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All Journal Jurnal Kesehatan Andalas Biomedical Journal of Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Health and Medical Journal Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmu Kesehatan Indonesia Prosiding Seminar Nasional Unimus
Gardenia Akhyar
Andalas University
Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : Biomedical Journal of Indonesia

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The Effectiveness of Giving Growth Hormone to Children with Chronic Kidney Disease: Systematic Literature Review Afdhila , Irhamni Nur; Fitrisia Amelin; Gardenia Akhyar
Biomedical Journal of Indonesia Vol. 7 No. 3 (2021): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i3.537

Abstract

Chronic Kidney Disease (CKD) can cause growth problems in children. This condition will affect children’s social life and increase morbidity and mortality. Growth hormone (GH) is one of medication that has been used for treatment of impaired growth in children with chronic kidney disease. In Indonesia, this management has not been provided, because it is expensive and its effectiveness is uncertain. This research was conducted to determine the effectiveness of growth hormone in increasing linear growth in children with CKD. This study is a systematic review of the Randomized Controlled Trial (RCT) study to determine the effectiveness of growth hormone as a treatment for children with CKD. Literature search was conducted using five databases, namely Pubmed, Google Scholar, DOAJ, BMC and CENTRAL that matched the inclusion and exclusion criteria. The guide used in the literature selection was the PRISMA flow chart. A Total of 10 studies were included in the systematic review. Growth hormone is effective in increasing linear growth in children with CKD. Generally there was a significant increase in height (standard deviation (SD)), high velocity (SD or cm) in the therapy group compared to the control group. The dose of growth hormone that is given varies, but the most is 4 IU / m2 / day, once a day, by subcutaneous injection. The duration of growth hormone administration varied from 6 months to 5 years with an average of 1.7 years. Growth hormone did not aggravate kidney problems in children with CKD and can increase important factors in bone formation, namely alkaline phosphatase and osteocalcin.
The Effectiveness of Giving Growth Hormone to Children with Chronic Kidney Disease: Systematic Literature Review Irhamni Nur Afdhila; Fitrisia Amelin; Gardenia Akhyar
Biomedical Journal of Indonesia Vol. 7 No. 3 (2021): Vol 7, No 3, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i3.537

Abstract

Chronic Kidney Disease (CKD) can cause growth problems in children. This condition will affect children’s social life and increase morbidity and mortality. Growth hormone (GH) is one of medication that has been used for treatment of impaired growth in children with chronic kidney disease. In Indonesia, this management has not been provided, because it is expensive and its effectiveness is uncertain. This research was conducted to determine the effectiveness of growth hormone in increasing linear growth in children with CKD. This study is a systematic review of the Randomized Controlled Trial (RCT) study to determine the effectiveness of growth hormone as a treatment for children with CKD. Literature search was conducted using five databases, namely Pubmed, Google Scholar, DOAJ, BMC and CENTRAL that matched the inclusion and exclusion criteria. The guide used in the literature selection was the PRISMA flow chart. A Total of 10 studies were included in the systematic review. Growth hormone is effective in increasing linear growth in children with CKD. Generally there was a significant increase in height (standard deviation (SD)), high velocity (SD or cm) in the therapy group compared to the control group. The dose of growth hormone that is given varies, but the most is 4 IU / m2 / day, once a day, by subcutaneous injection. The duration of growth hormone administration varied from 6 months to 5 years with an average of 1.7 years. Growth hormone did not aggravate kidney problems in children with CKD and can increase important factors in bone formation, namely alkaline phosphatase and osteocalcin.
Co-Authors Abdiana Abdiana, Abdiana Afdhila , Irhamni Nur Alimuddin Tofrizal Anum, Qaira Endrinaldi Ennesta Asri Ennesta Asri Fauzana Nazifah Fitrisia Amelin Fitrisia Amelin Fortuna, Fory I. Izrul Indah Indria Sari Irdawati Izrul Irhamni Nur Afdhila M. Ashar Mardhiati Mardhiati Meligasari L Gaya Mutia Sari Nailatul Fadhila Nurul Izzah Rahma Ledika Veroci Rina Gustia Riri Prima Yolanda Rizkia Chairani Asri Satya Wydya Yenny Tutty Ariani Vesri Yossy Yenni Raflis Yola Fadilla Yosse Rizal Yusticia Katar