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Biomolecular and Health Science Journal

BHSJ
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Published by Universitas Airlangga

ISSN : - EISSN : 26208636 DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

Bimolecular and Health Science Journal (BHSJ) is a scientific peer-reviewed medical doctor which relevant to a medical doctor and other health-related professions by the Faculty of Medicine Universitas Airlangga, Indonesia. BHSJ provides a forum for original article, review article, editorial, case report(s), letter(s) to the editor, short communication and it will be published two times a year. Studies that focus on evaluating and understanding the complex medical importance are welcomed in BHSJ.

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Articles 140 Documents

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Characteristic of Hemophilia A Patients in Initial Diagnosis in Dr. Soetomo General Hospital Surabaya Angela Dinaria Kemala Swary; Mia Ratwita Andarsini; Arifoel Hajat
Biomolecular and Health Science Journal Vol. 2 No. 1 (2019): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: This research is conducted to describe the characteristic of Hemophilia A patients.Methods: Cross-sectional study conducted in 55 patients with Hemophilia A. The variables were age, bleeding episode, factor VIII level, and bleeding site. The data presented descriptively.Results: The largest group was 2-10 years old (52,73%). The most common bleeding episode occured in the patients was moderate level (60,0%). The most common patient’s factor VIII level was moderate level (52,7%). The patient’s bleeding most likely took place in muscle or known as hematoma (41,8%). While the less likely bleeding were intracranial and nose bleeding.Conclusion: 2-10 years old patient are the largest group because of hemophilia A mostly diagnosed in childhood, where children are actively moved so that the spontaneous bleeding or abnormal bleeding can be seen easily. Parents needs to be aware if there were abnormal or spontaneous bleeding which takes place in muscle or known as hematoma with moderate episode of bleeding which meant that the occurrence of spontaneous bleeding is periodically happened or in prolonged bleeding accompanied by minor trauma or invasive action.

CHOP and R-CHOP Therapeutic Responses in Non-Hodgkin Lymphoma Patients in Dr. Soetomo General Hospital Surabaya Rina Syarifah Salma; Made Putra Sedana; S. Ugroseno Yudho
Biomolecular and Health Science Journal Vol. 1 No. 2 (2018): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: Non-Hodgkin Lymphoma (NHL) is a group of lymphoid-derived malignant disease with heterogenic biological and clinical manifestations. For over 30 years, CHOP (Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone) has been the first choice of chemotherapy for aggressive NHL. Later in 1997 Rituximab as anti-CD20 monoclonal antibody was introduced and then combined with CHOP as R-CHOP. The objective of this study is to acknowledge the response of the CHOP and R-CHOP therapy in Non-Hodgkin Lymphoma patients at Dr. Soetomo General Hospital.Methods: The design of this study was retrospective observational study using secondary data obtained from patient’s medical records from 2011 to 2015. The data selected from the medical records are the result of the therapy, as well as patient’s gender and age. Results: The results of patients’ therapy were classified into four categories: The study showed that 51.28% patients had Complete Response, followed by Partial Response (28.21%), Progressive Disease (17.95%), and No Change (2.56%). Sample characteristics showed male patients in higher percentage (66.67%), and the majority of patients’ age between 51-60 years old (30.77%). The use of CHOP and R-CHOP regiment were 76.92% and 20,52% respectively.Conclusion: Most of the patients had a complete response. The CHOP regiment is more commonly used in patients compared to R-CHOP.

Role of Bariatric Surgery for Reducing Glycated Hemoglobin (Hba1c) in Type 2 Diabetes Mellitus Compared to Current Medicaments Therapy Firas Farisi Alkaff; Ricardo Adrian Nugraha; Michael Jonatan; Sulistia wati
Biomolecular and Health Science Journal Vol. 1 No. 1 (2018): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: Type II is the most common type of Diabetes Mellitus, and one of the most common non-communicable diseases globally. In Indonesia, diabetes contributes to 6% of total deaths. Current medicaments therapy available can only control the disease, not to cure it. Recently, there has been new treatment that has been recommended into standard care for type II Diabetes Mellitus. It was in September 2015 at the second Diabetes Surgery Summit that the introduction of bariatric surgery has been put into standard care for type II Diabetes Mellitus.Objective: To draw a comparison of the effectiveness between bariatric surgery and current medicaments therapy in reducing HbA1c to achieve remission.Methods: Literature study was conducted to identify relevant literature showing comparison study between bariatric surgery and medicaments therapy, and comparison study between types of bariatric surgery. 16 Studies are included in this article from 230 studies found.Results: HbA1c remission in bariatric surgery is significantly higher than medicaments therapy in all studies, ranging from 66.7% vs 0% to 57.1% vs 9.5% during 6-24 months after therapy. Between all types of bariatric surgery, most of the studies shows that Roux-en-Y Gastric Bypass achieves HbA1c remission higher than other types of surgery.Conclusion: Bariatric surgery is better than current medicaments therapy in achieving HbA1c remission.

Comparison of High-sensitivity C-reactive Protein Level between Chronic Kidney Disease Stages Mochammad Thaha; Tri Asih Imroati; Aditia Wardana; Widodo Widodo; Pranawa Pranawa; chandra irwanadi
Biomolecular and Health Science Journal Vol. 1 No. 1 (2018): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

ABSTRACTAim : This research is to evaluate the hs-CRP level comparison between CKD stages in Dr. Soetomo General Hospital Surabaya.Methods: An analytic observational cross-sectional study, evaluating the differences of hs-CRP level between CKD stages in 72 patients (mean age 55.49±7.62 years, the ratio between male:female was 1:1.48, mean BMI 24.18±3.64 kg/m2, 36.11% diabetics, 43.05% on ACEI/ARB, 29.16% on statin), recruited from Nephrology Outpatient Clinic, Dr Soetomo General Hospital, Surabaya, from January to May 2014. The stages were stratified according to the MDRD formula.Results: The mean hs-CRP of CKD stage 3 was 2.29±2.86, stage 4 was 2.48 ± 2.19, and non-dialysis stage 5 was 2.09 ± 2.54. The analysis using Kruskal-Wallis test showed no significant differences among patients with CKD stage 3, stage 4, and non-dialysis stage 5 (median 1.25 vs 1.80 vs 1.05 mg/L; p=0.430). No significant differences of the serum hs-CRP level were detected between diabetics and non diabetics in stage 3, 4, and non-dialysis stage 5 (p=0.673 vs 0.666 vs 0.138); between patients with and without ACEI/ARB treatment (p=0.610 vs 0.649 vs 0.671); and between patients with and without statin treatment (p=0.852 vs 0.341 vs 0.309).Conclusion: The elevation of serum hs-CRP level can not indicate the decline of kidney function, but it still needs further investigations.

Correlative Study Between Nutritional Status and Remission Outcome in Childhood Acute Lymphoblastic Leukemia in Dr. Soetomo General Hospital Surabaya Asma' Athifah; Siti Nurul Hidayati; Sulistiawati Sulistiawati
Biomolecular and Health Science Journal Vol. 2 No. 1 (2019): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: The most common malignancy that is diagnosed in children is acute lymphoblastic leukemia. Undernourished children tend to have poorer long term survival. This descriptive analytic study is aimed towards analyzing the correlation between nutritional status at diagnosis and outcomes of induction phase therapy in childhood acute lymphoblastic leukemia at the Department of Pediatrics Dr. Soetomo General Hospital Surabaya in 2014.Methods: A cross-sectional method using the medical records of patients is used in this study. The nutritional statuses of patients are calculated using weight for length/height trough curves of WHO 2006 or CDC 2000.Results: The results show that from 45 children diagnosed with ALL, 53% are of the age ≤ 5 years old, with 58% males and 42% females. 13% of the patients are in the high risk group and 87% are in the standard risk group. Nutritional statuses of patients are 2% of them obese experienced remission after induction phase therapy, 56% normal with 80% of them experienced remission. 40% underweight with 89% of them experienced remission and 11% not experienced remission, 2% malnutrition and experienced remission. There is no correlation between the nutritional status of children with acute lymphoblastic leukemia with the outcome of induction phase (p = 0.798).Conclusion: In conclusion, there is no correlation between nutritional status and remission outcome of patients with ALL in the induction phase of therapy. However, high percentage of underweight patients shows nutrition needs special attention to improve therapy outcomes.

The Role of JAK2 in Myeloproliferative Diseases Diagnosis Yudith Annisa Ayu Rezkitha; S. Ugroseno Yudho Bintoro; Ami Ashariati
Biomolecular and Health Science Journal Vol. 1 No. 2 (2018): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Janus Kinase 2 (JAK2) plays an important role in mediating transduction signal of hematopoiesis, including in the pathogenesis of Myeloproliferative diseases (MPD). Various studies have been carried out to identify the position of aleles in tyrosine encoding mutations. Although the effect of JAK2 mutations is still not fully understood, the discovery of these mutations might be able to differentiate the types of polycythaemia vera, essential thrombocytemia, and primary myelofibrosis with malignant abnormalities. WHO has revised the MPD diagnosis criteria following this finding. This review will discuss the role of JAK2.

Keratosis Obturans Management A.C Romdhoni
Biomolecular and Health Science Journal Vol. 1 No. 1 (2018): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Keratosis obturans is a large accumulation of plaque from desquamated keratin distributed in the ear. The etiology of keratosis obturans remains unclear. Keratosis obturans generally occurs in young patients between the ages of 5-20 years and can attack one or both ears. Patients suffering from keratosis obturans and have a history of bronchiectasis or sinusitis reported 77% of adolescent cases, only 20% of adult cases. The diagnosis of keratosis obturance is made on the basis of anamnesis and clinical examination, while CT scan is performed to determine whether or not bone erosion is present. This disease can be controlled by performing clearance of the ear canal periodically every one to three months to reduce debris accumulation. Ear dropping of mixtures of alcohol or glycerin in 3% peroxide, three times a week can often be helpful.

The Role of Imaging In The Diagnosis of Pulmonary Embolism Alfian Nur Rosyid; M. Yamin; Arina Dery Puspitasari
Biomolecular and Health Science Journal Vol. 2 No. 1 (2019): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Pulmonary embolism is a common condition and sometimes can be life-threatening. A proper diagnosis can reduce mortality. Some examinations are needed to diagnose pulmonary embolism, including assessing the risk factors, clinical examination, D-dimer tests, and imaging. Imaging is necessary when the previous assessment requires further investigation. There are more imaging that can be used to diagnose and assess the severity of pulmonary embolism. However, it is still controversial regarding imaging modalities for optimizing pulmonary embolism diagnose. Chest X-Ray cannot exclude pulmonary embolism, but it is needed to guide the next examinations and to find alternative diagnoses. Pulmonary Multi-Detector CT Angiography is the gold standard to diagnose pulmonary embolism.

Characteristics of Patients with End-Stage Renal Disease at Dialysis Unit Dr. Soetomo General Hospital Surabaya Leny Silviana Farida; Muhammad Thaha; Dwi Susanti
Biomolecular and Health Science Journal Vol. 1 No. 2 (2018): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: The prevalence of end stage renal disease (ESRD) in Indonesia is increasing over the last decade. Most cases highest risk factor are Diabetes Mellitus (DM) and hypertension. Other factors such as lifestyle and environment; both play important role in the development of ESRD. Thus, this study aimed to assess the characteristic of patient with ESRD.Methods: This was a descriptive study acquired by interviewing 126 patients with ESRD who have been undergoing continuous hemodialysis in dialysis unit of Dr. Soetomo General Hospital Surabaya for at least 3 months using questionnaire about history of disease, smoking habit, sex, and ethnic group. All data was analyzed using frequency distribution and percentage.Results: Form 126 patients, consist of 61 male patients (48.4%) and 65 female (51.6%). 45 patients (35.7%) have the history of DM; 98 patients (77.0%) of hypertension; 35 patients (27.8%) of hypertension and DM; and 19 patients (15.1%) have none of them. Later age adult (36-45 years old) has the largest group proportion (34.13%). There are 36 patients (28%) who are smokers. 108 patients (85.7%) are Javanese.Conclusion: Most of the patients have hypertension as the risk factor and in later age group adult. Characteristics of patient with ESRD is caused by multifactorial factors. Therefore, patient with high risk factor should be aware and do preventive steps in progressiveness of the disease.

The Effect of Sapodilla Leaves (Achras Zapota) Infusum towards Mice (Mus Muculus) Diarrheal Activity Induced by Oleum Ricini Glabela Christiana Pandango; Ramadhani R. B; Irfiansyah Irwadi
Biomolecular and Health Science Journal Vol. 1 No. 1 (2018): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: Diarrhea is a significant health problem, especially in countries with low income. In many cases, diarrhea even can cause death. Treatment for diarrhea has been done both pharmacologically (including the usage of herbal remedies) and non-pharmacologically. Decoction of the sapodilla’s leaves is often used to treat diarrhea, but no studies directly demonstrates the effects of sapodilla’s leaves’ decoction towards living creatures. The purpose of this study was to determine the effect of sapodilla leaves’ (Achras zapota) infusum towards diarrheal activity of mice (Mus musculus) which can be seen through the onset and frequency of diarrhea, and the consistency and quantity / weight of feces.Methods: 30 mice were divided into five groups. Negative controls (group I) were administered with oleum Ricini, positive controls (group II) were administered with oleum Ricini and Loperamide HCl after half-an hour, and group III, IV, and V, were administered with oleum Ricini and sapodilla leaves’ (Achras zapota) infusum ( with the concentration of 5 g %, 10 g %, and 20 g %) after half-an hour. Then, those mice were observed for 3 hours for their diarrheal activity (diarrheal onset, frequency, fecal consistency, and fecal weights).Results: Analysis by Kruskal-Wallis method showed significant differences of diarrheal activities among the five groups (p = 0.023). Whilst, analysis by Mann-Whitney method showed significant differences between group I and II (p = 0.04), group I and III (p = 0.012), and group I and IV (p = 0.006).Conclusions: Based on the result showed sapodilla leaves’ (Achras zapota) infusum could reduce diarrheal activity of mice (Mus musculus).

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Home Page

OAI Link

Editorial Team

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Contact Name Muhammad Miftahussurur

Contact Email bhsj@journal.unair.ac.id

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Journal Mail Official bhsj@journal.unair.ac.id

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Location Kota surabaya, Jawa timur INDONESIA

Abstract

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Abstract

Contact Name
Muhammad Miftahussurur

Contact Email
bhsj@journal.unair.ac.id

Phone
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Journal Mail Official
bhsj@journal.unair.ac.id

Editorial Address
-

Location
Kota surabaya,

Jawa timur

INDONESIA