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All Journal Jurnal Kedokteran Jurnal Sains Teknologi dan Lingkungan (JSTL) Jurnal Medika Malahayati ISM (Intisari Sains Medis) : Jurnal Kedokteran Jurnal Medika Hutama Jurnal Psikiatri Surabaya (Surabaya Psychiatry Journal) PrimA: Jurnal Ilmiah Ilmu Kesehatan Jurnal Pepadu
Indah Sapta Wardani
Fakultas Kedokteran Universitas Mataram, Lombok, Indonesia
Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Journal : Jurnal Kedokteran

 1 
Tatalaksana Sepsis Berat pada Pasien Lanjut Usia Wardani, Indah Sapta
Jurnal Kedokteran Vol 7 No 4 (2018)
Publisher : Faculty of Medicine Universitas Mataram

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Abstract

Sepsis adalah permasalahan yang memiliki mortalitas dan morbiditas yang tinggi terutama pada orang lanjut usia. Usia tua merupakan faktor predisposisi sepsis yang disebabkan adanya komorbiditas, pemanjangan dan berulangnya rawat inap, penurunan imunitas serta keterbatasan fungsional yang semuanya disebabkan faktor penuaan itu sendiri. Diagnosis sepsis pada lansia lebih sulit, karena lansia memberikan respon dan gejala klinis sepsis yang kurang jelas. Tatalaksana sepsis berat pada lansia secara cepat dan tepat sangat diperlukan untuk memberikan terapi yang optimal.
Tasigna Induced Musculoskeletal Disorder pada Pasien Chronic Myeloid Leukemia Indah Sapta Wardani
Jurnal Kedokteran Vol 8 No 1 (2019)
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v8i1.330

Abstract

Chronic myeloid lekemia (CML) merupakan salah satu jenis leukemia yang banyak dijumpai pada usia dewasa. Tasigna (Nilotinib) merupakan salah satu pengobatan yang digunakan sebagai target terapi pada CML. Efek samping Tasigna jarang ditemui dan sampai saat ini patogenesisnya belum jelas. Dalam naskah ini dilaporkan sebuah kasus seorang laki-laki 34 tahun yang telah tegak dengan CML fase kronis berdasarkan pemeriksaan sitogenetik dengan BCR-ABL Ph+ dan mendapat targeted therapy Tasigna yang merupakan suatu multiprotein kinase inhibitor dengan target menghambat autofosforilasi BCR-ABL, dengan dosis 2x300 mg. Dalam perjalanannya pasien mengalami suatu efek samping terapi yang bermanifestasi berupa perdarahan yang disebabkan oleh trombositopenia yang diinduksi oleh Tasigna dan manifestasi muskuloskeletal yang kemungkinan disebabkan oleh gangguan keseimbangan elektrolit dan mineral, yang membaik dengan penundaan pemberian Tasigna selama perawatan. Tata laksana pasien dilakukan penghentian pemberian Tasigna dan diberikan terapi suportif. Pemberian kembali Tasigna dipertimbangkan apabila efek samping yang ada telah hilang. Bila efek samping menetap, berat, atau muncul pada pemberian ulang, dianggap pasien tersebut tidak toleran terhadap Tasigna dan harus diganti dengan agen target terapi yang lain.
PENGARUH EKSPRESI RESEPTOR INSULIN PANKREAS TERHADAP EKSPRESI GLUT4 NEURON HIPOKAMPUS PADA TIKUS MODEL DIABETES Sahly, Aliza Raudatin; Hunaifi, Ilsa; Lestari, Rizka Vidya; Wardani, Indah Sapta; Padauleng, Novrita; Nurhidayati; Harahap, Herpan Syafii
Jurnal Kedokteran Vol 9 No 4 (2020): Jurnal Kedokteran volume 9 no 4 2020
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v9i4.441

Abstract

Background: Diabetes Melitus (DM) is a degenerative diseases characterized by hyperglycemia condition. Basic Health Research data for 2018, shows an increase in prevalence of DM in Indonesia over last 5 years with 6,9% in 2013 to 8,5% in 2018. Pancreatic insulin receptor expression can be a marker for assessing presence of ? cells, production and secretion of insulin. Insulin could cause GLUT4 to be translocated to cell membrane of hippocampal neurons. In DM conditions, there may be changes in expression of pancreatic insulin receptors accompanied by changes in expression of GLUT4 hippocampal neurons. Methods: This experimental research used 16 white rats (Rattus Novergicus) which divided randomly into 4 groups, namely 2 control grups (A0 and A1) and 2 treatment groups (B0 and B1). Treatment group were induced by diabetes with a single dose of nicotinamide 110 mg/kgBB and streptozotocin 70 mg/kgBB intraperitoneally. The research data were obtained from immunohistochemical analysis of pancreatic and hippocampal tissue. Result: The mean expression of pancreatic insulin receptor in diabetic rat group was higher but not significant on the 14th day observation compared to the 0th day (p>0,05), while the mean GLUT4 expression of hippocampal neurons was significantly higher on 14th day of observation compared to the 0th day (p<0,05). The result of correlation test did not show a significant results in each group both at the 0th and 14th day observation (p>0,05). Conclusion: There was no significant effect of pancreatic insulin receptor expression on hippocampal neuron GLUT4 expression in diabetic model rats.
PROFIL EFEK SAMPING PENGGUNAAN ANTIRETROVIRAL PADA PENDERITA HIV/AIDS DI POLIKLINIK VCT DI KOTA MATARAM TAHUN 2019 Mitha Yunda Pertiwi; Indah Sapta Wardani; A.A Ayu Niti Wedayani
Jurnal Kedokteran Vol 9 No 4 (2020): Jurnal Kedokteran volume 9 no 4 2020
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v9i4.443

Abstract

Background: In treating HIV infection, Indonesia uses the fast track 90-90-90 approach, which one indicator is giving early ARV treatment to infected patients. First line ARV used in Indonesia today is a fixed-dose combination (FDC) consisting of tenofovir, lamivudine/emtricitabine, and efavirenz. ARV use might cause adverse drug reactions (ADR) with ADR range from mild to severe in HIV patients. This research aims to identify the adverse drug reactions caused by ARV in HIV/AIDS patients in VCT Polyclinic in Mataram City in 2019. Methods: This research is a quantitative descriptive study done in VCT Polyclinic in Mataram city. The subjects are HIV patients in VCT Polyclinic in Mataram city who had met the criteria. This research used secondary data from patients’medical records. Result: Total subjects are 27 patients. ADR occurred in 8 patients (29.6%). These ADR were found in 7 patients using atripla with malaise, dizziness, vomiting, and increased SPOT/SGPT being the most common ADR. One patient using duviral/neviral were found with nausea, vomiting, and itchiness. These ADR came 100% from first degree drug toxicity. Conclusion: The most common ADR were vomiting, malaise, dizziness, and increased SGOT/SGPT. All adverse drug reactions were mild (first degree) therefore therapy was continued and there was no need to consider switching treatment. Keywords: HIV infection, ARV, Atripla, Duviral/Neviral, side effects, first degree
Variation of Saliva Sampling Procedures in Detecting SARS-CoV2 with Real Time Polymerase Chain Reaction: A Scoping Review Dewi Suryani; Devi Rahmadhona; Prima Belia Fathana; Indah Sapta Wardani; Ika Nurfiria Tauhida; Mohammad Rizki
Unram Medical Journal Vol 10 No 4 (2021): Jurnal Kedokteran Volume 10 nomor 4 (Desember) 2021
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v10i4.611

Abstract

Background: Currently there is a rise in the study of saliva as alternative clinical samples for the detection of SARS-CoV2 as it is considered less invasive, able to be obtained independently by patients and does not cause discomfort compared to nasopharyngeal swab (NPS). Nevertheless, there has been an inconsistency of methods applied in sample collection, storage and laboratory assay from previous research. As the pre analytical phase may influence diagnostic result, therefore this scoping review would like to identify the varation approach of saliva collection methods conducted by previous studies. Study Design: We conducted a scoping review of the literature in 3 databases (PubMed, Science Direct and Google Scholar) and included articles published bewteen January 2020 until March 2021. Results: This review included 22 publications that met the inclusion criteria. All articles compared saliva with nasopharyngeal swabs. There were variations of sample collection approach which include type of saliva collected, type of container, the use of presrvative or stabilizing agent, time and volume of saliva collected and requirements for patients prior to sample collection. Moreover, not all study included a detailed information regarding salivary collection methods. Conclusion: Information regarding saliva sample collection and prepartion is required to not only be reproduced by following research but also to determine the best approach for optimal outcome.
Vitamin D and Type 2 Diabetes Mellitus: Role in Insulin Resistance, Glycemic Control and Long Term Complications Indah Sapta Wardani; Aliza Raudatin Sahly; Indana Eva Ajmala; Dewi Suryani
Unram Medical Journal Vol 11 No 2 (2022): vol 11 no 2 2022
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v11i2.763

Abstract

Vitamin D has a number of roles in various body systems with receptors scattered in many organs,1,2 showing a link between vitamin D and several chronic diseases such as cancer, diabetes and autoimmune disease.3,4 Several studies have shown the role of vitamin D in type 2 diabetes in controlling blood sugar levels and HbA1c levels. Vitamin D plays a role in increasing insulin sensitivity and secretion and suppressing inflammation in type 2 diabetes. Vitamin D has a protective role in various complications of type 2 diabetes, including diabetic nephropathy, diabetic neuropathy and diabetic retinopathy.5 Monitoring of vitamin D levels and vitamin D supplementation have a therapeutic role to controlling glycemic blood glucose and prevent complications in type 2.6
Co-Authors A.A Ayu Niti Wedayani Aliza Raudatin Sahly Daffa Muhammad Rizky Decky Aditya Z Devi Rahmadhona Dewi Suryani Dewi Suryani Dewi Suryani Fahmi Akbar Utomo Herpan Syafii Harahap I Dewa Ayu Natih Canis Paloma I Putu Diatmika Ika Nurfiria Tauhida Ilsa Hunaifi Indana Eva Ajmala Jurnal Pepadu Karina Khilmi Adzuba Layus Iranna Umayya Lestari, Rizka Vidya Liya Maulidianti Metta Octora Mitha Yunda Pertiwi Mohammad Rizki Mohammad Rizki Muhammad Gasim Al aydrus Ni Luh Made Mirah Rahayu Ni Luh Putu Harta Wedari Nurhidayati Padauleng, Novrita Prima Belia Fathana, Prima Belia Sahly, Aliza Raudatin Zanetha Mauly Ilawanda