mosquito drugs. Allethrin enters the body through inhalation, allegedly can disrupt the quality of spermatozoa by decreasing its amount, motility, viability and morphology. Many studies suggested that with sufficient intake of vitamin C and E would be able to minimize free radicals caused by allethrin. This study aims to investigate the effect of giving antioxidant vitamin C and E on spermatozoa quality of white rat (Rattus norvegicus) strain Wistar male with allethrin exposure.Methods: This research was a post-test design randomized control group design using Rattus novergicus male strains Wistar exposed to allethrin (LPB IPB veterinary stem cell). A total of 16 white rat strains Wistar male divided into 4 groups, one control group (without any treatment) and 3 treatment groups (given antioxidant vitamin C, vitamin E and both). The exposure of mosquito coils was performed 8 hours per day for 45 days and on the 46th day, spermatozoa was observed. The data were analyzed using ANOVA one way and BNT.Results: The results showed that treatment with vitamins affected the amount, motility and viability of rat spermatozoa exposed to allethrin. The mean amount of control group spermatozoa and treatment was 14,93, the mean spermatozoa motility control and treatment groups were 45,13 and the mean spermatozoa viability of control and treatment groups was 58,88. This is shown by the real difference between the control group and the treatment (p <0,05). Similarly, in the control group found morphological abnormalities.Conclusion: Exposure of mosquito coils 8 hours/day for 45 days decreased the spermatozoa quality. Overall, the admission of antioxidant vitamin C and E are able to maintain the quality of spermatozoa instead of one type of vitamin.

Hematemesis on Hepatic Cirrhosis Patients in Area with Limited Facilities Yudha Klahan; Firas Farisi Alkaff
Biomolecular and Health Science Journal Vol. 1 No. 1 (2018): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Esophageal variceal haemorrhage is one of the more dangerous complications of hepatic cirrhosis. Initial treatment can determine patient mortality and morbidity. But not all hospitals have adequate facilities and medicines to handle it. The 53-year-old woman came with a diagnosis of ascites and hematemesis. At the initial examination found hypotension. Laboratory results show anemia, thrombocytopenia, and leukocytosis. The next morning the patient's condition worsened and was transferred to ICU. During the ICU patients receive 10 lpm oxygen support, cefobactam, pantoprazole, PRC transfusion, and dopamine. Patients begin conscious on the 5th day of treatment. Then the patient started getting diuretics on day 6 and propranolol on day 9. On day 13 the patient's condition improved and the patient was discharged for outpatient treatment. Limitations of the endoscopic tool cause not every hospital in Indonesia can perform emergency endoscopy for therapy. However, with rapid and appropriate pharmacological therapy, patients can be helped not to fall into mortality and prevent recurrent bleeding.

Infant Birth Weight in Mothers with Maternal Anemia at Dupak Public Health Center Surabaya Working Area in 2017 Marisabell Giovanni; Gwenny Ichsan Prabowo; Widati Fatmaningrum
Biomolecular and Health Science Journal Vol. 2 No. 1 (2019): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: Anemia in pregnant women is a factor that directly affects the incidence of LBW and can be measured to determine nutritional status during pregnancy. This research is to determine the association of infant birth weight in mothers with maternal anemia at Public Health Center working area in Surabaya.Methods: This research was a cross-sectional approach The sample of this research were 75 pregnant women at Dupak Public Health Center in Surabaya City in 2017 taken by total sampling technique. The data used was taken from the 2017 mother cohort book.Results: The incidence of LBW at Dupak Public Health Center Surabaya working area in 2017 was 12 people (16%). The incidence of anemia at Dupak Public Health Center Surabaya working area in 2017 was 38 people (50.7%). The correlation between LBW and anemia in pregnancy using Chi-Square was p = 0.496.Conclusion: There was no correlation between maternal anemia and LBW There are other factors that can affect the incidence of LBW, such as body weight and maternal height, the number of parity, a short pregnancy distance, and the existence of problems in the history of previous pregnancy and childbirth.

Risk Factors for Urinary Tract Infection in Hospitalized Patients Hadiati Setyorini; Nunuk Mardiana; Artaria Tjempakasari
Biomolecular and Health Science Journal Vol. 2 No. 1 (2019): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: Urinary tract infection (UTI) is the most common infection that can be fatal and has higher rate mortality especially in some patient. This study is aim to analyze risk factors for urinary tract infection in hospitalized patients for prevention and more aggressive approach can be taken.Methods: Consecutively, medical records of 285 patients with urinary analysis was recorded for risk factors and urine culture results if suspected UTI. Risk factors for sex, age, urinary catheter, urolithiasis, DM, and immobilization was analyzed with bivariate analysis and multivariate analysis.Results: From 285 patients, 92 patients had UTI with average age was 52.45 years old, 48 (56.49%) were female. Most common pathogen were E. coli (41.3%), Enterobacter sp. (8.8%) and Enterococcus faecalis (7.6 %). From bivariate analysis, geriatric age (>60 years) has RR 1.421 (95% CI 1.015-1.989, p=0.046) and immobilization has RR 1.861 (95% CI 1.266-2.738, p=0.007), whereas sex (RR 1.190 95% CI 0.851 – 1.664, p=0.310), diabetes (RR 1.171 95% CI 0.833 – 1.645, p=0.367), insulin usage (RR 0.900 95% CI 0.519 – 1.561, p= 0.703), glycosuria (RR 1.152 95% CI 0.741 – 1.791, p=0.522), and CKD (RR 1.475 95% CI 0.896 – 2.430, p= 0.126) give insignificant result. From multivariate analysis, urinary catheter has OR 4.506 (95% CI 2.312-8.872, p=0.000), urolithiasis with OR 4.970 (95% CI 1.931-12.787, p=0.001), and hyperglycemia has OR 2.871 (95% CI 1.485-5.551, p=0.002).Conclusion: Geriatric age and immobilization are risk factors for urinary tract infection, and urinary catheter, urolithiasis, and hyperglycemia are independent risk factors for urinary tract infection.

Salmonella sp. Detection in Elementary School Street Foods in Surabaya Adelia Anggasta Adzhani; Marijam Purwanta; Ivan Rahmatullah
Biomolecular and Health Science Journal Vol. 1 No. 2 (2018): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: Street foods are food and drink which are processed on the selling spot and/or served as ready-to-consume foods by food vendors to sell to people. Foods and drinks which are rested for too long in the environment will make it possible to get contaminated by pathogen microbes and then results in disease. One of the microbes that is considerably contaminating street foods is Salmonella. We aim to identify Salmonella on drink which are offered in the canteens of Public Elementary School.Methods: This research is design as a descriptive observational, including incubation in Selenite broth, streak in MacConkey agar, and species identification using biochemical tests.Results: There were no Salmonella sp. in drinks sample of street foods which are offered both inside and outside the canteens of Public Elementary School 1 Surabaya, but other gram-negative bacteria contaminated foods.Conclusion: The street foods in elementary school, both the main ingredients and tools used during food processing and serving, still have contamination from pathogen, especially gram-negative bacteria. The vendors and sellers need to be taught how to process and serve foods in better hygiene.

Altered Ghrelin Secretion Pattern and Sense of Hunger by Providing Low and High Density Breakfast in Obese Female Adolescents Ni Luh Putu Ayu Putrisari Putri; Elyana Asnar; Purwo Sri Rejeki
Biomolecular and Health Science Journal Vol. 1 No. 1 (2018): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: Ghrelin has been recognized to have a major influence on energy balance. Hence, the discovery of various regulatory factors that control ghrelin secretion may have major implications for the development of drugs and diet control. This study aims to analyze differences in ghrelin secretion pattern and prevention of hunger in the provision of breakfast in low-calorie breakfast, low energy density and high energy density in obese female adolescents.Methods: Subjects were female students aged 18-22 years with a BMI=25 kg/m², receiving low-calorie breakfast with low (n=8) and high energy density (n=8). Before the breakfast, subjects fasted for 12 hours and were subjected to plasma ghrelin level and hunger measurement using visual analog scale (VAS). Breakfast was done at 08.00, divided into three parts and each was taken for 5 minutes. Measurement of plasma ghrelin was carried out again post prandial (PP) at 2 hours and 4 hours. VAS filling was done 1 hour PP, 2 hours PP, 3 hours PP, and 4 hours PP.Result: There were differences in plasma ghrelin level, but not significant. VAS 1 analysis of hunger (p=0.040) at 4 hours PP and VAS 3 of satiety (p=0.025) was significantly different at 3 hours PP. Conclusion: Food density did not affect the plasma ghrelin levels. Low density foods are more effective to prevent hunger in 4 hours PP and increases satiety in 3 hours PP.

Effects of Climatic Factors on The Incidence Rate of Dengue Virus Infection in Surabaya During 2010-2013 Winni Aprillia Putri; Abu Rohiman; Sulistiawati Sulistiawati; Dwiyanti Puspitasari
Biomolecular and Health Science Journal Vol. 2 No. 1 (2019): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: Dengue Virus Infection (DVI) is one of cautious mosquito-borne virus disease that transmitted by Aedes aegypti and Aedes albopictus. Surabaya has the highest incidence rate of DVI in East Java. Transmission of dengue virus were significantly affected by the change of climatic factor components (precipitation, temperature, and humidity). This study is aimed to analyze the correlation between climatic factor components with the incidence rate of DVI in Surabaya and its distribution.Methods: This is a cross-sectional study using analytic observational approach. The Incidence rate of DVI during 2010-2013 datas were taken from Surabaya Health Office. Climatic factor datas on the same years were taken from Juanda Meteorological Station. Correlation tests were performed by using Spearman Test.Results: As the result, there were 7,685 DVI patients during 2010-2013. Male patients have less proportion (51.89%). The highest DVI cases are from the age group of 5-14 years (>40%). Incidence rate of DVI was increased during February to April, and highest incidence rate occured in 2010 (n=3,379). There were significant correlation between precipitation (r=0.419, p-value p=0.003) and humidity (r=0.502, p-value=0.000) with the incidence rate of DVI in Surabaya during 2010-2013.Conclusion: Therefore, precipitation and humidity are two climatic factor components that may effect the incidence rate of DVI in Surabaya.

The Effects of High-fat Diet on Histological Changes of Kidneys in Rats Hotimah Masdan Salim; Lintan Farizqi Kurnia; Tri Wahyu Bintarti; Handayani Handayani
Biomolecular and Health Science Journal Vol. 1 No. 2 (2018): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction Hypercholesterolemia contributes as a risk factor for endothelial dysfunction in the kidneys and worsens the condition of patients with previous kidney damage. This study aimed to examine the effect of hypercholesterol diet in kidney structure.Methods: This was an experimental study, a case control using eight-week-old Rattus novergicus, divided into control and treatment group. High-fat diet (HFD) was administrated orally to treatment group for 14 days. All data statistically analyzed with two-paired ANOVA and post hoc for comparison.Results: Histological analysis using hematoxylin-eosin staining showed degeneration in nephrons, including glomerulosclerosis, segmental necrosis and tubular defects. The mononuclear cell infiltration was Increased in HFD group significantly (P<0.05).Conclusion: We concluded that a high fat diet induced obesity and may lead to renal deformities as a result of histopathological changes such as dilatation, tubular defects, inflammation and connective tissue enlargement of the kidney.

The Effect of Hypertension on Hearing Sense A.C Romdhoni
Biomolecular and Health Science Journal Vol. 1 No. 1 (2018): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Hypertension is an important health problem because it has a high prevalence and can cause damage to target organs. The relationship between hypertension and hearing loss is not difficult to understand, when blood pressure becomes high blood vessel damage occurs. Hearing loss cases caused by hypertension are considerable, in America 64 million people aged 18 to 75 years suffer from hypertension, 40% with hearing loss. This damage is not centered on one area of the body, but the whole body is also affected, including the ears. The incidence of hearing loss in hypertension is due to the occurrence of inner ear damage due to high pressure in the vascular system, changes in microcirculation and the occurrence of ionic changes.

Epidemiological Study of Clinical and Laboratory Profiles of Patients with Acute Lymphoblastic Leukemia at Dr. Soetomo Hospital Surabaya Kezia Warokka Putri; I Dewa Gede Ugrasena; Yetti Hernaningsih
Biomolecular and Health Science Journal Vol. 2 No. 1 (2019): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: Considering the high number of acute lymphoblastic leukemia (ALL) and it being the type of cancer with the highest fatality rate among the children, this study seeks to determine the epidemiological description of the clinical and laboratory profiles of patients with ALL.Methods: This research used a descriptive study by using medical data record of patients with ALL. The research variables were gender, age, leukemia history of the patient’s family, nutritional status, symptoms and signs, laboratory examination, ALL subtypes, risk factors, and result outcomes. All data presented descriptively.Results: From a total of 50 patients, 54 % of them were male aged 1,5 – 10 years old. 84% of the patients’ family had no medical record related to leukemia. 42% of the patient malnutrition. Pale (78%), fever (64%), pain (32%), hepatomegaly (38%), lymphadenopathy (28%), splenomegaly (26%), patients with anemia (82%), leukocytosis (38%), thrombocytopenia (54%). The highest types were ALL–LI (68%), SR-ALL (54%), and remission outcome reached 82%.Conclusion: Insidence higher in male, aged 1,5 – 10 years old, malnourished at the start of the diagnosis. Most of the patients’ family had no medical history of leukemia. Symptoms and medical signs mostly appeared were pale, fever, and bone/joint pain. The physical examination showed hepatomegaly, lymphadenopathy, and splenomegaly and laboratory first test showed the patients had anemia, leukocytosis, and thrombocytopenia.

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Home Page

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Contact Name Muhammad Miftahussurur

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Journal Mail Official bhsj@journal.unair.ac.id

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Location Kota surabaya, Jawa timur INDONESIA

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Contact Name
Muhammad Miftahussurur

Contact Email
bhsj@journal.unair.ac.id

Phone
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Journal Mail Official
bhsj@journal.unair.ac.id

Editorial Address
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Location
Kota surabaya,

Jawa timur

INDONESIA