Jurnal Kedokteran Diponegoro
JKD : JURNAL KEDOKTERAN DIPONEGORO ( ISSN : 2540-8844 ) adalah jurnal yang berisi tentang artikel bidang kedokteran dan kesehatan karya civitas akademika dari Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang dan peneliti dari luar yang membutuhkan publikasi . JURNAL KEDOKTERAN DIPONEGORO terbit empat kali per tahun. JURNAL KEDOKTERAN DIPONEGORO diterbitkan oleh Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang.
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<![CDATA[Relationship of Myopia Degree with Retinal Detachment Incidence at Diponegoro National Hospital ]]>
<![CDATA[Pradya Rahmawati Subagyo]]>;
<![CDATA[Trilaksana Nugroho]]>;
<![CDATA[Arnila Novitasari Saubig]]>
<![CDATA[ JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 2 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia ]]>
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DOI: 10.14710/dmj.v11i2.32528
<![CDATA[Background: Myopia is one of the visual disorders that has a high prevalence in the world. Based on the severity degree, myopia is divided into three criteria, namely mild, moderate and severe. Severe-degree myopia patients are more likely to suffer from certain eye diseases, especially those associated with the retina, such as retinal detachment.Objective: To analyze the relationship between the degree of myopia and the incidence of retinal detachment.Methods: This research is an observational analytical with cross-sectional approach. The research data was obtained using consecutive sampling from the medical records of myopia patients in Diponegoro National Hospital during 2015-2020. Research subjects used in this research were 70 patients who fulfill the inclusion and not the exclusion criteria. The data were analyzed using Chi Square test. Results: The prevalence of retinal detachment is dominated by the age group of 51-60 years old (18.6%), male (35.7%) and a severe degree of myopia (34.3%). The results of the Chi Square test show that there is a significant relationship between the severity degree of myopia and the incidence of retinal detachment.Conclusion: There is a significant relationship between the degree of myopia and the incidence of retinal detachment.]]>
<![CDATA[Relationship Between Frequency Of Tension Type Headache (TTH) In Epilepsy With Cognitive Function ]]>
<![CDATA[Diah Patlika]]>;
<![CDATA[Herlina Suryawati]]>;
<![CDATA[M.I. Widiastuti]]>;
<![CDATA[Endang Kustiowati]]>;
<![CDATA[Hexanto Muhartomo]]>;
<![CDATA[Arinta Puspita Wati]]>
<![CDATA[ JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 2 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia ]]>
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DOI: 10.14710/dmj.v11i2.32620
<![CDATA[Background : Epilepsy is a chronic disease that increases the risk of interictal headaches, one of which is tension type headache (TTH). TTH in epilepsy is triggered by recurrent neurogenic inflammation and central sensitization leading to pericranial tenderness. Recurrent neurogenic inflammation can affect cognitive function. The frequency of TTH in epilepsy is thought to be related to cognitive function score.Objective : Analyzing the relationship between the category of TTH frequency, onset of epilepsy, seizure frequency, age and education with cognitive score.Methods : Our study is an analytic observational study with a cross sectional design that took place from April to September 2021. The subjects of the study were epilepsy patients suffering from TTH at Dr. Kariadi Hospital, Semarang who met the inclusion and exclusion criteria. Patients’s data was obtained by filling out a questionnaire form. Assessment of the category of TTH frequency used ICHD-3 beta 2013 criteria. Assessment of cognitive function used the MoCA-Ina score. Data was analyze with Spearman correlation test, the results were significant if the p value <0.05.Results : Forty one epilepsy patients consist of 14 infrequent episodic TTH, 14 frequent episodic TTH and 13 chronic TTH. There was significant relationship between the MoCA-Ina score and the TTH frequency category (r=0,362; p=0,02), and education level (r=0,493; p=0,001). There was a weak relationship between the MoCA-Ina score and the onset of epilepsy or seizure frequency, while there was no relationship with age.Conclusion : There was a moderate relationship between the TTH frequency in epilepsy with cognitive function. Keywords : epilepsy, tension type headache (TTH), Montreal Cognitive Assesment - Indonesian version (MoCA-Ina)]]>
<![CDATA[Correlation between Interleukin 10 Serum Levels and Severity of Peripheral Neuropathy in Multibacillary Leprosy Patients a Research Article ]]>
<![CDATA[Fajar Sekti Reliyana]]>;
<![CDATA[Hexanto Muhartomo]]>;
<![CDATA[Endang Kustiowati]]>;
<![CDATA[Yosep Ferdinand Rahmat Sugiyanto]]>;
<![CDATA[Retnaningsih Retnaningsih]]>;
<![CDATA[Arinta Puspita Wati]]>;
<![CDATA[Rahmi Ardhini]]>;
<![CDATA[Aditya Kurnianto]]>
<![CDATA[ JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 2 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia ]]>
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DOI: 10.14710/dmj.v11i2.32648
<![CDATA[ABSTRACT Background of the ResearchLeprosy is a chronic infectious peripheral neuropathy caused by Mycobacterium leprae. Clinical presentations of leprosy neuropathy are obtained when the nerve damage is more than 30% of peripheral nerve fibers. The anti-inflammatory property of interleukin 10 is supposed to protect tissue from the damage caused by proinflammatory cytokines. Instead, it causes extensive nerve damage due to suppression of the cellular immune system, failure of forming granuloma to limit the growth of Mycobacterium leprae. As a result, it multiplies and spreads. Purpose of the ResearchThe purpose of the research is to analyze the correlation between interleukin levels 10 serum and the severity of peripheral neuropathy. Methods of the ResearchThe method used is cross-sectional research on 30 subjects with multibacillary leprosy aged 18-65 at the Neurology Department of Kelet Hospital Jepara from September to October 2021. The questionnaire was used to collect data of the patients. Interleukin level 10 serum evaluation is assessed by examining blood serum. Data analysis used Spearman Correlation Test. The significant result occurs if it is p<0.05. Research resultPatients with multibacillary leprosy are mostly men (73.3%). There is also a strong significant correlation between interleukin 10 levels and the severity of peripheral neuropathy (p<0.001) with rho (0.7) ConclusionThere is a strong and significant correlation between serum interleukin 10 levels and the severity of peripheral neuropathy in multibacillary leprosy Keywords: multibacillary leprosy, interleukin 10, peripheral neuropathy]]>
<![CDATA[OSTEOPENIA IN MALE AND FEMALE PATIENTS USING CARBAMAZEPIN AND VALPROIC ACID COMBINATION THERAPY: Analysis of Prevalence and Its Relationship with Epilepsy Characteristics ]]>
<![CDATA[Krisninda Anggonowati]]>;
<![CDATA[Endang Kustiowati]]>;
<![CDATA[M.I. Widiastuti]]>;
<![CDATA[Amin Husni]]>;
<![CDATA[Aris Catur Bintoro]]>;
<![CDATA[Rahmi Ardhini]]>
<![CDATA[ JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 2 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia ]]>
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DOI: 10.14710/dmj.v11i2.32744
<![CDATA[ABSTRACT Background : Epilepsy is a chronic condition with unprovoked seizures. One of the changes affected by anti-epileptic drugs is a decrease in bone density. Gender and sex hormones have implications on bone density.Objective : To determine the prevalence difference osteopenia between male and female, and relationship with clinical characteristics epilepsy patients taking a combination of carbamazepine and valproic acid.Methods: A cross-sectional study with 22 epileptic patients with age range of 18-60 years taking combination of carbamazepine and valproic acid at the Neurology Department Dr. Kariadi Semarang during June to October 2021 who met the inclusion and exclusion criteria. Patient data were obtained by filling out a questionnaire. The assessment of osteopenia was carried out by examination of Bone Mineral Densitometry. Data analysis was using Chi Square test and Spearman correlation test. The result was determined to be significant if the p value <0.05.Results : There were 11 male subjects and 11 female subjects. Chi Square resulted in significant difference between male and female (p<0.05). Spearman correlation test showed a relationship between osteopenia and duration before combination therapy, for men rho 0.734 (p<0.05), women rho 0.786 (p<0.001). There was a relationship between osteopenia and the onset of epilepsy, male rho 0.603 (p<0.05), female rho 0.757 (p<0.001). There was a relationship between osteopenia and age, male rho 0.487 (p=0.129), female rho 0.780 (p<0.001). There was also a relationship between osteopenia and seizure frequency, male rho 0.457 (p<0.05), female rho 0.467 (p=0.026).Conclusion: There was a significant osteopenia prevalence difference between male and female epilepsy patients taking combination of carbamazepine and valproic acid. Moderate and strong relationship were found between osteopenia and clinical characteristics epilepsy. Keywords : Epilepsy, osteopenia, carbamazepine, valproic acid]]>
<![CDATA[Characteristics of Endometriosis Patients in RSUP Dr. Kariadi Semarang in 2018 ]]>
<![CDATA[Syarifah A Mansur]]>;
<![CDATA[Yuli Trisetiyono]]>;
<![CDATA[Muflihatul Muniroh]]>;
<![CDATA[Nurul Setiyorini]]>
<![CDATA[ JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 2 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia ]]>
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DOI: 10.14710/dmj.v11i2.30722
<![CDATA[Background : Endometriosis is one of the gynecological disorders that affects women at reproductive age between 20-35 years. Based on the above, endometriosis can cause pain that can interfere daily activity and infertility.Aim : To found the incidence and characteristics of patients with endometriosis who undergoing treatment and surgery in RSUP Dr. Kariadi Semarang Method: This study was a descriptive study. Data retrieved from medical records of endometriosis’s patients who undergoing treatment and surgery at RSUP Dr. Kariadi Semarang 2018. The result presented in distribution and frequency characteristics tables.Result : The incidence of endometriosis in RSUP Dr. Kariadi Semarang in 2018 were 176 cases of 8690 inpatients in the obstetric and gynecology wards. Characteristics of endometriosis patients are most at the age of 20 - 35 years, nullipara, with complaints of menstrual pain / dysmenorrhoea, location in the ovary, by managing the surgery and using GnRH agonists, and not a recurrent endometriosis patient.Conclusion : The incidence of endometriosis in RSUP Dr. Kariadi Semarang 2018 was 176 cases of 8690 patients at the Obstetrics and Gynecology (2 %). Endometrosis highest incidence was in the reproductive age (20-35 years).]]>
<![CDATA[The Effect of Carbonated, Isotonic, and Yoghurt Drinks to the Hardness of Bulk Fill Composite Resin ]]>
<![CDATA[Tyagita Haning Ratnasari]]>;
<![CDATA[Nadia Hardini]]>;
<![CDATA[Yoghi Bagus Prabowo]]>;
<![CDATA[Faizah Fulyani]]>
<![CDATA[ JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 2 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia ]]>
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DOI: 10.14710/dmj.v11i2.31349
<![CDATA[Background: Composite resin often used as a restoration material due to its advantages in the aesthetic field. The bulk-fill type is one of the composite resin that can be applied directly into cavities as deep as 4 mm, so that restoration procedure becomes easy and effective. Hence, exposure to various acidic drinks can reduce the hardness of composite resins and eventually lead to failure of the tooth restoration process.Objective: This research aimed to evaluate the effects of several commercial acidic drinks, (carbonated, isotonic, and yogurt) on the hardness of bulk-fill composite resins.Method: This research was an experimental study with a post-test control group design. Twenty-four specimens were made with the size 10 x 4 mm using the metal mold rings. Specimens were divided into 4 groups for artificial saliva (served as a control), carbonated, isotonic, and yogurt. Specimens were immersed in storage agents for 5 seconds followed by artificial saliva for 5 seconds. This cycle was repeated 20 times for 14 days. The bulk-fill composite resin hardness was measured using a Micro Vickers Hardness Tester with a load of 100 grams for 10 seconds. Statistical analysis was performed using One Way ANOVA and Post Hoc LSDResults: Data were normally distributed and homogeneous with p > 0.05. The One Way ANOVA test showed the biggest difference in bulk fill composite resin between 4 groups (p < 0.001). The Post Hoc LSD test showed significant differences between all groups (p < 0.001)Conclusion: Carbonated, isotonic, and yogurt drink significantly decreased surface microhardness of bulk-fill composites resin but the carbonated drinks greatly reduce the hardness value since it has the lowest pH of 2.3.]]>
<![CDATA[Relationship of Hand Sanitizer Usage Frequency with the Incidence of Irritant Contact Dermatitis during COVID-19 Pandemic ]]>
<![CDATA[Almira Dwixie Dhara Desira]]>;
<![CDATA[Puguh Riyanto]]>;
<![CDATA[Liza Afriliana]]>;
<![CDATA[Dea Amarilisa Adespin]]>
<![CDATA[ JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 2 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia ]]>
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DOI: 10.14710/dmj.v11i2.32631
<![CDATA[Background: Irritant Contact Dermatitis (ICD) is an eruption of the skin caused by the non-immunologic inflammatory response of the skin to the irritant agents. The government urged to implement health protocols 3M, one of them is hand hygiene by used hand sanitizer to prevent the spread of COVID-19 infection. Repeated use of hand sanitizer can cause skin irritation and inflammatory response such as dryness, cracks, and other symptoms of ICD.Objective: To analyze the relationship between the frequency of use of hand sanitizer and the incidence of ICD.Methods: Observational analytics study cross-sectional design. The research subject were 260 medical faculty students of Diponegoro University who had to agree with informed consent, filled questionnaires and qualified by research criteria. Diagnostic of ICD based on questionnaires and physical examination of ICD. The statistical analysis data was used Chi-square test.Results: The results showed after analyze data use Chi-square test that there was not significantly related frequency use the hand sanitizer to the incidence irritant contact dermatitis during the COVID-19 pandemic with a p-value is 0,078 (p>0,05). The most frequent use of hand sanitizers is 5-10 times a day (56,5%), the most symptoms in ICD are dry, scaly, and peeling skin (30%), and the incidence of ICD due to the use of hand sanitizers are 33,5%.Conclusion: There was no significant relationship between frequency of use of hand sanitizer and irritant contact dermatitis during pandemic the COVID-19.]]>
<![CDATA[Air Pollution Exposure and Physical Exhaustion in Relation to GSH:GSSG Ratio of Online-Based Motorcycle Drivers ]]>
<![CDATA[Nabilla Nurcahya Junior]]>;
<![CDATA[Dodik Pramono]]>;
<![CDATA[Fathur Nur Kholis]]>;
<![CDATA[Lusiana Batubara]]>
<![CDATA[ JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 2 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia ]]>
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DOI: 10.14710/dmj.v11i2.33245
<![CDATA[Background: Online motorcycle drivers work more than 10 hours a day, surpassing the international working hour regulations. Working hours are directly proportional to air pollution exposure generating reactive oxygen species (ROS). On the other hand, physical exercise also contributes to the generation of ROS due to greater oxygen utilization by mitochondria. The ratio of GSH to GSSG represents the oxidative stress level in body tissues.Objective: This study aimed to analyze the relationship between the length of air pollution exposure and the level of physical exhaustion to GSH:GSSG ratio of online motorcycle drivers.Methods: This research was a cross-sectional study of 16 male online motorcycle drivers. The GSH:GSSG ratio was assessed by ELISA with cyclic DTNB reaction principle. Length of air pollution exposure and level of physical exhaustion data were obtained from the interview. Statistical analysis was done to determine the correlation between variables.Results: The mean GSH:GSSG ratio in studied population is 0.69 ± 0.26, lower than 1 value of GSH:GSSG ratio represents high oxidative stress condition. Based on the correlation test, there are no correlation between length of air pollution exposure (r = -0.464, p = 0.070) and level of physical exhaustion (r = -0.439, p = 0.089) to GSH:GSSG ratio in online motorcycle drivers.Conclusion: Our findings suggested that online motorcycle drivers have a high level of oxidative stress, length of air pollution exposure, and status of physical exhaustion, which is not associated with the GSH:GSSG ratio.]]>
<![CDATA[Air Pollution Exposure Duration and Its Correlation with Triglyceride, HDL, and Atherogenic Index in Online Motorcycle Drivers ]]>
<![CDATA[Adrian Stefanus Herawan]]>;
<![CDATA[Edward Kurnia Setiawan Limijadi]]>;
<![CDATA[Donna Hermawati]]>;
<![CDATA[Lusiana Batubara]]>
<![CDATA[ JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 2 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia ]]>
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DOI: 10.14710/dmj.v11i2.33794
<![CDATA[Background: The most restoration material used currently in dentistry was composite resin. The newest generation of composite resin was bulk-fill composite resin. The bulk-fill composite resin had advantages of lower polymerization contraction and a more straightforward and faster restoration technique. One of the factors which could affect the hardness of composite resin was the consumption of acidic drinks. The acidic beverage that people often consumed is coffee. A few coffee brewing methods were espresso and drip brewing.Objective: This research aimed to identify the effects of coffee soaking through espresso and drip brewing methods on bulk-fill composite resin's hardness.Methods: his research was experimental research, with a post-test control group design and a total sample of 27 samples. The soaking process was taken for seven days at a temperature of 37˚C on artificial saliva, espresso, and drip brewing coffee methods. The hardness of bulk-fill composite resin was measured after seven days by using Vickers hardness. The statistic test exerted One-Way ANOVA.Results: This research found a significant difference in bulk-fill composite resin's hardness among all groups, p-value = 0.00 (p<0.05). The result of the post-hoc LSD test showed a significant difference in the change of bulk-fill composite resin hardness between the artificial saliva group and espresso group (p=0,00) and no significant difference found between the artificial saliva group and drip brewing group (p=0.85).Conclusion: Soaking with espresso coffee has the smallest hardness value compared to soaking with drip brewing coffee and artificial saliva, so soaking with espresso coffee is the most influential on the hardness of the bulk fill composite resin. ]]>
<![CDATA[The Effect of Espresso and Drip Brewing Coffee Methode to The Hardness of Bulk-Fill Composite Resin ]]>
<![CDATA[Rahmadani Widya Atmani]]>;
<![CDATA[Diah Ajeng Purbaningrum]]>;
<![CDATA[Faizah Fulyani]]>;
<![CDATA[Lusiana Batubara]]>
<![CDATA[ JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 2 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia ]]>
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DOI: 10.14710/dmj.v11i2.31162
<![CDATA[Background: The most restoration material used currently in dentistry was composite resin. The newest generation of composite resin was bulk-fill composite resin. The bulk-fill composite resin had advantages of lower polymerization contraction and a more straightforward and faster restoration technique. One of the factors which could affect the hardness of composite resin was the consumption of acidic drinks. The acidic beverage that people often consumed is coffee. A few coffee brewing methods were espresso and drip brewing.Objective: This research aimed to identify the effects of coffee soaking through espresso and drip brewing methods on bulk-fill composite resin's hardness.Methods: his research was experimental research, with a post-test control group design and a total sample of 27 samples. The soaking process was taken for seven days at a temperature of 37˚C on artificial saliva, espresso, and drip brewing coffee methods. The hardness of bulk-fill composite resin was measured after seven days by using Vickers hardness. The statistic test exerted One-Way ANOVA.Results: This research found a significant difference in bulk-fill composite resin's hardness among all groups, p-value = 0.00 (p<0.05). The result of the post-hoc LSD test showed a significant difference in the change of bulk-fill composite resin hardness between the artificial saliva group and espresso group (p=0,00) and no significant difference found between the artificial saliva group and drip brewing group (p=0.85).Conclusion: Soaking with espresso coffee has the smallest hardness value compared to soaking with drip brewing coffee and artificial saliva, so soaking with espresso coffee is the most influential on the hardness of the bulk fill composite resin.]]>
