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All Journal Indonesian Journal of Pharmaceutical Science and Technology Jurnal Sains dan Teknologi Pangan JISIP: Jurnal Ilmu Sosial dan Pendidikan Dharma Raflesia : Jurnal Ilmiah Pengembangan dan Penerapan IPTEKS Mukaddimah: Jurnal Studi Islam Anoa : Jurnal Pengabdian Masyarakat Sosial, Politik, Budaya, Hukum. Ekonomi Jurnal Biofiskim: Pendidikan dan Pembelajaran IPA Datokarama English Education Journal (deejournal)
Ruslin, Ruslin
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Journal : Indonesian Journal of Pharmaceutical Science and Technology

 1 
Potensi Metabolit Sekunder, Antosianin Total dan Antioksidan Beras Wakawondu (Oriza nivara L.) Endemik Buton Utara Nasrudin, Nasrudin; Ruslin, Ruslin; Jabbar, Asriullah; Nurlansi, Nurlansi; Mulyana, Wa Ode; Wandira, Ayu
Indonesian Journal of Pharmaceutical Science and Technology 2024: Suppl. 6, No. 2 (Universitas Halu Uleo Conference)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v6i2.53352

Abstract

Wakawondu merupakan beras yang berwarna merah endemik Buton Utara mempunyai tekstur, rasa dan aroma yang khas menjadi pembeda dengan beras yang berwarna merah lainya, sehingga menarik dikembangkan potensinya untuk diversifikasi pangan berkhasiat kesehatan. Karena itu, penelitian dilakukan untuk mengetahui potensi metabolit sekunder dan antosianin total serta aktivitas antioksidan beras wakawondu yang diperoleh di pasaran. Serbuk wakawondu dimaserasi dengan etanol 96% yang diasamkan dengan HCl 1%. Kandungan metabolit sekunder ditentukan dengan metode fitokimia, kadar antosianin total dengan metode pH differensial dan aktivitas antioksidan dengan metode DPPH. Hasil skrining fitokimia ekstrak etanol wakawondu yang diperoleh di pasaran mengandung senyawa golongan alkaloid, triterpenoid, flavonoid dan polifenol dengan kadar antosianin total 3,156 mg/100 g lebih tinggi diatas rata-rata beras berwarna merah lainya dan nilai IC50 antioksidan 241,55±0,2147 µg/mL, sedangkan vitamin C 11,923±0,2197 µg/mL sebagai antioksidan standar. Disimpulkan bahwa potensi antosianin ekstrak etanol wakawondu diatas rata-rata beras berwarna merah lainya, terkonfirmasi dengan hasil skrining fitokimia yang positif mengandung flavonoid dan polifenol.
Sansevieria trifasciata Prain. : A Review on Its Phytochemicals and Pharmacological Potential Sida, Nurramadhani A; Kasmawati, Henny; Ruslin, Ruslin
Indonesian Journal of Pharmaceutical Science and Technology 2024: Suppl. 6, No. 2 (Universitas Halu Uleo Conference)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v6i2.52626

Abstract

Sansevieria trifasciata Prain is known to contain phytochemical compounds and has the potential to treat various diseases. A systematic review was conducted by searching articles on Google Scholar, PubMed, NCBI, and Science Direct to gather information on identified chemical compounds and the pharmacological test results of S. trifasciata Prain leaves, both in vitro, in vivo, and in silico. The result showed that phytochemicals were derivatives of the flavonoids, alkaloids, steroids, saponins, glycosides, polyphenols, and fatty acids groups. These phytochemicals exhibit pharmacological properties, including antidiabetic, antibacterial, anticancer, antihelminthic, antimalarial, antifungal, antioxidant, antiwound healing, antianalgesic, and antiallergic properties. Acute toxicity tests indicate that S. trifasciata Prain. is safe for use, with an LC50 value exceeding 2000 mg/kgBW. We can conclude that Sansevieria trifasciataPrain. is a potential herb as medicine to treat various diseases based on its chemical compounds.Sansevieria trifasciata Prain is known to contain phytochemical compounds and has the potential to treat various diseases. A systematic review was conducted by searching articles on Google Scholar, PubMed, NCBI, and Science Direct to gather information on identified chemical compounds and the pharmacological test results of S. trifasciata Prain leaves, both in vitro, in vivo, and in silico. The result showed that phytochemicals were derivatives of the flavonoids, alkaloids, steroids, saponins, glycosides, polyphenols, and fatty acids groups. These phytochemicals exhibit pharmacological properties, including antidiabetic, antibacterial, anticancer, antihelminthic, antimalarial, antifungal, antioxidant, antiwound healing, antianalgesic, and antiallergic properties. Acute toxicity tests indicate that S. trifasciata Prain. is safe for use, with an LC50 value exceeding 2000 mg/kgBW. We can conclude that Sansevieria trifasciata Prain. is a potential herb as medicine to treat various diseases based on its chemical compounds.
Rigid and Flexible Docking Study with ADME Evaluation of Hesperetin Analogues as LecB Inhibitors in Pseudomonas aeruginosa Arfan, Arfan; Rayani, Nur; Ruslin, Ruslin; Kasmawati, Henny; Aman, La Ode; Asnawi, Aiyi
Indonesian Journal of Pharmaceutical Science and Technology 2024: Suppl. 6, No. 2 (Universitas Halu Uleo Conference)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v6i2.52623

Abstract

Infections caused by Pseudomonas aeruginosa pose a considerable challenge in terms of treatment. The bacterium's key virulence factor, particularly LecB, plays a significant role in bacterial adherence, infections, biofilm formation, and suppression of the host immune response. This study aims to assess the affinity and interactions of hesperetin analogs against LecB in P. aeruginosa. The investigation utilized the molecular docking method, employing a combination of rigid and flexible docking. The docking results successfully identified hesperetin 7-O-glucoside and hesperetin 7-O-rhamnoside, demonstrating superior binding energies compared to MJO as the reference ligand. Rigid docking indicated binding energies of -7.0 and -7.2 kcal/mol for hesperetin 7-O-glucoside and hesperetin 7-O-rhamnoside, respectively. Subsequently, flexible docking revealed lower binding energies for both compounds, reaching -10.3 kcal/mol. These top-performing compounds exhibited interactions with critical residues, including Asn70, Arg72, Thr98, Asp99, Asp96, Asn21, and Ser23, strategically positioned in LecB's substrate-binding site in P. aeruginosa. Notably, hesperetin 7-O-rhamnoside displayed an excellent ADME profile and a favorable safety profile, as it was predicted not to inhibit CYP enzymes. The hesperetin analog also met Lipinski's rules, suggesting its suitability as an oral drug. In conclusion, this research unveils the potential antibacterial activity of hesperetin analogs and provides an opportunity for experimental verification of these compounds as candidates for antibacterial drugs against P. aeruginosa.
Co-Authors Aiyi Asnawi Arba, Muhammad Arfan Arfan Ari Sartinah, Ari Armadani, Fery Indradewi Aspadiah, Vica Ayu Wandira Bafadal, Mentarry Dedu, La Ode Arfan Eka, Bau Mirna Ayu Fadhliyah Malik Fahyuddin Fahyuddin, Fahyuddin Fana Riskiana Jabbar, Asriullah Jahidin Jahidin Jaya, Muhammad Imin Kasmawati, Henny La Aba La Harimu La Ode Aman Makrawati, Makrawati Mistriyani, Mistriyani Muh Nurtanzis Sutoyo Muhammad Jefriyanto B Muliatin, Muliatin Mulyana, Wa Ode Munasari, Dian Nasrudin nuralifa, nuralifa Nurlansi, Nurlansi Nurramadhani A. Sida Pascayantri, Asniar Rahman, Abraham Rayani, Nur Ridwan, Harnina Ruben, Sony Sabarudin Sabarudin Sahumena, Muhamad Handoyo Sakti, La Ode Awal Sarimu, La Sarmadan Sarmadan, Sarmadan Sitti Aisyah Sunandar Ihsan, Sunandar Suryani Suryani Syahbuddin Syahbuddin Wardana, Gede Yogi Prana Yuni Amelia Zaid, Sudirman