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All Journal Jurnal Farmasi Klinik Indonesia Majalah Obat Tradisional Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS) Jurnal Aisyah : Jurnal Ilmu Kesehatan Science Midwifery Journal of Health Sciences and Medicine Jurnal Ilmiah Medicamento Jurnal Farmasi Indonesia Usadha
Ketut Agus Adrianta
Universitas Mahasaraswati Denpasar
Agriculture, Biological Sciences & Forestry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary Other

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Molecular docking activity of peristrophe bivalvis on non small cell lung cancer Santoso, Puguh; Adrianta, Ketut Agus; Wibawa, Agung Ari Chandra; Gunawan, I Wayan Suardi Adi
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 8, No 2: June 2023
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1505.7 KB) | DOI: 10.30604/jika.v8i2.1935

Abstract

Cancer is a genetic disease in which cells are unable to control their functions normally. As cancer develops, old cells will survive when they should die, and new cells will grow when they are not needed. These extra cells can divide endlessly and can form growths called tumors . This research was carried out to know whether peristrophine, apioside, and pelargonidin 3-Sambubioside compounds could be developed as a drug in Non-Small Cell Lung Cancer (NSCLC) with the in silico method at the ROS1 receptor with the Protein Data Bank code 3ZBF with the native ligand crizotinib. Peristrophine, apioside, and pelargonidin 3-Sambubioside compounds have an affinity for ROS1 protein with binding energies of -6.12 kcal/mol on peristrophine, -6.74 kcal/mol on apioside, and -7.54 kcal/mol of pelargonidin 3-Sambubioside. Peristrophine, apioside, and pelargonidin 3-Sambubioside have a molecular mechanism in inhibiting ROS1 in Non-Small Cell Lung Cancer (NSCLC) through the formation of hydrogen bonds in the protein ROS1. From Lipinski's analysis, the peristrophine test compound has met the requirements and seen from the LD50 value of the peristrophine test compound, apioside and pelargonidin 3-Sambubioside has the same toxicity class as the comparison compound, namely crizotinib at class 4 toxicity.
Uji Aktivitas Antiinflamasi serta Toksisitas Senyawa Peristrophine terhadap Reseptor Prostaglandin Sintase 2 (PTGS2) secara In Silico I Putu Windra Gunawan; Puguh Santoso; Dewa Ayu Ika Pramitha; Ketut Agus Adrianta
Usadha Vol 1 No 1 (2021): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

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Abstract

Indonesia merupakan salah satu negara yang banyak memiliki kasus penyakit yang diakibatkan oleh inflamasi. Rasa sakit atau nyeri sering menjadi penyebab gangguan aktivitas sehari-hari. Inflamasi merupakan suatu respon dari tubuh yang terjadi akibat cedera maupun infeksi. Peristrophine adalah salah satu turunan senyawa antosianin yang berasal dari tanaman magenta (Peristrophe bivalvis L. Merr). Tujuan dari penelitian ini adalah untuk mengetahui aktivitas antiinflamasi dan nilai LD50 dari senyawa peristrophine secara komputasi. Metode dalam penelitian ini dilakukan secara in silico untuk meminimalisir terjadinya kegagalan pada uji in vivo ataupun in vitro. Bahan yang digunakan dalam penelitian ini menggunakan data makromolekul yang dipakai sebagai reseptor yang didapatkan dari situs web Protein Data Bank (PDB) dengan PDB ID 5IKR menggunakan native ligand asam mefenamat sebagai senyawa pembanding. Hasil yang diperoleh dari penelitian ini adalah senyawa peristrophine memiliki nilai aktivitas sebesar -6.90 kkal/mol pada asam amino Tyr 385A dengan nilai toksisitas 650,974 mg/kg, sedangkan asam mefenamat memiliki nilai aktivitas sebesar -7.58 kkal/mol dengan nilai toksisitas 595.50 mg/kg. Dari hasil yang didapat, seyawa peristrophine diprediksi memiliki aktivitas farmakologi sebagai antiinflmasi.
The Effect of N-Acetylcysteine on Glomerulus Filtration Rate in Patients with Chronic Kidney Disease Post Percutaneous Coronary Intervention Putu Rika Veryanti; Gamaliel Agripa; Ketut Agus Adrianta
Jurnal Farmasi Klinik Indonesia Vol 11, No 3 (2022)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2022.11.3.217

Abstract

The use of contrast for percutaneous coronary intervention (PCI) procedures in chronic kidney disease (CKD) patients can worsen kidney function. N-Acetylcysteine is widely used as a preventive therapy for contrast-induced nephropathy (CIN). However, previous studies have shown inconsistent results, so that further research regarding the effectiveness of N-Acetylcysteine to prevent CIN is needed. This study aimed to determine the effect of N-Acetylcysteine on glomerulus filtration rate (GFR) in patients with CKD who underwent PCI. This research was conducted at Jakarta's national central general hospitals from July to December 2019 with a retrospective study design. Through the purposive sampling method, we obtained 72 samples. The sample was selected from the patient's medical records in the period January-June 2019. Patients who underwent PCI and had a history of CKD were included in the study. The data were analyzed by t and chi-square tests to determine the effect of N-Acetylcysteine on the patient's GFR. The results showed that CKD patients underwent PCI were dominated by male (61.11% vs 38.89%) and 33.33% of patients aged 55-64 years. Most patients had GFR values between 30-59.99 ml/min/1.73m2 with 100 ml of contrast administration. The ratio of contrast amount to GFR > 3.7 was found in 47.22% of patients. The administration of N-Acetylcysteine as a preventive therapy for CIN post-PCI increased the GFR value of CKD patients by 2.69±5.72. N-Acetylcysteine had a significant effect on the GFR of post-PCI CKD patients (p=0.000).
Co-Authors Agung Ari Chandra Wibawa Bagus Komang Satriyasa Debby Juliadi Desak Made Wihandani Dewa Ayu Ika Pramitha Fitria Megawati Gamaliel Agripa Gunawan, I Wayan Suardi Adi Herleeyana Meriyani I Gede Made Suradnyana I Gusti Agung Ayu Kusuma Wardani I Gusti Agung Ayu Kusuma Wardani I Made Jawi I Nyoman Gede Tri Sutrisna I Putu Windra Gunawan IGAA Kusuma Wardani Meriyani, Herleeyana Ni Nyoman Wahyu Udayani Ni Putu Siska Sugiantari Ni Putu Udayana Antari Puguh Santoso Puguh Santoso puguh santoso, puguh Putra, I Made Agus Sunadi Suena, Ni Made Dharma Shantini Veryanti, Putu Rika Wardani, I Gusti Agung Ayu Kusuma Yeni Cendana