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All Journal Jurnal Farmasi Udayana Jurnal Matematika & Sains Journal of Mathematical and Fundamental Sciences Jurnal Penelitian Sains PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Molekul: Jurnal Ilmiah Kimia
Euis Holisotan Hakim
Departemen Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam, Institut Teknologi Bandung,
Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics

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Journal : Journal of Mathematical and Fundamental Sciences

 1 
Bergenin, Suatu Dihidroisokumarin dari Kayu dan Kulit Batang Shorea Stenoptera Burck§ Euis Holisotan Hakim; Rudiyansyah Rudiyansyah; Iqbal Musthapa; Koichi Takeya
Journal of Mathematical and Fundamental Sciences Vol. 35 No. 2 (2003)
Publisher : Institute for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/itbj.sci.2003.35.2.1

Abstract

Bergenin, a dihydroisocoumarin derivative of glucopyranosyl gallic acid had been isolated for the first time from ethyl acetate extracts of the heartwood and tree bark, together with (-)-α-viniferin from the tree bark of Shorea stenoptera. The structure of bergenin was elucidated based on analysis of spectroscopic data UV, IR, MS, 1H and 13C NMR. Bergenin showed weak cytotoxic activity against murine leukemia P-388 cells (IC50 >100 μg/mL), and also weak toxicity against Artemia salina shrimps (LC50 >500 μg/mL).
Artelastokromen Suatu Diprenilpiranoflavon dan B-Resorsilaldehid dari Kayu Batang Artocarpus Lanceifolius Didin Mujahidin; Sjamsul Arifin Achmad; Yana Maolana Syah; Euis Holisotan Hakim; Lukman Makmur; Norio Aimi; Mariko Kitajima; Hiromitsu Takayama; Rusjdi Tamin
Journal of Mathematical and Fundamental Sciences Vol. 32 No. 2 (2000)
Publisher : Institute for Research and Community Services (LPPM) ITB

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Abstract

Abstrak. Dua senyawa, yaitu artelactokromen (1), suatu diprenil piranoflavon, dan B-resorsilaldehid (2) telah ditemukan untuk pertama kalinya pada kayu batang tumbuhan Artocarpus lanceifolius Roxb. (Moraceae), suatu tumbuhan langka yang endemic untuk Indonesia dan dikenal dengan nama Keledang. Struktur molekul kedua senyawa tersebut telah ditetapkan berdasarkan data fisika dan spektroskopi (MS, 1H dan 13C NMR). Baik artelastokromen (1) maupun B-resorsilaldehid (2) tidak terlalu toksik terhadap nauplii udang Artemia salina Leach., masing-masing dengan LC50 298,2 dan 79,7 ug/mL. Artelastochromene a Diprenylphyranoflavone and Î’-Resorcylaldehyde from the Wood Trunk of Artocarpus LanceifoliusAbstract. Two phenolic constituent, namely artelastochromene (1), a diprenyl pyranoflavone, and β-resorcylaldehyde (2) had been isolated from the wood trunk of Artocarpus lanceifolius Roxb. (Moraceae), an endemic species of Indonesia, locally known as Keledang. The structures of both compounds were elucidated based on physical and spectroscopic data (MS, 1H and 13C NMR). Both artelastochromene (1) and β-resorcylaldehyde (2) showed very slight toxic effect against shrimp nauplii Artemia salina Leach., LC50 298,2 and 79,7 μg/mL, respectively.
Suatu Senyawa Stilbene Terprenilasi dari Kayu Akar Tumbuhan Artocarpus Altilis Euis Holisotan Hakim; Valentina Adimurti; Lukman Makmur; Sjamsul Arifin Achmad; Didin Mujahidin; Yana Maolana Syah; Norio Aimi; Mariko Kitajima; Hiromitsu Takayama
Journal of Mathematical and Fundamental Sciences Vol. 33 No. 3 (2001)
Publisher : Institute for Research and Community Services (LPPM) ITB

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Abstract

Suatu stilben terprenilasi, trans-4-(3-metil-E-but-l-enil)-3,5,2',4'-tetrahidroksistilben telah ditemukan untuk pertama kalinya dari ekstrak kloroform kayu akar tumbuhan Artocarpus altilis (Moraceae), yang dikenal dengan nama Sukun. Struktur molekul senyawa ini telah ditetapkan berdasarkan data fisika dan spektroskopi UV, IR, MS, 1H dan 13C NMR. Senyawa ini bersifat toksik (LC50 = 45,7 µg/mL) terhadap benur udang Artemia salina Leach. A prenylated stilbene from the root trunk of Artocarpus altilisA prenylated stilbene, trans-4-(3-methyl-E-but-l-enyl)-3,5,2',4'-tetrahydroxystilbene had been isolated for the first time from the chloroform extract of the root trunk of Artocarpus altilis (Moraceae), locally known as Sukun. The structure of this compound was Elucidated based on physical and spectroscopic data UV, IR, MS, 1H and 13C NMR. It showed strong toxicity (LC50 = 45,7 µg/mL) agains Atrtemia salina Leach shrimp.*Bagian ke-25 dari seri "llmu Kimia Tumbuhan Moraceae lndonesia". Untuk Bagian ke-24 lihat pustaka (5)
Artonol B and Sikloartobilosanton dari Artocarpus teysmanii MIQ Lukman Makmur; Syamsurizal Syamsurizal; Tukiran Tukiran; Yoharmus Syamsu; Sjamsul Arifin Achmad; Euis Holisotan Hakim; Didin Mujahidin; Norio Aimi; Mariko Kitajima; Hiromitsu Takayama
Journal of Mathematical and Fundamental Sciences Vol. 31 No. 2 (1999)
Publisher : Institute for Research and Community Services (LPPM) ITB

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Abstract

Dua senyawa masing-masing turunan santon lakton, yaitu artonol B (1) dan turunan furanodihidrobenzosanton, yakni Sikloartobilosanton (2), telah ditemukan pada tumbuhan Artocarpus teysmanii Miq. (Moraceae), suatu tumbuhan langka yang endemik untuk Indonesia dan dikenal dengan nama Tipulu. Struktur molekul kedua senyawa tersebut telah ditetapkan berdasarkan data fisika dan spektroskopi (MS, 1H dan 13C NMR). Artonol B (1) dan sikloartobilosanton (2) memperlihatkan toksisitas yang tinggi terhadap udang Artemia salina, dan senyawa 2 juga memperlihatkan aktivitas antimitotik yang rendah terhadap target cdc2 kinase dan cdc25 fosfatase. Artonol B and Cycloartobiloxanthone from Artocarpus teysmanii MIQTwo compounds, a xanthone lactone derivative, namely artonol B (1) and a furanodihydrobenzoxanthone derivative, namely cycloartobiloxanthone (2) had been isolated from Artocarpus teysmanii Miq. (Moraceae), locally known as Tipulu. The structures of both compounds were elucidated based on physical and spectroscopic data (MS, 1H and 13C NMR). Both artonol B (1) and cycloartobiloxanthone (2) showed strong toxicity against Artemia salina in the shrimp bioassay, and compound 2 also showed weak antimitotic activity against cdc2 kinase and cdc25 phosphatase as the targets. Bagian ke-8 dari seri Ilmu Kimia Tumbuhan Moraceae Indonesia, untuk bagian ke-6 lihat pustaka [10].
Senyawa Turunan Piranoflavon dan Furanodihidrobenzoxanton dari Artocarpus Ianceifolius Euis Holisotan Hakim; Asnizar Asnizar; Fera Kurniadewi; Tedi Abdul Ghofar; Sjamsul Arifin Achmad; Lukman Makmur; Didin Mujahidin; Norio Aimi; Mariko Kitajima; Hiromitsu Takayama; Rusjdi Tamin
Journal of Mathematical and Fundamental Sciences Vol. 31 No. 2 (1999)
Publisher : Institute for Research and Community Services (LPPM) ITB

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Abstract

Sari. Dua senyawa turunan piranoflavon dan furanodihidrobenzosanton, masing-masing artelastin (1) dan sikloartobiloksanton (2), telah ditemukan masing-masing pada kayu dan kulit batang tumbuhan Artocarpus lanceifolius Roxb. (Moraceae), suatu tumbuhan langka yang endemik untuk Indonesia dan dikenal dengan nama Keledang. Struktur molekul kedua senyawa tersebut telah ditetapkan berdasarkan data fisika dan spektroskopi (MS, 1H dan 13C NMR). Artelastin (1) sangat menghambat transportasi asam amino leusin melalui membran usus ulat sutera Bontbyx mori, sedangkan sikloartobilosanton (2) menunjukkan toksisitas yang tinggi terhadap udang Artemia salina. Pyranoflavone and Furanodihydrobenzoxanthone Derivatives from Artocarpus IanceifoliusAbstract. Two pyranoflavone and furanodihydrobenzoxanthone derivatives, namely artelastin (1) and cycloartobiloxanthone (2), had been isolated respectivelfy from the wood and the tree bark of Artocarpus lanceifolius Roxb. (Moraceae), an endemic species of lndonesia, locally known as Keledang. The structures of both compounds were elucidated based on physical and spectroscopic data (MS, 1H and 13C NMR). Artelastin (1) strongly inhibited leucin amino acid transport in Bombyx mori midgut, while cycloartobiloxanthone (2) showed high toxicity against Artemia salina shrimp. Bagian ke-6 dari seri Ilmu Kimia Tumbuhan Moraceae Indonesia, untuk bagian ke-5 lihat Pustaka (8)
Three Flavan-3-ols from Artocarpus reticulates Sjamsul Arifin Achmad; Murniana Murniana; Silvester Sigit Udjiana; Euis Holisotan Hakim; Lukman Makmur; Norio Aimi
Journal of Mathematical and Fundamental Sciences Vol. 30 No. 2 (1998)
Publisher : Institute for Research and Community Services (LPPM) ITB

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Abstract

Tiga senyawa turunan flavan-3-ol, yakni afzelekin-3-O-a-L-ramnosida (1), katekin (2), dan afzelekin (3), telah ditemukan pada kulit batang dan kulit akar tumbuhan Artocarpus reticulatus Miq. (Moraceae), suatu tumbuhan langka yang berasal dari Sulawesi dan endemik untuk Indonesia, serta dikenal dengan nama daerah maumbi. Struktur molekul ketiga senyawa tersebut telah ditetapkan berdasarkan data fisika dan spektroskopi. Three Flavan-3-ols from Artocarpus reticulatesThree flavan-3-ol derivatives, namely afzelechin-3-O-α-L-rhamnoside (1), catechin (2) and afzelechin (3), were isolated from the tree and the root barks of Artocarpus reticulaltus Miq. (Moraceae), a rare species found in Sulawesi and endemic to lndonesia, locally known as maumbi. The structures of all these compounds were elucidated based on physical and spectroscopic data.
Artocarpin ad Heteroflavanone-A, Two Bioactive Flavonoids from Artocarpus champeden Euis Holisotan Hakim; Emilia Evi Marlina; Didin Mujahidin; Sjamsul Arifin Achmad; Lukman Makmur; Emilio L. Ghisalberti
Journal of Mathematical and Fundamental Sciences Vol. 30 No. 1 (1998)
Publisher : Institute for Research and Community Services (LPPM) ITB

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Abstract

Suatu senyawa flavon terisoprenilasi, yaitu 3-(y,y-dimetilalil)-6-(3-metil-1-butenil)-7-metoksi-5,2, 4-trihidroksiflavon atau artokarpin (1), bersama-sama dengan suatu senyawa flavanone langka, yakni 5-hidroksi-7,2,4,6-tetrametoksiflavanon atau heteroflavanon-A (2); telah ditemukan masing-masing pada kayu dan kulit batang tumbuhan Artocarpus champeden Spreng (Moraceae), suatu tumbuhan pangan yang endemik untuk Indonesia dan dikenal dengan nama cempedak. Struktur molekul kedua senyawa tersebut telah ditetapkan berdasarkan data fisika dan spektroskopi. Kedua senyawa flavonoid ini menghambat transportasi asam amino leusin melalui membran usus ulat sutera Bombyx mori, sedangkan artokarpin (1) juga menunjukkan toksisitas yang tinggi terhadap udang Artemia salina. Artocarpin ad Heteroflavanone-A, Two Bioactive Flavonoids from Artocarpus champedenAn isoprenylated flavone, 3-(γ,γ-dimethylallyl)-6-(3-methyl-1-butenyl)-7-methoxy-5,2',4'-trihydroxyflavone or artocarpin (1), together with rare flavanone derivative, 5-hydroxy-7,2',4',6'-tetramethoxyflavanone or heteroflavanone-A (2) were isolated from the wood and the tree bark of Arocarpus champeden Spreng (Moraceae), an endemic plant of Indonesia, locally known as cempedak. The structures of both compounds were elucidated based on physical and spectroscopic data. Both flavonoids inhibited the amino acid transport in Bombyx mori midgut, while artocarpin (1) also showed high toxicity against Artemia solina shrimp.
Ilmu Kimia Tanaman Lauraceae Indonesia: VI. Kriptokaryon dari Cryptocarya Laevigata BL. (Lauraceae) Sjamsul Arifin Achmad; Effendi Effendi; Emilio L. Ghisalberti; Euis Holisotan Hakim; Lia Dewi Juliawaty; Lukman Makmur; Allan H. White
Journal of Mathematical and Fundamental Sciences Vol. 24 No. 2/3 (1991)
Publisher : Institute for Research and Community Services (LPPM) ITB

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Abstract

Ekstraksi kulit akar dan kulit barang tanaman Cryptocarya laevigata Bl. (Lauraceae) dengan n-heksan menghasilkan suatu calkon yang diidentifikasi sebagai kriptokaryon (I). Struktur senyawa ini ditetapkan berdasarkan data spektroskopi dan analisis Kristal sinar-X. Kesimpulan mengenai struktur kriptokaryon (I) mendukung saran peneliti sebelumnya, yang terlah merevisi struktur (II) yang pertama kali disarankan. C. laevigata adalah spesies kedua anggota suku Lauraceae yang telah ditemukan mengandung kriptokaryon (I). Tambahan pula, kriptokaryon (I) adalah senyawa alam kedua dari jenis flavonoid yang mengandung cincin A yang tereduksi sebagian, yang pernah ditemukan. Extraction of the root and the tree barks of Cryptocarya laevigata Bl. (Lauraceae) with n-hexane yielded a chalcone identified as cryptocaryone (I). The structure of this compound had been elucidated based on spectroscopic measurements and X-ray crystal analysis. Conclusions about the structure of cryprocaryone (I) confirm the previous suggestion, which revised the structure (ll) suggested earlier. C. laevigata is the second species of Lauraceae which contains cryptocaryone (I). Furthermore, cryptocaryone (I) is a second naturally occurring flavonoid containing a reduced A ring system which has so far been isolated.
Ilmu Kimia Tanaman Lauraceae Indonesia: V. Eritrodiol 3-Asetat dari Litsea elliptica Bl. (Lauraceae) Sjamsul Arifin Achmad; Afrizal Afrizal; Emilio L. Ghisalberti; Euis Holisotan Hakim; Lukman Makmur
Journal of Mathematical and Fundamental Sciences Vol. 24 No. 2/3 (1991)
Publisher : Institute for Research and Community Services (LPPM) ITB

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Abstract

Suatu triterpen, jenis oleanan, yang diperoleh dari kulit akar tanaman Litsea elliptica Bl. (Lauraceae) telah diidentifikasi sebagai olean-12-en-3,28-diol-3-asetat atau eritrodiol 3-asetat (I). Telah ditemukan pula suatu ftalat dan telah diidentifikasi sebagai bis(2-etilheksil) ftalat (III). Struktur kedua senyawa ini telah ditetapkan dengan menggunakan cara spektroskopi. Isolat lain, suatu triterpen yang diberi nama litselligenin, masih terus diteliti. Baik eritrodiol 3-asetat (I) maupun bis(2-etilheksil)ftalat (III) tidak pernah ditemukan sebelumnya pada tanaman Lauraceae, sedangkan senyawa terakhir merupakan senyawa ftalat kedua yang ditemukan pada Luaraceae. An oleanane-type triterpene isolated from the root bark of Litsea elliptica Bl. (Lauraceae) has been identified as olean-12-en-3,28-diol-3-acetate or erythrodiol 3-acetate (I). A phthalate has also been isolated and identified as bis(2-ethylhexyl)phthalate (III). The structure of both compounds have been elucidated based on spectroscopic methods. Work on another isolate, a triterpenoid named litselligenin, is in progress. Neither erythrodiol 3-acetate (l) nor bis(2-ethylhexyl)phthalate (III) have been isolated previously from the Lauraceae, and the latter compound represents a second phthalate to be isolated from Lauraceae.
Ilmu Kimia Tanaman Lauraceae Indonesia: III*. Isolasi Aktinodafnin dan Boldin dari Litsea glutinosa Sjamsul Arifin Achmad; Euis Holisotan Hakim; Lukman Makmur; Helmi Rizal; Adel Zamri
Journal of Mathematical and Fundamental Sciences Vol. 23 No. 1 (1990)
Publisher : Institute for Research and Community Services (LPPM) ITB

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Abstract

Aktinodafnin (I) dan boldin (lI), dua senyawa alkaloid dari jenis benzilisokuinolin, telah dipisahkan dari kulit akar tanaman Litsea glutinosa (Lour) C.B. Robinson var. littoralis Bl., suatu varitas yang belum pernah diselidiki peneliti lain. Struktur kedua alkaloid ini telah ditetapkan dengan cara-cara spektroskopi. Penemuan ini melanjutkan penemuan kami sebelumnya tentang suatu alkaloid fenantren baru, yang dinamai itebein, dari spesies tanaman yang sama. Two benzylisoquinoline alkaloids, actinodaphnine (I) and boldine (II), have been isolated from the root bark of Litsea glutinosa (Lour) C.B. Robinson var. littoralis Bl., a variety which has not yet been investigated by other workers. The chemical structures of both alkaloids have been determined by spectroscopic methods. This is to follow-up our previous work on the isolation of a new phenanthrene alkaloid, named itebeine, from the same plant species.
Co-Authors Adel Zamri Afrizal Afrizal Allan H. White Asnizar Asnizar Didin Mujahidin Didin Mujahidin Didin Mujahidin Didin Mujahidin Didin Mujahidin Effendi Effendi Emilia Evi Marlina Emilia L Ghisalberti Emilio L Ghisalberti Emilio L. Ghisalberti Emilio L. Ghisalberti Emilio L. Ghisalberti Eri Bakhtiar Fera Kurniadewi Ferlinahayati Ferlinahayati Hanapi Usman Haryoto Haryoto Helmi Rizal Hiromitsu Takayama Hiromitsu Takayama I Nyoman Adi Winata Ikram M. Said Iqbal M. Choudhary Iqbal Musthapa Jalifah Latip Koichi Takeya Lia Dewi Juliawati Lia Dewi Juliawaty Lia Dewi Juliawaty Lia Dewi Juliawaty Lukman Makmur Lukman Makmur Lukman Makmur Lukman Makmur Lukman Makmur Lukman Makmur M I Choudhary Mariko Katajima Mariko Kitajima Mariko Kitajima Muhammad N. Jalaluddin Muhtadi Muhtadi Murniana Murniana Nizar Happyana Nordin Hj Lajis Norio Aimi Norio Aimi Norio Aimi Norio Aimi Noviany Noviany Nunuk H Soekamto Riga Riga Rudiyansyah Rudiyansyah Rusjdi Tamin Rusjdi Tamin Sahidin Sahidin Silvester Sigit Udjiana Sjamsul Arifin Achmad Sjamsul Arifin Achmad Sjamsul Arifin Achmad Sjamsul Arifin Achmad Sjamsul Arifin Achmad Sjamsul Arifin Achmad Sri Atun Suwandri Suwandri Suwandri Suwandri Syamsurizal Syamsurizal Tedi Abdul Ghofar Tjodi Harlim Tukiran Tukiran Valentina Adimurti Yana Maolana Syah Yana Maolana Syah Yana Maolana Syah Yoharmus Syamsu