Pharmaciana: Jurnal Kefarmasian
Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022
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<![CDATA[In vitro penetration of alpha arbutin niosome span 60 system in gel preparation ]]>
<![CDATA[Rise Desnita]]>;
<![CDATA[Sri Luliana]]>;
<![CDATA[Silvana Anggraini]]>
<![CDATA[ Pharmaciana Vol 7, No 2 (2017): Pharmaciana ]]>
Publisher : <![CDATA[Universitas Ahmad Dahlan ]]>
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DOI: 10.12928/pharmaciana.v7i2.6799
<![CDATA[Alpha arbutin is a hydrophilic compound which is difficult to pass trough the stratum corneum. One of the effort to increase the penetration of the drug through the stratum corneum is by making in niosome system. This study aims to determine the optimum concentration of span 60 to improve the entrapment efficiency of niosome and investigate the increasing penetration of alpha arbutin using the niosome system in the preparation of the gel in vitro. Niosome consist a mixture of span 60 and cholesterol it made by thin layer hydration method. Concentration of span 60 was varied into three formulas were 100, 150 and 200 µmoL. The formulation of gel was made in two formulas including formulation of niosome alpha arbutin and alpha arbutin in gel. The determination of enterapment efficiency showed that formula 100µmol has an optimum enterapment efficiency by 99.09%±0.1. The in vitro penetration tests with shed snake skin membrane showed that usage span 60 as a niosome composer could increase penetration of alpha arbutin in gel formulation with cumulative numbers of diffusion in 8 hours was 91.62%±2.32 compared to alpha arbutin in gel without niosome system about 73.00%±0.94.7.]]>
<![CDATA[Cytotoxic effect of 2,3-dihydro-6-hydroxy-2-methylenenaphtho[1,2-b] furan-4,5-dione compound from the bark of faloak (Sterculia quadrifida R.Br) in breast cancer cells T47D ]]>
<![CDATA[Rollando Rollando]]>;
<![CDATA[Rokiy Alfanaar]]>
<![CDATA[ Pharmaciana Vol 7, No 2 (2017): Pharmaciana ]]>
Publisher : <![CDATA[Universitas Ahmad Dahlan ]]>
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DOI: 10.12928/pharmaciana.v7i2.6699
<![CDATA[Faloak (Sterculia quadrifida R.Br) is used empirically by residents of East Nusa Tenggara for drug plant. The information of the active compound contained in the faloak bark yet specifically published. This study aims to determine the active compound contained in the faloak bark that have cytotoxic activity to T47D breast cancer cells. Extraction process using maceration method, isolation process using gradien isolation method, elusidation using combination of information of IR spectra, 1D-NMR, 2D-NMR and LC-MS, and cytotoxic activity test on T47D breast cancer cells using MTT method. The isolation result obtained that isolate of naphthoquinone derivative compound is 2,3-dihydro-6-hydroxy-2-methylenenaphtho [1,2-b] furan-4,5-dione with IC50 value on T47D breast cancer cell was 9,88 µg/mL and with an index selectivity value was 30,23. ]]>
<![CDATA[Effectiveness of web based educational on improving knowledge of acne vulgaris self medication among senior high school students ]]>
<![CDATA[Lolita Lolita]]>;
<![CDATA[Ni Putu Isabela Meita Putri]]>
<![CDATA[ Pharmaciana Vol 7, No 2 (2017): Pharmaciana ]]>
Publisher : <![CDATA[Universitas Ahmad Dahlan ]]>
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DOI: 10.12928/pharmaciana.v7i2.7240
<![CDATA[The presence of technology can provide real alternatives to build knowledge in delivering health education materials. The aim of this study was to investigate if web-based education methods may rising a student’s knowledge about self medication of acne. This research using an experimental pretest-posttest control group design while the sampling technique using convenience nonprobability sampling. Inclusion criteria for participants were senior high school students aged 13-19 years, active social media users, and willing to fill out the research questionnaire. Participants were allocated to the exclusion criteria as students who perform routine skin care in the acne treatment. Control group consisted of 62 respondents who were given face to face education and treatment group consisted of 62 respondents who were given website-based education. Data analysis were performed with a student t-test to assess the effect of educational intervention on student’s knowledge. The independent t-test showed there was a significant increase of knowledge between the control and the treatment groups  (p = 0,000) with 95% confidence level. This study demonstrate that web-based educational intervention had a significant increase on the student’s knowledge about acne vulgaris self medication.]]>
<![CDATA[Antioxidant activity of methanolic extract from yellow paprika (Capsicum annuum, L.) by DPPH radical scavenging method ]]>
<![CDATA[Warsi Warsi]]>;
<![CDATA[Any Guntarti]]>
<![CDATA[ Pharmaciana Vol 7, No 2 (2017): Pharmaciana ]]>
Publisher : <![CDATA[Universitas Ahmad Dahlan ]]>
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DOI: 10.12928/pharmaciana.v7i2.3905
<![CDATA[Yellow paprika (Capsicum annuumL.) is one of fruit that contains of carotenoid compounds as an antioxidant. This reasearch was aimed to know an antioxidant capacity of methanolic extract from yellow paprika with 2,2–diphenyl–1–picrylhydrazyl (DPPH) radical scavenging method. The fresh yellow paprika was determined of its loss of drying by gravimetric. The yellow paprika extract was obtained by maceration using methanol as solvent. The content of β–carotene from this extract was analyzed qualitively by thin layer chromatography and UV-Vis spectrophotometer. The antioxidant activity of methanolic extract from yellow paprika was determined base on measurement of residual DPPH by UV–Vis spectrophothometric at wavelength of 515.6 nm. The data was used to calculate % inhibition. Furthermore, IC50 value was determined to know potency of its antioxidant. The result of loss of drying yellow paprika fruit was obtained 6.33 ± 0.02 %. The analysis with thin layer chromatography and UV-Vis spectrophotometer showed that this fruit was contain of β–carotene. The result of antioxidant activity analysis from yellow paprika fruit was obtained IC50 value of 0.3028 ± 0.0093 mg/mL. The result of the research showed that the antioxidant potency of yellow paprika was less than β–carotene (IC50 0.0852 ± 0.0009 mg/mL).]]>
<![CDATA[Pakan banyu (Croton argyratus Blume) stembark ethanol extract effectiveness to total spermatogenic cells of white male rats (Rattus norvegicus) ]]>
<![CDATA[Noor cahaya]]>;
<![CDATA[M. Aditya Sholihin]]>;
<![CDATA[Nurlely Nurlely]]>
<![CDATA[ Pharmaciana Vol 7, No 2 (2017): Pharmaciana ]]>
Publisher : <![CDATA[Universitas Ahmad Dahlan ]]>
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DOI: 10.12928/pharmaciana.v7i2.6842
<![CDATA[Stembark of Pakan Banyu (Croton argyratus Blume) empirically used as traditional contraception. The stembark contained active substances as steroids, saponins and alkaloids tannins alleged antifertillity for men. The purpose of this study was to demonstrate the potential of Pakan Banyu stembark ethanol extract to the total number of spermatogonium cells, primary spermatocytes, spermatids and spermatozoa in male rats. This study was an experimental research design posttest only control group design using 20 male rats into 4 groups of 5 mice. The control rats were used in treatment group, the rats were given the pakan banyu stembark extract at a dose of 100, 200 and 500 mg / kg with 0.5% CMC Na suspending agent. The treatment was given orally for 15 days at the 16th days surgery was done to the testicles organs, then microanatomy preparations were made using paraffin method and using HE colour. Analysis of data using One-way ANOVA and Kruskal Wallis with 95% confidence level. The results showed that there is no effect of Pakan Banyu stembark ethanol extract against spermatogonium cells, primary spermatocytes, spermatids and spermatozoa. ]]>
<![CDATA[Factors relate to the hypercreatininemia event of patients at the risk of metabolic syndrome in Jetis I public health center ]]>
<![CDATA[Akrom Akrom]]>;
<![CDATA[Endang Darmawan]]>;
<![CDATA[Nuril Maulida]]>
<![CDATA[ Pharmaciana Vol 7, No 2 (2017): Pharmaciana ]]>
Publisher : <![CDATA[Universitas Ahmad Dahlan ]]>
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DOI: 10.12928/pharmaciana.v7i2.6717
<![CDATA[Metabolic syndrome (MS) is a risk factor for chronic kidney disease (CKD). Adherence to drug therapy is one of the keys to achieving therapeutic targets in MS. Hyperuricemia (>7mg/dL in men &>5.4mg/dL in women) and hypercreatininemia (>1.3 mg/dL) is a sign of kidney function deficiency. Kidney function deficiency is the result of uncontrolled blood pressure and blood sugar levels in MS patients. The objective of the study was to know the description of the incidence of hypercreatininemia and factors related to the incidence of hypercreatininemia in outpatient at risk of  MS at Jetis Public health center (PHC) I, Bantul, Yogyakarta. The analytical observational research with cross sectional design was performed on 99 MS outpatient at Jetis I Public Health Center (PHC) who fulfilled the inclusion criteria and approved the participation in the study. Blood urea and creatinine levels were determined by spectrophotometer 5010. Demographic, diagnosis and treatment data were colleccted  from medical record. Patient adherence data were collected by interview. Patient compliance was measured by a medication compliance questionnaire. Demographic and clinical  data are presented descriptively. Bivariate analysis with chisquare was performed to determine the value of the relationship between sex, age, hyperuricemia and adherence to the incidence of hypercreatininemia.  About 30.3% of total of outpatients at risk of MS at Jetis I PHC, Bantul, is non-adherence and 69.7% is adherence to the treatment. As many as 44.4% of respondents have hypercreatininemia and 8.1% of respondents have hyperuricemia. There was a relationship between adherence and female sex with the prevalence of hypercreatininemia with an odds ratio of 3.8, 0.26 and 7.1 respectively. Based on the data of the study concluded that non-adherence, male sex and hyperuricemia are associated with the prevalence of hypercreatininemia in patients at risk of MS in Jetis I PHC.]]>
<![CDATA[Application method of Fourier Transform Infrared (FTIR) combined with chemometrics for analysis of rat meat (Rattus Diardi) in meatballs beef ]]>
<![CDATA[Any Guntarti]]>;
<![CDATA[Seshilia Rarasati Prativi]]>
<![CDATA[ Pharmaciana Vol 7, No 2 (2017): Pharmaciana ]]>
Publisher : <![CDATA[Universitas Ahmad Dahlan ]]>
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DOI: 10.12928/pharmaciana.v7i2.4247
<![CDATA[Food product forgery begins to become a new problem in Indonesia, the main problem is there is a concern that food product is mixed with forbidden meat, one of may is rat meat in meatball. This study is expected to become one basic in order to meet meatball authenticity guarantee.Study about the utilization of infrared spectrophotometry Fourier Transform (FTIR) which was combined with chemometric was carried out to identified rat meat in meatball quantitative and qualitatively. Concentration variation of beef and rat meat in producing meatball is 0%, 25%, 35%, 65%, 75% and 100% rat meat in meatball dough and 5 samples of market meatball. Beef and rat fat which were contained in meatball was extracted by Soxhlet in temperature ≤ 70oC for 7 hours with n-hexane solvent.Qualitative and quantitative analysis was carried out in wave range 750-1600 cm-1 by using partial least square (PLS) multivariate analysis technique and principal component analysis (PCA). The result of calibration with y = 0,9720x + 1,580, coefficient of determination (R2) = 0,9941, and root mean square error of calibration (RMSEC) value was 1.63%. Validation model with, mean root mean square error of cross validation (RMSECV) value was 1.79%, and root mean square error of prediction (RMSEP) value was 2.60%. Using Principal Component Analysis (PCA), grouping of cow fat and mouse fat in the meatballs successfully. ]]>
<![CDATA[Analytical method validation and determination of dexamethasone in divided powder using reverse phase HPLC ]]>
<![CDATA[Florentinus Dika Octa Riswanto]]>;
<![CDATA[Dita Maria Virginia]]>;
<![CDATA[Dina Christin Ayuning Putri]]>;
<![CDATA[Sri Hartati Yuliani]]>
<![CDATA[ Pharmaciana Vol 7, No 2 (2017): Pharmaciana ]]>
Publisher : <![CDATA[Universitas Ahmad Dahlan ]]>
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DOI: 10.12928/pharmaciana.v7i2.7259
<![CDATA[Dexamethasone as glucocorticoids has been widely used to reduce inflammation and tissue damage in a variety of conditions. It was commonly prescribed in combination with the other compounds such as chlorpheniramine maleate for the relief of asthma. It was important to observe the quality and safety of the combination dosage form, called pulveres or puyer in order to serve the patient oriented medication. This research aimed to develop analytical method validation and determine the content uniformity of the divided powder containing dexamethasone compounded by pharmacy in Yogyakarta and hospital in Central Java, Indonesia. A validated high performance liquid chromatography (HPLC) method was chosen to determine dexamethasone in the samples. The column of ACE 5 C18 (250 x 4.6 mm) was used in this research and the methanol:water (65:35) was used as the mobile phase at the flow rate of 1 mL/min. The UV detection was performed at 239 nm. Analytical method validation was performed on the parameters of system suitability, limit of detection, limit of quantification, accuracy, precision, and linearity. The results showed that dexamethasone contains in divided powder compounded by pharmacy in Yogyakarta and hospital in Central Java were met the acceptance requirement.  ]]>
<![CDATA[Comparison of antioxidant activities from four species of piper ]]>
<![CDATA[Muhamad Insanu]]>;
<![CDATA[Lia Marliani]]>;
<![CDATA[Nabila Pandu Dinilah]]>
<![CDATA[ Pharmaciana Vol 7, No 2 (2017): Pharmaciana ]]>
Publisher : <![CDATA[Universitas Ahmad Dahlan ]]>
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DOI: 10.12928/pharmaciana.v7i2.6935
<![CDATA[Some species from Piper genus were known for traditional medicine and ornamental plant. Previous studies showed that Piper betle and Piper acre had antioxidant activities. But, the study of antioxidant activity from other species of Piper was still limited. Because of that, the purposes of this study were to determine the antioxidant activity, and total flavonoid content of Piper nigrum, Piper aduncum, Piper retrofractum, and Piper crocatum. Extraction was done by gradient maceration using n-hexane, ethyl acetate, and ethanol as solvents. The extracts were concentrated by rotary evaporator. Antioxidant activity was evaluated by DPPH (1,1-diphenyl-2-picrylhydrazyl) free scavenging method. Total flavonoid determination was done by colorimetry method using aluminum chloride (AlCl3) as a reagent. The result showed that the IC50 values of Piper nigrum, Piper aduncum, Piper retrofractum, and Piper crocatum were ranged between 58-1249 μg/mL. The total flavonoid values of all extracts were between 1.4-8.3 mg QE/100 mg. The extract which had the strongest antioxidant activity was the ethanol extract of Piper nigrum with an IC50 value was  57.72 μg/mL. The highest values of total flavonoid was showed by the ethanol extract of Piper aduncum which was 8.3 mg QE/100 mg extract.]]>
<![CDATA[Clearance profile of radioactive gold nanoparticle (198Au) conjugates-poliamidoamin generation 4-nimotuzumab ; potential radio-pharmaceutical theranostic agent ]]>
<![CDATA[Nurhatidjah Awaliyah Halid]]>;
<![CDATA[Abdul Mutalib]]>;
<![CDATA[Anung Pujiyanto]]>;
<![CDATA[Adang Hardi Gunawan]]>
<![CDATA[ Pharmaciana Vol 7, No 2 (2017): Pharmaciana ]]>
Publisher : <![CDATA[Universitas Ahmad Dahlan ]]>
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DOI: 10.12928/pharmaciana.v7i2.6725
<![CDATA[Theranostic agents are agents that combine diagnostic and therapeutic capabilities into a single agent. The presence of conjugated cancer which is therapeutic agents such as nimotuzumab monoclonal antibodies with radioactive gold nanoparticles stabilized with Polyamidoamine Generation 4 (PAMAM G4) dendrimer can actively interact with specific cancer cells. Radioactive gold (198Au) as a radiation transmitter β (961 keV) capable for killing cancer cells and (412 keV) γ rays that give a golden image in the body, thus acting as a theranostic agent. The purpose of this study was to obtain confident results of conjugate safety by observing the constituent clearance of 198AuNP-PAMAM G4-Nimotuzumab. The result of the conjugate clearance will be the reference for the metabolic state as a new, stable and complete radiofarmaka upon reaching the desired target. This study began with the synthesis of the conjugate of 198AuNp-PAMAM G4-nimotuzumab and then tested the clirens and analyzed the results of urine and mouse feces that had been injected with conjugate. Total clearance was obtained about 47.38% of the 198AuNP-PAMAM G4-Nimotuzumab conjugates that have been excreted through urine (18.26%) and stool (29.11%.). Urine and feces were analyzed with SDS-PAGE giving the spot above the 150 kDa band and showing the conjugate molecular weight. FTIR analysis of urine and feces by showing aldehyde functional groups (C = O), alcoholic groups (O-H), amine groups (C-N), and amine groups (N-H) indicating the presence of AuNP-PAMAM G4-Nimotuzumab conjugates in urine and mouse feces. The results of urine and fecal excretion of the conjugate are still conjugate-shaped supported by SDS PAGE analysis, UV-Vis spectrophotometer absorption analysis and functional group analysis with FTIR that has been conducted.]]>
