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INDONESIA
Indonesian Journal of Cancer
Published by Rumah Sakit Kanker Dharmais (Pusat Kanker Nasional)
ISSN : 19783744     EISSN : 23556811     DOI : -
Core Subject : Health,
Health Professions
The Indonesian Journal of Cancer (official journal of the Dharmais Cancer Center Hospital) is a peer-reviewed, quarterly, open access journal. Submissions are reviewed under a broad scope of topics relevant to experimental and clinical cancer research. The journal publishes original research articles, case reports, systematic literature reviews, and letters to the editor under the following categories: Cancer prevention, diagnosis, surgery, systemic therapy, radiotherapy, paliative therapy, and molecular biology.
Arjuna Subject : -
Articles 448 Documents
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Perbedaan Kesintasan 5 Tahun Pasien Leukemia Limfoblastik Akut dan Leukemia Mieloblastik Akut pada Anak di Rumah Sakit Kanker “Dharmais”, Jakarta, 1997-2008 Simanjorang, Chandrayani; Kodim, Nasrin; Tehuteru, Edi
Indonesian Journal of Cancer Vol 7, No 1 (2013): Jan - Mar 2013
Publisher : "Dharmais" Cancer Center Hospital

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Abstract

Penelitian ini membahas tentang perbedaan kesintasan 5 tahun pasien leukemia akut tipe LLA dan LMA di RSKD dengan menggunakan desain kohort retrospektif. Data didapatkan dari data rekam medis dan register pasien leukemia anak di RSKD yang didiagnosis pada 1997-2008. Pengumpulan data dilakukan secara retrospektif dengan mengikuti subjek untuk meneliti kejadian yang belum terjadi sejak pertama didiagnosis di RSKD hingga pengamatan berakhir Juni 2012. Rancangan penelitian dibatasi waktu 5 tahun untuk terjadinya event. Dari 95 pasien leukemia akut pada anak didapatkan probabilitas kesintasan 5 tahun secara keseluruhan sebesar 22,6%; angka kesintasan 5 tahun untuk tipe LMA 4,6%; dan tipe LLA 28,9%. Risiko kematian (Hazard Ratio) setelah 5 tahun pada LMA 1,643 kali dibandingkan LLA.Kata kunci: kesintasan 5 tahun, tipe leukemia akut.
Isolasi dan Identifikasi Fraksi Toksik Ekstrak Tumbuhan Iler (Coleus scutellarioides [L.] Benth) SWANTARA, MADE DIRA
Indonesian Journal of Cancer Vol 4, No 1 (2010): Jan - Mar 2010
Publisher : "Dharmais" Cancer Center Hospital

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Abstract

Coleus scutellariodes L, Benth, locally known as Iler, has been traditionally used as medicines such as for treatment of fever, ears infection, diabetes, and dyspepsia. The polar constituents in Iler extracts are believed can inhibit the growth of leukemia cell. This research aims to isolate and identify any toxic compounds from toxic fraction of Iler which could be potential as anticancer agents. Extraction of metabolites from Iler leaves was carried out at room temperature using maceration methods with 85 % ethanol eluent. The crude extract was then fractionated into n-hexane, chloroform, and ethyl acetate respectively. Both extract and fractions were tested towards Artemia salina. The most active fraction was purified on silica gel column chromatography using n-hexane:chloroform (2:1) as eluent. Four compounds were identified in the most toxic fractions (LC50 90.72) using Gas Chromatography-Mass Spectrometry as palmitic acid ( 24.41), stearic acid (19.53%), 9-Octadecenamide (22.95%), and hexadioic acid, diocttyl ester (33.11%). Keywords: isolation, identification, toxic fraction, Coleus scutellarioides [L.] Benth  
Sacral Tumor: Experience in a Single Institution KAMAL, ACHMAD FAUZI
Indonesian Journal of Cancer Vol 9, No 1 (2015): Jan - Mar 2015
Publisher : "Dharmais" Cancer Center Hospital

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Abstract

ABSTRACTIntroduction. Sacral tumors are rare, and experience of these tumors is usually limited to a small number of patients. Inthis study, we evaluated profile, survival rates, and functional outcome in a series of sacral tumor treated in our institution.Method. We retrospectively reviewed the records of 22 sacral tumor patients from January 1995 to February 2014 inCipto Mangunkusumo National Central Hospital, Jakarta, Indonesia. Kaplan-Meier method was used to describedsurvival and functional outcome. Their correlation with clinical profile, histological type, level of sacral involvement,treatment, and complication were analyzed by Log rank test.Results. From 22 patients, 5 of them were excluded from this study. Thus, there were 17 cases of sacral tumor, 16 ofthem were malignant and one case was benign. In Kaplan-Meier Analysis, there were no significant difference insurvival found between sex, age group, biopsy type, level of sacral involvement, treatment, and complication. There wassignificant difference in survival found between histopathology result (p=0.012), and giant cell tumor GCT showed thehighest survival, followed by chordoma, metastatic lession, and Ewing Sarcoma. Sacral tumor at the level of S2 andbelow had better functional outcome compared to the one above S2 (p=0.001). There were no difference in functionaloutcome found between histopathology type and treatment (p=0.137 and p=0.210).Conclusion. The majority of primary tumors of sacrum are chordoma which present with nonspecific early signs andsymptoms. Survival rate and functional outcome of the sacral tumor patients were determined by histopathology resultand level of sacral involvement. Lower level of sacral involvement lead to better survival and functional outcome.Keyword: sacral tumors, chordoma, giant-cell tumor, metastasis, survival, functional outcomeABSTRAKPendahuluan. Tumor sakrum sangat jarang ditemukan; dan pengalaman mengenai tumor sakrum biasanya terbataspada sejumlah kecil pasien. Dalam studi ini, kami mengevaluasi profil, tingkat kesintasan, dan luaran fungsional dariserangkaian tumor sakrum yang dirawat di institusi kami.Metode. Kami telah mengevaluasi 22 pasien tumor sakrum dari Januari 1995 sampai Februari 2014 secara retrospektif diRumah Sakit Umum Pusat Nasional Cipto Mangunkusumo Jakarta Indonesia. Metode Kaplan-Meier digunakan untukmenganalisis angka kesintasan dan luaran fungsional. Hubungan antara kesintasan dan luaran fungsional dengan profilklinis, jenis histopatologi, level sakrum yang terlibat, penatalaksanaan, dan komplikasi dianalisis dengan Log rank test.Hasil. Dari 22 pasien, hanya 17 pasien tumor sakrum yang dimasukkan ke dalam studi ini (5 kasus diekslusi), 16 kasusdengan tumor ganas dan 1 kasus dengan tumor jinak. Hasil analisis Kaplan-Meier menunjukkan tidak ada perbedaanyang bermakna pada angka kesintasan terhadap jenis kelamin, kelompok umur, jenis biopsi, level sakrum yang terlibat,penatalaksanaan, dan komplikasi. Hasil uji statististik menunjukkan perbedaan yang bermakna antara kesintasandengan hasil histopatologi (p = 0,012), giant cell tumor menunjukkan kesintasan hidup tertinggi, diikuti oleh Chordoma,lesi metastasis, dan Ewing Sarcoma. Tumor sakrum setinggi S2 ke bawah memiliki luaran fungsional yang lebih baikdibandingkan dengan level di atas S2 (p = 0,001). Hasil uji statistik menunjukkan tidak ada perbedaan yang bermakna antara luaran fungsional dengan jenis histopatologi dan penatalaksanaan(p = 0,137 dan p = 0,210). Kesimpulan. Mayoritas tumor primer pada tulang sakrum adalah chordoma yang muncul dengan gejala dan tanda-tanda awal yang tidak spesifik. Angka kesintasan dan luaran funsional pasien tumor sakrum dipengaruhi oleh jenis histopatologi dan level sacrum yang terlibat. Semakin rendah level sacrum yang terlibat, semakin baik kesintasan dan luaran fungsional.Kata Kunci: Tumor sakrum, Chordoma, giant cell tumor, metastasis,kesintasan, luaran fungsional
Peran Relawan dalam Memberikan Pendampingan kepada Anak Penderita Kanker dan Keluarganya Irene, Uria Regina
Indonesian Journal of Cancer Vol 2, No 1 (2008): Jan - Mar 2008
Publisher : "Dharmais" Cancer Center Hospital

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Abstract

Kanker dapat menyerang bagian manapun dari anggota tubuh manusia dan tidak memandang usia. Kanker bisa juga terjadi pada anaK-anak. Bagi penderita kanker, menanggulangi penyakit kanker dan prosedur pengobatannya bukanlah suatu hal mudah. Hal ini tentu juga sangat dirasakan oleh anak penderita kanker. Selain itu,jika salah satu anggota keluarga terkena kanker, maka dampaknya sangat dirasakan oleh seluruh keluarga.Penanganan anak penderita kanker tidak hanya tergantung pada tim medis saja, sebab penanganan bagi penderita kanker tidak hanya dilihat dari segi medis tetapi juga dilihat dari pengatasan seluruh masalah penderitaan yang mencakup segi psikologis dan segi sosialnya. Salah satu unsur yang dapat membantu memberikan pengobatan non-medis kepada pasien adalah relawan. Oleh karena itu, tujuan dari makalah ini adalah untuk memahami peranan relawan bagi anak penderita kanker dan keluarganya.Dari hasil temuan lapangan dapat dilihat bahwa bentuk peran yang dijalankan relawan dalam memberikan pendampingan bagi anak penderita kanker dan keluarganya tampak seperti bentuk peran Pekerja Sosial Medis (PSM). Oleh karena itu, penting untuk melibatkan PSM agar pelayanan pengobatan yang terpadu dapat diberikan kepada pasien dan keluarganya, dari yang memiliki jenis penyakit kronis apapun dan dalam seluruh kelompok usia, karena seorang PSM mempunyai bekal pengetahuan (knoivledge), ketrampilan (skill), dan nilai {value), sebagai bentuk kesatuan dari the helping profession.
Penelitian Epidemiologi Untuk Program Pencegahan Kanker Serviks DJUITA, RATNA
Indonesian Journal of Cancer Vol 4, No 5 (2010): Workshops 2010
Publisher : "Dharmais" Cancer Center Hospital

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Abstract

Penelitian Epidemiologi Untuk Program Pencegahan Kanker Serviks Full text : http://www.scribd.com/doc/43595037/Penelitian-Epidemiologi-Untuk-Program-Pencegahan-Kanker-Serviks
Dharmais Cancer Center (DCC): Where Are We Now? P, SONAR SONI
Indonesian Journal of Cancer Vol 4, No 5 (2010): Workshops 2010
Publisher : "Dharmais" Cancer Center Hospital

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Abstract

https://www.scribd.com/doc/43608132/Dharmais-Cancer-Center-DCC-Where-Are-We-Now
Operative Treatment for Advanced Colorectal Cancer in RSKD -, Ajoedi; Kastomo, Dukut
Indonesian Journal of Cancer Vol 2, No 5 (2008): Workshop 2008
Publisher : "Dharmais" Cancer Center Hospital

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Abstract

Operative Treatment for Advanced Colorectal Cancer in RSKD full text: http://www.scribd.com/doc/45153087/Operative-Treatment-for-Advanced-Colorectal-Cancer-in-RSKD
Building Sustainable Cancer Control Capacity and Infrastructure in Developing Countries Burton, Robert
Indonesian Journal of Cancer Vol 3, No 5 (2009): Workshops 2009
Publisher : "Dharmais" Cancer Center Hospital

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Abstract

https://www.scribd.com/doc/45503390/Building-Sustainable-Cancer-Control-Capacity-and-Infrastructure-in-Developing-Countries
Potensi Astaxantin sebagai Senyawa Antikanker Pratiwi, Reny; Limantara, Leenawaty
Indonesian Journal of Cancer Vol 2, No 4 (2008): Oct - Dec 2008
Publisher : "Dharmais" Cancer Center Hospital

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Abstract

Astaxantin merupakan salah satu golongan karotenoid xantofil yang memiliki peran penting dalam menjaga kesehatan tubuh. Pada berbagai studi telah dibuktikan peran astaxantin dalam melindungi sel dan jaringan dari kerusakan terutama akibat stres oksidatif yang juga dapat memicu terjadinya kanker. Dalam tulisan ini akan dibahas mengenai potensi astaxantin sebagai senyawa antikanker.Kata Kunci: astaxantin, antioksidan, antikanker.
Factors Which Influenced on Two Years Recurrence of Epithelial Ovarian Cancer Patients After Surgery and Platinum Based Chemotherapy SARI, RESTI MULYA
Indonesian Journal of Cancer Vol 8, No 4 (2014): Oct - Dec 2014
Publisher : "Dharmais" Cancer Center Hospital

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Abstract

Ovarian cancer was the leading cause of death in gynecologic cancer which had the two years recurrence rate of 50%. We used retrospective cohort design with survival analysis technique to examine the role of post-surgery residual tumor size, cancer cell histological subtype and cancer cell grading on epithelial ovarian cancer recurrence. We also want to know the prevalence of HER-2 (Human Epidermal Receptor-2) overexpression in epithelial ovarian cancer patients. Sixty-five epithelial ovarian cancer patient (1998-2012) who had achieved remission were observed for 24 months. We reported median age of 50 years with recurrence rate of 36.9% and mean time of first recurrence was 19.15 months. Size of post-surgery residual tumor more than 1 cm increase Hazard Ratio (HR) of two years recurrence of epithelial ovarian cancer with p value 0.02 and HR of 3.31 (95% CI 1.46-7.49) but papillary serous histology subtype and poor differentiated cancer cell grading did not influence the recurrence. One of 38 patients showed cytoplasmic staining in HER-2 overexpression examination by immunohistochemistry methods. Conclusion: Size of post-surgery residual tumor more than 1 cm increase Hazard Ratio of two years recurrence of epithelial ovarian cancer while papillary serous histology subtype and poor differentiated cancer cell grading did not influence the recurrence. One sample showed cytoplasmic staining on HER-2 overexpression examination.

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