Anny Setijo Rahaju, Anny Setijo
Department of Anatomic Pathology, Faculty of Medicine/Universitas Airlangga, Soetomo General Hospital Surabaya.

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CORRELATION BETWEEN BLOOD SERUM PSA LEVEL AND MMP-2 IN PROSTATE ADENOCARCINOMA Rahaju, Anny Setijo; Meidi, Aniek; Mastutik, Gondo; Mustokoweni, Sjahjenny; Mustika, Arifa
Indonesian Journal of Urology Vol 23 No 2 (2016)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v23i2.220

Abstract

Objective: This study aims to prove the correlation between Prostate Specific Antigen (PSA) blood level and Matrix Metalloproteinase-2 (MMP-2) expression in patients with prostate adenocarcinoma. Material & method: Prostate cancer patients’ data from January 2009 to May 2012 were collected at the Department of Pathology, Soetomo General Hospital Surabaya. Data collected included patient medical documents, PSA blood examination, and histopathological examination. Histopathology slides and paraffin blocks of needle biopsies, Transurethral Resection of Prostate (TURP) and radical prostatectomy of prostate cancer patients werere-read, then the samples that met the inclusion criteria were stained by immunohistochemistry using antibodies MMP-2. Results: Data collection was done to obtain data samples of prostate cancer patients in 2009 to 2012 comprising as many as 22 patients between the ages of 52-91 years. Prostate adenocarcinoma in age of 70-79 was found in 8 patients, with a mean age of 68 years. PSA values obtained from medical documents were between 8.6-594.41 ng/ml. Spearman's test performed in this study showed a positive correlation (one-tailed) (correlation coefficient (r) 0431, p < 0.05) between blood PSA level and MMP-2 expression in patients with prostate adenocarcinoma. Conclusion: Blood PSA level correlates positively with MMP-2 expression in prostate adenocarcinoma.
Tinjauan Literatur : PATOGENESIS INFEKSI HUMAN PAPILLOMAVIRUS SEBAGAI DASAR DALAM PENGEMBANGAN PENCEGAHAN DAN TERAPI BARU PADA KANKER PENIS Trianto, Heru Fajar; Rahaju, Anny Setijo
Majalah Kesehatan FKUB Vol 8, No 3 (2021): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.majalahkesehatan.2021.008.03.7

Abstract

Kanker penis merupakan salah satu keganasan pada pria yang jarang terjadi. Berbagai faktor risiko berperan dalam kejadian kanker penis, salah satunya adalah infeksi Human Papillomavirus (HPV). Infeksi HPV merupakan salah satu penyakit menular seksual yang terjadi pada usia reproduktif. Tinjauan literatur ini bertujuan untuk menjelaskan peran infeksi HPV terhadap kejadian kanker penis,  perkembangan vaksin untuk mengurangi risiko terjadinya kanker penis serta imunoterapi untuk meningkatkan angka kesembuhan dan menurunkan angka kematian akibat kanker penis. Artikel didapatkan melalui penelusuran secara online menggunakan Pubmed, Sage Journals, dan Google Cendekia menggunakan kata kunci human papillomavirus, penile cancer, kanker penis, vaccine, atau targeted therapies. Hasil penelusuran offline melalui hasil penelitian yang tidak dipublikasikan dan buku referensi. Hasil pencarian online mendapatkan 9110 artikel yang terkait dengan kata kunci, namun hanya 31 artikel yang ditelaah. Hasil telaah mejelaskan bahwa patogenesis infeksi HPV pada proses onkogenesis kanker penis melibatkan berbagai jalur molekuler dan sistem imun di sekitar tumor yang dapat digunakan sebagai dasar dalam pengembangan upaya pencegahan dan terapi baru. Salah satu cara pencegahan kanker penis adalah dengan pemberian vaksin HPV menggunakan teknologi Virus-Like Particles (VLP) yang dapat mencegah kejadian lesi genital. Kaitan antara HPV dan sistem imun dikembangkan sebagai terapi target yang baru. Beberapa penelitian mengenai terapi target pada kanker yang berkembang saat ini menunjukan bahwa pemberian immune checkpoint inhibitors dapat meningkatkan sistem imun dalam proses eliminasi sel kanker. Terapi target tersebut dapat meningkatkan angka kesembuhan dari penderita dan mengurangi efek samping dari terapi yang ada saat ini. 
HISTOPATHOLOGICAL EXAMINATIONS PROFILE OF BLADDER DISEASES IN DR. SOETOMO GENERAL ACADEMIC HOSPITAL FROM JANUARY 2015 TO DECEMBER 2019 Krismaningrum, Veronika Intan; Rahaju, Anny Setijo; Herawati, Lilik; Soetojo
Indonesian Journal of Urology Vol 29 No 1 (2022)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v29i1.761

Abstract

Objective: This study aimed to analyze the profile of bladder disease in Soetomo General Hospital based on histopathological examination. Material & Methods: This study was using secondary data. Histopathological examination data of patients with bladder disease were evaluated based on age, gender, and histopathological types. Results: There were 419 patients with bladder abnormalities. Non-neoplasm bladder diseases were found in 62 patients consisted of 56 patients (90.32%) with cystitis and 6 patients (9.67%) with glandular cystitis. Neoplastic bladder diseases were found in 357 patients and were divided into benign and malignant neoplasm. Benign neoplasms were found in 11 patients consisted of 5 patients (45.45%) with UP and 6 patients (54.54%) with IUP. Malignant neoplasms were found in 340 patients consisted of 300 patients (88.23%) with urothelial carcinoma, 26 patients (7.64%) with adenocarcinoma, 14 patients (4.12%) with SCC. Moreover, six male patients with PUNLMP were also reported. Conclusion: Histopathological examination in patients with bladder abnormalities shows that neoplastic bladder diseases (357/419, 85.20%) were more common than non-neoplastic bladder disease (62/419, 14.80%).