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All Journal Jurnal Kesehatan Masyarakat Indonesia Medula Juke jurnal niara Biomedical Journal of Indonesia Jurnal Pengabdian Pada Masyarakat Holistik Jurnal Kesehatan Jurnal Dunia Kesmas JURNAL ILMIAH KESEHATAN SANDI HUSADA Bioscientia Medicina : Journal of Biomedicine and Translational Research Indonesian Journal of Global Health research JK Unila (Jurnal Kedokteran Universitas Lampung) Essential: Essence of Scientific Medical Journal Jurnal Kesehatan Saintika Meditory Archives Pharmacia Bioscientia Medicina : Journal of Biomedicine and Translational Research Buguh: Jurnal Pengabdian Kepada Masyarakat Action Research Literate (ARL) Jurnal Ilmu Medis Indonesia Asian Journal of Health and Applied Sciences Majority
Ratna Dewi Puspita Sari
Faculty Of Medicine, Universitas Lampung
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : Medula

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Efektivitas Nutrasetikal sebagai Agen Kemopreventif dalam Melawan Sel Kanker Payudara Tesya Agustin; Ratna Dewi Puspita Sari
Medula Vol 10 No 4 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i4.126

Abstract

Cancer is the leading cause of death with breast cancer cases that occupies the highest incidence rate in Indonesia. Breast cancer is a growth of abnormal cells in the epithelium of the ducts or lobules of the breast, causing malignancy in the breast tissue. Beacuse the breast cancer is the most common cancer case, so early detection is carried out and accompanied by recommendations for the most effective treatment for confirmed patients. However, some of these therapies trigger unexpected side effects, then a lot of efforts were made to prevent and control the growth of malignant cells in breast cancer. This malignancy can be inhibited by consuming nutraceutical, which is a combination of nutrition and pharmaceuticals. Nutraceutical is a type of food whose nutritional composition has benefits for health, both prevention and treatment of a disease. The chemopreventive components in fruit and vegetables that are classified as nutritional, besides having effect on health, also having the potential for the anti-carcinogen and anti-mutagenic action. The compounds contained in it are able to against cancer cells with minimal side effects. There are many of them such as ginger, turmeric, cruciferous vegetables, soybeans, tomatoes, garlic, black cumin, and pomegranate have potential anticancer action by reducing the growth of cancer cells, inhibiting cell proliferation, and inducing apoptosis of cancer cells. Thus, nutracetical has potential as a chemopreventive agent with various mechanism of action to against breast cancer cells effectively.
Bacillary Dysentery jefri irawan; Meilisa Hidayah Putri; Rani Himayani; Ratna Dewi Puspita Sari
Medula Vol 11 No 3 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v11i3.211

Abstract

Gastrointestinal infection due to amoeba is one of the causes of diarrhea which appears to be a public health problem with a high incidence in the community. Bacillary dysentery/shigellosis has become a major cause of morbidity and mortality in children in developing countries, and is also an important cause of morbidity in industrialized countries. Shigella sp. is a diarrheal pathogen that is closely related to Escherichia coli. The pathogen was named by Kiyoshi Shiga, who in 1898 identified the most virulent strain of shigella, Shigella dysenteriae, as the causative agent of shigellosis. Shigella spp. is a Gram-negative bacillus from the family Enterobacteriaceae. Therefore, the aim of this literature review is to further review the management of bacillary dysentery. Shigellae is transmitted by the faecal-oral route or through ingestion of contaminated food and water. This research is a literature review involving as many as 10 library sources with the keywords used, namely 'management and shigellosis' with the year published between 2012 - 2021. Abstracts and full text of the journal are read and examined, then an analysis of the contents contained in the research objectives is carried out and research results/findings. Results. Various studies have shown over the last few decades, Shigella spp. have undergone mutations, developing mechanisms to damage cell processes in the gastrointestinal tract. Therefore, innovative methods and appropriate management are needed to prevent antibiotic resistance in the treatment of shigellosis.
Multigravida Preterm dengan IUGR pada Preeklampsia Berat: Sebuah Laporan Kasus Febrina Halimatunisa nisa; Ratna Dewi Puspita Sari
Medula Vol 12 No 2 (2022): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v12i2.409

Abstract

Intrauterine growth restriction (IUGR) is a baby born at term but has a low birth weight (LBW) due to impaired fetal growth while in the mother's womb. Intrauterine growth restriction (IUGR) is closely related to severe preeclampsia (PEB). In PEB there is interference with placental implantation, thereby reducing blood flow to the fetus. Reduced blood flow causes inadequate nutrition for fetal growth. Intrauterine growth restriction (IUGR) is a fairly common complication, where the prevalence reaches 3-7% of all pregnancies in developing countries. This study is a case report where Mrs. Ni, 41 years old with G3P2A0 34 weeks pregnant came to PONEK with clear discharge and heartburn up to the waist. On the os, it was found that the conjunctiva was anemic and the height of the uterine fundus did not match the gestational age. Laboratory examinations showed hemoglobin 10.4 g/dL, Hematocrit 32%, erythrocytes 3.7 million/ul, proteinuria ++. Based on the data above, the patient was diagnosed as Mrs. Ni, G3P2A0, 41 years old, 34 weeks gestation, single live fetus, intrauterine, breech presentation, right back, not yet inpartu with IUGR.
Wanita G2P1A0 Hamil 39 Minggu Belum Inpartu dengan Eklampsi Janin Tunggal Hidup dan Suspek Pertumbuhan Janin Terhambat Karina Azlia Amanda; Karunia Santi; Ratna Dewi Puspitasari
Medula Vol 12 No 4 (2022): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v12i4.548

Abstract

Eclampsia is a syndrome characterized by hypertension and proteinuria after 20 weeks of gestation and can be accompanied by organ damage and seizures. Preeclampsia and eclampsia are the causes of 30-40% of perinatal deaths and are one of the obstetric complications that cause a lot of morbidity and mortality in addition to bleeding and infection. The female patient, 21 years old, was taken to Abdul Moeloek Hospital by her family at the referral of Bumi Waras Hospital with complaints of pregnancy with high blood pressure and a history of seizures before hospital admission. From the examination of an obgyn specialist outside, an ultrasound was performed with the results of intauterine growth restriction. The gestosis index in this patient is 10. The diagnosis in this patient Gravida 2 Partus 1 Abortion 0 (G2P1A0) 39 weeks pregnant and not yet parturition with eclampsia of a live singleton fetus with cephalic presentation and suspect IUGR (intrauterine groth restriction). The patient received active management after receiving medical and observative therapy. Medical therapy consists of MgSO4, nifedipine and dexamethasone. The diagnosis and management in this case have been adjusted according to the reference.
Sarkoma Ewing: Diagnosis dan Tatalaksana Hisbul Waton; Helmi Ismunandar; Oktadoni Saputra; Ratna Dewi Puspita Sari
Medula Vol 13 No 2 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i2.657

Abstract

Ewing's sarcoma (ES) is the second most common bone malignancy. It is accompanied by osteosarcoma. Ewing's sarcoma is most common in people between the ages of 10 and 20, or becomes more common in their 20s, and most cases affect males. The exact cause of Ewing's sarcoma is unknown, but it is currently associated with a translocation of chromosomes 11 and 12 which results in fusion of the EWS and FL-1 genes in 90% of cases. Ewing's sarcoma is often diagnosed with an extensive lesion and metastases, so the patient's prognosis is poor. Complaints that are often found in patients with Ewing's sarcoma are pain, fever, mass and fracture pathology. In addition, laboratory tests found an increase in blood sedimentation levels (ESR), anemia followed by an increase in white blood cells, lactate dehydrogenase (LDH). Radiographs show ill-defined, punctate, penetrating, or moth-eaten lesions, onion-like periosteal reaction, and abundant soft tissue around the diaphysis or metaphysis. Treatment of Ewing's sarcoma is a multimodal approach that combines chemotherapy, physical therapy, and radiation therapy. This combination has been shown to increase the 5-year survival rate of patients with Ewing's sarcoma to over 50%.
Hubungan Konsumsi Kafein dengan Kejadian Depresi Indah Salsabila; Putu Ristyaning Ayu Sangging; Intanri Kurniati; Ratna Dewi Puspitasari
Medula Vol 13 No 6 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i6.488

Abstract

Depression is a mood disorder. Depression is characterized by a feeling of sadness that lasts continuously and for a long time, which can interfere with a person's physical condition and social life. Around 121 million people in the world suffer from depression. It is estimated that only 30% of people with depression get proper treatment. This number does not include people who have clinical symptoms of depression but are not actually diagnosed. Some patients are also considered not to get proper treatment. The number of Indonesian populations aged more than 15 years and diagnosed with depression is 12 million sufferers. Pharmacological therapy in depressed patients is antidepressants such as serotonin and noradrenaline reuptake inhibitors (SNRIs), and selective serotonin reuptake inhibitors (SSRIs). However, there are side effects that can result from long-term use of these drugs. Therefore, other treatments such as giving herbal medicines are needed to reduce symptoms in people with depression. Giving caffeine with the right dose can reduce the risk of depression, because of its ability to block the adenosine receptor subunit. However, caffeine consumption with doses above 68mg and below 509mg per day is assessed to have the opposite effect that increases the risk of developing depression.
Co-Authors Alvira Balqis Soraya Ari Irawan Romulya Arif Yudho Prabowo Arli Suryawinata Asep Sukohar Bakrie, Samsul Citra Yuliyanda Pardilawati Dedy Miswar Desta Stallaza Alifka Dian Isti Angraini Dian Pratiwi Diana Mayasari Dinda Annisa Fitria Dwi Rani Sukma Dyah Wulan Sumekar Rengganis Wardani Efriyan Imantika Ety Apriliana Evi Kurniawati, Evi Evriana Citra Fakhri Wisa Amrulloh Febrina Halimatunisa nisa Fiana Deswita Fitriani Antika Dhamayanti Hardiyanti, Rahma Helmi Ismunandar Hisbul Waton Indah Salsabila Intanri Kurniati Jeffrey Surya jefri irawan Karina Azlia Amanda Karunia Santi Mallarangeng, Andi Nafisah Tendri Adjeng Maulana Irfan Hazairin Siregar Meilisa Hidayah Putri Muhammad Hasbi Sahbani Muhartono Muhartono Naza Tsasbita Hayuning Adila Nurul Islamy Nurul Islamy Nurul Utami Oktadoni Saputra Putu Ristyaning Ayu Rachmi Lestari Rukmono Rafa Habiba Sono Rani Himayani Rasmi Zakiah Oktarlina Ratu Nirmala Wahyunindita Regina Pingkan Reni Indriyani Reni Indriyani Reni Indriyani Reni Indriyani Reni Zuraida Reni Zuraida Retno Arienta Sari Rika Lisiswanti Ringgi Tantra Setiawan Risti Graharti Rodiani Rodiani, Rodiani Samsul Bakri Samsul Bakrie Sangging, Putu Ristyaning Ayu Sofyan Musabiq Wijaya Sofyan Musyabiq Wijaya Soraya Rahmanisa Suharyani Susan Yulia Laura Howay Sutarto Sutarto Sutarto Sutarto Sutyarso TA Larasati Taufiqurrahman Rahim Tesya Agustin Tiara Cornela Azqinar Tri Lamtiur Pakpahan Winda Trijayanthi Utama, Winda Trijayanthi Zahra Dewi Difa