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All Journal Jurnal Saintika Medika Berkala Ilmu Kesehatan Kulit dan Kelamin Folia Medica Indonesiana Indonesian Journal of Cancer Majalah Obstetri dan Ginekologi Health Notions Oto Rhino Laryngologica Indonesiana Majalah Patologi Indonesia JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Majalah Biomorfologi (Biomorphology Journal) Jurnal Pengabdian Masyarakat dalam Kesehatan Indonesian Journal of Cancer

KUSUMASTUTI, ETTY HARY

Departemen Patologi Anatomi Fakultas Kedokteran Universitas Airlangga Surabaya

Author-ID : 2536979

Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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ANALYSIS OF THE EXPRESSION OF FAS/CD95 AND HSP70 IN LOW AND HIGH GRADE UROTHELIAL CELL CARCINOMA OF THE BLADDER Heryanto Heryanto; Etty Hary Kusumastuti; Anny Setijo Rahaju
Folia Medica Indonesiana Vol. 53 No. 4 (2017): December 2017
Publisher : Faculty of Medicine, Universitas Airlangga

Urothelial Cell Carcinoma (UCC), also called transitional cell carcinoma of the bladder, is the most common malignancy in urinary tract. The prognosis of this disease is highly dependent on the histological grading at diagnosis. Fas/CD95 has a role in apoptotic process, whereas HSP70 has an antiapoptotic role. This study aimed to analyze the expression of Fas/CD95 and HSP70 in low grade and high grade urothelial cell carcinoma in the bladder. This was an analytic observational study with cross sectional approach. Population and sample were paraffin blocks of urothelial cell carcinoma in the Laboratory of Anatomic Pathology, Dr. Soetomo Hospital, Surabaya in the period of January 2011-December 2016. Each grading of urothelial cell carcinoma was randomly sampled. Immunohistochemystry with Fas/CD95 and HSP70 were performed. Expression of Fas/CD95 and HSP70 were assessed semiquantitatively. Expression of Fas/CD95 and HSP70 were analyzed using Mann-Whitney test and Spearman test. The results showed there was significant different in expression of Fas/CD95 and HSP70 in low and high grades in urothelial cell carcinoma. There was no significant correlation between the expression of Fas/CD95 and HSP70 in urothelial cell carcinoma. As a conclusion, the role of CD95 and HSP70 expression can be useful as marker for the diagnosis, especially in the determination of the grade of differentiation.

Comparison of Breast Cancer 3-years Survival Rate Based on the Pathological Stages Nur Imroatul Mursyidah; Ami Ashariati; Etty Hary Kusumastuti
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 10 No. 1 (2019): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Faculty of Medicine Universitas Airlangga

Introduction: The aims of this study was to determine the differences of breast cancer survival rate based on Pathological stages.Methods: This study was conducted with a retrospective case control design using secondary data from Dr. Soetomo General Hospital's medical records. The technique used to take the samples was purposive sampling. The sample was 45 breast cancer patients in Dr. Soetomo General Hospital In January 2015, that able to be contacted again and had a medical record in the oncology center in Dr. Soetomo General Hospital Surabaya. The variables studied is breast cancer survival based on the pathological stages.Results: Breast cancer patients at the stage of IIA have 100% 3-year survival rate, stage IIB by 83.3%, stage IIIA by 71.4%, stage IIIB by 53.8%, IIIC by 50%, and stage IV by 30%. With a comparison of the log-rank significance p = 0.104.Conclusion: The survival rate of breast cancer patients is lower in line with the increasing pathological stage of breast cancer.

CORRELATION BETWEEN HORMONAL STATUS OF ESTROGEN RECEPTOR AND MALIGNANCY DEGREE OF INVASIVE DUCTAL BREAST CANCER Windy Ayustyas Trisna; Sahudi Sahudi; Etty Hary Kusumastuti
Majalah Biomorfologi Vol. 31 No. 1 (2021): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v31i1.2021.1-5

Background: Globocan data in 2018 shows the cancer incidence in Indonesia. The highest case in women is breast cancer. The chance of survival for patients with high malignancy (Grade III) is only 11.86%, while for patients with low malignancy (Grade I) can reach 71.69%. Estrogen exposure is a risk factor for breast cancer. The hormone causes its effect through the estrogen receptor which is a core protein. Patients with positive receptor have 5 and 10 years survival rate which is better than patients with negative estrogen receptor. Objective: To identify correlation between hormonal status of estrogen receptor and malignancy degree of invasive ductal breast cancer. Materials and Methods: This research was an observational analytic study. The sample used was patients’ medical record data in 2015-2017 in Anatomic Pathology Unit, Central Laboratory Installation, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. Results: The data used were 694 patients medical record in 2015-2017. Approximately 56 patients (86%) had hormonal status of positive estrogen receptor with grade I cancer, 180 patients (70%) were in grade II, and 217 patients (45%) were in grade III. Approximately 9 patients (14%) had hormonal status of negative estrogen receptor with grade I cancer, 71 patients (28%) were in grade II, and 161 patients (34%) were in grade III. The result using Chi-Square test found Chi-Square value of 27.413 with a significance of 0.000 (p <0.01). Conclusion: There was a positive correlation between the hormonal status of estrogen receptor and malignancy degree of invasive ductal breast cancer.

EARLY DETECTION OF BREAST AND CERVICAL CANCER OF THE RESIDENTS OF PROPPO PAMEKASAN DISTRICT Dyah Fauziah; Alphania Rahniayu; Nila Kurniasari; Anny Setijo Rahaju; Etty Hary Kusumastuti; Gondo Mastutik; I Ketut Sudiana
Jurnal Pengabdian Masyarakat Dalam Kesehatan Vol. 3 No. 1 (2021): APRIL 2021
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jpmk.v3i1.21584

Introduction: Breast cancer and cervical cancer are common cancers in females. Both of these cancers can be detected early. Early detect vion can reduce cancer morbidity and mortality. The community outreach activities are required to increase knowledge about breast cancer and cervical cancer, in addition to screening as preventive efforts for these two cancers.Methods: The activity of raising knowledge about the prevention and early detection of breast cancer and cervical cancer was carried out through community counseling to 94 females who were members of the PKK and young females in the Kecamatan Proppo, Kabupaten Pamekasan. Pre and post tests were given before and after the community counseling. After the community counseling, 86 participants were screened for breast cancer by clinical palpation and 46 participants were screened for cervical cancer using the pap smear method.Results: The result of the post test showed a 27.53% increase in knowledge. The results of the pap smear examination on participants showed 96% concluded as Papanicolau Class II, 2% Class I, and 2% Class IV. The patient with class IV results was referred to an obstetrician.Conclusion: Community counseling about breast self examination (BSE) and Pap smear can increase people's knowledge about early detection of breast cancer and cervical cancer.

Clinicopathological profile of nasopharyngeal carcinoma in 2016-2019 at Dr. Soetomo General Hospital Karindra Amadea Susetiyo; Etty Hary Kusumastuti; Muhtarum Yusuf; Rosa Falerina
Oto Rhino Laryngologica Indonesiana Vol 52, No 1 (2022): VOLUME 52, NO. 1 JANUARY - JUNE 2022
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v52i1.474

ABSTRACTBackground:.The number of nasopharyngeal carcinoma (NPC) cases is increasing and causing death, placing this cancer in fifth place as the cause of death in Indonesia. The initial clinical symptoms that are less specific often cause patients coming with advanced stage conditions. Therefore, the study of clinical and pathological profiles of NPC patients are required. Objective: To find out the clinicopathological profile of NPC patients in Dr. Soetomo General Hospital in 2016-2019. Methods: This study was descriptive research with a retrospective study using medical records of NPC patients in Dr. Soetomo General Hospital from 2016 to 2019. Results: 192 NPC patients that meet the criteria were divided according to their age, gender, histopathological classification, stage, and post-therapy response. Out of 192 patients, 22 patients had post-therapy response based on histopathological data. Conclusion: NPC patients in Dr. Soetomo General Hospital in 2016-2019 were found in the range of 14-77 years old, most patients were in the age group 41-≤50 years old (66 patients, 34%). There were more male than female patients (73%). The most common clinical symptoms experienced by patients were a lump on the neck (82%), local ear complaints (79%), and local nasal complaints (75%). The most common histopathological subtype was non-keratinizing squamous cell carcinoma undifferentiated in 181 patients (94%). The highest stage of patients was IV A in 122 patients (64%). In 18 (82%) from 22 patients, based on histopathology examination had good criteria on therapy response. ABSTRAKLatar belakang: Angka kasus karsinoma nasofaring yang (KNF) kian meningkat dan dapat menyebabkan kematian, menempatkan kanker ini pada urutan ke lima di Indonesia. Gejala klinis awalnya yang kurang spesifik seringkali menyebabkan penderita datang dengan kondisi stadium lanjut. Oleh karena itu, profil penderita KNF secara klinis dan gambaran histopatologinya perlu diteliti lebih lanjut. Tujuan: Mengetahui profil klinikopatologi penderita KNF di RSUD Dr. Soetomo tahun 2016-2019. Metode: Penelitian secara deskriptif dengan studi retrospektif menggunakan rekam medis penderita KNF di RSUD Dr. Soetomo tahun 2016-2019. Hasil: Sebanyak 192 penderita KNF yang memenuhi kriteria dibagi berdasarkan kategori usia, jenis kelamin, klasifikasi histopatologi, stadium, dan respon pasca terapi. Dari 192 penderita ditemukan sebanyak 22 penderita memiliki data respon pasca terapi berdasarkan histopatologi. Kesimpulan: Penderita KNF di RSUD Dr.Soetomo tahun 2016-2019 ditemukan pada rentang usia 14-77 tahun dengan penderita terbanyak pada rentang usia 41- 50 yaitu 66 (34%) serta lebih banyak terjadi jenis kelamin laki-laki yaitu 140 (73%). Gejala klinis yang paling banyak dialami penderita adalah benjolan pada leher 158 (82%), keluhan lokal telinga 151 (79%), dan lokal hidung 144 (75%). Subtipe histopatologi terbanyak adalah nonkeratinizing squamous cell carcinoma undifferentiated yaitu 181 (94%) penderita. Stadium terbanyak penderita adalah IV A yaitu 122 (64%) penderita. Sebanyak 18 (82%) dari 22 penderita berkriteria baik pada respon terapi berdasarkan histopatologi.

Perbedaan Ekspresi HBME-1 dan E-Cadherin pada Nodular Hiperplasia, Karsinoma Papiler, dan Folikular Tiroid PRIMA ROOSANDRIS; ETTY HARY KUSUMASTUTI; NILA KURNIASARI
Indonesian Journal of Cancer Vol 11, No 4 (2017): October- December 2017
Publisher : National Cancer Center - Dharmais Cancer Hospital

Thyroid lesion can be neoplastic and non neoplastic, whether benign or malignant. There are some cases in which pathologists have difficulties to differentiated those lesions. Aim: To analyze the expression of HBME-1 and E-cadherin on nodular hyperplasia, papillary carcinomas and follicular carcinomas. Paraffin blocks of nodular hyperplasia, papillary carcinoma and follicular thyroid were collected from Departement of Pathology Dr Soetomo General Hospital from January 1st, 2012 to December 31th, 2014. Immunohistochemical staining for HBME-1 and E-cadherin were performed. The difference of expression HBME-1 and E-cadherin were analyzed by Mann Whitney test, and the correlation between HBME-1 and E-cadherin determined using Spearman test. There were significant difference of HBME-1 expression between Nodular hyperplasia and Thyroid carcinoma(p≤0,05). There were also significant difference of HBME-1 between papillary and follicular carcinoma thyroid(p≤0,05). There were no significant difference of E-cadherin expression between Nodular hyperplasia and Thyroid carcinoma(p≥0,05). Conclusion: HBME-1 can be used as a marker to distinguish benign and malignant lesion of thyroid gland, and also to distinguish papillary carcinoma and follicullar carcinoma thyroid. ABSTRAK Lesi tiroid dapat berupa lesi non-neoplastik dan neoplastik, baik jinak maupun ganas. Membedakan tumor tiroid jinak dan ganas sangat penting untuk penatalaksanaan klinis yang tepat sehingga sering kali patolog menemui kesulitan dalam membedakan lesi tiroid jinak dan ganas. Penelitian ini bertujuann membuktikan adanya perbedaan ekspresi HBME-1 dan E-cadherin antara nodular hiperplasi, karsinoma papiler, dan karsinoma folikular tiroid. Dilakukan pemeriksaan imunohistokimia pada blok parafin dari nodular hiperplasia, karsinoma papiler, dan karsinoma folikular yang tersimpan di Instalasi Patologi Anatomi RSUD Dr. Soetomo (1 Januari 2012 sampai dengan 31 Desember 2014 sebanyak 35 sampel sesuai kriteria inklusi) dengan antibodi HBME-1 dan E-cadherin. Ekspresi HBME-1 dan E-cadherin dianalisis dengan uji Mann Whitney, sedangkan korelasi antara HBME-1 dan E-cadherin diuji dengan Spearman Test. Hasil penelitian menunjukkan terdapat perbedaan ekspresi HBME-1 yang signifikan antara nodular hiperplasia dan karsinoma tiroid( p≤0,05); terdapat perbedaan ekspresi HBME-1 yang signifikan antara karsinoma papiler tiroid dan karsinoma folikular tiroid (p≤0,05). Tidak terdapat perbedaan ekspresi E-cadherin yang signifikan pada nodular hiperplasi dan karsinoma tiroid (p≥0,05). Penelitian ini menyimpulkan bahwa HBME-1 dapat digunakan sebagai marker untuk mebedakan lesi jinak dan ganas kelenjar tiroid, serta dapat digunakan untuk membedakan karsinoma papiler tiroid dan karsinoma folikular tiroid.

Role of CXCR4 and MMP-9 Expressions with Regional Cervical Lymph Nodes Metastatic Status in Papillary Thyroid Carcinoma Etty Hary Kusumastuti; Nurdhani Hi Djafar; Alphania Rahniayu
Indonesian Journal of Cancer Vol 15, No 2 (2021): June
Publisher : National Cancer Center - Dharmais Cancer Hospital

Background: Papillary thyroid carcinoma (PTC) that has metastasized has a higher risk because of the poor prognosis, ranging from decreased quality of life of the patient to death. There is a need for markers that can understand the image of the tumor so that it can predict earlier the level of aggressiveness and the ability of tumor cells to metastasize. Tumor cells that proliferate excessively will cause CXCR4 expression. Activation of CXCR4 will increase MMP-9 via the MAPK/ ERK line. MMP-9 will degrade the extracellular matrix causing tumor cell metastasis. This study is aimed to analyze the correlation of CXCR4 and MMP-9 expressions with lymph node metastasis (LNM) in PTC.Methods: This cross-sectional analytic observational study was conducted in 43 PTC samples taken from the Anatomical Pathology Laboratory of Dr. Soetomo Hospital from January 2011 to December 2018. The samples were divided into 2 groups based on the regional cervical LNM status. Immunohistochemical staining was used to assess the expression of CXCR4 and MMP-9. Spearman test was used to analyze the correlation of CXCR4 and MMP expression with cervical LNM status.Results: The expression of CXCR4 and MMP-9 was higher in the papillary thyroid carcinoma group with cervical regional LNM (p = 0.007 and p = 0.030). There was a significant positive relationship between CXCR4 and MMP-9 expressions with regional LNM status with rs = 0.468 and p = 0.001 (p < 0.05). Conclusions: Expression of CXCR4 and MMP-9 was proven to correlate with regional cervical LNM status in papillary thyroid carcinoma. Both can be used as predictive markers for metastasis in papillary thyroid carcinoma.

The Expression of CXCR4 and MMP13 in Colorectal Adenocarcinoma Dukes Stage A, B, C and D Rovi Anggoro; Etty Hary Kusumastuti
Indonesian Journal of Cancer Vol 12, No 1 (2018): Jan - Mar
Publisher : National Cancer Center - Dharmais Cancer Hospital

Background: Colorectal adenocarcinoma is the third most common cancer in the world with increasing incidence in Indonesia. Most presented ones were in late stage with more unfavorable prognosis. It is necessary to evaluate new markers for prognosis, identify staging and new possibilities for targeted therapy. Over-proliferating tumor cells will enhance the expression of CXCR4, a chemokine receptor. Activating CXCR4 will further activate various downstream signaling pathways, including one which will increase MMP13 secretion through MAPK/ERK signaling pathway. MMP13 then will degrade extracellular matrix, thus facilitate the migration or metastasis of tumor cells. Methods: A cross sectional study, conducted on 32 samples of colorectal adenocarcinoma. The samples were divided into four groups based on the Dukes staging system (A, B, C and D) and stained immunohistochemically with antibody against CXCR4 and MMP13. The expressions were assessed using immunoreactive score (IRS) and were statistically analyzed. Results: There were positive correlation between the expression of CXCR4 and MMP13 with Dukes staging, with rs = 0,628 and rs = 0,597, respectively. The expression of CXCR4 positively correlated with the expression of MMP13 with rs = 0,670 (p = 0,05). Conclusions: CXCR4 and MMP13 expressions were proven to correlate with the depth of invasion and migration of tumor cells in colorectal adenocarcinoma, hence could be considered as prognostic markers, however both could not be used as predictive marker for staging. Tailored therapies targeting these two proteins could be an interest for further investigation. ABSTRAKLatar Belakang: Adenokarsinoma kolorektal adalah keganasan terbanyak ketiga di dunia, dengan insidensi semakin meningkat di Indonesia. Sebagian besar kasus terdeteksi pada stadium lanjut dengan prognosis buruk. Diperlukan penemuan marker baru yang dapat membantu penentuan stadium, prognosis dan kemungkinan terapi target yang baru. Sel tumor yang berproliferasi berlebihan akan menyebabkan peningkatan ekspresi CXCR4, suatu reseptor kemokin. Aktivasi CXCR4 akan meningkatkan pelepasan proteinase MMP13 melalui jalur MAPK/ERK. MMP13 akan mendegradasi matriks ekstraseluler sehingga menyebabkan migrasi atau metastasis sel tumor. Metode: Studi cross sectional, dilakukan pada 32 sampel adenokarsinoma kolorektal. Sampel dibagi menjadi 4 grup; stadium Dukes A, B, C dan D. Dilakukan pulasan imunohistokimia dengan antibodi CXCR4 dan MMP13, ekspresi keduanya dinilai menggunakan immunoreactive score (IRS) dan dianalisis secara statistik. Hasil: Didapatkan korelasi positif bermakna antara ekspresi CXCR4 dan MMP13 dengan stadium Dukes, dengan rs = 0,628 dan rs = 0,597. Ekspresi CXCR4 berkorelasi positif dengan ekspresi MMP13 dengan rs = 0,670 (p = 0,05). Kesimpulan: Ekspresi CXCR4 dan MMP13 terbukti berkorelasi dengan kedalaman invasi dan migrasi sel ganas pada adenokarsinoma kolorektal. Keduanya dapat dipertimbangkan sebagai marker prognostik namun tidak dapat digunakan sebagai marker prediktif stadium. Targeted therapy untuk kedua protein ini menarik untuk dilakukan investigasi lebih jauh.

Co-Authors Afif Nurul Hidayati Alphania Rahniayu Ami Ashariati Anggoro, Rovi Anny Setijo Rahaju, Anny Setijo As'ad Naufal Cempaka Harsa Sekarputri Cita Rosita Sigit Prakoeswa Damayanti Damayanti Dian Yuliartha Lestari DYAH FAUZIAH, DYAH Falerina, Rosa Gondo Mastutik Heryanto Heryanto I Ketut Sudiana Indah Nur Damayanti Indra Yulianti Karindra Amadea Susetiyo Lutfia Ariska Ramadhani Nadya Divina Baihaqi Nila Kurniasari Nila Kurniasari Nur Imroatul Mursyidah Nurdhani Hi Djafar PRIMA ROOSANDRIS Ridholia Ridholia ROOSANDRIS, PRIMA Rovi Anggoro Sahudi Sahudi Trisniartami Setyaningrum Tuti Andayani Windy Ayustyas Trisna Yenny Meilany Sugianto Yusuf, Muhtarum

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