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Jurnal Kedokteran Diponegoro
Published by Universitas Diponegoro
ISSN : -     EISSN : 25408844     DOI : -
Core Subject : Health,
Medicine & Pharmacology
JKD : JURNAL KEDOKTERAN DIPONEGORO ( ISSN : 2540-8844 ) adalah jurnal yang berisi tentang artikel bidang kedokteran dan kesehatan karya civitas akademika dari Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang dan peneliti dari luar yang membutuhkan publikasi . JURNAL KEDOKTERAN DIPONEGORO terbit empat kali per tahun. JURNAL KEDOKTERAN DIPONEGORO diterbitkan oleh Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang.
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Articles 12 Documents
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Search results for , issue "Vol 10, No 6 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)" : 12 Documents clear
Acute COVID-19 cardiovascular syndrome: A case report Agus Layanto; Sofyan Rais Addin; Friska Anggraini Helena Silitonga; Ayudyah Nurani; Rakhma Yanti Hellmi; Charles Limantoro; K Heri Nugroho Hario Seno; Fathur Nur Kholis
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 6 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i6.30323

Abstract

A man 44 years old with metabolic syndrome and chronic kidney disease was presenting acute COVID-19 cardiovascular syndrome. The condition was aggravated by presence of ureterolithiasis and gout. After treatment, hemodialysis and ureteroscopic lithotripsy-double J ureteral stent, the patient was recovered from his condition
Insilico Analysis of Codon 131 Polymorphism in FcγRIIA Gene and it is Association with Clinical Symptoms Persistence of Dengue Patients Enny Nugraheni; Dwi Ramadhani; Mardhatillah Sariyanti; Ety Febrianti
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 6 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i6.31010

Abstract

Background. Dengue Hemorrhagic Fever (DHF) is infection caused by Dengue Virus. Failure of vascularization is a main symptom of Dengue Hemorrhagic Fever inducing mediator secretion by an immune cell. FcgRIIA  and CCL2 have a significant role in dengue pathogenesis and possibility in having a chance to cause dengue with a worse manifestation. Objective. Analysis of bio-informatic structure, function and expression of FcgRIIA  gene. Methods. Insilico analysis used NCBI database to find position and sequences. Analysis mutant use SNO and OMIM. Protein prediction withUniprot.  Result. FcgRIIA   human with access number of NM_001136219 by a length of 2429 bp has its full name as Fc Fragment of IgG receptor IIa, located in 1q23.3 chromosom. analyzed mutation was rs1801274 with type of missense protein residue function experiencing a change from Histidin (H) turning into Arginin (R) with allele of wild-type A and becoming G amino acid position of 166. there was structural difference of FcgRIIA   gene in wild type and mutant. Conclusion. Gene FcγRIIA  is a play a role of pathogenesis of dengue infection. Mutation in FcγRIIA  have polymorfisme at Dengue Hemorrage Fever
The Effect of Radiotherapy on Blood Components of Cervical Cancer Patients Afina Yuliani Putri; Yan Wisnu Prajoko; Julian Dewantiningrum; Ch Nawangsih Prihharsanti
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 6 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i6.30411

Abstract

Background: Radiotherapy exposure is known to have a lethal effect on blood cells because hematopoietic cells are very sensitive to radiation exposure even at low doses. Cervical cancer with radiotherapy can have the effect of reducing blood cells. Blood cells that may experience the effects of radiotherapy include haemoglobin, leukocytes and platelets.Objective: Knowing the effects of radiotherapy towards blood components of cervical cancer patients.Methods: This study was an observational study with the type of study before and after design. Data collected from medical records as secondary data in the Radiotherapy Unit of Dr. Kariadi Semarang in 2019-2020 with a total of 128 cervical cancer patients undergoing 3D radiotherapy. The statistical test used the Saphiro Wilk data normality test and the result data analysis used the Paired T Test and the Wilcoxon test.Results: Hypothesis testing for Hb levels using the Paired T Test showed an insignificant value of p=0.749 and p=0.141. Hypothesis test for the number of leukocytes and platelets using the Wilcoxon test. Leukocytes received a significant value of p=0.000 and insignificant p=0.957. Platelets received a significant value of p=0.000 and p=0.000. Hb value decreased by -0.44, leukocytes by -3.5, and platelets by -84.34.Conclusion: There was an insignificant decrease in haemoglobin levels yet significant decrease in leukocyte and platelet counts in cervical cancer patients undergoing radiotherapy where the platelets experienced the most decrease compared to haemoglobin and leukocytes.
THE EFFECT OF BEETROOT JUICE (Beta vulgaris L.) ON THE CONCENTRATION OF SPERMATOZOA IN WISTAR RATS EXPOSED TO MOSQUITO COIL SMOKE Dean Pandu Eko Sapto; Donna Hermawati; RR. Mahayu Dewi Ariani; Farmaditya Eka Putra
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 6 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i6.31222

Abstract

Background: Mosquito coil smoke contains Allethrin that can increase the free radical effect. This process  may result in the damage of the cell membranes that triggered by oxidative stress. Oxidative stress can affect spermatogenesis and decreasing the quality of spermatozoa, including the spermatozoa concentration. Beetroot contain flavonoid as an antioxidant which can counteract the free radicals in the body.Purpose: To identify the effect of beetroot juice in the spermatozoa concentration of Wistar rats that exposed by mosquito coil smoke.Method: This study used Post Test Only control group design. The samples were 28 male Wistar rats that divided into 4 groups. The Control Group(-) was a group without treatment. The Control Group(+) was only exposed by mosquito coil smoke. Group P1 was exposed by mosquito coil smoke and given 8 ml of beetroot juice. P2 group was exposed by mosquito coil smoke and given 16 ml of beetroot juice. For 56 days, on the 57th day all rats were terminated and spermatozoa concentrations were examined.Results: The average concentration of spermatozoa was: Group K(-)=20,00; Group K(+)=8,00; P1 group=12,40; P2 group=17,20. One Way ANOVA test found there were significant differences among the five treatment groups. Post-Hoc test found there were significant differences among K(-) with K(+), K(-) with P1, K(-) with P2, K(+) with P1, K(+) with P2 and P1 with P2.Conclusion: Beetroot juice administration increasing the spermatozoa concentration of male wistar rats that exposed by cigarette smoke.Keywords: Mosquito coil smoke, beetroot juice, spermatozoa concentration
FACTORS ASSOCIATED WITH MEDICATION ADHERENCE IN HYPERTENSION IN THE NGLUWAR PUBLIC HEALTH CENTER IN MAGELANG REGENCY Taufan Agung Wicaksono; Arwinda Nugraheni; Firdaus Wahyudi; Pipin Ardhianto
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 6 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i6.31477

Abstract

Background: Adherence is an important matter in the succession of hypertension medication. Despite the fact, it was found that many with hypertension had not used antihypertension medications as prescribed.Objective: To acknowledge the factors correlated to antihypertension medication adherence.Method: We used an observational, cross-sectional study model with a quantitative analytical approach. Some 131 qualified hypertensive patients of Ngluwar Public Health Center were recruited in February and March of 2021. A sampling method of purposive sampling was used. The data obtained were statistically analyzed using the chi-square test. Results: Eighty-two respondents (62.6%) had high medication adherence and 49 respondents (37.4%) were low at medication adherence. The statistical analysis results are as follows. Level of education (p = 0.374, PR = 1.264, CI 95% = 0.765-2.090), job status (p = 0.025, PR = 0.591, CI 95% = 0.367-0.953), comorbidity (p = 0.366, PR = 1.239, CI 95% = 0.772-1.988), duration of hypertension (p = 0.604, PR = 1.124, CI 95% = 0.722-1.751), family support (p = 0.142, PR = 1.396, CI 95% = 0.890-2.190), health worker support (p = 0.002, PR = 1.994, CI 95% = 1.313-3.028), affordability (p = 0.329, PR = 1.246, CI 95% = 0.802-1.937) and accessibility (p = 0.564, PR = 1.240, CI 95% = 0.623-2.468), and polypharmacy (p = 0.573, PR = 0.848, CI 95% = 0.488-1.474).Conclusion: Job status and health worker support were significantly correlated to antihypertensive medication adherence.
IDENTIFICATION OF SECONDARY METABOLITE COMPOUNDS IN TUNICATE (Polycarpa aurata) ASSOCIATED BACTERIA Sheila Raisa; Astika Widy Utomo; Rebriarina Hapsari; Endang Mahati
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 6 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i6.30103

Abstract

Background: Marine biodiversity in the last few decades has been explored and utilized as marine natural products. The secondary metabolites produced by marine organisms are utilized by humans in various aspects of life. One of the main source of secondary metabolites is marine invertebrates, such as tunicate. Several previous studies have shown that many metabolites have been identified in the last 40 years.Objective: This study aimed to identify the metabolite compounds produced by tunicate-associated bacteria.Methods: The two isolates of bacteria associated with tunicate Polycarpa aurata, Bacillus wiedmannii and Virgibacillus salarius, obtained from the culture collection of Tropical Marine Biotechnology laboratory, Faculty of Fisheries and Marine Sciences, Diponegoro University, Semarang were used as material in this study. This study was carried out in Integrated Laboratory Diponegoro University from July to September 2020. Laboratory experiment was conducted by culturing these bacteria in Zobell Marine Broth 2216 at room temperature. The incubated culture was then added with ethyl acetate in a ratio of 1: 2 and then the supernatant was separated and evaporated. Analysis of the tunicate-associated bacteria methanol extract was carried out using Gas Chromatography-Mass Spectrophotometry (GC-MS).Results: 3-N-Hexyl-Delta-9-Tetrahydrocannabinol compound (100%) was discovered by GC-MS analysis from the tunicate-associated bacteria B. wiedmannii and V. salarius extract.Conclusion: 3-N-Hexyl-Delta-9-Tetrahydrocannabinol compound is an isomer compound of Delta-9-Tetrahydrocannabinol (Δ9-THC) which needs further research on its application in medical and non-medical aspects.
The Association between Face Mask Use and Headache: A Challenge in the New Normal Era Wira Dharma Utama; Erlina Purnamayani
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 6 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i6.32104

Abstract

Abstract Background: Indonesia has entered a new normal in the Covid-19 era and implemented strict health protocols in day-to-day activities. Transportation sectors, including air transportation, have been allowed to continue their services as long as they follow the health protocols, such as the mandatory use of face masks. Unfortunately, face masks now deal with several negative health issues, e.g., headache.Objective: To observe the association between face mask use and headache among airport officers and the average degree of the headache experience.Methods: The study was conducted at the Sultan Mahmud Badaruddin II (SMB II) International Airport in Palembang. The data were collected by a questionnaire gathered from December 2020 to January 2021. The data were processed using a quantitative approach with analytical methods.Results: From 207 airport officers, the major characteristics were female (57.9%), indoor workplaces (78.3%), face masks use ≤ 4 (four) hours per day (58.9%), and no headaches while using face masks (70.1%). There was a significant relationship between headache and face masks used > 4 hours per day (p < 0.001; 95% CI = 6.201 {3.215-11.958}). The mean of headaches degree using the VAS score was 2.3 (scale 0 - 10).Conclusion: Headaches could result from wearing facemasks for more than 4 hours per day. The mean degree of headaches due to facemasks used was relatively mild. The present research suggests that face masks must not cause other health problems. Improvement in face masks is the key to facing the Covid-19 pandemic and as important as washing hands and physical distancing.Keywords: Face mask; Headache; VAS Score
Correlation between Body Mass Index, Muscle Mass, and Muscle Explosive Power in First-Year Medical Students of Diponegoro University Devi wahyu arum sari; Hafizhil Uzhma Al Ahmadi; Timothy Jordan; Buwono Puruhito; Edwin Basyar; Darmawati Ayu Indraswari
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 6 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i6.31687

Abstract

Abstract Background: Muscle explosive power as a component of physical fitness is an important factor that supports athletic performance in most sports. jump height and vertical jump performance in assessing explosive muscle power are influenced by various factors, including physiological, biomechanical, and anthropometric factors. Body mass index, muscle mass, and fat mass are important anthropometric factors in supporting jumping performance.Objective: To analyze the relationship between body mass index and muscle mass with legs muscle explosive power in first-year medical students of Diponegoro University.Methods: This study is an observational analytic study with a cross-sectional design. The subjects consist of 60 males and 108 females in first-year medical students of Diponegoro University who met the criteria. Body mass index and muscle mass were measured by Omron bioelectrical impedance analyzer, and muscle explosive power was measured by vertical jump test. Data were analyzed with the Kolmogorov Smirnov normality test and Spearman correlation test.Results: The average value of body mass index was 21.760±2.7734, muscle mass was 29.468±4.3283, and muscle explosive power was 29.468±4.3283. Muscle mass was positively correlated with legs muscle explosive power (p=0.00, R= 0.583) and negatively correlated between body mass index and legs muscle explosive power but it was not statistically significant (p=0.823 dan R=- 0.017) in first-year medical students of Diponegoro University.Conclusion: Muscle mass was positively correlated with legs muscle explosive power and body mass index showed no significant correlation with muscle explosive power. Keywords: body mass index, muscle explosive power, muscle mass, vertical jump test
POTENTIAL USE OF VIRTUAL REALITY IN OVERCOMING NEEDLE PHOBIA IN COVID-19 VACCINATION Penggalih Mahardika Herlambang; Nanang Wiyono; Hendry Gunawan; Rani Tiyas Budiyanti
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 6 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i6.31504

Abstract

Background: Vaccination is very important because it can help prevent diseases that can be prevented by immunization (PD3I) such as polio, tetanus, diphtheria, measles, mumps, and rubella. During the Coronavirus Disease -19 (COVID-19) pandemic, the role of vaccination is very crucial, especially to reach herd immunity. However, there are many problems related to the implementation of vaccination, including needle phobia, which is a phobia of needles because it is considered painful. Virtual reality is a technology that develops in the form of a virtual image that can be used in vaccination services. This study aims to determine the potency of virtual reality to solve the needle phobia in vaccination services.Methods: The method used in this study is a literature review with sources from journals in the Scopus, ProQuest, and ScienceDirect database that was published in 2000 until 2020, and also books and articles with the keywords "virtual reality" "AND" "immunization," virtual reality " AND " vaccination " , "Needle phobia" "AND" "vaccination". This research was conducted from January to February 2021.Results: Based on the results obtained, virtual reality can be used in vaccination services, especially in the treatment of needle phobia. Virtual reality can become a distraction so that the patient will be distracted from fear and can lower the pain threshold. In addition, virtual reality can also be used as a means of education about immunization.Conclusion: Product development and clinical research need to be developed to assess the use of virtual reality in vaccination services during the COVID-19 pandemic. The use of virtual reality for other medical procedures that use needles can also be further investigated
Antidiarrheal Effect of Lime Peel Extract on Bisacodyl-Induced Mice Abraham Talent Bawadi Sibarani; Hesti Triwahyu Hutami; Nani Maharani; Yora Nindita
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 6 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i6.32144

Abstract

Background: Diarrhea is a condition of increased fecal water content of more than 200 grams or 200 ml/24 hours with a liquid or semi-liquid consistency. Complications of diarrhea, dehydration and malnutrition are still world health problems. Lime peel extract contains tannins which have astringent properties. Tannins are indicated as an alternative anti-diarrheal agent by tightening and forming a protective layer on the intestinal mucosa thereby reducing osmolarity.Aim: To examine the consistency, fecal water content, and frequency of defecation of bisacodyl-induced diarrhea in mice that are given lime peel extract.Methods: This research was an experimental with post test only group design. Thirty-six male mice were included and then divided into 5 groups with bisacodyl induction and 1 normal control group (KM) without bisacodyl induction. The negative control group (KN) was given 0.5 ml Tween 80 1%, the positive control group (KP) was given attalpugite 0.4 mg/40gW, treatment group 1 (X1), treatment group 2 (X2), treatment group 3 (X3 ) were given lime peel extract at graded doses of 125, 250, and 500 mg/KgW. Consistency, fecal water content, and frequency of defecation were observed every 30 minutes for 4 hours by observing the consistency of feces, weighing wet and dry feces to measure the water content, and measuring the frequency of defecation in each group. Data were analyzed statitiscally using Kruskal Wallis test with Post Hoc Mann Whitney test.Results: There were significant differences between the comparison of defecation frequency in the X3 group and the KM group, for the fecal water content comparison between the X3 group and the KN group, and no significant differences in the following group comparisons.Conclusion: Lime peel extract cannot reduce the frequency of defecation, fecal water content, and increase the consistency of feces significantly.Keywords: Diarrhea, lime peel extract, tannins, astringent, consistency, fecal water content, frequency of defecation.

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