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All Journal Bioscience Biota Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Pelita Eksakta Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks TROPICAL GENETICS Tropical Genetics
Elsa Badriyya
Fakultas Farmasi, Universitas Andalas
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Other

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Unique Pattern of Hypertension Fingerprints S. Syamsurizal; Sudarni; Rapidah; Elsa Badriyya; Sintia Putri
Tropical Genetics Vol. 2 No. 2 (2022):
Publisher : Genetikawan Muda Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/tg.v2i2.27

Abstract

The fingerprint pattern (dermatoglyphics) of each individual is not the same. Fingerprint patterns are often used as an identification tool in criminal cases and disease diagnosis. Fingerprint patterns for health diagnosis are usually diseases caused by genetic factors, for example hypertension. The purpose of this study was to describe the characteristics of fingertip dermatoglyphics of hypertensive patients. The research sample was 60 people consisting of 30 people with hypertension who visited the DR. M. Djamil Padang and controls 30 non-hypertension (normal) people from Biology FMIPA UNP students. Simple random sampling. The research variables are tendril patterns on the fingertips, the number of tendrils on the fingertips and the atd angle on the palms. The Chi-square test was used to analyze the tendril pattern data of hypertension patients. To compare the number of tendrils and the angle atd, a t-test was used. The results showed that the arch fingerprint pattern is a unique character in hypertensive patients.
Polymerase chain reaction (PCR) primer design to identify SNP rs7901695 transcription factor 7 like 2 (TCF7L2) Elsa Badriyya; Afifatul Achyar
Bioscience Vol 7, No 1 (2023): Biology
Publisher : UNIVERSITAS NEGERI PADANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/0202371122575-0-00

Abstract

ABSTRACT. Transcription Factor 7 Like 2 (TCF7L2) is a gene that produces a protein that controls the expression and function of several incretin hormones. One of the primary activities of incretin hormones is to increase insulin production, which is important in glucose and energy homeostasis. Single Nucleotide Polymorphism (SNP) in the TCF7L2 gene is reported to be association with Type II Diabetes Mellitus (T2DM). T2DM is featured by persistent hyperglycemia because of the decrease in insulin production, insulin resistance, or both. In patients with diabetes mellitus, chronic hyperglycemia can damage organ systems and cause metabolic abnormalities. SNP rs7901695 TCF7L2 gene has been linked to T2DM in a number of places, including South Asia, Iceland, and the United States. The polymorphism at location 112.994.329 from nucleotide Timine (T) to Cytosine (C) enables the recognition of SNP rs7901695. Polymerase Chain Reaction (PCR) was used to identify the polymorphism. The objective of this research was to generate a precise primer for the PCR recognition of the SNP rs7901695 in the TCF7L2 gene. The research's methodology comprises DNA isolation, primer designing with Geneious, target amplification with PCR, and DNA sequencing for bioinformatic analysis. As a result of the study, four primers for the SNP rs7901695 TCF7L2 gene have been developed. The reaction obtained two fragments, sized 177 and 367 bp. The primers used were rs7901695-F, rs7901695-R, rs7901695-F(C), and rs7901695-R(T), which were used to detect the T allele.  ABSTRAK. Transcription Factor 7 Like 2 (TCF7L2) adalah gen yang menghasilkan protein yang mengontrol ekspresi dan fungsi beberapa hormon inkretin. Salah satu aktivitas utama hormon inkretin adalah meningkatkan produksi insulin, yang penting dalam homeostasis glukosa dan energi. Single Nucleotide Polymorphism (SNP) pada TCF7L2 gene dilaporkan adanya hubungan dengan Diabetes Mellitus Tipe II (DMT2). DMT2 ditandai dengan hiperglikemia persisten karena penurunan produksi insulin, resistensi insulin, atau keduanya. Pada penderita diabetes melitus, hiperglikemia kronis dapat merusak sistem organ dan kelainan metabolisme. Gen SNP rs7901695 TCF7L2 dilaporkan memiliki asosiasi dengan DMT2 di sejumlah daerah, termasuk Asia Selatan, Islandia, dan Amerika Serikat. SNP rs7901695 ditandai dengan polimorfisme pada lokasi 112.994.329 dari nukleotida Timin (T) menjadi Sitosin (C). Metode yang digunakan untuk mengidentifikasi polimorfisme adalah Polymerase Chain Reaction (PCR). Penelitian ini bertujuan untuk menghasilkan primer yang tepat untuk pengenalan PCR terhadap SNP rs7901695 pada gen TCF7L2. Metodologi penelitian meliputi isolasi DNA, perancangan primer dengan aplikasi Geneious, amplifikasi target dengan PCR, dan sekuensing DNA untuk analisis bioinformatik. Sebagai hasil penelitian, empat primer untuk deteksi gen SNP rs7901695 TCF7L2 telah dikembangkan. Dua fragmen, berukuran 177 dan 367 bp, diperoleh dari reaksi tersebut. Primer yang digunakan adalah rs7901695-F, rs7901695-R, rs7901695-F(C), dan rs7901695-R(T), yang digunakan untuk mendeteksi alel T.
PPUPIK “SIPODEH” Jahe Merah Instan Peluang Bisnis Mahasiswa Departemen Biologi S. Syamsurizal; Sa`diatul Fuadiyah; Elsa Badriyya
Pelita Eksakta Vol 6 No 1 (2023): Pelita Eksakta Vol. 6 No. 1
Publisher : Fakultas MIPA Universitas Negeri Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/pelitaeksakta/vol6-iss1/201

Abstract

Ginger (Zingiber officinale) is an Indonesian spice plant which is widely used as traditional medicine. Another type of ginger that has more properties and a stronger spicy taste, namely red ginger. Red ginger is predicted to be able to inhibit the infection process of the SARS-CoV-2 virus in human host cells. Red ginger can increase the body's immunity, increase IgM levels and reduce the circulation of pro-inflammatory cytokines. The PPUPIK service team in collaboration with the HMJ Biology KWU Unit has developed the instant red ginger “Sipodeh” product well. Currently we are expanding the marketing system. Some of the good practices that have been carried out are training the PPUPIK team to understand the basic concepts of marketing, studying marketing strategies, making simple bookkeeping. The results of this product marketing training were directly applied to various national scale activities by participating in bazaars at POMNAS at UNP. At the provincial level the "SIPODEH" team played an active role in the West Sumatra Malagak event sponsored by the West Sumatra regional government together with West Sumatra HIPMI. Participating in national and provincial scale activities succeeded in introducing "Sipodeh" instant red ginger well to consumers.
Peningkatan Pengetahuan Masyarakat tentang Penggunaan Obat yang Rasional melalui Edukasi Pengenalan Obat Dian Ayu Juwita; Elsa Badriyya; Lailaturrahmi Lailaturrahmi
Warta Pengabdian Andalas Vol 30 No 3 (2023)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.30.3.423-428.2023

Abstract

One of the factors influencing the level of drug usage is the level of knowledge. Knowledge is an essential aspect in shaping concrete actions. In society, various issues related to drug usage often arise due to a lack of understanding and incorrect behaviours regarding drug usage. Educating the public about the selection and rational use of drugs is compulsary cause of that. This activity was carried out on May 7, 2023, at Jondul Housing, Padang City. The education method employed was a lecture delivered to 35 participating mothers. This method has proven effective for all segments of society, regardless of their educational background. The general public showed high enthusiasm in participating and actively engaged in interactions, asking questions, and discussing with the speaker. The conclusion drawn from this activity is that education and outreach enhanced the public knowledge about the rational use of drugs.
Design of primer Ipomoea batatas chloroplast gene matK S. Syamsurizal; Ardi Ardi; Des M; Resti Fevria; Yusni Atifah; Elsa Badriyya; Afifatul Achyar
Tropical Genetics Vol. 1 No. 1 (2021)
Publisher : Genetikawan Muda Indonesia

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Abstract

Sweet potato varieties (Ipomoea batatas) Pucuk Hitam Panyalaian and Madu Pucuk Hitam Panyalaian have the potential to be a superior commodity in West Sumatra, but the information of genetic diversity is very limited. Data on the diversity of sweet potato germplasm is beneficial in the selection of plants to obtain superior cultivars in plant breeding. Aim: The aim of the study was to find specific primers for the study of sweet potato genetic markers using Ipomoea batatas chloroplast genes matK. Methods: DNA extraction from sweet potato young leaves; designing forward and reverse primers Ipomoea batatas chloroplast genes matK; PCR; sequencing; bioinformatics analysis and species identification by comparing the NCBI database. Results: Plant DNA barcoding PCR using designed primers matK were successfully resulting single DNA band in different amplicon size in some samples. This indicating that the designed primers used were able to distinguish variation in one species.
Pedigree analysis of diabetes mellitus in Minangkabau ethnic S. Syamsurizal; Siti Halifah; Elsa Badriyya
Tropical Genetics Vol. 1 No. 2 (2021)
Publisher : Genetikawan Muda Indonesia

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Abstract

Diabetes mellitus has a tendency to be inherited. The inheritance pattern of diabetes mellitus in the Minangkabau ethnic group follows the mitochondrial and autosomal inheritance pattern. Patients with diabetes mellitus in the Minangkabau ethnicity have a equal distribution between men and women. Patients with diabetes mellitus in this ethnic group generally know that they suffer from diabetes mellitus in old age or after other complications arise due to diabetes mellitus.
Literature Study : Chromosomal Changes in The Class Mammalia Genus Neacomys, Class Actinopterygii Genus characidium, Class Reptile Family Boidae Nindya Ananda Latifa; Sintia Putri; Elsa Badriyya
Tropical Genetics Vol. 2 No. 1 (2022):
Publisher : Genetikawan Muda Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/tg.v2i1.24

Abstract

Chromosomes become an important substance for an organism because they contain information useful for cell regulation and as a hereditary agent. The character of an organism is determined by genes located on chromosomes. Changes in chromosomes will have a significant influence on the evolution of a species. One of the factors that influence changes in chromosomes is mutation. Mutation is a form of defense of an organism in the face of the changing state of nature. Neacomys diversification is caused by gene fusion events, translocations, amplications, and constitutive heterochromatin (CH). In the family Crenuchidae genus Caracidium there was a revision in the diversification of chromosomes 2n of 50 chromosomes composed of 32 metacentric + 18 sub-metacentrics. This is due to differences in the number of rDNA sites, heterochromatin blocks, number of B chromosomes and the size of sex chromosomes, as well as repeated DNA dynamics on chromosomes observed among species forming diversification and chromosomal speciation. In the boidae family reptile class there was a fusion of chromosomes which resulted in the conclusion that the kariotype configuration in snakes is currently the clade of primitive Neotropic snakes.
Review Article: SNP rs11196205 Transcription Factor 7 Like 2 (TCF7L2) as a Metabolic Disorder Genetic Marker Elsa Badriyya; Siti Fatimah Putri Hasyul
Tropical Genetics Vol. 2 No. 2 (2022):
Publisher : Genetikawan Muda Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/tg.v2i2.26

Abstract

A metabolic disorder appears when unusual chemical reactions impair the metabolism process in the body. This condition affects how the body distributes and processes macronutrients, including protein, lipids, and carbohydrates. Transcription Factor 7 Like 2 (TCF7L2) is a 217,460 bp gene, found in chromosome 10q25, and encodes the High Mobility Group (HMG) box with a role in the Wnt signaling pathway. The Wnt signaling pathway involves several processes during development, healthy homeostasis, and illness. The reactions that follow the pathway's activation regulate both proliferation and differentiation. Single Nucleotide Polymorphism (SNP) in the TCF7L2 gene has been linked to a variety of metabolic disorders incidence. SNP rs11196205 was found to have a significant association with type 1 and type 2 diabetes mellitus, gestational diabetes mellitus, glucose homeostasis, obesity-related parameters, and renal function. Mechanism SNPs causing the metabolic disorder are still unexplained, but SNPs are suspected to affect transcription and splicing processes. SNPs of TCF7L2 genes are reported to affect proinsulin conversion to insulin, decrease incretin hormone production, and decrease insulin sensitivity throughout the body. It can conclude that the screening for the SNP can be a sign of metabolic process abnormalities, especially in diabetes Mellitus.
Unique Pattern of Hypertension Fingerprints S. Syamsurizal; Sudarni; Elsa Badriyya; Sintia Putri
Tropical Genetics Vol. 2 No. 2 (2022):
Publisher : Genetikawan Muda Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/tg.v2i2.27

Abstract

The fingerprint pattern (dermatoglyphics) of each individual is not the same. Fingerprint patterns are often used as an identification tool in criminal cases and disease diagnosis. Fingerprint patterns for health diagnosis are usually diseases caused by genetic factors, for example hypertension. The purpose of this study was to describe the characteristics of fingertip dermatoglyphics of hypertension patients. The research sample was 60 people consisting of 30 people with hypertension who visited the DR. M. Djamil Padang and controls 30 non-hypertension (normal) people from Biology FMIPA UNP students. Simple random sampling. The research variables are tendril patterns on the fingertips. The Chi-square test was used to analyse the tendril pattern data of hypertension patients. The results showed that the arch fingerprint pattern is a unique character in hypertensive patients.
Co-Authors Afifatul Achyar Afifatul Achyar Ardi Ardi Atifah, Yusni Des M Dian Ayu Juwita Dwi Hilda Putri Hengki Saputra Indra Hartanto Lailaturrahmi Lailaturrahmi Lailaturrahmi Lailaturrahmi Linda Advinda Nindya Ananda Latifa Rapidah Resti Fevria Resti Fevria S. Syamsurizal S. Syamsurizal S. Syamsurizal Sa`diatul Fuadiyah Sa’diatul Fuadiyah Sintia Putri Siti Fatimah Putri Hasyul Siti Fatimah Putri Hasyul Siti Halifah Sudarni