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Hubungan Tingkat Pengetahuan dengan Swamedikasi Penyakit Neurodermatitis pada Pekerja Proyek di PT. Boyang Purbalingga Anggestia Zakina; Peppy Octaviani; Rani Prabandari
BORNEO JOURNAL OF PHARMASCIENTECH Vol 7 No 1 (2023): Borneo Journal of Pharmascientech
Publisher : Sekolah Tinggi Ilmu Kesehatan Borneo Lestari Banjarbaru

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v7i1.437

Abstract

Neurodermatitis or lichen simplex chronicus is defined as a common form of chronic neurodermatitis that presents as dry, patchy areas of skin that are scaly and thick. Self-medication is a person's effort to help himself in the form of self-medicating. This study aims to determine the relationship between knowledge level and self-medication of neurodermatitis in project workers at PT. Boyang Purbalingga. This study used a cross sectional time approach. Research based on SPSS with spearman-rank test of neurodermatitis knowledge level on project workers of PT. Boyang Purbalingga found that most of the respondents had sufficient knowledge level as many as 24 respondents (21.8%) and good knowledge as many as 86 respondents (78.2%). Based on SPSS with spearman-rank test, the level of self-medication of neurodermatitis in project workers of PT. Boyang Purbalingga as many as 7 respondents (6.4%) have sufficient knowledge and 103 respondents (93.6%) have good knowledge. The results of the analysis based on the spearman-rank test obtained a p-value of 0.167 with a significance degree of 5% (0.05). It can be concluded that statistically there is a relationship between the level of knowledge and self-medication of neurodermatitis disease in project workers at PT. Boyang Purbalingga.
UJI AKTIVITAS ANTI INFLAMASI EKSTRAK ETANOL BAWANG MERAH (Allium Cepa L.) VARIETAS BIMA BREBES PADA TIKUS PUTIH JANTAN GALUR WISTAR Abidia Kamil; Adita Silvia; Rani Prabandari
Jurnal Farmasi & Sains Indonesia Vol 5 No 1 (2022)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol5no1p60-64

Abstract

Shallots are one of the leading vegetable commodities in Indonesia. The center for shallot production is Central Java Province, especially in the Brebes Regency area. Shallots (Allium cepa L) can be used as medicine, one of which is as an anti-inflammatory. The purpose of this study was to determine the anti-inflammatory activity and to determine the best dose of ethanolic extract of shallot (Allium cepa L) which has anti-inflammatory activity against male white rats of wistar strain. The method used is the experimental method. Shallot extract (Allium cepa L.) was extracted using 70% ethanol by maceration method. The test animals used were white male rats wistar strain as many as 25 rats weighing 200-250 grams. The test animals were divided into 5 groups, namely the negative control group (Na CMC 0.5%), the positive group (Na Diclofenac), the onion extract dose variation group (25 mg/KgBW, 50 mg/KgBW, and 100 mg/KgBW). . Treatment 1 hour afterthe hind legs of rats was induced by subplantar carrageenin. The measurement of the volume of edema on the soles of the rats' feet was observed once every 1 hour for 6 hours. The results of the study showed that there was antiinflammatory activity at the three doses (25 mg/KgBW, 50 mg/KgBW and 100 mg/KgBW) ethanol extract of shallot (Allium cepa L) Bima Brebes in male white rats of the Wistar strain. The best dose of ethanolic extract of shallot (Allium cepa L) which has anti-inflammatory activity against male white rats of wistar strain is 50 mg/KgBW.
Formulasi Antibakteri Mouthwash Ekstrak Etanol Daun Kirinyuh (Chromolaena odorata (L.) R.M.King & H.Rob.) Pada Bakteri Streptococcus mutans STCC 31987 Esti Erdiyati; Rani Prabandari; Sunarti Sunarti; Desi Nawangsari
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p17-27

Abstract

Kirinyuh leaves (Chromolaeina odorata (L.) R.M.King &; H.Rob.) contain secondary metabolites in the form of flavonoids, saponins, steiroids, tannins that can inhibit the growth of antibacterial growth. Based or its antibacterial properties, kirinyuh leaf extract can be developed into mouthwash to prevent dental plaque. The purpose of this study was to determine the physical stability test of the kirinyuh leaf ethanol extract mouthwash preparation and to determine the antibacterial activity of the kirinyuh leaf ethanol extract against Streptococcus mutans ATCC 31987 bacteria, so that a  formulation of the kirinyuh leaf ethanol extract mouthwash preparation could be made. Mouthwash is an antiseptic preparation that is used to clean the oral cavity and is used by gargling. The extraction used was remaceration method with 70% ethanol solvent, made in various extracts with concentrations of 10%, 20%, 30%. Further evaluation of the preparation includes : organoleptic test, pH test, viscosity test. The results of the One Way ANOVA analysis showed that there was no significant difference in the pH test, viscosity test with a p>0,05 value. Organoleptic test during 6 cycles of storage in a stable state during storage. The results showed that the ethanol extract of kirinyuh leaf mouthwash was able to inhibit the growth of Streptococcus mutans bacteria, namely in F1 the weak category was 2.43±0.81 mm, F2 was 10.21±3.56 mm the strong categori, F3 was 13.38±2.72 mm strong category.   Keywords : Antibacterial, Kirinyuh leaves, Mouthwash