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All Journal Jurnal Surya Medika Logista: Jurnal Ilmiah Pengabdian Kepada Masyarakat Reswara: Jurnal Pengabdian Kepada Masyarakat Indonesia Berdaya Borneo Journal Of Pharmascientech Jurnal Farmasi dan Sains Indonesia (JFSI) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Farmasis: Jurnal Sains Farmasi Dinamika Kesehatan: Jurnal Kebidanan dan Keperawatan Journal of Pharmaceutical Care and Sciences Jurnal Rumpun Ilmu Kesehatan Sains Medisina Majalah Cendekia Mengabdi

Noval Noval

Universitas Sari Mulia

Author-ID : 2598627

Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Efek Ekstrak Etanol Akar Pasak Bumi (Eurycoma Longifolia, Jack) terhadap Ekspresi HRAS pada Organ Hati Tikus Galur Sprague Dawley pada Pemberian Doxorubicin Noval Noval; Raihana Raihana
Jurnal Surya Medika (JSM) Vol 5 No 1 (2019): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Doxorubicin chemotherapy agents cause serious side effects in normal cells, especially in the liver and heart caused by free radicals. RAS is an important component of the signal transduction pathway that controls cell proliferation, differentiation and survival. The pasak bumi root (Eurycoma longifolia, Jack) has been reported to have acted as an antioxidant and hepatoprotector. This study aims to determine the effect of giving ethanol extract of pasak bumi root on HRAS expression in healthy mice given doxorubicin. This research was conducted by dividing the test animals into 7 groups, namely doxorubicin control group 4.67 mg / kgBB, group II control ethanol extract of pasak bumi roots 200 mg / kgBB, group III, IV and V were the treatment groups given doxorubicin 4.67 mg / kgBW with ethanol extract of the pasak bumi root, each 50 mg / kgBB; 100 mg / kgBB; 200 mg / kgBW, group VI solvent control and group VII healthy control. The study was continued by painting using an immunohistochemical method to see the expression of HRAS in each experimental group. Data analysis was performed by calculating per cent expressions, then proceed with statistical tests using SPSS. The results of statistical tests showed that there were significant differences between the doxorubicin control group (18.56 ± 1.85) and the treatment of group 5 (10.43 ± 1.71) and there were no significant differences between the doxorubicin control group (18.56 ± 1, 85) with group 3 treatment (17.80 ± 4.23) and group 4 treatment (16.70 ± 1.97). From the results of the study concluded that the ethanol extract of pasak bumi roots at a dose of 200 mg / KgBB can reduce the expression of HRAS in the administration of doxorubicin

Phytochemical Screening and Antimicrobial Activity of Bundung Plants Extract by Dilution Method Noval Noval; Iwan Yuwindry; Dahlia Syahrina
Jurnal Surya Medika (JSM) Vol 5 No 1 (2019): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Bundung plants (Actinuscirpus Grossus) are widely spread in Borneo and used by society empirically as antimicrobials. Nevertheless, the use of Bundung plants as traditional medicine has not been equipped with convincing data, because there is no research that is related to the plants. In order to the use of the plants accountable, it is necessary to conduct research about phytochemical screening studies and tests the antimicrobial activity of ethanol extract of Bundung plants to staphylococcus aureusandEschericia Coli bacteria. Moreover, extraction does with maceration method. Secondary metabolite groups which are contained in the ethanol extract of Bundung plants were determined qualitatively using several of phytochemical reagents. The result of phytochemical screening test showed that ethanol extract of Bundung plants contains a group of secondary metabolites; namely flavonoid, tannin, saponin, phenolic, steroid and terpenoid. The method that was used to test antimicrobial activity to Staphylococcus aureusandEschericia Coli bacteria was a liquid dilution method with variations in extract concentration of 0,5%, 1%, 2%, 4% and 8% by considering at the clarity of each sample. The result of antimicrobial activity of liquid dilution to bacteria had inhibition at all concentrations and the biggest inhibitory activity was shown at concentration 8% with the clearest level and the MIC grade of the test is at a concentration of 1%. Based on the findings, it can be concluded that ethanol extract of Bundung plants has the potential of activities of an antimicrobial, especially from secondary flavonoid metabolites.

Formulasi Dan Evaluasi Sediaan Obat Kumur (Mouthwash) Dari Ekstrak Etanol Tanaman Bundung (Actinoscirpus Grossus) Sebagai Antiseptik Mulut Noval Noval; Melviani Melviani; Novia Novia; Dahlia Syahrina
Jurnal Surya Medika (JSM) Vol 6 No 1 (2020): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v6i1.1626

Research of mouthwash formulation and evaluation of bundung plants extract (Actinoscirpus grossus) as an oral antiseptic also has been tested in Streptococcus mutants bacteria by variation in the concentration of extract 2%, 2,5%, 3% and 3,5%, which aims to determine the most ideal formula in physical quality and has the highest antibacterial activity based on an inhibition zone of Streptococcus mutants bacteria in mouthwash formula. The methods used include the step of extraction of Bundung plants, preparation of mouthwash with 4 formula F1 (2%), F2 (2,5%), F3 (3%) and F4 (3,5%) followed by an evaluation that includes organoleptic, pH test, viscosity test and the test of inhibition zone bacteria. The test of inhibition zone bacteria used MHA media with diffusion method. Stability performed on weeks 1, 2, 3, 4, 5, and 6. The result showed variation in the concentration of extract bundung plants in a mouthwash formula has and effect on the diameter of the inhibition zone. But did not have a significant effect on the physical stability properties of the mouthwash formula. Mouthwash formula which has the highest antibacterial activity based on inhibition zone of Streptococcus mutants that is 3,5% contained in formula IV.

Dispersi Padat untuk Peningkatan Laju Disolusi Natrium Diklofenak dengan Variasi Konsentrasi Polivinil Pirolidon K30 Noval Noval; Rosyifa Rosyifa
Jurnal Surya Medika (JSM) Vol 6 No 2 (2021): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v6i2.2125

Diclofenac sodium is included in the class II category based on the biopharmaceutics classification system (BCS), sodium diclofenac has low solubility and high permeability. Low solubility will affect the absorption of drugs in the body because the rate of dissolution will decrease. Polyvinyl Pyrrolidone (PVP) K30 is an inert carrier that dissolves easily in water and can affect the solubility of an active drug substance. To know solid dispersion system increasing dissolution rate of sodium diclofenac by adding variations concentration of PVP K30. Solid dispersion uses a solvent method with variations concentration of PVP K30 1:3, 1:5, 1:7, and 1:9. Test physical properties of solid dispersions using a moisture test and compressibility. Solid dispersion dissolution test using type 2 dissolutions test and determination of concentration using UV-VIS spectrophotometry. Test results were analyzed using One Way ANOVA and continued test. Solid dispersion has a good physical whit moisture percentage not >5% and compressibility not >20%. Solid dispersion of sodium diclofenac with the addition of PVP K30 can increase dissolution rate compared to pure sodium diclofenac (p<0,05) with the highest ratio 1:7. Each comparison has a significant difference (p<0,05) except in ratio 1:9. Solid dispersion of sodium diclofenac with PVP K30 can increase the dissolution rate of pure sodium diclofenac.

Formulasi Buah Tampoi (Baccaurea macrocarpa) dalam Sediaan Masker Gel sebagai Antiaging Ika Avrilina Haryono; Noval Noval; Bayu Nugraha
Jurnal Surya Medika (JSM) Vol 6 No 2 (2021): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v6i2.2126

Antioxidants are able to suppress free radicals, reducing the occurrence of oxidation reactions, and are also effective in preventing skin damage due to the aging process. The use of tampoi fruit extract as a gel mask preparation could have a purpose as an antioxidant to treat skin problems. The method is an experimental laboratory by making a gel mask preparation from tampoi fruit. The making of a gel mask begins with mixing the base mask consisting of PVA (Polyvinyl Alcohol), Propylene Glycol, Carbomer 940 then added with tampoi fruit extract. The tampoi fruit gel mask formulation in this study was made based on variations in PVA of FI (3%), FII (6%), FIII (12%), and FIV (18%) which aims to determine its effect and the most optimal formula. The steps taken include the extraction of tampoi fruit, making gel masks with 4 formulas F1 (3%), F2 (6%), F3 (12%), and F4 (18%) followed by evaluation of formulas which include organoleptic tests, pH test, viscosity test, spreadability test, and adhesion test. Physical stability testing was carried out for 4 weeks. Furthermore, the data were analyzed by using the ANOVA statistical test. The results showed that there was a significant effect on the evaluation of the viscosity test and the adhesion test for each formula. Meanwhile, the pH test and spreadability test did not have a significant effect on each formula. The optimal formula is in F1 with a PVA concentration of 3%.

Evaluasi Pengaruh Konsentrasi Pati Biji Cempedak (Artocarpus champeden) sebagai Bahan Pengisi pada Formulasi Tablet Paracetamol Noval Noval; Rizka Appriliani; Husda Oktaviannoor
Jurnal Surya Medika (JSM) Vol 6 No 2 (2021): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v6i2.2127

Cempedak plants are widely distributed in Indonesia, one of which is Kalimantan. Cempedak is a tropical plant, so its potential can be used as an additive in the manufacture of pharmaceutical preparations. Previous studies used cempedak seed starch as a binding agent in tablet formulations. This study aims to determine the effect of variations in concentration and optimum concentration of Cempedak seed starch (Artocarpus champeden) as a filler for Paracetamol tablets. The study used a True Experimental Design design with a posttest-only control group design. Making tablets using the wet granulation method. Data analysis used the one-way ANOVA test followed by the LSD test and the Kruskal-Wallis H test which continued with the Mann Whitney Test as a derivative test of the one-way ANOVA. Granule evaluation includes organoleptic, flow properties, tapping test, and stationary angle test. The results of the evaluation of the granules produced granules produced from each formulation are in accordance with the requirements. Tablet evaluation included organoleptic, uniformity in weight, the hardness of tablet, friability, and disintegration time. The results of the tablet evaluation showed that the maximum concentration of cempedak seeds was found in F1 because it showed the evaluation results that were in accordance with the requirements. In evaluating the uniformity of weight and hardness of tablets with the Kruskal Wallis H test and the Mann Whitney test, the results show that there are differences in each formula with a P-value <0.05. The results of the evaluation of tablet friability and disintegration time with one-way ANOVA test and LSD test showed differences in each formula with a P-value <0.05. Cempedak seed starch (Artocarpus champeden) can be used as a filler in the loading of Paracetamol tablets by the wet granulation method.

Formulasi dan Evaluasi Floating System Tablet Difenhidramin HCl Menggunakan Kombinasi Matriks HPMC K4M dan Na. CMC Khusnul Berty Indartantri; Noval Noval; Husda Oktaviannoor
Jurnal Surya Medika (JSM) Vol 7 No 1 (2021): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v7i1.2634

A floating system tablet was made using HPMC K4M and Na matrices. CMC with the active substance diphenhydramine HCl, which absorption in the stomach. The research aims to determine the effect of a combination of HPMC K4M and Na. CMC matrices are optimal in a floating system formulation. This research used an experimental method with a RAL design. Tablets were made by direct compression and were evaluated. The results were then analyzed statistically using One Way ANOVA. The loss results on the drying test, the tapped density test, and the measurement of the angle of repose of all formulations met the requirements. The powder flow rates of all formulations did not meet the requirements. The resulting tablet is white, bitter, round, and smells of medicine. Tablets in all formulations have uniform weight according to requirements. The hardness test results showed that only formulation 3 met the requirements, while all formulations did not meet the requirements in the friability test. In the lag time test, the results obtained in formulation 1 and formulation 2, formulation 3, and formulation 4 are 4 seconds, 4 seconds, 3 seconds, and 1 second. In contrast, the floating time results show that all formulations can float for 24 hours. All evaluation results indicate that the optimal formulation in formulation 3.

Uji Aktivitas Antioksidan Kombinasi Infusa Daun Sirih (Piper betle L), Ekstrak Etanolik Tanaman Bundung (Actinuscirpus grossus) dan Kulit Jeruk Nipis (Citrus aurantifolia) Kunti Nastiti; Noval Noval; Darini Kurniawati
Jurnal Surya Medika (JSM) Vol 7 No 1 (2021): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v7i1.2647

Piper betle L., the leaf, is the most often used for treatment and has been scientifically proven to have antibacterial activity. Actinuscirpus grossus plants are commonly found in Kalimantan and have antimicrobial properties. Citrus aurantifolia peel has antioxidant effects and nutritious chemical compounds in medicine. The purpose of this study was to determine the effect of antioxidant activity in a combination of Piper betle L., leaf infusion, ethanolic extract of Actinuscirpus grossus plant, and Citrus aurantifolia peel. The research method was experimental by making Piper betle L. leaves infused with water solvent. Simplisia powder of Actinuscirpus grossus plants and Citrus aurantifolia peel extracted by maceration with 95% ethanol solvent. The combination of the three plants was then tested for antioxidants by the DPPH method. Quercetin is used as a positive control. The results showed that the combination of the three plants had moderate antioxidant activity (IC50 128 ppm), but the antioxidant activity was smaller than quercetin (IC50 16.88 ppm). The combination of Piper betle L., leaf infusion, ethanolic extract of Actinuscirpus grossus plant, and Citrus aurantifolia peel has a moderate antioxidant category.

Formulasi Sediaan Tablet Effervescent dari Ekstrak Etanol Tanaman Bundung (Actionoscirpus grossus) sebagai Antioksidan Noval Noval; Ilham Kuncahyo; Adam Ferdian Sigit Pratama; Syafira Nabillah; Roosma Hatmayana
Jurnal Surya Medika (JSM) Vol 7 No 1 (2021): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v7i1.2649

Bundung (Actinoscirpus grossus) is a plant that contains an antioxidant compound proven in previous studies, which has a moderate antioxidant or IC50 by 128 ppm. Antioxidant compounds can reduce the negative impact of oxidants, including metal binding enzymes and proteins. Antioxidant compounds act by donating one electron to the oxidant compound to inhibit oxidants activity. The purpose of this study was to formulate the Bundung plant extract into effervescent tablets, obtain effervescent samples that are physically stable, and can be used as antioxidants to inhibit free radicals in the body. The research method was experimental by using scoring parameters to determine the most optimal formulation. Physical evaluation includes organoleptic, weight uniformity, friability, hardness, and dissolving time. The results showed that the optimum formula was the formula I with a concentration of 68 mg of citric acid and sodium bicarbonate. Tablet effervescent is a brown color and characteristic odor of Bundung plant extract. Effervescent tablets have an weight uniformity (0.314 grams), friability (0.05%), hardness (7.75 ± 0.43 kg). Variations in citric acid and sodium bicarbonate concentration can affect uniformity, friability, hardness, and dissolving time. Room conditions cause this during the production process of effervescent tablets.

Optimasi Kombinasi Asam Sitrat dan Asam Tartrat sebagai Zat Pengasam pada Tablet Effervescent Ekstrak Ubi Jalar Ungu (Ipomoea batatas L) Dahlia Syahrina; Noval Noval
Jurnal Surya Medika (JSM) Vol 7 No 1 (2021): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v7i1.2651

Purple sweet potato has the content of anthocyanin compounds that are efficacious as antioxidants. To deliver these efficacious compounds, formulations of effervescent tablets are required as antioxidants with a combination of citric acid and tartrate acid to accelerate the solubility of the drug. The research aims to optimize the combination of citric acid and tartrate acid as a sourgent on effervescent tablets of purple sweet potato extract using the simplex lattice design method. The manufacture of tablets using a direct pumping method with effervescent powder evaluation includes flow rate test, silent angle, compressibility, and powder moisture. Evaluation of tablets includes organoleptic tests, uniformity of tablet weight, hardness, fragility, and soluble time of tablets—data analysis using simplex lattice design software design expert version 10. The results of effervescent powder evaluation include a test of flow rate, quiet angle, compressibility, and moisture of powder in each formula that already meets the requirements. The physical evaluation results on the effervescent tablet weight uniformity test on F3, F4, and F5 have met the requirements. The evaluation of tablet hardness F1 and F2 also meet the requirements. The results of the evaluation of fragility and time dissolve tablets have met the requirements of all formulas. The simplex lattice design analysis results obtained F5 as the most optimal formula with a concentration of citric acid 103.25 mg and tartrate acid 44.25 mg. The combination of citric acid and tartaric acid affects the evaluation of hardness, fragility, and time-soluble effervescent tablets of purple sweet potato extract. The optimal concentration based on simplex lattice design analysis was obtained in F5 with a citric acid concentration of 103.25 mg and tartrate acid of 44.25 mg.

Co-Authors Adam Ferdian Sigit Pratama Ahmad Faisal Ainun Yuniarti Ali Rakhman Hakim Amalia Safitri Bayu Nugraha Dahlia Syahrina Darini Kurniawati Darini Kurniawati Dede Mahdiyah Deni Setiawan Desilestia Dwi Salmarini Dyan Fitri Nugraha Dyan Fitri Nugraha Faisal Rahman Giovanni Ulima Nibras Giovanni Gunawan Gunawan Haryono, Ika Avrilina Husda Oktaviannoor Ika Friscila Ilham Kuncahyo, Ilham Istiqamah Istiqamah Iwan Yuwindry Jesika Claudia Khaliza Natasya Dilla Khusnul Berty Indartantri Kunti Nastiti Kunti Nastiti Liling tryasmono M. al Gifari Mahmudah Mahmudah Martinah Martinah Mayna Mayna Melviani Mia Audina Nadya Novianty Ni Ketut Linda Puspa Yani Novia Novia Nur Azizah Nur Hidayah Nurul Auliyani Onny Ziasti Fricillia Puteri Wulan Ramadhan Putri Vidiasari Darsono Rahmadani Rahmadani Raihana Raihana Raihanah Raihanah Rizka Appriliani Rizki Adhie Ramadhani Rohama Rohama Roosma Hatmayana Rosyifa Rosyifa Safti Aryzki Samsul Hadi Sept Enno Putri Setia Budi Sita Fitriah Siti Malahayati Siti Malahayati Syafira Nabillah Syafira Nabillah Tumanggor, Agustina Hotma Uli Tuti Alawiyah Wijaya, Eka Setya Yuditha Mutia Windy Yulia Puteri Rahmida Yusri Yusri

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