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The Effectiveness of Giving Growth Hormone to Children with Chronic Kidney Disease: Systematic Literature Review Afdhila , Irhamni Nur; Fitrisia Amelin; Gardenia Akhyar
Biomedical Journal of Indonesia Vol. 7 No. 3 (2021): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i3.537

Chronic Kidney Disease (CKD) can cause growth problems in children. This condition will affect childrenâ€™s social life and increase morbidity and mortality. Growth hormone (GH) is one of medication that has been used for treatment of impaired growth in children with chronic kidney disease. In Indonesia, this management has not been provided, because it is expensive and its effectiveness is uncertain. This research was conducted to determine the effectiveness of growth hormone in increasing linear growth in children with CKD. This study is a systematic review of the Randomized Controlled Trial (RCT) study to determine the effectiveness of growth hormone as a treatment for children with CKD. Literature search was conducted using five databases, namely Pubmed, Google Scholar, DOAJ, BMC and CENTRAL that matched the inclusion and exclusion criteria. The guide used in the literature selection was the PRISMA flow chart. A Total of 10 studies were included in the systematic review. Growth hormone is effective in increasing linear growth in children with CKD. Generally there was a significant increase in height (standard deviation (SD)), high velocity (SD or cm) in the therapy group compared to the control group. The dose of growth hormone that is given varies, but the most is 4 IU / m2 / day, once a day, by subcutaneous injection. The duration of growth hormone administration varied from 6 months to 5 years with an average of 1.7 years. Growth hormone did not aggravate kidney problems in children with CKD and can increase important factors in bone formation, namely alkaline phosphatase and osteocalcin.

Correlation Between Density of House Dust Mites and Recurrence of Urticaria Gardenia Akhyar; Rahma Ledika Veroci
Jurnal Kesehatan Andalas Vol 8, No 3 (2019): Online September 2019
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v8i3.1035

Beberapa kasus urtikaria pada paparan debu dan diantaranya menghubungkan sensitivitas tungau debu rumah (TDR) dengan urtikaria berdasarkan riwayat pasien dan pemeriksaan uji intradermal. Tujuan penelitian ini adalah menentukan korelasi antara kepadatan TDR dan rekurensi urtikaria. Jumlah sampel pada penelitian ini 30 orang. Kepadatan TDR dari tiap kamar sampel dihitung dengan mengumpulkan debu, dan sampel dinilai sensitivitas terhadao TDR dengan pemeriksaan skin prick test (SPT). Diagnosis urtikaria berdasarkan anamnesis, kemudian ditanyaan rekurensinya dalam tiga bulan terakhir. Hasil: Dari 30 peserta, tujuh (23,3%) sampel memiliki kepadatan TDR sedang sementara 23 (76,7%) memiliki kepadatan rendah. Selain itu, 15 sampel positif SPT terhadap alergen TDR. Dari anamnesis, 12 (40%) sampel didiagnosis urtikaria dan diantaranya, 11 orang (91,67%) positif terhadap SPT. Tidak ada sampel yang memiliki rekurensi urtikaria dalam tiga bulan terakhir. Kesimpulan: Meskipun penelitian ini tidak menunjukkan korelasi yang signifikan antara kepadatan TDR dan tingkat kekambuhan urtikaria (p> 0,05), TDR memang bisa memicu eksaserbasi. Penelitian ini membutuhkan penyelidikan lebih lanjut dengan ukuran sampel yang lebih besar.

Studi retrospektif erupsi obat alergik di RS dr. M. Djamil Padang periode Januari 2014 – Desember 2016 Meligasari L Gaya; Gardenia Akhyar
Jurnal Kesehatan Andalas Vol 7 (2018): Supplement 2
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v7i0.827

Latar belakang: Erupsi obat alergik (EOA) dapat terjadi pada semua usia dengan berbagai manifestasi klinis. Obat penyebab terbanyak EOA umumnya adalah golongan antibiotik dan anti-konvulsan. Terdapat peningkatan kasus EOA di RSUP dr. M. Djamil Padang dari tahun ke tahun. Tujuan penelitian: Mengetahui profil EOA berdasarkan jumlah dan variasi kasus, usia, jenis kelamin, serta obat terbanyak yang dicurigai menyebabkan EOA di RSUP dr.M.Djamil Padang periode Januari 2014 – Desember 2016. Metode: Penelitian dilakukan secara retrospektif berdasarkan rekam medis pasien rawat inap dan rawat jalan di RSUP DR.M.Djamil Padang periode Januari 2014 – Desember 2016. Hasil: Selama periode Januari 2014 – Desember 2016 didapatkan kasus EOA sebanyak 179 kasus. Tipe makulopapular merupakan EOA terbanyak (26,25%), diikuti oleh Sindrom Steven Johnson (SSJ) (24,02%) dan eritroderma (24,02%). Kelompok usia 25 - 44 tahun (37%) merupakan usia terbanyak pada semua tipe EOA. Berdasarkan jenis obat penyebab, cefadroxil merupakan obat penyebab terbanyak pada kelompok makulopapular dan eritroderma, sedangkan karbamazepin merupakan obat penyebab terbanyak penyebab SSJ. Kesimpulan: Pada penelitian ini, antibiotik dan anti-konvulsan merupakan obat tersangka terbanyak yang menyebabkan EOA, sama seperti banyak penelitian sebelumnya. Antibiotik (cefadroxil) merupakan obat penyebab terbanyak pada kelompok makulopapular dan eritroderma, sedangkan anti-konvulsan (karbamazepin) merupakan obat penyebab terbanyak pada kelompok SSJ.

Pengabdian Masyarakat dan Penelitian tentang Skabies di Puskesmas Koto Berapak Kecamatan Bayang Kabupaten Pesisir Selatan GARDENIA AKHYAR
Jurnal Pengabdian Warta Andalas Vol 23 No 2 (2016): Warta Pengabdian Andalas
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar

Infectious skin disease consists of a skin disease caused by bacterial, fungal, viral, and parasitic infestations. Health education "Scabies disease" refers to the people on Koto Berapak, Bayang, District of Pesisir Selatan.

Bullous Systemic Lupus Erythematosus Mimicking Bullous Pemphigoid: A Case Report Vesri Yossy; Gardenia Akhyar; Alimuddin Tofrizal
Health and Medical Journal Vol 3, No 2 (2021): HEME July 2021
Publisher : Universitas Baiturrahmah

Introduction: Bullous systemic lupus erythematosus (BSLE) is an infrequent but distinct presentation of systemic lupus erythematosus (SLE) in less than 5% of lupus cases. It is characterized by vesicobullous skin eruption in SLE that can develop either before or after SLE diagnosis has been established. Distinguish between BSLE with other autoimmune blistering diseases such as bullous pemphigoid (BP), dermatitis herpetiformis, linear IgA, etc., is very important to prevent misdiagnosis. The physician must be able to combine clinical, histological and immunofluorescence finding for the diagnosis approach. We report a case of blistering skin eruption in SLE patient. Case Report: A 19-year-old female patient complained of tense blistering on her lip, face and wrists since one month ago. She was diagnosed with SLE two weeks ago. The dermatological state showed bullae and vesicle on erythematous/ normal base, erosions, excoriation and blackish red crust on the lip, face, armpit, neck, abdomen and wrists. Histopathological examination of the lesion showed sub-epidermal bullae containing PMN leukocytes consist of abundant neutrophils, only occasional eosinophils and the presence of keratotic plugs. Direct immunofluorescence (DIF) of the skin showed linear deposition of IgG, IgA, IgM and C1q at the dermo-epidermal junction. This patient exhibited similar features to both BSLE and BP with tensed clear blisters and subepidermal cleft. BSLE differ from BP by abundant neutrophils found on histopathological examination, whereas BP has abundant eosinophils. Conclusion: Immunofluorescence examination shows linear IgG in BP, whereas linear or granular IgG in BSLE. Establishing the correct diagnosis is important to prevent misdiagnosis and mistreatment.

Pengaruh Suplementasi Oral Vitamin D terhadap Penurunan Keparahan Gejala pada Urtikaria Spontan Kronis: Sebuah Tinjauan Naratif Nurul Izzah; Gardenia Akhyar; Abdiana Abdiana
Jurnal Ilmu Kesehatan Indonesia Vol 2 No 1 (2021): Maret 2021
Publisher : Fakultas Kedokteran, Universitas Andalas

Background: Chronic Spontaneous Urticaria (CSU) is a common allergic skin disease. The etiopathogenesis remains unclear. Recommended therapy is only aimed to reduce and control the symptoms. Vitamin D is a potential immunomodulator that can be used as an alternative therapy of urticaria. Objective: This literature study aims to explores various original research literature about the effect of vitamin D in CSU and the mechanism behind that. Methods: Narrative review of the literature that searched through three databases with determined keywords, then selected based on inclusion and exclusion criteria. Results: There are six literatures with 621 CSU cases. Conclusion: Vitamin D supplementation can reduce the severity of the symptom in CSU patient

Identifikasi Penyakit Kulit dan Pemeriksaan Lesi Kulit kepada Masyarakat di Daerah Binaan Universitas Andalas Qaira Anum; Rina Gustia; Satya Wydya Yenny; Gardenia Akhyar; Ennesta Asri; Tutty Ariani; Mutia Sari; Rizkia Chairani Asri
Warta Pengabdian Andalas Vol 28 No 3 (2021)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.28.3.334-340.2021

Universitas Andalas has an assisted area in the campus environment located in Limau Manis, Pauh. Skin disease, commonly encountered in the community, is a critical disease group in primary healthcare. However, there is no data on skin disease prevalence in Pauh Primary Care Unit. The purpose of this community service is to find out the characteristics of skin diseases that exist in the Pauh Primary Care Unit. Identifying the prevalence of skin disease is indispensable to planning health services and providing preventive actions against related diseases. The method used primary data from dermatologic status examinations on September 14, 2021. In addition, patients' quality of life was assessed using the Dermatology Life Quality Index (DLQI) questionnaire. The activity results obtained the most diseases were superficial fungal infections, and most skin diseases impact the patient's life. So, treatment and education are essential things in this activity.

The Effectiveness of Giving Growth Hormone to Children with Chronic Kidney Disease: Systematic Literature Review Irhamni Nur Afdhila; Fitrisia Amelin; Gardenia Akhyar
Biomedical Journal of Indonesia Vol. 7 No. 3 (2021): Vol 7, No 3, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i3.537

Chronic Kidney Disease (CKD) can cause growth problems in children. This condition will affect children’s social life and increase morbidity and mortality. Growth hormone (GH) is one of medication that has been used for treatment of impaired growth in children with chronic kidney disease. In Indonesia, this management has not been provided, because it is expensive and its effectiveness is uncertain. This research was conducted to determine the effectiveness of growth hormone in increasing linear growth in children with CKD. This study is a systematic review of the Randomized Controlled Trial (RCT) study to determine the effectiveness of growth hormone as a treatment for children with CKD. Literature search was conducted using five databases, namely Pubmed, Google Scholar, DOAJ, BMC and CENTRAL that matched the inclusion and exclusion criteria. The guide used in the literature selection was the PRISMA flow chart. A Total of 10 studies were included in the systematic review. Growth hormone is effective in increasing linear growth in children with CKD. Generally there was a significant increase in height (standard deviation (SD)), high velocity (SD or cm) in the therapy group compared to the control group. The dose of growth hormone that is given varies, but the most is 4 IU / m2 / day, once a day, by subcutaneous injection. The duration of growth hormone administration varied from 6 months to 5 years with an average of 1.7 years. Growth hormone did not aggravate kidney problems in children with CKD and can increase important factors in bone formation, namely alkaline phosphatase and osteocalcin.

Exacerbation of Psoriasis Vulgaris Induced by Vaccine COVID-19 in HIV Patient: A Case Report Gardenia Akhyar; I. Izrul; M. Ashar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 12 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i12.620

Background: Psoriasis is a chronic and inﬂammatory skin disease. Many triggering factors can cause exacerbation of psoriasis, such as infection, trauma, and drugs. Several vaccines are known to cause new lesions or exacerbation of psoriasis, including Bacillus Calmette-Guerin (BCG), influenza, tetanus-diphtheria, and pneumococcal polysaccharide. In the COVID-19 pandemic, the COVID-19 vaccine is known to cause the appearance of new lesions or exacerbation of psoriasis. Case presentation: A woman, 31 years old, came to the clinic with itchy reddish patches with white scales on her face, chest, stomach, back, arms, and both legs, and increased since 2 weeks ago. Previously, the patient got the first COVID-19 vaccine (Sinovac), and three days later, red patches appeared with white scales on the chest, stomach, and back. The patient had been diagnosed with psoriasis 3 years ago. Dermatology examination showed reddish patches with white scales on the face, chest, stomach, back, arms, and both legs. Auspitz sign and Kaarvetsvlek phenomen were positive. PASI score was 9,2. Dermoscopy examination showed red dot distribution on light pink background and white scales. She was treated with desoximetasone cream 0,05% twice a day and cetirizine tablet 10 mg once a day. After 2 months of therapy, reddish patches were decreased, and the PASI score was 6,9. Conclusion: COVID-19 vaccine can cause exacerbations in psoriasis patients, but this vaccine can still be given to psoriasis patients. It is based on the documented eﬃcacy of the COVID-19 vaccine in the prevention of severe COVID-19 infection and fatality. Psoriasis patients should be consulted before getting vaccinated for COVID-19, and prompt clinical visits should be available if exacerbation develops.

Exacerbation of Psoriasis Vulgaris Induced by Vaccine COVID-19 in HIV Patient: A Case Report Gardenia Akhyar; I. Izrul; M. Ashar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 12 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i12.620

Background: Psoriasis is a chronic and inﬂammatory skin disease. Many triggering factors can cause exacerbation of psoriasis, such as infection, trauma, and drugs. Several vaccines are known to cause new lesions or exacerbation of psoriasis, including Bacillus Calmette-Guerin (BCG), influenza, tetanus-diphtheria, and pneumococcal polysaccharide. In the COVID-19 pandemic, the COVID-19 vaccine is known to cause the appearance of new lesions or exacerbation of psoriasis. Case presentation: A woman, 31 years old, came to the clinic with itchy reddish patches with white scales on her face, chest, stomach, back, arms, and both legs, and increased since 2 weeks ago. Previously, the patient got the first COVID-19 vaccine (Sinovac), and three days later, red patches appeared with white scales on the chest, stomach, and back. The patient had been diagnosed with psoriasis 3 years ago. Dermatology examination showed reddish patches with white scales on the face, chest, stomach, back, arms, and both legs. Auspitz sign and Kaarvetsvlek phenomen were positive. PASI score was 9,2. Dermoscopy examination showed red dot distribution on light pink background and white scales. She was treated with desoximetasone cream 0,05% twice a day and cetirizine tablet 10 mg once a day. After 2 months of therapy, reddish patches were decreased, and the PASI score was 6,9. Conclusion: COVID-19 vaccine can cause exacerbations in psoriasis patients, but this vaccine can still be given to psoriasis patients. It is based on the documented eﬃcacy of the COVID-19 vaccine in the prevention of severe COVID-19 infection and fatality. Psoriasis patients should be consulted before getting vaccinated for COVID-19, and prompt clinical visits should be available if exacerbation develops.

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