Article Per Year (5 Year)
p-Index From 2019 - 2024
0.444
P-Index
This Author published in this journals
All Journal Eksergi Nexus Kedokteran Komunitas Nexus Kedokteran Klinik Nexus Biomedika Nexus Kedokteran Translasional Smart Society Empowerment Journal
Sigit Setyawan
Unknown Affiliation
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Health Professions Medicine & Pharmacology Public Health Other

Published : 14 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 14 Documents
Search

 1   2 
Pengaruh Penggunaan Kontrasepsi Depo Provera terhadap Angka Kejadian Hipertensi di Puskesmas Ngoresan Surakarta Viola Belivia Tripuspita; Yulia Lanti Retno Dewi; Sigit Setyawan
Nexus Kedokteran Komunitas Vol 2, No 3 (2013): Nexus Kedokteran Komunitas
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.115 KB)

Abstract

Background: One of health problem which often suffered by Depo Provera contraception acceptor is hypertension. Ngoresan Public health Center is one of Health center in Surakarta which has many Depo Provera user as acceptor of Family Planning. Looking at mortality number because of hypertension in Indonesia is quite high and the complication which emerged as much as well, so that writer is interested to do research about contraception user of Depo Provera influence towards hypertension emergence at Ngoresan Surakarta Public Health Center. Methods: The research was used observation analytical methods with Cohort Retrospective study approach which conducted on March-April 2013. The research has done to 60 women, age 20-40. Sample was taken using fixed exposure sampling technique. The data was analyzed with Chi Square (x2) test. Results: The result shows that there was significant impact for contraception use of Depo Provera towards hypertension case number in Ngoresan Surakarta Public Health Center. Based on calculation which done with chi square test with significance level 5%, calculation using SPSS 20, obtained that p=0.009 < significant value limit p= 0.05 Conclusions: Depo Provera contraception increased hypertension case number of acceptor Family Planning between aged 20-40 year women in Ngoresan Surakarta Public Health Center. Keywords: Depo Provera contraception, hypertension
Faktor-faktor Risiko Hipertensi di Wilayah Puskesmas Andong, Kabupaten Boyolali, Jawa Tengah Anggun Pulihana Wilujeng; Apriliana Vivy Candra; Ardhia Fefrine Indarta; Aulia Farah Diba; Auliya Salsabilla; Sigit Setyawan; Ony Hardoko; Sumardjo .
Nexus Kedokteran Komunitas Vol 7, No 1 (2018): Nexus Kedokteran Komunitas
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Pendahuluan : Dilaporkan bahwa 1 dari 3 orang di dunia terdiagnosis hipertensi. Penyakit ini juga menempati posisi ke-6 pada 10 besar penyakit yang terdapat di Puskesmas Andong. Hipertensi merupakan penyakit yang disebabkan oleh kombinasi banyak faktor risiko. Hal tersebut menandakan bahwa hipertensi memiliki urgensi untuk segera diatasi, salah satunya dengan menganalisis faktor-faktor risiko yang mempengaruhi timbulnya hipertensi. Metode : Penelitian dilakukan dengan desain penelitian cross-sectional di Puskesmas Andong, Kecamatan Andong, Kabupaten Boyolali, Jawa Tengah pada bulan Maret April 2019. Data didapatkan dari pengumpulan data primer melalui wawancara dan penghitungan antropometri ke pasien poli umum dan rawat inap serta pengumpulan data sekunder dari data pasien yang mengikuti PROLANIS Puskesmas Andong. Hubungan antar variabel dianalisis dengan menggunakan Chi-Square. Regresi logistik dilakukan untuk menganalisis faktor resiko dari hipertensi. Hasil : Ditemukan bahwa terdapat hubungan antara faktor usia, IMT, aktivitas fisik, tingkat edukasi tentang hipertensi, dan penyakit penyerta Diabetes Mellitus (DM). Hanya usia dan IMT yang berpengaruh parsial secara signifikan sebagai faktor risko kejadian hipertensi di Puskesmas Andong. Kesimpulan : Hal ini menunjukkan bahwa perlu adanya perhatian lebih pada penjagaan berat badan secara dan pengukuran tekanan darah secara teratur untuk mencegah peningkatan risiko hipertensi.Kata Kunci : Hypertension, Risk Factor, BMI, Age, Andong
Pengaruh Penggunaan Kontrasepsi Depo Provera terhadap Timbulnya Melasma di Puskesmas Ngoresan Surakarta Firstiafina Tiffany; Yulia Lanti Retno Dewi; Sigit Setyawan
Nexus Kedokteran Komunitas Vol 2, No 3 (2013): Nexus Kedokteran Komunitas
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: One side effect of Depo Provera Contraceptive usage is the emergence of melasma on the face. Research about the influence of Depo Provera contraceptive usage on the incidence of melasma has never existed in Ngoresan Public Health Center Surakarta. Therefore, the authors are interested to know whether a speckling of hyperpigmentation / melasma on the face can be caused due to the usage of contraceptive Depo Provera. Methods: This study used analytic observational with a retrospective cohort study approach. This study was conducted in March-April of 2013. Subjects in this study were women aged 20-40 years in Ngoresan Public Health Center Surakarta. The sampling technique used was fixed exposure sampling to the sample size of 60 people. Data collection used questionnaires and direct observations. Then, data were analyzed using the chi square test at 95% confidence level (p > 0.05). Results: Based on the calculation, obtained p value = 0.010 < limit value of significance p = 0.05 level. So H0 is rejected and H1 is accepted. Means there is a significant effect on the Depo Provera contraceptive usage on the incidence of melasma on the face at the Ngoresan Public Health Center Surakarta. Conclusions: From the research it can be concluded that the obtained statistically significant results on the effect of Depo Provera contraceptive usage on the incidence of melasma on the face at the Public Health Center Ngoresan Surakarta. The longer the usage of contraceptive Depo Provera more likely arise melasma. Keywords: Depo Provera Contraception, Melasma
Hubungan Andropause dengan Penyakit Jantung Koroner di RSUD Dr. Moewardi Surakarta Hanne Dianta Pramono; Endang Syahrir; Sigit Setyawan
Nexus Kedokteran Klinik Vol 3, No 2 (2014): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.046 KB)

Abstract

Background : Andropause is a syndrome of aging that can be interpreted by the cessation of physiological processes in men. It is estimated there are at least 25 million men in America between 40 and 55 years have some degree of andropause. The loss of testosterone can occur in men age 35 years , gradually , with testosterone levels decreased only 1 % to 1.5 % per year. Coronary heart disease is a pathological condition of the coronary arteries ( atherosclerosis ) that causes changes in the structure and function of arteries and decrease blood flow to the heart. Coronary heart disease is a major health problem in developed countries . While the cause of death remains ranked No. 3. Study aimed to analyze the correlation between andropause with coronary heart disease in Dr . Moewardi hospitals Surakarta. Methods : This study was an observational analytic cross sectional approach . Subjects were patients with coronary heart disease and who do not suffer from coronary heart disease who present in Cardiac clinic Dr . Moewardi hospital Surakarta . A total of 104 subjects were selected using purposive sampling method . Data were collected by direct interviews and questionnaires . Data were analyzed by multiple logistic regression analysis and processed with the Statistical Product and Service Solutions ( SPSS ) 16.0 for Windows . Results : Patients with coronary heart disease have a risk of andropause with moderate levels of correlation of 0.32 with the use of contingency correlation test. Conclusions : There is a significant association between andropause with coronary heart disease in elderly men in Surakarta Moewardi Hospital with moderate levels of correlation. Keywords : Andropause , Coronary Heart Disease
In Vitro Antihelmintic Effect of Mahagoni (Swietenia mahagoni Jacq) Seeds Etanol ExtractAgainst Ascaris suum Goeze Yusuf Arif Salam; Yulia Sari; Sigit Setyawan
Nexus Biomedika Vol 6, No 2 (2017): Nexus Biomedika
Publisher : Nexus Biomedika

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (13.864 KB)

Abstract

Introduction: Mahagoni seeds contain flavonoid, saponin, and tannin that that have been known having anthelmintic effect. This study aimed to determine the antihelmintic effect of mahagoni (Swietenia mahagoni Jacq) seeds etanol extract against Ascaris suum Goeze in vitro. Methods:The study was a laboratory experimental research using post test only controlled group design. The subject were adult Ascaris suum Goeze worms. The sampling technique used was quota sampling. This research was using mahagoni (Swietenia mahagoni Jazq) seeds etanol extractwith concentration 30% w/v, 50% w/v, 70% w/v, 90% w/v, NaCl 0.9% (negative control), and albendazol 0.5% (positive control).Data were analyzed with Pearson correlation test to determine correlation between concentration of mahagoni (Swietenia mahagoni Jacq) seeds etanol extract and amount of worms death. Probit analysis has been done to find LC50. Results: Pearson correlation test showed significant result p=0.00 and strong correlation r = 0.87. Probit analysis results showed LC50mahagoni (Swietenia mahagoni Jacq) seeds etanol extract was 40.66% w/v. It means that 40,66% concentration of mahagoni (Swietenia mahagoni Jacq) seeds etanol extract can cause the death of half sample. Conclusions:Mahagoni(Swietenia mahagoni Jacq) seeds etanol extract had effects to the mortality of Ascaris suum Goeze in vitro with strong correlation between additional amount of extract concentration and amount of worms with LC50value= 40,66% w/v. Keywords :Antihelminthic, Swietenia mahagoni Jacq, alkaloid, Ascaris suum Goeze
Antifungal Test of Caricature Plant (Graptophyllum pictum [L.] Griff.) Ethanol Extract to The Growth of Candida albicans In Vitro Victoria Husadani Permata Sari; Sri Haryati; Sigit Setyawan
Nexus Biomedika Vol 6, No 1 (2017): Nexus Biomedika
Publisher : Nexus Biomedika

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (13.864 KB)

Abstract

Introduction: Much of data states that there has been resistance to candidiasis therapy drugs. It is necessary to consider candidiasis therapy using alternative medicines. Caricature plant (Graptophyllum pictum [L.] Griff.) investigated because it suspected contains compounds that have the potential against the growth of Candida albicans, such as alkaloid, saponin, tannin and flavonoid. The purpose of this research is to determine the antifungal effect of caricature plant (Graptophyllum pictum [L.] Griff.) ethanol extract to the growth of Candida albicans in vitro. Methods: This type of research is an laboratory experimental, post test only with control group design. Research conducted at the Laboratory of Parasitology, Faculty of Medicine Sebelas Maret University. The subject of this research is Candida albicans cultured. The measured variable is the caricature plant (Graptophyllum pictum [L.] Griff.) ethanol extract with concentration 15%, 20%, 25%, 30%, 35%, and diameter of inhibition zone. The data were taken after incubation at 37C for 48 hour. Data were analyzed with Pearson correlation test dan one way ANOVA test with Post-Hoc Tamhane test. Results: Pearson correlation test showed that there are positive correlation between the antifungal effect with increase concentration of caricature plant (Graptophyllum pictum [L.] Griff) ethanol extract. There is significant differences between all concentrations with negative control. There is no significant differences between antifungal effects of concentration 35% with ketoconazole. Conclusion: Caricature plant (Graptophyllum pictum [L.] Griff.) ethanol extract starting concentration at 15% has antifungal effect to the growth of Candida albicans. Caricature plant (Graptophyllum pictum [L.] Griff) ethanol extract concentration of 35% is thought to have an equal effect with the antifungal ketoconazole. Keywords: Caricature plant (Graptophyllum pictum [L.] Griff.) ethanol extract, the antifungal effect, Candida albicans
The Nefroprotector Effect of Salam Leaf Extract (Syzygium polyanthum) in Mices Renal Cell which is Induced by Paracetamol Asaduddien Faras; Endang Listyaningsih S; Sigit Setyawan
Nexus Kedokteran Translasional Vol 2, No 2 (2013): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.207 KB)

Abstract

Background : Salam Leaf (Syzygium polyanthum) contains antioxidants such as flavonoids, selenium, vitamin A, vitamin C, vitamin E, triterpenes, tannins, saponins, niacin, and essential oils as an antioxidant compounds. In present study, Syzygium polyanthum leaves extract was evaluated for its protective effect on paracetamol- induced renal damage in mice. Methods: This study was laboratory experimental research with Randomized Controlled Trial design. A total of 28 Swiss Webster mices were equally divided into 4 groups. Mices for control group (KK) and the first group (KP1) will be given aquades for 14 day. The second(KP2) and third (KP3) group will be given Salam leaf extract with dose 7 mg/20 g and 14 mg/20 g weight of mice for 14 days. While paracetamol in toxic dose was given on to KP1, KP2, KP3, with dose 0,1 ml/ 20 g weight of mice on day 12, 13 and 14. Mice were sacrificed with neck dislocation on the 15th day and histological preparation was made to evaluate histological damage on proximal tubular renal cells stained by Hematoxillin Eosin (HE). Renal histological features were assesed by counting the number of proximal tubular renal cells histogical damage. Data were analyzed by One-Way ANOVA test (? = 0,05) continued by Post Hoc Multiple Comparisons test (LSD)(? = 0,05). Results: The results of One-Way ANOVA test showed p < 0.05 that there was significant difference between four-groups. LSD test results showed p < 0,05 there was significant difference between grups. Conclusion: Salam leaf extract can prevent the renal cell damage of mice. The difference dose of salam leaf extract give different effects nefroprotector in mices renal cell. Keywords : salam leaf extract, paracetamol, renal histologic structure damage
Antibacterial Activity Test of Aloe vera L. Leaf Extracts on Extended Spectrum ?-Lactamase (ESBL) Producing Bacteria from Surgical Site Infection Isolate . Zakiatunnisa; . Maryani; Sigit Setyawan
Nexus Kedokteran Translasional Vol 4, No 1 (2015): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.207 KB)

Abstract

Background: Surgical site infection is clinically defined as a discharge of purulent around wounds or cellulitis inside postoperative wounds. One of the factors that cause surgical site infections is the ESBL producing bacteria that developed a resistance towards most antibiotics. Aloe vera L. is known to possess a lot of antibacterials potent against various bacteria, either gram-positive or gram-negative. This research aims to prove the effects of the administration of Aloe vera L. leaf extracts towards the growth of ESBL producing bacteria from surgical site infection isolates. Method of research: This research was an experimental laboratory research (post test only with control group design) with sampling technique non-probability sampling ; consecutive sampling. The research was done in the UNS Faculty of Medicines Laboratory of Microbiology. Extraction of samples was done in the Dr. Moewardi Public Hospital Laboratory of Microbiology.The independent variable of this research was 70% ethanol extracts of Aloe vera L. leaf with concentrations of 25%, 50%, 75%, and 100%. The research subject was surgical site infection isolate ESBL producing bacteria, standardized with Mc Farland 0.5. Sensitivity test on the Muller-Hinton medium used the diffusion method with cefoperazon/sulbactam as positive control and aquades as negative control. The result of research was tested with Kruskal-Wallis testing method followed by Mann-Whitney testing method. Results: Kruskal-Wallis test results indicates a significant interception potential between two treatment groups (P = 0.000). Mann-Whitney test results indicates a significant difference of interception potentials on every treatment group, with the exception of the interception potential groups of 75% concentration extract and 100% concentration extract, no significant interception potential was found (P = 0.179). Conclusion: Aloe vera L. leaf extract proves to possess potential activity interception towards the growth of ESBL producing bacteria from surgical site infection isolates. The concentrations of Aloe vera L. leaf extract possess a positive correlation towards the interception potentials on surgical site infection ESBL producing bacteria. Keywords: Infection, postoperative wound, ESBL, Aloe vera.
The Effect of Mangosteen Peel (Garcinia mangostana L) Extract Against Mice (Mus musculus) Kidney Cell Damage Induced by Paracetamol Namira Qisthina; Bambang Widjokongko; Sigit Setyawan
Nexus Kedokteran Translasional Vol 3, No 1 (2014): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (35.966 KB)

Abstract

Background: Mangosteen peel (Garcinia mangostana L) contains antioxidant such as xanthone core, ?-mangostin, ?-mangostin, ?- mangostin, and garcinone which is thought to be nefroprotector. This study is aimed to investigate the mangosteen peel (Garcinia mangostana L) extracts nefroprotector effect against mice (Mus musculus) kidney cell damage induced by Paracetamol. Methods: This is an experimental laboratory study with post test only controlled group design. Swiss Webster mice weighing around 20 g were selected as sample. Those mice were divided into 4 groups randomly, each group consist of 7 mice. Incidential sampling was used as a sampling technique. Mice in control group (KK) and first treatment group (KP1) were given aquades, while second treatment group (KP2) and third treatment group (KP3) were given 10 mg and 15 mg of mangosteen peel extract respectively. KP1, KP2, and KP3 were given 0.1 ml paracetamol on the 8th, 9th, and 10th day of the treatment. Mice were sacrificed on 4th day and the kidneys were made into preparate using paraffin block and HE staining method. Histological kidney cells were assesed by the sum of pyknosis, karyorrhexis, and karyolysis cells. Data were analyzed using One Way ANOVA test continued by Post Hoc Multiple Comparisons (LSD). Result: One-Way ANOVAs test result showed a significant differences between four groups. LSDs test result showed a significant differences between KK-KP1, KK-KP2, KK-KP3,KP1- KP2, KP1- KP3, KP2-KP3. Conclusion: Mangosteen peel extract can prevent mices kidney cell damage induced by parasetamol. Keywords: Mangosteen peel extract, parasetamol, mices kidney cell damage
The Effect of Mangosteen Rind Extract (Garcinia mangostana L) to the Damaging of Hepar Cell of Mice (Mus musculus) Induced by Paracetamol Winda A Panjaitan; S B Widjokongko; Sigit Setyawan
Nexus Kedokteran Translasional Vol 3, No 1 (2014): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.207 KB)

Abstract

Background: The antioxidant properties of mangosteen rind extract such as xanthones, vitamin B1, vitamin B2, and vitamin C are estimated can protect hepar from free radicals and reducing NAPQI which produced by paracetamol metabolism. The purpose of this research is to know the effect of mangosteen rind ethanol extract to the damaging of hepar cell of mice induced by paracetamol. Methods: This research was a laboratorial experiment with post test only control group design. Samples of 28 male mice, Swiss webster type, 2-3 months old age and 20 gram of each weight, were divided into 4 groups in random or 7 mice each group. Aquadest were administered to mice in Control Group (KK) and the First Treatment Group (KP1), while mangosteen rind extract were administered to the Second Treatment Group (KP2) and the Third Treatment Group (KP3) with the dose of 10 mg/20 g body weight of mice and 15 mg/20 g body weight of mice. Paracetamol were administered to KP1, KP2, KP3, with dose 5.07 mg/20 g body weight of mice. On day 4th, mice were sacrificed with neck dislocation. Hepar cell slides were made and stained by HE. The hepar cell damage of mice were observed by counting number of necrosis cell. The data was analized by One-Way ANOVA test (? = 0.05) and continued by Post Hoc Multiple Comparisons using Least Significant Differences (LSD) test (? = 0.05). Results: The data showed that average number of necrotic nucleus of KK was 9.71; KP1 was 72.86; KP2 was 14.00; and KP3 was 22.29. The results of One-Way ANOVA test showed a significant difference in all group (p < 0.05). The statistical data result showed a significant difference of necrotic nucleus between K-KP1, K-KP2, K-KP3, KP1-KP2, KP1-KP3, and KP2-KP3 (p < 0.05). Conclusion: The feeding of mangosteen rind was able to decrease hepar cell damage of mice which is induced by paracetamol. Keywords: mangosteen rind extract, paracetamol, the damaging of hepar cell
Co-Authors . Maryani . Zakiatunnisa Afifah Syifa Khairunnisa Agik Dwika Putra Akrom, Akrom Anggun Pulihana Wilujeng Apriliana Vivy Candra Ardhia Fefrine Indarta Asaduddien Faras Aulia Farah Diba Auliya Salsabilla Bambang Widjokongko Dimas Agung Pramudikto Dwi Budi Narityastuti Endang Listyaningsih S Endang Syahrir Firstiafina Tiffany Hanne Dianta Pramono Ilham Satria Raditya Putra Lilik Wijayanti Namira Qisthina Ony Hardoko S B Widjokongko Satya Nugroho Senyum Indrakila Siti Marufah Sri Haryati Sugeng Purnomo Teguh Ariyanto Victoria Husadani Permata Sari Viola Belivia Tripuspita Widia Susanti Winda A Panjaitan Yulia Lanti Retno Dewi Yulia Sari Yusuf Arif Salam