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Journal Pharmactive
Published by Institut Teknologi dan Kesehatan Bintang Persada
ISSN : 28293444     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health
Journal Pharmactive is a journal managed and published by the Institute for Research and Community Service (LPPM) Institut Teknologi dan Kesehatan Bintang Persada, with ISSN 2829-3444. Journal Pharmactive was first published in April 2022 and has a publishing period twice in a year, namely in April and Oktober.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 28 Documents
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GAMBARAN POLA PERESEPAN ANTIBIOTIK PADA PASIEN ISPA RAWAT JALAN DI POLIKLINIK ANAK RUMAH SAKIT X DI GIANYAR Gede Trima Yasa
Journal Pharmactive Vol. 1 No. 2 (2022): Jurnal Pharmactive Oktober
Publisher : Institut Teknologi dan Kesehatan Bintang Persada

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Abstract

Acute Respiratory Infection (ARI) is a disease that is still a health problem in developing countries, including Indonesia. Administration of antibiotics is one of the treatments for ARI.The supporting factor for the success of drug therapy, especially antibiotics is the accuracy in prescribing antibiotics. This study aims to determine the pattern of antibiotic prescribing in outpatient ARI patients at the children's polyclinic at RSU Premagana. The method used in this research is cross-sectional with purposive sampling technique. Data were taken using prescription sheets and medical records of ARI patients for the period October-December 2021. The results of this study that from 164 samples, the characteristics of ARI patients were dominated by children aged 0-5 years (83.5%) with the highest gender in men (61%). The diagnosis of ARI is classified by the distribution of nasopharyngitis (33,5%), non-specific ARI (28,0%), acute pharyngitis (25,6%), tonsillitis (9,1%) and tronchiolitis (3,7%). The most commonly prescribed class of antibiotics is the third generation cephalosporin of the cefixime type (56.7%) and the first generation cephalosporin group, cefadroxil (39.0%) with the type of antibiotics single therapy (100%). Based on the diagnosis, cefixime most given to ARI not specific and pharyngitis, while cefadroxil is mostly given to nasopharyngitis and tonsillitis Keywords: Dagusibu, Knowledge Level, Drugs
PEMANFAATAN DAN POTENSI ANTIOKSIDAN PADA BUNGA TELANG (Clitorea ternatea L.) : Literatur Review Ni Wayan Rika Kumara Dewi
Journal Pharmactive Vol. 1 No. 2 (2022): Jurnal Pharmactive Oktober
Publisher : Institut Teknologi dan Kesehatan Bintang Persada

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Abstract

Abstrak Latar belakang : Bunga telang memiliki potensi antioksidan karena memiliki kandungan antosianin dan flavonoid lainnya. Antosianin diketahui mampu memberikan aktivitas antioksidan. Selain itu bunga telang juga sering dimanfaatkan dalam bidang pangan. Hal ini menunjukkan potensi besar pemanfaatan bunga telang oleh masyarakat luas, sehingga perlu dikaji terkait pemanfaatan dan potensi antioksidan bunga telang (Clitoria ternatea L.) Tujuan: Untuk mengetahui manfaat dan potensi antioksidan dari bunga telang (Clitoria ternatea L.) dengan berbagai metode yaitu DPPH, FRAP, ABTS, BTA, CUPRAC. Metode: Penelitian ini menggunakan metoda deskriptif dengan menggunakan metode review artikel terstruktur. Pengumpulan data dilakukan menggunakan basis data Google Scholar, Science Direct danPubMed dengan kata kunci “Clitoria ternatea L. antioxidant activity”, “Clitoria ternatea L.”, “phytochemical analysis of Clitoria ternatea L.”, “traditional use of Clitoria ternatea L.”Hasil: Berdasarkan studi literatur pemanfaatan bunga telang digunakan dalam bidang pangan dan kesehatan yaitu mencegah glikasi protein dan kerusakan DNA oksidatif, Mengerahkan efek protektif terhadap Bisphenol A (BPA) terhadap kinerja reproduksi dalam meningkatkan persentase kehamilan dan ukuran anak, memodulasi efek perlindungan terhadap paparan UVR pada kulit, dan meningkatan stabilitas dalam pangan fungsional dalam bentuk bubuk minuman fungsional dan sebagai pewarna makanan Kesimpulan: Bunga telang (Clitoria ternatea L.) memiliki aktivitas biologis sebagai antioksidan dan memiliki manfaat di bidang pangan dan kesehatan. Pada potensi antioksidan yang diperoleh dari beberapa literatur dengan metode yang berbeda memberikan perbedaan nilai IC50.
PROFIL PENGGUNAAN OBAT PADA PASIEN DEPRESI RAWAT JALAN DI APOTEK “X” DENPASAR PERIODE JANUARI-APRIL 2022 Putu Ika Indah Indraswari; Ni Luh Sudi Astini; Ella Yunita
Journal Pharmactive Vol. 1 No. 2 (2022): Jurnal Pharmactive Oktober
Publisher : Institut Teknologi dan Kesehatan Bintang Persada

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Abstract

Depression is a mood disorder characterized by deep feelings of sadness and indifference The symptoms of depression in adolescents are often characterized by feelings of irritability, distress, fear, lacklusterness, sadness, conflicts with friends, and conflicts with family. The highest incidence of depression was in the Southeast Asian region of 86.94 (27%) out of 322 billion individuals. Indonesia itself is in fifth place with a depression incidence rate of (3.7%). This study aims to determine the profile of drug use in outpatient depression patients at Karuna Pharmacy for the period January-April 2022. This research is a descriptive research that uses a cross-sectional research design with a retrospective approach and is processed qualitatively. The results of a study of 110 patients who entered the inclusion criteria, namely the use of antidepressants, namely selective serotonin reuptake inhibitors (SSRI) class drugs with a combination of psychotropic group drugs with a total of 53 (48.18%) people.
PROFIL PENGGUNAAN OBAT PADA PASIEN DEPRESI RAWAT JALAN DI APOTEK “X” DENPASAR PERIODE JANUARI-APRIL 2022 Putu Ika Indah Indraswari; Ni Luh Sudi Astini; Ella Yunita
Journal Pharmactive Vol. 1 No. 2 (2022): Jurnal Pharmactive Oktober
Publisher : Institut Teknologi dan Kesehatan Bintang Persada

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Abstract

Depression is a mood disorder characterized by deep feelings of sadness and indifference The symptoms of depression in adolescents are often characterized by feelings of irritability, distress, fear, lacklusterness, sadness, conflicts with friends, and conflicts with family. The highest incidence of depression was in the Southeast Asian region of 86.94 (27%) out of 322 billion individuals. Indonesia itself is in fifth place with a depression incidence rate of (3.7%). This study aims to determine the profile of drug use in outpatient depression patients at Karuna Pharmacy for the period January-April 2022. This research is a descriptive research that uses a cross-sectional research design with a retrospective approach and is processed qualitatively. The results of a study of 110 patients who entered the inclusion criteria, namely the use of antidepressants, namely selective serotonin reuptake inhibitors (SSRI) class drugs with a combination of psychotropic group drugs with a total of 53 (48.18%) people
MONITORING KEPATUHAN MINUM OBAT SERTA KEBERHASILAN TERAPI PADA PASIEN TUBERKULOSIS PARU di UPTD PUSKESMAS KARANGASEM I Putu Ika Indah Indraswari; Ni Nengah Widiasih Tegmini; I Nyoman Okadana Arsana
Journal Pharmactive Vol. 1 No. 1 (2022): Jurnal Pharmactive April
Publisher : Institut Teknologi dan Kesehatan Bintang Persada

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Abstract

Kepatuhan minum obat merupakan kunci tercapainya keberhasilan terapi pada pasien tuberkulosis paru mengingat bahwa tuberkulosis bisa saja kambuh kembali jika pengobatan tidak adekuat. Penelitian ini bersifat deskriptif observasional (non eksperimental) dengan rancangan studi cross sectional, pengumpulan sampel dilakukan dengan metode total sampling sesuai dengan kriteria inklusi penelitian. Analisa hasil penelitian menggunakan analisa bivariat untuk menemukan adanya korelasi antara kepatuhan minum obat dengan keberhasilan terapi pengobatan tuberkulosis paru dengan uji statistik Chi Square. Berdasarkan hasil penelitian yang telah dilakukan, ditemukan adanya korelasi antara kepatuhan minum obat anti tuberkulosis dengan keberhasilan terapi pengobatan tuberkulosis, ditunjukkan dengan nilai Asymp.Sig sebesar 0,001 sehingga dapat dinyatakan kepatuhan minum obat anti tuberkulosis memberi pengaruh signifikan pada keberhasilan terapi pengobatan tuberkulosis. Rata-rata kesembuhan pasien TB paru mencapai 85% dimana telah mampu melampaui target kesembuhan pasien TB Paru Kabupaten Karangasem yakni sebesar 84%.
ANALISIS ABC DALAM PERENCANAAN OBAT GOLONGAN ANTIBIOTIK DI INSTALASI FARMASI RAWAT INAP RSU X DENPASAR Oviani Gusti Ayu; Listiani Putu Ayu Ratih; Cahyani Ni Gusti Ayu Dwi
Journal Pharmactive Vol. 2 No. 1 (2023): Jurnal Pharmactive April
Publisher : Institut Teknologi dan Kesehatan Bintang Persada

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Abstract

Planning and procurement of drugs is one of the important functions in the logistics management stage of drugs, including antibiotic drugs. A good management system will ensure the availability of drugs according to patient needs. The purpose of the study was to determine the ABC analysis based on use value and investment value in planning antibiotic class drugs at the Inpatient Pharmacy Installation of RSU X Denpasar. This type of research is descriptive non-experimental using quantitative data. The data is obtained from a review of reports or systems, data in the form of reports on the types of antibiotic class drugs used in the 2021 period, reports on the number of antibiotic class drugs used and reports on the price of antibiotic drugs. The value of using antibiotics was group A consisting of 29 items (27.35%) with a total usage of 72,591 items (79.42%); group B consisted of 26 items (24.52%) with a total usage of 14,197 items (15.53%); group C consisted of 51 items (48.11%) with a total usage of 4,613 items (5.04%). The investment value for antibiotics is group A consisting of 17 items (16.03%) with a total investment of IDR 6,414,357,620 (79.94%); group B consists of 20 items (18.86%) with a total investment of IDR 1,193,164,115.00 (14.86%); group C consisted of 69 items (65.09%) with a total investment of IDR 417,102,141.50 (5.20%).
VOLUME PENOTOLAN MEMPENGARUHI FINGERPRINT EKSTRAK METANOL HERBA SAMBILOTO (ANDROGRAPHIS PANICULATA (BURM. F.) NEES) DENGAN KLT-SPEKTROFOTODENSITOMETRI Ugrasena Putu Yudha; Puspita Sari Dyah Ratna Ayu; Kumara Dewi Ni Wayan Rika
Journal Pharmactive Vol. 2 No. 1 (2023): Jurnal Pharmactive April
Publisher : Institut Teknologi dan Kesehatan Bintang Persada

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Abstract

Spotting volume is an important factor affecting the resolution value of the chromatogram, the number of peaks and separation, peak profile and peak broadening, as well as the asymmetry of the peaks. This study aims to determine the effect of bottling volume on fingerprint chromatography of the methanol extract of Andrographis paniculata (Burm. F.) Nees herb and to determine fingerprint chromatography at optimum volume. The chromatographic system used refers to the Indonesian Herbal Pharmacopoeia. Sambiloto herbal samples were spotted with a variety of 3 µL bottling volumes; 5µL; 10µL; 15µL; 20 µL and 25 µL on a 60 GF254 silica gel plate were then eluted with a mixture of chloroform P and methanol P (9:1) v/v. The plates were scanned with a TLC Scanner 3 (CAMAG) at a wavelength of 210 nm. Spectra were made for each spot at a wavelength of 190-400 nm. Parameters that were calculated were resolution values, tailing factor from andrographolid peaks, and cosine functions (C) from volume variation chromatograms to determine the effect of spotting volume. The bottling volume selected from the optimization step was 5 µL with andrographolid peak resolution with the previous and following peaks being 1.57 and 1.16, respectively. The tailing factor value was 1 and the number of peaks that appeared was 10. The average value of C in the 5 µL bottling volume precision test was 99.36 with a VC of 1.17% (VC <2%)
ANTIBACTERIAL POTENTIAL OF RED BETEL LEAVES (Piper crocatum Ruiz and Pav) Kumara Dewi Ni Wayan Rika; Ugrasena Putu Yudha; Puspita Sari Dyah Ratna Ayu
Journal Pharmactive Vol. 2 No. 1 (2023): Jurnal Pharmactive April
Publisher : Institut Teknologi dan Kesehatan Bintang Persada

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Abstract

Background: Red betel leaf (Piper crocatum Ruiz and Pav.) is one of the medicinal plants which empirically has the efficacy of healing spiritual ailments. The secondary metabolite compounds contained in red betel leaves are essential oils, flavonoids, alkaloids, saponins, tannins, terpenoids, and phenolic compounds which have antibacterial activity. Objective: To determine the antibacterial potential of red betel leaves (Piper crocatum Ruiz and Pav.) Method: This study uses a descriptive method using a structured article review method. Data collection was carried out using the Google Scholar database, Science Direct and PubMed with keywords “Piper crocatum Ruiz and Pav”, “Piper crocatum”, “Screening phytochemical”, Piper crocatum”, “Leaf Piper crocatum”, and “antibacterial Piper crocatum”. Results: Based on literature studies, the antibacterial potential of red betel leaves (Piper crocatum Ruiz and Pav.) can be seen from the inhibition zones produced for both gram-positive and gram-negative bacteria, although with different values of the resulting inhibition zones.
GAMBARAN FAKTOR-FAKTOR YANG MEMPENGARUHI MINAT MASYARAKAT TERHADAP VAKSIN COVID-19 DI DESA MANGGISSARI KECAMATAN PEKUTATAN Marangyana I Gede Bagus Indra; Yunita Ella; Yunita Sari Ni Kadek Dwi
Journal Pharmactive Vol. 2 No. 1 (2023): Jurnal Pharmactive April
Publisher : Institut Teknologi dan Kesehatan Bintang Persada

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Abstract

This study aims to describe the factors that influence people's interest in the Covid-19 vaccine in Manggissari Village, Pekutatan District. This type of research is a quantitative study using the Cross-Sectional method. The sampling technique in this study was Simple Random Sampling, the total sample population was 237 in Manggissari Village, Pekutatan District. The results obtained from the frequency distribution show that from a total sample of 237 it can be seen that as many as 23.2% of the respondents who have not been vaccinated, not yet fully vaccinated (27.4%) and have had complete vaccines (49.4%), the community still has mostly low knowledge (49.8%), lack of information about the covid-19 vaccine (15.6%), lack of support from family (49.4%) and the influence of the community environment mostly (46.4%) . Based on the research above, there are factors that influence public interest in the Covid-19 vaccine. This research is expected to increase high awareness of carrying out the Covid-19 vaccination.
PENGARUH METODE PENGOLAHAN TERHADAP PENETAPAN KADAR AKRILAMIDA PADA POPCORN SECARA KROMATOGRAFI CAIR KINERJA TINGGI Iswandi Iswandi; Sasongko Roshinta Wulandari; Anita Nilawati
Journal Pharmactive Vol. 2 No. 2 (2023): Jurnal Pharmactive Oktober
Publisher : Institut Teknologi dan Kesehatan Bintang Persada

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Abstract

Acrylamide is a compound that is known to cause cancer and is potentially carcinogenic in humans. Acrylamide is formed in foods that contain carbohydrates and proteins when exposed to high temperature. One popular food that has the potential to generate acrylamide is popcorn. This research aims to determine the levels of acrylamide in popcorn using different processing methods, namely frying and baking, through High Performance Liquid Chromatography. Popcorn samples were obtained from the frying and oven method at 1560C. Sample preparation was carried out by extraction technique using dichlormethane and ethanol solvents. Acrylamide analysis was performed using High Performance Liquid Chromatography method with column C18, UV – Vis detector, wavelength 210 nm, mobile phase of 85% phosphoric acid in acetonitrile : aquabidest (5 : 95) and flow rate of 0.5 mL/min. Acrylamide testing begins with method validation including linearity, LOD, LOQ, accuracy and precision along with the determination of acrylamide levels. Data analysis using SPSS with the Shapiro – Wilk method and Independent Sample t – test. Based on the research, it was found that the results of method validation on the linearity coefficient were 0.999, the LOD test obtained 0.3933 ppm and LOQ 1.1918 ppm. The accuracy test obtains a recovery value of 97.29% and a precision value of 1.36%. Acrylamide levels for fried popcorn samples obtained an average level of 0,0417 g/kg. Acrylamide levels for oven popcorn samples obtained an average level of 0,0501 g/kg. The results of this study showed that there was no significant difference between fried popcorn and oven popcorn as evidenced by the SPSS test with a sig value of > 0.05.

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