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Biomedika
Published by Universitas Muhammadiyah Surakarta
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Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
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Articles 399 Documents
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PERBEDAAN FUNGSI KELUARGA DAN KUALITAS HIDUP ISTRI ANTARA ISTRI BEKERJA DAN TIDAK BEKERJA Candrasari, Anika; Probandari, Ari Natalia
Biomedika Vol 5, No 1 (2013): Biomedika Februari 2013
Publisher : Universitas Muhamadiyah Surakarta

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Abstract

Along economic progress and increase in women education, so many housewives today serve not only as manager of their household, but also work outside home. It will have various social implications, such as stress due to work overloads, increased teenage delinquency due to lack of parental attention, lack of marriage or family values. This study aimed to analyze the differences of family function and wife’s quality of life among wife with and without occupation. Location of study was Bolon village, District Colomadu, Karanganya, Central Java. The study used an observational analytic design, with a cross-sectional approach. The study population was wives. Sampling used 128 wives. The instruments were APGAR, SCREEM family function and WHOQOL. From t test, it showed signifi cant differences family function and wife’s quality of life among wife with and without occupation (APGAR p = 0.023, SCREEM p = 0.001 and wife’s quality of life p = 0.043).Keywords: family function, quality of life, wife, work.
EFEK ANTIINFLAMASI INFUSA RIMPANG TEMU PUTIH (Curcuma zedoaria (Berg) Roscoe) PADA TIKUS YANG DIINDUKSI KARAGENIN Sujono, Tanti Azizah; Patimah, Raudatul; Yuliani, Ratna
Biomedika Vol 4, No 2 (2012): Biomedika Agustus 2012
Publisher : Universitas Muhamadiyah Surakarta

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Abstract

In-flammation is the body’s reaction to foreign substances that enter the body with signs of redness, heat, swelling, pain, and impaired organ functions. Curcuma rhizome including medicinal plants that have properties relieve the pain and inflammation of the skin. The purpose of this research was to examine the anti-iflammation effect of Curcuma zedoaria (Berg) Roscoe Rhizome infusion on carrageenan induced paw edema in rats. This research used experimental method with completely randomized design. Twenty five healthy Wistar male rats, 2-3 months old and 150-250 g divided into five groups and each group consist of 5 rats. Rats in group I that served as negative control were given 2.5 mL/200gbw of aquadest. Rats in group II as positive control were given sodium diclofenac with dose of 6.75 mg/kgbw. Group III, IV, and V were given Curcuma zedoaria (Berg) Roscoe Rhizome infusion with dose of 0.625, 1.250 and 2.500 g/kgbw, respectively. Treatments were given per oral 1 hour before injection of 0.1 ml carrageenan 1% subplantar. Rat paw edema volume was measured before and after carrageenan injection. The measurement was done every 0.5 hour for 6 hours observation. Area Under the Curve (AUC) that is calculated from paw edema volume data, was use to calculate percentage of anti-inflammatory effect. Data were analyzed with one way Anova and Least Signifi cant Difference with confi dence level 95%. Infusion of Curcuma zedoaria Rhizome with doses of 0,625, 1,250, and 2,500 g/kgbw had anti-inflammatory effect in Wistar male rats which were induced by Carrageenan 1%. Percentage of anti-inflammation effect (44,16+5,11)%, (48,70+7,05)%, (59,09+9,61)% respectively and the effects were equivalent with positive control.Key words: Anti-inflammation, Curcuma zedoaria (Berg) Roscoe, infusion, Carrageenan.
HUBUNGAN ANTARA HIPERTENSI DENGAN PREMENSTRUAL SYNDROME PADA WANITA USIA REPRODUKTIF Rahmawati, Azhim; Siryaningsih, Retno; Jatmiko, Safari Wahyu
Biomedika Vol 6, No 2 (2014): Biomedika Agustus 2014
Publisher : Universitas Muhamadiyah Surakarta

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Abstract

Premenstrual syndrome (PMS) is a cycle disorder which is commonly occured during the luteal phase of the menstrual cycle and will dissapear at the time of menstruation. Ninety percent of women on reproductive ages experience symptomps of PMS and 10% of them experience severe premenstrual symptomps that cuse physical disturbance, medical care necessity, even worst death. Hypertension is a risk factor for a PMS. The aim of this research is to find out a conection between PMS and hypertension. This research was designated using analytic observational with cross sectional approach. We used purposive sampling to get sample. Based on sample formula, we got 104 respondents which is consist of 52 women with hypertension and 52 women normotensive. To obtain data, we used shortened premenstrual syndrome assesment form (SPAF). Data collected were analyzed by chi square test. The result showed that the value of p = 0.00 (p<0.005). This result indicated that there is a conection between hypertension and PMS occurence in reproductive age. The probability of hypertension women to get PMS is 6.75.Keywords: Hypertension, Premenstrual Syndrome, reproductive age
PEMISAHAN SENYAWA-SENYAWA YANG BERSIFAT SITOTOKSIK TERHADAP SEL MURIN LEUKEMIA P388 DARI EKSTRAK METANOL KULIT BATANG DIPTEROCARPUS CONFERTUS SLOOT (DIPTEROCARPACEAE) Muhtadi, .; Indrayudha, Peni
Biomedika Vol 5, No 1 (2013): Biomedika Februari 2013
Publisher : Universitas Muhamadiyah Surakarta

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Abstract

Six compounds, KP-1 up to KP-6 were isolated from the methanol extract of the tree bark of Dipterocarpus confertus Sloot (Dipterocarpaceae). The cytotoxic activities of these compounds were evaluated against murine leukemia P388 cells. Result of these examination indicated that KP-2 compound and KP-1 were very active with each IC 50 value of these compounds were 2.25 and 5.1 μg/mL, respectively. While the others were not active against murine leukemia P388 cells.Keywords: Dipterocarpaceae, Dipterocarpus confertus Sloot, isolated compounds, cytotoxic, and leukemia P-388 cell
UJI DAYA ANTIMIKROBA EKSTRAK ETANOL DAUN SIRIH MERAH (Piper Crocatum Ruiz & Pav.) TERHADAP PERTUMBUHAN Staphylococcus aureus ATCC 6538, Eschericia coli ATCC 11229 DAN Candida albicans ATCC 10231 SECARA IN VITRO Candrasari, Anika; Romas, M. Amin; Astuti, Ovi Rizky
Biomedika Vol 4, No 1 (2012): Biomedika Februari 2012
Publisher : Universitas Muhamadiyah Surakarta

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Red betel leaf contains flavonoids, alkaloids and essential oils that are suspected able to inhibit the growth of microbes. This study aims to analyze antimicrobial activity of ethanol extract of red betel leaf agains to Staphylococcus aureus, Eschericia coli and Candida albicans. Subjects were red betel leaf ethanol extract at concentration of 2.5%, 5%, 10%, 20%, 40%, 80% and 100%. As a positive control used amoxycilin, chloramphenicol and ketoconazole. The study showed that concentration 10 % - 100 % inhibit the growth of Staphylococcus aureus. In Escherichia coli all the data obtained, having an average which is not much different from the mean of the negative control. While on Candida albicans average diameter of inhibition zone of extract concentration 40% p = 0.197 concluded that statistically has significant antifungal power compared with ketokonazole.Keywords: Ethanol extract, Piper Ruiz & Pav crocatum, Antimicrobial, Staphylococcus aureus, Escherichia coli, Candida albican
PENGARUH PEMBERIAN AIR SEDUHAN BERAS YANG DIFERMENTASI OLEH MONASCUS PURPUREUS (ANGKAK) TERHADAP PENURUNAN KADAR KOLESTEROL SERUM PADA TIKUS PUTIH Wicaksono, Adhimass; Sintowati, Retno; Fitriyah, Sa’idatul
Biomedika Vol 6, No 1 (2014): Biomedika Februari 2014
Publisher : Universitas Muhamadiyah Surakarta

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Abstract

The using of plant-based medicine is a popular approach to health care. A study presented by American Hearth Association showing that brown rice can lower cholesterol level in bood serum. To know the benefi ts of Angkak’s steeping water to decrease serum cholesterol levels in mice and determine the effects of Angkak’s steeping water to decrease serum cholesterol levels in rats compared with simvastatin. This study used an experimental research design, and using pre and post test control group design, performed in the laboratory of biomedical III FK UMS on November 1, 2012 to date of January 1, 2013. The purposive sampling technique, sampel determinaton using formula Federer by the number of sample of 30 male white rats wistar strain. After the data is collected, analyzed using the Shapiro-Wilk test, ANOVA, LSD, and the unpaired t test. The result of this study demnstrate hypothesis testing using ANOVA test with signifi cant level 95% of the negative control group, the treatment group a dose of 1, 2, and 3, it was found p<0,05 were signifi cantly different meaning. In the test dose of LSD between treatment groups 2 and 3 the value of p=0,839 (p>0,05) wich means no signifi cant difference. In the unpaired T test between the treatment group a dose of 1, 2, and 3 with positive control group were signifi cant difference. The unpaired T test between the treatment group a dose of 1, 2, and 3 with white rice also found signifi cant difference. Conclusion: Angkak’s steeping water can lower serum cholesterol levels of white rat as well as the water steepimg Angkak has the same effectiveness with simvastatin to decrease serum cholesterol levels of mice.Keyword: Cholesterol, Angkak
STUDI PERBANDINGAN DUA KELOMPOK UMUR TERHADAP MULA KERJA DAN MASA KERJA ANESTETIKA LOKALPADA KASUS PENCABUTAN GIGI MOLAR I ATAU MOLAR II ATAS Kholifa, Mahmud
Biomedika Vol 3, No 2 (2011): Biomedika Agustus 2011
Publisher : Universitas Muhamadiyah Surakarta

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Effect of in ltration due to the action of anesthesiasubstance on terminal nerve  bers maxillary molars the anesthesia uid  ow through the bone viahavers channels.This study is a quasi-experimental studies (clinical trials), which aims to determine the difference of onset and durationLidocaine between age groups 15-24 years age group 25-34 years in the case of extraction a molar tooth I or II maxilla conducted on patients who came to the Polyclinic FKG UGM, Yogyakarta. The number of samples obtained was 34 samples divided into two groups, Group I were patients with 15-24 years of age or younger, group II is patients aged 25-34 years or older. The data obtained areonset and duration of the age group 15-24 years compared with onset and duration of Lidocaine in the age group 25-34 years. The data obtained were analyzed by t-test with signicance level (p <0.05). The results of this study indicate that there are no signi cant differences between the onsetLidocaine in the age group 15-24 years with onset on the Lidocaine group 25-34 years. There is also a non-signi cant difference between Lidocaineduration in the group aged 15 - 24 years with a duration of Lidocaine on the group 25-34 years at p <0.05. The mean - median onsetLidocaine in the age group 15-24 years was 60.3 seconds with a range between 22-95 seconds while the onset on the Lidocaine group 25-34 years was 55.5 seconds with a range between 14-111 seconds. The mean - average durationLidocaine in the age group 15-24 years was 162.59 minutes with a range between 120-195 minutes while the duration of Lidocaine on the group 25-34 years was 184.41 with a range between 120-330 minutes.
EFEK LARVISIDAL EKSTRAK ETANOL DAUN KEMANGI (Ocimumsanctum Linn) TERHADAP LARVA INSTAR III Culexquinquefasciatus LA, Wijayani; S, Isti’anah
Biomedika Vol 6, No 2 (2014): Biomedika Agustus 2014
Publisher : Universitas Muhamadiyah Surakarta

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Abstract

Filariasis carried by mosquito Culex quinquefasciatus. Filariasis cause elephantiasis sequelae that often lower the sufferers productivity . Eradication of the disease is difficult, then , an attempt to do is to control the vector. The other way is to use insecticide vector control plant. Basil (Ocimum sanctum Linn) which contain fiavonoids, saponins, and eugenol has been shown in the laboratory have larvicidal effect. This study aimed to determine the larvicidal effects from Ethanol extract 96% of basilleaf (Ocimum sanctum Linn) against third instar larvae of Culex quinquefasciatus. This is an laboratory experimental methods with Post test only control group design. The Ethanol extract of basil leaf (Ocimum sanctum Linn) diluted to a concentration of 5000 ppm, 4500 ppm, 4000 ppm, 3500 ppm, 3000 ppm, 2000 ppm, 1500 ppm, 1000 ppm. The experiments were repeated three times. Each experiment included a control ie Tween 20 of 0.25% in distilled water. Statistical analysis was performed with Kruskal-Walls test and probit analysis to determine LC50 and LC90. In the analysis result of Kruskal Walls (CI: 95%) it obtained the results that each test group had a significant difference (p=0,005) in mortality of third instar larvae of Culex quinquefasciatus.The results of probit analysis showed that the ethanol extract of basil leaf give the concentration LC50 and LC90 2281.931 ppm and 5016.314 ppm. Ethanol extract 96% of basilleaf (Ocimum sanctum Linn) has an larvicidal effect on third instar larvae of Culex quinquefasciatus.Keywords: Culex quinquefasciatus - larvicidal - ethanol extract - Basilleaf (Ocimum sanctum Linn).
HUBUNGAN TINGKAT PENDAPATAN KELUARGA DENGAN STATUS GIZI BALITA DI WILAYAH KERJA PUSKESMAS KALIJAMBE Handini, Dian; Ichsan, Burhannudin; Nirlawati, Dona Dewi
Biomedika Vol 5, No 2 (2013): Biomedika Agustus 2013
Publisher : Universitas Muhamadiyah Surakarta

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Abstract

The state of nutritional status of children in Central Java based on index of height for age data obtained 16.9% of children who have growth in a very short, short 17.0% of infants and 66.1% of normal infants. Economic growth in Sragen in 2000 was 2.85%, decreased in 2001 to 2.26%, and increased in 2002-2003, respectively 2.93% and 3.26%. Research methode was observational cross sectional analytic approach. The number of samples was 65 toddlers. Data analysis using Chi Square. The nutritional status of children by index weight for age (W/A) were experiencing malnutrition while the remaining 13.8% as having good nutrition as much as 86.2%, and the index based on height for age (H/A) which had malnutrition as much as 46.2% while the rest had good nutrition as much as 53.8%, while the index by weight according to height (W/H) were experiencing malnutrition while the remaining 13.8% as having good nutrition as much as 86.2% . The results of the analysis obtained p count is 0.009 to the sample distribution based on W/A, and 0.010 for sample distribution based H/A, and 0.009 for the distribution of the sample by W/H. There is a relationship between the level of family income to the nutritional status of children in the working area Public Health Center Kalijambe.Keywords: Family Income, Nutritional Status of Children
UJI EFEK ANTIBAKTERI EKSTRAK ETIL ASETAT DAN KLOROFORM MENIRAN (Phyllanthus niruri Linn) TERHADAP PERTUMBUHAN BAKTERI Staphylococcus aureus ATCC 6538 DAN Escherichia coli ATCC 11229 SECARA in vitro Rahman, Dwiariawan Tauchid; Sutrisna, EM; Candrasari, Anika
Biomedika Vol 4, No 2 (2012): Biomedika Agustus 2012
Publisher : Universitas Muhamadiyah Surakarta

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Abstract

Meniran is one of traditional plants that contains several compounds such as terpenoid, flavonoid, and alkaloid that role as antibactrial agent. The aims of the research are to determine the antibacteria effect of extract aethyl acetat and chloroform of meniran. This research was conducted as a laboratory experimental by using post test control group design only. The concentration of extract aethyl acetat and chloroform meniran are 5%, 10%, 20%, 40%, and 80%. The result indicate that extract aethyl acetat of meniran have not effect to Escherichia coli. Meanwhile, to Staphyloccus aureus have an effect (p=0,003). The concentration of the extract chloroform meniran are effective to inhibite the growth of Escherichia coli (p=0,029) and Staphylococcus aureus (p=0,004). The extract aethyl acetat of meniran have an antibacteria effect to Staphylococcus aureus but not to Escherichia coli. Whereas, the extract chloroform of meniran have an antibacteria effect to Staphylococcus aureus and Escherichia coli.Keyword : The aethyl acetat and chloroform extract of Meniran (Phyllanthus niruri L.), antibacteria effect, Staphylococcus aureus and Escherichia coli

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