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All Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Abdi Laksana Edu Masda Journal Edu Dharma Journal: Jurnal penelitian dan pengabdian masyarakat Pharmaceutical Science Journal Jurnal Kefarmasian Indonesia
Ismaya, Nurwulan Adi
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Journal : Jurnal Kefarmasian Indonesia

 1 
Pola Pengadaan Obat di 4 Apotek Jaringan Wilayah Bumi Serpong Damai (BSD) Tangerang Selatan Ismaya, Nurwulan Adi; Pratiwi, Rita Dwi; Sari Indah, Fenita Purnama; Aulia, Gina; Sumarwati, Sumarwati
Jurnal Kefarmasian Indonesia VOLUME 12, NOMOR 1, FEBRUARI 2022
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v0i0.4937

Abstract

Pharmacies are an inseparable part of the drug distribution chain until it reaches the patient. However, patients often hear complaints about the availability of drugs in pharmacies because sometimes there are drug shortage. The aim of this study was to identify the drug procurement pattern in four network pharmacies in the Bumi Serpong Damai (BSD) area in 2019. A retrospective study of four network pharmacies in the Bumi Serpong Peace (BSD) area of South Tangerang was carried out. A total of 8,959 samples were obtained by census from procurement documents of all drugs sold beginning in 2019. (A, B, C, and D pharmacies). The ABC and VEN methods were used in this study. The information gathered includes the name of the drug, the unit, the manufacturer's name, the creditor's name, and the amount and selling price. During 2019, four pharmacies had a total of 2,876 medicinal items of pharmacy A, 1,918 medicinal items of pharmacy B, 1,939 medicinal items of pharmacy C, and 2,226 medicinal items of pharmacy D, with a total drug expenditure of pharmacy A Rp.2,649,438;pharmacy B Rp.683,389,661; pharmacy C Rp. 881,540,329; and pharmacy D Rp. 1,245,520,143. Based on the findings of the study, it is possible to conclude that the four pharmacies have the most drugs in the essential category based on the VEN analysis. However, based on the Pareto ABC analysis, there are still many drugs in four network pharmacies in the BSD Region that fall into the Pareto C category, necessitating further investigation of the procurement.
Formulasi Sediaan Minuman Serbuk Fungsional Kombinasi Biji Jagung (Zea mays L. ) dan Madu Utami, Sheila Meitania; Ismaya, Nurwulan Adi; Ratnaningtyas, Tri Okta; Yunarto, Nanang
Jurnal Kefarmasian Indonesia VOLUME 12, NOMOR 2, AGUSTUS 2022
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v0i0.5536

Abstract

Corn is a food ingredient that contains carotenoids that are very potential in preventing cancer, adding endurance, as antivirals, fungi, and parasites, carotenoids are also good for vision, growth and reproduction. The highest carotenoid compound in corn is lutein which has potential as an immunomodulator. Honey is also immunomodulatory by triggering macrophages to produce cytokines involved in killing bacteria and tissue repair. The combination of corn and honey in one drink will produce a health supplement preparation that contains antioxidants and immunomodulators that are good for health. The goal of this study was to get the best formula of instant granules physically. Instant granules are made from corn kernels that have been dried with a combination of honey which is processed by dry granulation with variations of corn kernels FI & FIV (15%), FII & FV (25%), FIII & FVI (35%), and FI & FIV honey (35%), FII & FV (25%), FIII & FVI (15%). Instant granules are conducted physical test evaluations including organoleptic tests, flow time, angle of repose, compressibility index, time of granules to dissolve, particle distribution, pH, viscosity of reconstituted and RDA test. The results showed that the granule flow time, angle of repose, compressibility index, time of granules to dissolve, granules particle distribution and viscosity of reconstituted overall physical testing showed no noticeable differences, except against the most preferred taste parameters FVI. So the best formulation has obtained is FVI and shows the result of the RDA test with total energy of 350 kcal/100 grams.
Formulation and Evaluation of Gummy Candy from the Extract of Jathropa Leaf (Jatropha curcas L.) Aulia, Gina; Sayyidah, Sayyidah; Fadhilah, Humaira; Ismaya, Nurwulan Adi; Indah, Fenita Purnama Sari
Jurnal Kefarmasian Indonesia VOLUME 13, NUMBER 2, AUGUST 2023
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v13i2.6429

Abstract

People are becoming more interested in nutraceutical preparations to maintain health as the world's health problems worsen. Jatropha curcas leaves (Jatropha curcas L.) have anthelmintic properties due to tannin compounds that act as anti-worms. This study aims to produce jelly candy preparations from Jatropha curcas leaves and evaluate these preparations. There are two stages of research: raw material preparation and verification, and jelly candy formulation. This study showed that the best concentration of Jatropha leaf extract was Formula 2. Based on the phytochemical test, there were alkaloids in the Jatropha leaf extract.  The pH value of gummy candies preparations of castor leaf extract, weight uniformity test, passed the moisture content test because they met the requirements for a wide range of dosage values. Meanwhile, the Hedonic Test results show that Formula 2 is the most preferred by children. So, based on the evaluation and hedonic test results, Formula 2 is the best preparation for jelly candy from jatropha leaves.
Potentially Inappropriate Medication (PIM) Prescribing According to Beers Criteria among Elderly Outpatients at Pasar Minggu Hospital, Jakarta Pebriani, Mala; Sumarny, Ros; Arozal, Wawaimuli; Eviarini, Prawitasari; Ismaya, Nurwulan Adi
Jurnal Kefarmasian Indonesia VOLUME 14, NUMBER 1, FEBRUARY 2024
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Elderly patients generally have physiological changes that cause multipathological conditions, so they require several drugs to treat these conditions, it is necessary to evaluate the use of drugs to optimize the treatment of geriatric patients. Beers Criteria 2019 is a criteria that is commonly used to present Potentially Inappropriate Medication (PIM). This study aimed to examine the inaccuracy of prescription drugs in the elderly using Beer's criteria 2019. This research is an observational analytic study with a cross-sectional descriptive design. The Beer's 2019 criteria classify PIM into five categories. Data were taken retrospectively as many as 847 prescriptions met the inclusion criteria at the Pasar Minggu Hospital Outpatient Polyclinic. Data were analysed by Univariate and Bivariate. The results showed that from 847 prescriptions for geriatric patients, there are 160 prescriptions for geriatric patients who experienced PIM (18.89%). Percentage of PIM incidents by category; namely, category 1 was 29.17%, category 2 was 6.77%, category 3 was 44.79%, category 4 was 16.67%, and category 5 was 2.60%. The results of the analysis showed that there was a significant relationship between the number of drugs and Heart Failure and CAD with the incidence of PIM with a p value of 0.000 and 0.035. DM and Heart Failure are 2 diseases that significantly influence the incidence of PIM. This study concludes that the elderly are at risk for receiving potentially inappropriate medications.
In vivo Study of Uric Acid Inhibitory of Catechin from Gambir [Uncaria gambir (Hunter) Roxb] in Male Rats Yunarto, Nanang; Ismaya, Nurwulan Adi; Reswandaru, Uud Nourma; Hermiyanti, Evika; Gumilang, Nabila Cahya; Salina, Fitri
Jurnal Kefarmasian Indonesia VOLUME 14, NUMBER 1, FEBRUARY 2024
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Hyperuricemia is a metabolic disease characterized by high levels of uric acid in the blood. In silico studies of catechin compounds using molecular docking were able to inhibit the activity of the xanthin oxidase enzyme so that it could reduce uric acid levels. One of the native Indonesian plants that contains catechin is gambier (Uncaria gambir (Hunter) Roxb). This research aims to obtain the efficacy and safety of gambier leaf catechins in reducing uric acid levels. In vivo efficacy testing at doses of 20, 40, and 40 mg/Kg BW with allopurinol as a comparison and the safety of gambier leaf catechin in hyperuricemic male mice through macroscopic and microscopic examination of the liver and kidney organs. The results of research on determining catechin levels using HPTLC obtained levels of 96.06%. Gambier leaf catechin at doses of 20, 40, and 40 mg/Kg BW was able to reduce uric acid levels in the blood serum of mice. The higher the dose of catechin, the better the anti-hyperuricemia effect. In the results of the safety parameters, gambier leaf catechins, there were no specific abnormalities in the liver and kidneys of mice both macroscopically and microscopically. Based on research, it can be concluded that gambier leaf catechin has great potential as an anti-hyperuricemia drug and has good safety if consumed for a long time.
Co-Authors Afriyani, Mirta Sepi Al-Hafiz, Mohammad Alwiyati, Nurkhikmah Andriati, Riris Annisa, Fitra ARDIYANTI, WIDYA Arief, Ilham Aripin Aulia, Gina Ayuningtyas, Gita Azzahra, Elsa Darmayanti, Desy Eviarini, Prawitasari Fadhilah, Humaira Fahriati, Andriyani Rahmah Fitriah, Nada Gumilang, Nabila Cahya Hakim, Amelia Nurul Hermiyanti, Evika Jaya, Fadly Putra Nanang Yunarto Nur Hasanah Nurhaetami, Cut Intan Nursobah, Ihsan Oktovina, Magdalena Niken Pebriani, Mala Permatasari, Putri Indah Puji, Lela Kania Rahsa Ratnaningtyas, Tri Okta Reswandaru, Uud Nourma Rita Dwi Pratiwi Romlah, Siti Novy Ros Sumarny Salina, Fitri Sari Indah, Fenita Purnama Sayyidah, Sayyidah Silvester Maximus Tulandi Sitorus, Christina Apnirosi Sumarwati Utami, Sheila Meitania Wafa, Wafa Wawaimuli Arozal Yulianti Yulianti