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Jurnal Ilmiah Farmasi Akademi Farmasi Jember
Published by Akademi Farmasi Jember
ISSN : 25034707     EISSN : 2615756X     DOI : https://doi.org/10.53864/jifakfar
Core Subject : Health,
Medicine & Pharmacology
Jurnal Ilmiah Farmasi Akademi Farmasi Jember merupakan Jurnal yang menampung artikel ilmiah hasil penelitian di seluruh bidang Farmasi, seperti Farmasi Bahan Alam, Kimia Farmasi, Farmasetika, Farmasi Klinis, Farmasi Komunitas, dan bidang farmasi lainnya.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 70 Documents
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UJI FISIK FORMULASI TABLET FLOATING TEOFILIN DENGAN MATRIK HPMC Dewi Rashati, Siti Mursidatur Rohmah
JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER 2016: April - Vol.1 No.1
Publisher : AKADEMI FARMASI JEMBER

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (140.082 KB) | DOI: 10.53864/jifakfar.v1i1.6

Abstract

The purpose of this study was to determine the physical properties of theophylline floating tablet formulation with HPMC as matrix. Floating tablets of theophylline is manufactured by direct compression. Composition per tablet formulation consisting of theophylline 270 mg, HPMC, avicel, magnesium stearate, and sodium bicarbonate. The results of data showed average of tablet weight uniformity 501mg, tablet hardness 6,99 kg, tablet friability 0,593%, disintegration time of tablets 738 seconds, floating lag time (FLT) 584,3 seconds and floating duration time (FDT) more than 8 hours. Floating tablet formulation of theophylline resulted in a good physical test.Keyword: floating, theophylline, HPMC, tablet
HUBUNGAN AKTIVITAS SEKSUAL USIA DINI DENGAN HASIL PEMERIKSAAN PAP SMEAR SEBAGAI DETEKSI DINI KANKER SERVIKS DI KABUPATEN SIDOARJO Acivrida Mega Charisma, Farida Anwari
JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER 2017: Desember - Vol.2 No.2
Publisher : AKADEMI FARMASI JEMBER

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (439.558 KB) | DOI: 10.53864/jifakfar.v2i2.22

Abstract

Cervical cancer is the number one cause of death in Indonesian women. Cervical cancer is a malignant tumor that grows inside the cervix / cervix is the lowest part of the uterus attached to the top of the vagina.Terjantung cancer always begins with precancerous conditions which further leads to advanced cancer conditions. Pap smear test is a test that is accurate enough to detect early cervical cancer if routinely performed, because this test can detect any abnormal cells changes. This study aims to determine the relationship between sexual activity performed at an early age by the respondents with the results of pap smear examination.This research use cross sectional analysis method, simple random sampling sample of 184 people. The result is made of frequency table, cross tabulation and then analyzed by chi square test and spearman correlation test.The results showed that the results of Pap smears class II and III (Not In Normal Limit) on the respondents who do sexual activity at age 18 years there are 45 (71.4%) people and the respondents who do not do sexual activity at age 18 years only 41 (33.9%) people. The same thing happened for the age factor, in respondents with age 35 (at risk) there were 66 (54,2%) people who had the result of examination of Class II and III papsmear (Not in Normal Limit) and at age 35 years old only 20 (33.3%) persons who have the results of papsmear examinations Class II and II (Not In Normal Limit). The analysis using chi square test showed significant correlation between age and early age sexual activity with pap smear with indigo ρ = 0.025 and ρ = 0.018 (α = 0.05).The hope of this study can be an important lesson for the younger generation to be able to control the association in order to avoid doing activities at the age of too young and for all married women (ever doing sexual activity) to perform pap smear examination early to detect any abnormalities before developed into cancer.Keywords : early childhood sexual activity, cervical cancer, pap smear, cervical cancer risk factor
POTENSI STREPTOMYCES ENDOFIT RIMPANG KENCUR DAN DAUN SIRIH MERAH SEBAGAI ANTITUBERKULOSIS PADA MYCOBACTERIUM TUBERCULOSIS GALUR SENSITIF Siti Nur Azizah, Mikhania Cristiningtyas Eryani
JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER 2019: Juli - Vol.3 No.1
Publisher : AKADEMI FARMASI JEMBER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53864/jifakfar.v3i1.38

Abstract

The objective of this research was to obtain Endophitic Streptomyces from some medical plants which have antituberculosis effect and also to test its antitubercullosis activity againts sensitive stain of Mycobacterium tuberculosis. Medicinal plants used in this study were Kaemferia galanga, Hibiscus sabdariffa and Piper cronatum. Streptomyces was isolated using two different media namely Humic Acid Vitamin (HV) agar and HV with plant extract, and purified on Yeast Malt Agar (YMA) medium. Morphological characterization of Streptomyces obtained was observed including aerial mycelium and substrate mycelium, pigmentation, and colony surface. A total of 5 endophitic Streptomyces genus were obtained from medicinal plant. Isolates K.J3A, K.J3B, K.J4 and K.J11 from Kaemferia galanga radix, S.MJ1 from Piper cronatum folium. Streptomyces was not found from Hibiscus sabdariffa calyx. Each isolate had variety of characteristics which could be seen in aerial mass color, substrate mass color, and pigmentation. Antitubercullosis activity showed that total of 5 endophitic Streptomyces were not capable to inhibit the growth sensitive stain of M. tubercullosis.Keywods: Antituberculosis, endophitic actinomycetes, Kaemferia galanga, Hibiscus sabdariffa
TINGKAT KEPUASAN APOTEK DI WILAYAH LUMAJANG TERHADAP DISTRIBUSI OBAT OLEH PEDAGANG BESAR FARMASI Kukuh Judy Handojo,Pradanu Satria Rakhmanta,Diyan Ajeng R
JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER 2017: Juli - Vol.2 No.1
Publisher : AKADEMI FARMASI JEMBER

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (359.973 KB) | DOI: 10.53864/jifakfar.v2i1.17

Abstract

PBF services in Lumajang region need to improve the quality of service, includingdelivery time often exceeds the time that had been promised, complaints regarding medication errors and difficulty getting accountability, the price has changed in a short time, and the service was not constant. The purpose of this study was to determine the level of drug store Lumajang region against drug distribution by PBF in tangible dimension (direct evidence), reliablity (reliability), responsivines (responsiveness),assurance (assurance), empathy (caring). Samples were selected in this research is all drug store in Lumajang totaling 30 pharmacies. The research design in this study is descriptive by using survey method.Based on the data collection process,there were only 30 drug store that are willing to be respondenden has qualified for data processing and it can be concluded that the level of satisfaction Pharmacy Lumajang region on tangible dimension (direct evidence) of 86.24%, expressed satisfaction,reliability dimension (reliability) by 80%, otherwise satisfactory, dimensions responsiviness (responsiveness) of 75.84%, expressed quite satisfactory, dimensions assurance (guarantee) amounting to 86.11%, declared satisfactory, the dimensions of empathy (caring) amounted to 86.94%, otherwise satisfactory. Based on the above data,it needs to be evaluated in five dimensions, from the evaluation it would appear that satisfaction level of drug store in Lumajang to PBF service (drug distribution)reach 83,02% and including the satisfactory category .Keywords: Level of satisfaction - Drugs distribution – PBF
SINTESIS DAN UJI AKTIVITAS ANTIBAKTERI SENYAWA TURUNAN AMOKSISILIN TERHADAP Escherichia coli Hadi Barru Hakam Fajar Siddiq, Siti Nur Azizah, Amaliyah Nurul Hidayah, Dewi Riskha Nurmalasari, Mau
JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER 2019: Desember - Vol.3 No.2
Publisher : AKADEMI FARMASI JEMBER

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (246.552 KB) | DOI: 10.53864/jifakfar.v3i2.33

Abstract

Amoxicillin derivate compounds from the reaction of amoxicillin with p-aminophenol are synthesized compounds by reacting amoxicillin and p-aminophenol. . Escherichia coli is a flora normal bacteria that can causing infectious diseases. This research aimed to determine the antibiotic activity of amoxicillin derivat compound (amoxicillin with p-aminophenol) on the growth of E. coli. This research was conducted using the disc diffusion method. amoxicillin derivat compound (amoxicillin with p-aminophenol) were characterized by organoleptic test, melting point determination, pH test determination, Rf value, and maximum wavelength. The results of the organoleptic test showed that amoxicillin derivates from amoxicillin and p-aminophenol reaction is crystal powder, dark brown and bit bitter. Melting point of amoxicillin derivates from amoxicillin and p-aminophenol reaction was 160ºC. pH test of amoxicillin derivates from amoxicillin and p-aminophenol reaction was 6,5. Rf value of amoxicillin derivates from amoxicillin and p-aminophenol reaction was 0,79. The results of UV wavelength scanning showed that amoxicillin derivates from amoxicillin and p-aminophenol reaction at 295 nm. Antibiotic activity showed by the clear zone form around the paper disk. The results showed that E. coli was resistant to pure amoxicillin. Amoxicillin derivat compound (amoxicillin with p-aminophenol) with concentrations of 100% and 12,5% have the largest inhibitory zones (6,33 mm) compared with concentrations of 50% and 25%, 5,33 and 6,00 mm respectively. Based on these results it can be concluded that derivat compound of amoxicillin (amoxicillin with p-aminophenol) has antibiotic activity against the growth of E. coli that has been resistant to pure amoxicillin.Keywords: Derivate compound of amoxicillin, Escherichia coli, antibiotic activity
THE EFFECT OF VARIATIONS IN THE CONCENTRATION SORBITOL AND CASSAVA LIQUID SUGAR (Manihot esculenta Crantz) OF SWEETENER ON THE PHYSICAL PROPERTIES OF GUMMY CANDIES PARACETAMOL Dewi - Rashati
JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER Vol 4, No 2 (2021): JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER
Publisher : AKADEMI FARMASI JEMBER

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (429.034 KB) | DOI: 10.53864/jifakfar.v4i2.74

Abstract

Gummy candies paracetamol is chew candy containing the active subtance paracetamol with sweetener of sorbitol and cassava liquid sugar. The purpose of this study was to determine the effect of variations in the concentration of sorbitol and cassava liquid sugar as sweeteners on the physical properties of gummy candies paracetamol. Formulation of paracetamol gummy candies using diference concentration of sorbitol (20%, 15%, 10%) and cassava liquid sugar (40%, 45%, 50%).was used as the method pre-experimental design research method with one-shot case study design. Testing the physical properties of the preparations that have become chewing gum includes organoleptic tests, weight uniformity tests, pH tests and then the results are compared with the requirements in the literature. The results of the research on the physical properties of paracetamol gummy candy concluded that variations in the concentration of sorbitol sweetener and cassava liquid sugar had an effect on the uniformity of weight. Variations in the concentration of sorbitol sweetener and cassava liquid sugar did not affect the physical organoleptic properties of aroma, color, taste, texture, and physical properties of pH.Keywords : paracetamol, gummy candies, sorbitol, cassava liquid sugar
PENGARUH VARIASI KONSENTRASI MINYAK ZAITUN (OLIVE OIL) TERHADAP KELEMBUTAN SABUN CAIR Mikhania Christiningtyas Eryani, Dewi Rashati
JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER 2016: Desember - Vol.1 No.2
Publisher : AKADEMI FARMASI JEMBER

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (329.354 KB) | DOI: 10.53864/jifakfar.v1i2.12

Abstract

Zaitun tree (Olea europaea) comes from the Middle East and widely grown in Asia. The fruit and oil extraction widely used as food and medicine. The oil derived from olives is known as olive oil. Olive oil can be used for skin emolient. The aims of this study was to determine olive oil variation concentration to liquid soap softness. The soap was made with varying olive oil concentration (20% known as F1, 30% known as F2 and 40% known as F3). True experimental design with The Posttest Only Experiment was used as the study design. Evaluation of the soap including organoleptic test, pH, spesific gravity, free alkali assay, and responden emolient test. Responden emolient test was taken from 20 responden who has given questioner. The data from emolient test study was calculate by Kruskal Wallis test. The organoleptic test result showed that all formula showed liquid green, homogen, and jasmine odor. pH from F1, F2 and F3 were 10,39; 9,75 dan 9,34 respectively. The spesicic gravity from F1, F2 and F3 were 1,648%; 1,441% dan 0,863 % respectively. The free alkali from F1, F2 and F3 were 0,032%; 0,08% dan 0,064% respectively. The responden emolient test showed that F1 was soft, F2 was midle soft and F3 was very soft.Keywords: oilive oil, soap, softness
OPTIMASI HIDROLISIS MEDIA PRODUKSI CANGKANG UDANG MENGGUNAKAN KITINASE SERRATIA MARCESCENS KAHN.15.12 TERHADAP KADAR N-ASETIL GLUKOSAMIN SEBAGAI BAHAN SEDIAAN Siti Nur Azizah, Rosida
JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER 2017: Desember - Vol.2 No.2
Publisher : AKADEMI FARMASI JEMBER

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (299.69 KB) | DOI: 10.53864/jifakfar.v2i2.28

Abstract

Limbah cangkang udang mengandung kitin yang tinggi yaitu sekitar 17-40%. Kitin tersebut dapat digunakan sebagai substat pertumbuhan bakteri kitinolitik yaitu S.marcescens KAHN 15.12. Bakteri tersebut akan mensekresikan enzim kitinase untuk mendegradasi kitin sebagai media pertumbuhannya hingga menghasilkan monomer N-asetil glukosamin (GlcNac). N-asetil glukosamin dapat dimanfaatkan sebagai bahan sediaan suplemen osteoartritis. Penelitian ini bertujuan untuk memproduksi GlcNac hasil hidrolisis kitin cangkang udang menggunakan kitinase Serratia marcescens KAHN.15.12. Hasil konfirmasi aktivitas kitinolitik menggunakan media selektif yaitu agar koloidal kitin 0,3% menunjukkan bahwa Serratia marcescens KAHN 15.12 memiliki index kitinolitik sebesar 2,3 yang ditunjukkan dengan adanya zona bening disekitar koloni. Hasil optimasi perbedaan konsentrasi media produksi menunjukkan bahwa tepung cangkang udang 2% menghasilkan kadar GlcNac tertinggi yaitu sebesar 376,35 μg/ml setelah diuji dengan metode kolorimetri menggunakan reagen shcales pada panjang gelombang 420nm. Berdasarkan hasil tersebut menunjukkan bahwa setiap hidrolisis 1 gram tepung cangkang udang yang mengandung 18,7% kitin akan menghasilkan sebesar 70,54 mg GlcNAc.Kata Kunci: N-asetil glukosamin, kitinase, Serratia marcescens
OPTIMASI FORMULA TABLET BUKAL MUKOADHESIVE GLIBENKLAMID MENGGUNAKAN MATRIKS CMC NA SERTA ASAM OLEAT SEBAGAI ENHANCHER ASA FALAHI; DEWI RASHATI
JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER Vol 4, No 1 (2021): JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER
Publisher : AKADEMI FARMASI JEMBER

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (540.034 KB) | DOI: 10.53864/jifakfar.v4i1.49

Abstract

Glibenclamide is a sulfonylurea class of antidiabetic drugs that works by stimulating insulin secretion in the pancreas so that it is effective only when the β-cells of the pancreas can still produce. The glibenclamide dosage form that is on the market is a conventional oral tablet which has various disadvantages in terms of pharmacokinetics. Based on this, it is necessary to develop a more effective drug delivery system for glibenclamide in order to avoid first-pass metabolism so as to increase the bioavailability of glibenclamide, namely by making mucoadhesive buccal tablets. This glibenclamide mucoadhesive buccal tablet is formulated using a variety of mucoadhesive polymers, namely CMC Na and oleic acid as enhancers. The manufacture of four mucoadhesive buccal tablet formulas used the direct compression method. The results of the weight uniformity test showed that they did not meet the NP requirements specified, all formulas had an NP of more than 15. The tablet hardness test also showed results that did not meet the test requirements. However, the results of the physical properties of the brittleness, pH and swelling index showed the results that met the test requirements. In this research, the optimum variation of CMC Na polymer and oleic acid as enhancers to physical properties (hardness, brittleness, pH, swelling ability) and the release of glibenclamide mucoadhesive tablets were CMC Na of 37.5 mg and oleic acid of 3.5. ml.
HUBUNGAN DUKUNGAN KELUARGA DENGAN TINGKAT KEPATUHAN PASIEN HEMODIALISA TERHADAP TERAPI GAGAL GINJAL DI RSUD BLAMBANGAN BANYUWANGI Diyan Ajeng, Dessy
JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER 2016: April - Vol.1 No.1
Publisher : AKADEMI FARMASI JEMBER

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (126.798 KB) | DOI: 10.53864/jifakfar.v1i1.7

Abstract

Chronic Renal Failure (CRF) is a chronic disorder of renal function is progressive and irreversible. In which the body fails to maintain metabolic and fluid and electrolyte balance, causing uremia and could eventually cause a disruption in the body's immune system. According Raharjo (1996) and Lopez (2006), the estimated number of patients with chronic renal failure continues to increase and the estimated growth of about 10% every year.This research design was a descriptive cross sectional study. Have done a study of 55 patients with chronic renal failure who had been treated at the Hospital Medicine at Blambangan, Banyuwangi in 2014 patient data information obtained from the patient visit checklist. This study was to determine the relationship of family support with chronic renal failure patient adherence to therapy in poly Haemodialysis Haemodialysis in hospital Blambangan, Banyuwangi in 2014.Research was obtained as many as 15 people (27.28%) patients with chronic renal failure aged 25-30 years, and 17 (30.9%) aged 41-50 years with a self-employed job and most of the heavy labor. Researchers hope that the hospitals can provide direction Blambangan Banyuwangi, in-depth knowledge about chronic kidney disease to patients and families of patients so that the family can fully support patient compliance in taking medication and undergoing therapy in a timely and appropriate.From the research, it was concluded that 9.1% of patients not adherent and 90.9% patient compliance with the treatment given by the hospitals Blambangan Banyuwangi.Keywords: Chronic Renal Failure, Hemodialysis, Family Support

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