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Jurnal Ilmu Kedokteran (Journal of Medical Science)

jik
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Published by Universitas Riau

ISSN : 1978662X EISSN : 27154467 DOI : https://doi.org/10.26891/JIK

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Public Health

Journal of Medical Science receives a script from health and medical lecturer, undergraduate, residents, hospital staff and those who interested in writing scientific papers. The scientific articles posted on JIK include: literature reviews, research article, case report and EBCR (Evidence Based Case Report). Article preferably basic science of medicine and health.

Arjuna Subject : Kedokteran - Review dan Referensi, Kedokteran

Articles 10 Documents

Search results for , issue "Vol 11, No 2 (2017): Jurnal Ilmu Kedokteran" : 10 Documents clear

Ethanol Extracts of Centella asiatica (L.) Urb. Leaf Increase Superoxide Dismutase-2 (SOD-2) Expression on Rat Cerebellar Purkinje Cells After Chronic Stress Desby Juananda; Dwi Cahyani Ratna Sari; Mawaddah Ar-Rochmah; Nur Arfian; Muhammad Mansyur Romi
Jurnal Ilmu Kedokteran Vol 11, No 2 (2017): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Beberapa penelitian menunjukkan bahwa stres kronis meningkatkan produksi reactive oxygen species (ROS), dan /atau menekan mekanisme pertahanan antioksidan. Efek neuroprotektif dari Centella asiatica (L.). Urb telah dilaporkandapat melindungi neuron dari kerusakan oksidatif. Tujuan dari penelitian ini adalah untuk mengetahui efek ekstraketanol C. asiatica leaf terhadap ekspresi superoxide dismutase-2 sel (SOD- 2) pada sel Purkinje serebelum tikussetelah diberikan kejutan kronis di kaki. Sebanyak 25 tikus Sprague Dawley jantan dewasa muda diacak ke dalam limakelompok. Kelompok kontrol negatif terdiri dari tikus yang tidak stres; kelompok kontrol stres menerima aquadest; dankelompok lain diobati dengan dosis yang berbeda (mg / kg berat badan / hari, p.o.) ekstrak etanol daun C. asiatica: 150,300 dan 600, masing-masing diikuti oleh pemberian kejutan kronis di kaki selama dua puluh delapan hari. Ekspresi SOD-2 dari lapisan sel Purkinje diukur menggunakan metode imunohistokimia. Data dianalisis dengan one-way ANOVA (p<0,05). Kami menemukan bahwa ekspresi SOD-2 (%) dari lapisan sel Purkinje untuk kelompok kontrol negatif, kelompokkontrol stres, CeA150, CeA300 dan CeA600 kelompok adalah 22,38 ± 9,73, 9,81 ± 2,21, 10,29 ± 3,60, 14,72 ± 6,65, dan22,75 ± 10,93, masing-masing (p <0,05). Analisis post-hoc menunjukkan perbedaan yang signifikan antara kelompokkontrol negatif dan kelompok kontrol stres (p <0,05). Ada juga perbedaan yang signifikan antara kelompok kontrolstres dan kelompok CeA600 (p <0,05), tetapi tidak ada perbedaan yang signifikan antara kelompok perlakuan (p> 0,05).Penelitian ini menunjukkan bahwa ekstrak etanol daun C. asiatica meningkatkan ekspresi SOD-2 pada sel Purkinjecerebellar tikus setelah stres kronis.

E-Reading Vs Traditional Reading: Can Internet, Social media and Gadgets Bridge the Gap between Reading and Learning among Medical Students? Forman Erwin Siagian; Esy Maryanti
Jurnal Ilmu Kedokteran Vol 11, No 2 (2017): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Membaca menjadi dasar dalam belajar dan dengan perkembangan teknologi komunikasi informasi (TIK), membacasecara modern sekarang ini menjadi pengalaman yang lebih menarik dibanding sebelumnya ( misalnya membaca secaratradisional); akibat ketersediaan bahan bacaan elektronik di internet. Meski terdapat potensi efek yang tidak diinginkan,hampir tidak mungkin membatasi penetrasi TIK dalam hidup keseharian kita. Pilihannya lebih kepada kendali atas efekyang tidak dibutuhkan dan disisi lain memaksimalisasi potensi e-reading di internet untuk keuntungan pembaca.

Mekanisme Kerja dan Target Molekuler Interleukin-1 receptor antagonist (Anakinra) pada Aterosklerosis M. Yulis Hamidy
Jurnal Ilmu Kedokteran Vol 11, No 2 (2017): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Inflammation plays an important role in the development and progression of a variety of cardiovascular conditions,most notably coronary atherosclerosis and congestive heart failure. A number of inflammatory molecules have beenimplicated in these processes, including interleukin-1 (IL-1). IL-1 receptor antagonist is an endogenous inhibitor of IL-1, which competitively binds to the IL-1 type I receptor without activating it. Anakinra is a nonglycosylated, recombinantform of human IL-1ra that, like endogenous IL-1ra, competitively inhibits IL-1 by binding the IL-1 type I receptor.

Perbandingan Indeks Massa Tubuh Pada Pasien Hipertensi Dengan Tekanan Darah Yang Terkontrol dan Tidak Terkontrol di RSUD Arifin Achmad Provinsi Riau Eka Bebasari; Dimas Pramita Nugraha
Jurnal Ilmu Kedokteran Vol 11, No 2 (2017): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

The nutritional status is a factor that related with blood pressure. The nutritional status that indicated by body massindex (BMI) needs to be considered in management of hypertension. This study was a cross-sectional analytic thatassess relationship between BMI and hypertension controlled. The subjects of the study were hypertension patientsthat visit outpatient clinic of Arifin Ahmad General Hospital, Riau Province. Datas were analyzed by unpaired t-test.The results showed that patients with obesity grade 1 were more frequent in controlled hypertension group comparedto uncontrolled hypertension (43.8% vs 32.5%). The BMI average in patients with controlled hypertension group was24.2, while in uncontrolled hypertension group was 24.8 (p>0.05). There was no statistically significant differencebetween BMI in both groups patients.

Gambaran Histopatologi Paru Mencit (Mus musculus) Setelah Pemaparan Paraquat Aulia Wiradi; Wiwit Ade Fidiawati; Sri Melati Munir
Jurnal Ilmu Kedokteran Vol 11, No 2 (2017): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Paraquat destroys organs including lung. Purpose of this study was to determine the effect of paraquat on histopathologyof lung, exspecially fibrosis in mice (Mus musculus). This study was an experimental study with post-test only withcontrol design and using 15 mice as sample. Samples were divided into 5 groups consist of one control group and fourdifferent doses of paraquat treatment group (25 mg / kg / day, 50 mg / kg / day, 75 mg / kg / day and 100 mg / kg / day for7 days with spraying). Analysis of the data have used One-Way ANOVA then post-hoc test with tukey to assesseddifferences of each groups. The results showed increasing of lung fibrosis with increasing doses and have significantcorrelations (p = 0.000). In conclusion, there are significant changes in lung histopathology of mice (Mus musculus)after paraquat exposure for 7 days.

Gambaran Hasil Pemeriksaan Monofilamen pada Pasien Diabetes Melitus (DM) yang Berkunjung ke Poliklinik Penyakit Dalam RSUD Arifin Achmad Provinsi Riau Viona Ayu Safitri; Dani Rosdiana; Riezky Valentina Astari
Jurnal Ilmu Kedokteran Vol 11, No 2 (2017): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Diabetes mellitus in increasing at an alarming rate and has become a global challenge. Diabetes mellitus type 2 is agroup of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin actionor both. One of the most complications of diabetes is diabetic neuropathy. Diabetic neuropathy refers to damage ofmotor nerves, sensory, and autonomic system. The aim of this study is to identify patients at risk for diabetic neuropathywith monofilament examination in internist polyclinic Arifin Achmad General Hospital from May to July 2017.Monofilament is an inexpensive, practical tool in everyday use and can be used in early detection of sensation loss inthe foot to prevent diabetic ulcer. This study is descriptive research with direct examination of patient diabetes type 2.There were 73 samples that fulfilled the inclusion criteria. Profile patients with diabetes in the polyclinic are female morethan male is 60,3%. The age group 56-65 years is the most age group of DM patients in the polyclinic is 52.1%.Duration of diabetes is 5-10 years (52.1%). The results of monofilament examination in patients with type 2 DM arescore 0-3 as many as 19 people (26%), score of 3.5-5 as many as 27 people (37%), and score> 5,5 as many as 27 people(37%).

Analisis Penggunaan Antibiotik pada Pasien Sepsis Neonatus di RSUD Arifin Ahmad Provinsi Riau Nazardi Oyong; Inayah Inayah; Yuni Novita; Rizki Giofani
Jurnal Ilmu Kedokteran Vol 11, No 2 (2017): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Sepsis that is commonly caused by bacterial infection may cause death in neonates. The appropiate antibioticadministered will increase the life expectancy of neonates with sepsis. Objective of this study was to know the patternof antibiotic use and appropriateness of antibiotic use based on sensitivity test. The study used observational methodwith cross sectional design. The collected data were retrospective. The study population were neonates with sepsis inperinatal ward from Januari – December 2014. The criteria of inclusion were positive blood culture with sensitivity testsand use of antibiotics. The percentage of particular antibiotics used in neonates with sepsis before sensitivity testwere amikacin 64,3%; meropenem 62,9% and piperazine/tazobactam 50% with suitability of 27,1%. However, aftersensitivity test there were meropenem 38,6%, amikacin 30%, vancomycin 14,3% and piperaciline/tazobactam 14,3%with appropriateness of 64,3%. The most number of antibiotic used before and after sensitivity test were amikacin andmeropenem, respectively. There was a suitability enhancement between the use of antibiotics and sensitivity testresults.

Profil Ergonomis dan Proporsi Keluhan Muskuloskeletal pada Tenaga Kerja Bongkar Muat di Pelabuhan Bongkar Muat Kota Pekanbaru Laode Burhanuddin M; Suyanto Suyanto; Zulfikar Zulfikar
Jurnal Ilmu Kedokteran Vol 11, No 2 (2017): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Ergonomics deals with optimization, efficiency, health, safety, and comfort in the workplace. One ofthis ergonomics principle approach is important for unloading workers in the harbour, because theirworkplace and work-system have high risk of workplace accidents if the principles of ergonomics isnot applied. So, the effectivity, efficiency, productivity, comfort, and health of workers in the harbourneed to be maintained and improved with ergonomics approach. This research was held on harbourin Pekanbaru city , with descriptive observasional method to describe risk of work ergonomy causedby bad application of ergonomics at work and musculosceletal symptoms proportion of 19 unloadingworkers by Nordic Body Map (NBM) questionnaire. The result is all unloading workers (100%) havemusculosceletal injury with various grade of injury. When being observed, none of all unloadingworkers lift the load with the right method and no special technique had been used by unloadingworkers to lift the load.

Pengaruh Pemberian Asam Alfa Lipoat terhadap Kadar Kolesterol Total pada Tikus Diabetes Melitus Tipe 2 Uli Kartika Lestari Sinaga; Ismawati Ismawati; Enikarmila Asni
Jurnal Ilmu Kedokteran Vol 11, No 2 (2017): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Hypercholesterolemia is complication in type 2 diabetes. Alpha lipoic acid (ALA) reduced total cholesterol by modulatingcholesterol synthesis pathway and reduced cholesterol biosynthesis genes expression. The goal of this research wasto investigate the prohibition of hypercholesterolemia in type 2 diabetes rat by ALA. Fifteen adult male wistar rats (2-3 months, 200-250 g body weight) were segregated into three groups (standard, type 2 diabetes and type 2 diabetes +ALA). Type 2 diabetes induced by streptozotocin 65 mg/kg and nicotinamide 110 mg/kg. ALA was given for 3 weeksafter type 2 diabetes induced.After 31 days total cholesterol of groups labelled is measured. The result showed therewas significant difference between ALA and type 2 diabetes groups (p= 0.012), and there was no significant differencebetween ALA and standard groups (p= 0.591). As the conclusion, this study proves that ALA has effects on totalcholesterol in type 2 diabetes rats.

Eosinophilic Ascites Due to Eosinophilic Gastroenteritis – Cytological Approach Ilhami Romus
Jurnal Ilmu Kedokteran Vol 11, No 2 (2017): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Eosinophilic ascites (EA) merupakan kasus yang sangat jarang. EA merupakan gejala yang paling jarang dari penyakitgastroenteritis eosinofilik (EGE). EA terjadi karena adanya edema dan peradangan eosinofilik dari lapisan serosa usushalus dan dapat melibatkan segmen lain pada saluran gastrointestinal. Kami melaporkan kasus seorang wanita berusia19 tahun dengan gambaran mikroskopik sitologi cairan asites tampak eosinofil yang cukup padat dan pemeriksaanhistopatologi dari biopsi lambung menunjukkan infiltrasi eosinofil. Data klinis menunjukkan adanya nyeri abdomendifus, mual, distensi abdomen, ascites sedang, dan diare. Hasil Magnetic Resonance Imaging (MRI) menunjukkanadanya penebalan dinding usus halus difus dan tidak mendeteksi keganasan primer. Hasil tes laboratorium menunjukkaneosinofilia pada pemeriksaan darah tepi, kadar IgE serum meningkat dan negatif untuk infeksi parasit. Pasien mendapatkanterapi SLE selama 1 tahun tanpa perbaikan yang nyata. Pengobatan dengan kortikosteroid menormalkan hasil teslaboratorium dan asites teratasi segera. EGE merupakan kasus yang langka dan harus diingat pada pasien dengangejala ascites yang tidak diketahui penyebabnya.

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Ilhami Romus

Contact Email
ilhamiromus@yahoo.co.id

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+6281371333123

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jikfkunri@gmail.com

Editorial Address
Sekretariat JIK (Jurnal Ilmu Kedokteran) Jl. diponegoro no. 1, Pekanbaru Riau

Location
Kota pekanbaru,

Riau

INDONESIA

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Ilhami Romus

Contact Email ilhamiromus@yahoo.co.id

Phone +6281371333123

Journal Mail Official jikfkunri@gmail.com

Editorial Address Sekretariat JIK (Jurnal Ilmu Kedokteran) Jl. diponegoro no. 1, Pekanbaru Riau

Location Kota pekanbaru, Riau INDONESIA

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Contact Name
Ilhami Romus

Contact Email
ilhamiromus@yahoo.co.id

Phone
+6281371333123

Journal Mail Official
jikfkunri@gmail.com

Editorial Address
Sekretariat JIK (Jurnal Ilmu Kedokteran) Jl. diponegoro no. 1, Pekanbaru Riau

Location
Kota pekanbaru,

Riau

INDONESIA