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All Journal Jurnal Penelitian Saintek Jurnal Ilmu Dasar Jurnal Matematika & Sains WIDYATAMA Pharmacon Journal of Community Services and Engagement Journal of Nutraceuticals and Herbal Medicine Jurnal Kreativitas PKM Jurnal Ners Jurnal Layanan Masyarakat (Journal of Public Service) Jurnal Kefarmasian Indonesia Jurnal Farmasi Jurnal Farmasi dan Sains Indonesia (JFSI) Jurnal Sains dan Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Farmasi Sains dan Praktis Proceeding ISETH (International Summit on Science, Technology, and Humanity) Prosiding University Research Colloquium Jurnal Ilmiah Kesehatan Usadha Journal of Pharmacy Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian
Haryoto Haryoto
Universitas Muhammadiyah Surakarta
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Education Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : Jurnal Kefarmasian Indonesia

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Penghambatan Enzim Alpha-Glukosidase oleh Daun Mimba (Azadirachta indica) dan Rimpang Temu Mangga (Curcuma mangga) Nursalinda Kusumawati; Haryoto Haryoto; Peni Indrayudha
Jurnal Kefarmasian Indonesia VOLUME 11, NOMOR 1, FEBRUARI 2021
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v11i1.3950

Abstract

Type 2 diabetes mellitus is a chronic disease of the digestive system characterized by high blood glucose levels. The main enzyme in carbohydrate metabolism is α-glucosidase. One of the therapeutic approaches to treat T2DM is to make glucose uptake into the blood delayed through inhibition of the α-glucosidase enzyme activity. Neem leaves and mango ginger are reported to reduce blood glucose levels. This study aims to determine the potential inhibitor of neem leaves extract and mango ginger extract and their respective fractions on α-glucosidase activity. Simplicia of neem leaves and mango ginger were macerated using 96% ethanol for 24 hours. The ethanol extract of neem leaves and mango rhizome were fractionated using silica gel 60 GF254 as adsorbent and a combination of ethyl acetate and n-hexane as eluent. The extracts of neem leaves and mango rhizome and fractions of both plants were tested for α-glucosidase inhibition with acarbose as a comparison. The results showed that both plants provided inhibitory activity on α-glucosidase with the lowest IC50 value from the semi-polar fraction of neem leaves about 24.16±4.58 μg/mL. Neem leaves and mango ginger have potential as α-glucosidase inhibitors to treat type 2 diabetes mellitus.
Co-Authors A Anifatussaa'dah Ahwanti Rukdiatma Nur’aini Alfa Frista Amalia Suci Medisusyanti Amaliyah Dina Anggraeni Andi Suhendi Annisa Meyndra Komala Ardalia Rinanda Oktaviani Asfy Nurany Atikah Hapsari Broto Santoso Burhanudin Ichsan Cast Torizellia Cita Hanif Muflihah Dewi, Listiana Masyita Diah Siwi Ardiyani Dina Ayu Amalia Dwi Bagus Pambudi Dwi Sarbini Dyera Forestryana Erika Nuur Anisa Putri Erna Herawati Euis Holisotan Hakim Fahriza Mei Trihatmoko Faridita khoirun Nisa' Fidhia Nur Rifaini Firstca Aulia Rachma Frida Rosenova Gita Firdaus Hafid Nugroho Hafiz Ramadhan Haliza Arzeti Nurseptiria Haya Nabilah Utama Heng Yen Khong Henggar Prasetyo Wikan Saputro Hidayah Karuniawati Ida Maesaroh Imam Prayitno Jalifah Latip Joko Kristianto Khusnul Khotimah Kosworo Kosworo Laila Dzafira Lia Dewi Juliawaty Lina Ayu Kusumastuti Listyana Dewi Prastiwi Mariska Sri Harlianti Marlupi Dwi Lestari Marsilia Rosa Sinensis HI Muhammad Irfan Muhammad Priyadi Muhtadi Muhtadi Niati Ambarsari Nugroho Adi Suseno Nursalinda Kusumawati Nur’aini, Ahwanti Rukdiatma Peni Indrayudha Pratiwi Widowati Putri Agustina Raafika Studiviani Rahardian Surya Basusena Rizki Ainun Fitriani Rosnah Rosnah Rusdin Rauf Sayyidah Nurul Muslihah Sendy Pradila Putri Sjamsul Arifin Achmad Suranto Suranto Tanti Azizah Sujono Tia Mella Citra Tista Ayu Fortuna Tri Aprilianingtyas Vitania Marsya Widowati, Pratiwi Yana Maolana Syah Yulia Dwi Nuryanti Yuliana Dwi Jayanti Yurnanda Ambar Mustika