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All Journal Dentika Dental Journal Dental Journal (Majalah Kedokteran Gigi) Conservative Dentistry Journal Indian Journal of Forensic Medicine & Toxicology
Kun Ismiyatin
Department Of Conservative Dentistry, Faculty Of Dental Medicine, Universitas Airlangga
Dentistry Public Health

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Effect of Hydrogel Epigallocatechin-3-Gallate (EGCG) to the Number of Fibroblast Cell Proliferation in the Perforation of Wistar Rat Tooth Pulp Ira Widjiastuti; Setyabudi setyabudi; Kun Ismiyatin; Djoko Agus Purwanto; Tiara Sukmawati
Conservative Dentistry Journal Vol. 9 No. 2 (2019): July - December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (621.987 KB) | DOI: 10.20473/cdj.v9i2.2019.93-96

Abstract

Background: Pulpitis can occur because the deep cavity preparation and it causes increasing of NO levels. Perforated teeth require direct pulp capping (DPC) treatment. The current standard DPC material is calcium hydroxide. However, several studies have found weaknesses of calcium hydroxide that can affect the success of DPC treatment and new, more biocompatible materials are needed. Epigallocatechin-3-gallate (EGCG) in green tea has many benefits, including antioxidant, anticolagenase, anticancer, anti-inflammatory and has the ability of radical scavenging to clean NO so that pulp healing can occur better by increasing the number of fibroblast cells that play a role in wound healing. Purpose: To determine the concentration of hydrogel EGCGs that are effective in increasing the number of fibroblast cell proliferation in the dental pulp perforation of Wistar rats. Method: This research is a laboratory experimental study with a randomized post test only control group design. Samples used in the study were 24 male Wistar rats which were divided into four groups, namely the negative control group and the treatment group were given EGCG 60 ppm, 90 ppm, and 120 ppm and were decapitated on the 7th day after treatment. The maxilla and the 1st molar were taken and decalcified, to process the HPA reading with HE staining. Observations were made using a microscope with a magnification of 400x. Results: There were significant differences in the treatment groups with 60 ppm and 90 ppm hydrogel hydrogels on the results of the Oneway ANOVA difference test (p <0.05). Conclusion: The concentration of hydrogel EGCG which is effective in increasing fibroblast cell proliferation is 90 ppm.
Effect of Epigallocatechin-3-Gallate (EGCG) on The Number of Lymphocyte Cells in Inflammation of Pulp with Mechanical Injury Kun Ismiyatin; Latief Mooduto; Putri Dea Amani Faadhilah
Conservative Dentistry Journal Vol. 10 No. 1 (2020): January-June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (692.317 KB) | DOI: 10.20473/cdj.v10i1.2020.9-13

Abstract

Background: Pulpitis is an inflammatory pulp that can caused by pulp perforation by mechanical injury. Emergency treatment of pulpitis is using Eugenol. High concentrations of Eugenol have a cytotoxic effect that causes local necrosis and inhibits the healing process. Because of negative effects from eugenol, then it’s necessary to consider a new ingredient with minimal side effects, and it’s epigallocatechin-3-gallate (EGCG) in green tea. As a polyphenol, it has good antioxidant effect and plays a role in shortening the duration of inflammation by radical scavenging against Nitric Oxide so that NO levels rapidly decrease which causes migration of neutrophil cells to the area of injury will decrease and the inflammatory process faster so that the healing process become faster. Lymphocyte is plays a role in tissue repair. Purpose: to explain the effect of EGCG hydrogel on the number of lymphocyte cells in pulp inflammation with mechanical injury. Methods: The study used 24 Wistar rats divided into four groups, namely control (C), and 3 groups of treatment (T1, T2, T3). Each group consisted of 6 rats prepared, then EGCG hydrogel 60 ppm was named T1, EGCG hydrogel 90 ppm was named T2, EGCG hydrogel 120 ppm was named P3. On the 3rd day, Wistar rats were decapitated for HPA preparations. Results: This study showed a significant difference in each group (p < 0.05) using One-Way Anova analysis. Conclusion: EGCG hydrogel 90 ppm is effective in increasing the number of lymphocyte cells in inflammation of the pulp with mechanical injury. 
Effect Of Epigallocatechin-3-Gallate (EGCG) On The Number Of Macrophage Cells In Inflammation Of Pulp With Mechanical Injury Kun Ismiyatin; Devi Eka Juniarti; Djoko Agus Purwanto; Adecha Ekalipta Primazafira
Conservative Dentistry Journal Vol. 10 No. 1 (2020): January-June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (543.476 KB) | DOI: 10.20473/cdj.v10i1.2020.31-35

Abstract

Background: Pulpitis is an inflammatory pulp that can occur due to mechanical trauma that causes perforation of the pulp. Treatment of pulpitis Emergency frequently using Eugenol. High concentrations of Eugenol have a cytotoxic effect that causes local necrosis and inhibits the recovery process. An alternative consideration with Epigallocatechin 3-gallate (EGCG) which has good antioxidant properties and increases the complexity of inflammation by inhibiting the production of inducible nitric oxide synthase (iNOS) and nitric oxide so that levels migration of inflammatory cells to the area of injury will decrease and inflammation will occur shorter then initiates the proliferation so the recovery process and tissue repair will be more rapidly occurring. One of the cells that support tissue repair is macrophages. Purpose: this study aims to explain the effect of EGCG on the number of macrophage cells in pulp inflammation with mechanical injury. Methods: The study used 24 Wistar rats teeth divided into four groups, namely control (C), and 3 treatment groups T1, T2, and T3. Each group consisted of 6 rats prepared, then T1 was named EGCG hydrogel 60 ppm, T2 was given EGCG hydrogel 90 ppm, while T3 was given EGCG hydrogel 120 ppm. On the 3rd day, Wistar rats were decapitated to continue making HPA preparations. Results:This study showed a significant difference in each group (p< 0.05) using One-Way Anova analysis. Conclusion: EGCG hydrogel 90 ppm  is effectivein increasing the number of macrophage cells. 
Antioxidant Potential of Epigallocatechin-3-gallate, Ascorbic Acid, and Sodium Ascorbate in Solution and Gel Forms by 2,2-diphenyl-1-picrylhydrazyl (DPPH) Assay Virdah Dwi Dewaantari; Setyabudi Setyabudi; Kun Ismiyatin
Conservative Dentistry Journal Vol. 11 No. 1 (2021): January-June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cdj.v11i1.2021.19-23

Abstract

Background: Free radicals are molecules without any electron pairs, unstable, and highly reactive. Antioxidants are needed to reduce free radicals. Antioxidants provide various benefits in dentistry as a preventive agent for caries, healing, bone formation, mouthwash, preventive and therapeutic cancer, and reduction of periodontal disease progressions. Additionally, research on antioxidants is still undergone due to the existence of free radical residues on bleached teeth. Epigallocatechin-3-gallate (EGCG), ascorbic acid (AA), and sodium ascorbate (SA) are ingridients that have antioxidant properties. Antioxidants can be in two forms solution and gel. Solutions have a higher substance releasing power than gel. Gel is extremely adhesive, so it does not flow easily. Meanwhile, solutions are rather unstable because it flows easily. Antioxidant activities were evaluated with 2,2-diphenyl-1-picrylhydrazyl (DPPH) Assay method. Purpose: Analyzing through literature reviews the potential antioxidants of EGCG, AA, and SA in solution and gel forms by DPPH Assay. Reviews: There were eight journal articles used in this review. The first article described antioxidant solutions in which EGCG was higher than sodium ascorbate. The second article showed that antioxidant gel EGCG was lower than sodium ascorbate. The third journal explained that ascorbic acid was higher than sodium ascorbate both in solution and gel forms. The other articles provided some information about the antioxidant activity percentages of EGCG, SA, and AA in the forms of gel and solutions by DPPH assay. Conclusion: EGCG has a higher antioxidant activity than SA, but it is lower when compared to AA in both solution and gel forms by DPPH assay.
The Role of Epigallocathecin-3-gallate as an Antioxidant After Dental Bleaching on Shear Bond Strength of Composite Resin Restoration Syarifah Nadhira Assyafira Al-Habsyi; Kun Ismiyatin; Galih Sampoerno
Conservative Dentistry Journal Vol. 11 No. 1 (2021): January-June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cdj.v11i1.2021.42-45

Abstract

Background: Tooth discoloration can be treated with dental bleaching using Hydrogen peroxide (H2O2). Dental bleaching may interfere with the shear bond strength of composite resins because the remaining free radicals can affect bonding polymerization. Epigallocatcehin-3-gallate (EGCG) as an antioxidant can neutralize the free radicals produced during bleaching process. Purpose: Analyze the role of EGCG antioxidants in increasing the shear bond strength of composite resin after bleaching.. Reviews: Of the seven journals included in this literature review, six journals reported significant difference, and one journal noted no significant difference in the shear bond strength of composite resin following the EGCG application. Conclusion: The use of EGCG can increase the shear bond strength value of post-bleaching composite resin restorations. 
Zirconia Inlay on Vital Teeth with Profunda Caries Sandra Kartika Sari; Kun Ismiyatin; Bagus Aji Wibowo; Rara Amorita Miranda
Conservative Dentistry Journal Vol. 11 No. 2 (2021): July - December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cdj.v11i2.2021.72-78

Abstract

Background: Dental caries has historically been considered the most critical component of the global burden of oral disease. Health facilities and dental health education counselling have been conducted, but public knowledge about dental caries is still low. The increasing number of dental caries is currently influenced by one of the factors of community behaviour. Most people do not realize the importance of taking care of oral and dental health. The ignorance of the community results in a decrease in productivity due to the influence of the perceived illness. Advances in dentistry since the last decade has allowed the use of conservative dental care. Modern restorative dentistry offers many methods for restoring teeth, both direct and indirect. The need for restoration of posterior teeth is related to aesthetic purposes and functional, biocompatibility and biomechanical aspects of the remaining tooth structure. Some materials that are widely used as tooth-coloured indirect restorations in posterior teeth are zirconia. Zirconia has its characteristics, especially in terms of functionality, such as mechanical strength, physical strength and aesthetics. Purpose: This study aims to determine the management of indirect restoration treatment using zirconia inlay on upper premolar. Case(s): A 46-yearold male patient complained that the filling of his upper left tooth was often loose and uncomfortable when used for eating because the food was stuck in it. The patient wants his teeth treated. The history of treatment on the tooth in question has been patched two times, but it often comes off partially. Case Management: From the examination that has been carried out, a clinical diagnosis of reversible pulpitis was established. The treatment plan that will be carried out is indirect pulpcapping using MTA and resin-modified glass ionomer cement as the base material. The planned restoration treatment is a fixed inlay restoration made of monolithic zirconia. Conclusion: Recently, zirconia has also been developed staining with improved translucency so that it becomes more aesthetic. Zirconia has a higher level of material resistance than otherrestorative materials such as composites. This is what makes zirconia the choice, especially for use as a framework for all-ceramic and partially-fixed crowns dental prosthesis.
The aesthetic management of diastema closure treatment with indirect veneer using lithium disilicate: A case report Kun Ismiyatin; Olivia Vivian Widjaja; Singgih Harseno; Ahmad Afif Dzulfiqar; Caeleb Fabrizio Sudarsono; Indira Moza Azzaria
Conservative Dentistry Journal Vol. 12 No. 1 (2022): January-June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cdj.v12i1.2022.1-5

Abstract

Background: Diastema is a space between two or more adjacent teeth that can interfere with the patient's aesthetic appearance. Various aesthetic treatments can be performed for diastema closure on anterior teeth, one of which is through the installation of veneers. The lithium disilicate ceramic material produces the thinnest veneer and has better properties than other materials, and is able to cover the anterior diastema with a fairly large width. Purpose: To describe the aesthetic procedure for closing the diastema of anterior teeth using indirect lithium disilicate ceramic veneer. Case(s): A 29-years-old male patient came with a complaint of dissatisfaction with her smile because of a gap between teeth 12 and 13. The teeth are in vital condition with normal overjet and overbite, and there are no systemic health problems. Case Management: The management of diastema closure on teeth 12 and 13 was carried out with indirect lithium disilicate veneer treatment. Lithium disilicate veneer has promising aesthetic results due to its enamel-like nature, minimally invasive because it requires minimal tooth reduction, good strength, and did not cause gingival irritation. As a result, this treatment could increase self-confidence of the patient. Conclusion: Diastema closure treatment using indirect lithium disilicate veneer is an effective treatment, gives satisfactory results and can increase the patient's confidence.
Single visit root canal treatment with post crown restoration Kun Ismiyatin; Widya Saraswati; Febriastuti Cahyani; Olivia Vivian Widjaya; Dede Ghozali Pangestu; Dea Arshila
Conservative Dentistry Journal Vol. 12 No. 2 (2022): July-December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cdj.v12i2.2022.57-62

Abstract

Background: Single visit endodontics has been shown to be an effective treatment modality when compared with multiple visit therapy and it does not deviate from achieving the objectives of proper biomechanical preparation, debridement, shaping, disinfection and 3 dimensional obturation of root canal system and is more beneficial to the patient and dentist provided there is careful case selection and strict follow of standard endodontic protocols. Symptomatic teeth can also be managed by single visit after controlling the abscess infection with antibiotic, provided the root canal is dry without any discharge.Purpose: This study aims to perform single visit root canals on teeth with irreversible pulpitis and restoration with post core and crown. Case(s): A 48-years-old female comes with dental complaints of upper left rear spontaneous pain at night. The tooth has had cavities since about two years ago and has never been previously treated. The patient said had not any systematic health disorder. There is a spontaneous pain that the patient feels. Case Management: From the examination that has been carried out, a clinical diagnosis of tooth 25 were symptomatic pulpitis irreversible with normal apical tissue. The restoration endodontic treatment plan was a single visit endodontic and the restoration is post core and crown. Conclusion: Symptomatic pulpitis irreversible with normal apical tissue treatment can be carried out single visit root canal treatment. Restoration of post endodontic treatment in this case need fiber post and core using composite and finally restoration using crown that made of zirconia. Zirconia has a higher level of material resistance than lithium disilicate. This is what makes zirconia the choice, especially for posterior teeth.
The Effect of Adding Epigallocatechin-3-gallate on the Porosity of Calcium Hydroxide Kun Ismiyatin; Widya Saraswati; Caeleb Fabrizio Sudarsono
Conservative Dentistry Journal Vol. 13 No. 1 (2023): January-June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cdj.v13i1.2023.11-15

Abstract

Background: Dental caries is a very common non-communicablae disease found in all age groups and found in 3.5 billion people in the world. Caries that harm the pulp tissue can be treated by direct or indirect pulp capping. One of the physical properties possessed by pulp capping is the porosity of material. The material most often used for pulp capping treatment of pulp perforations is calcium hydroxide (Ca(OH) 2 ). However, Ca(OH) 2 has a high pH that caused the porosity to be low. High porosity can facilitate cell development and ion exchange. Thus, additional materials with a lower pH are needed to increase porosity such as Epigallocatechin-3-gallate (EGCG). However, the porosity of the combination of EGCG with Ca(OH) 2 is still unclear, so it needs to be researched. Purpose: To explain the differences of Ca(OH) 2 porosity after the addition of EGCG. Methods: This study used a laboratory experimental study with a post test only control group design. This research using 16 samples for each control (Ca(OH) 2 – aquadest) and treatment (Ca(OH) 2 –EGCG) group. Samples from each group were subjected to freeze drying, observed with SEM, analyzed with ImageJ software, and tested with independent T-test. Results: There was a significant difference (p&lt;0.05) in the percentage of porosity between the addition of EGCG to Ca(OH) 2 namely 32,61% compared to Ca(OH) 2 with aquadest namely 23,38%. Conclusion: The porosity of the combination of calcium hydroxide with EGCG has a higher percentage compared to calcium hydroxide with aquadest.
The effect addition of epigallocatechin-3-gallate (EGCG) in nano hydroxyapatite on surface porosity as a candidate pulp capping materia Kun Ismiyatin; Nanik Zubaidah; Indira Moza Azzaria
Conservative Dentistry Journal Vol. 13 No. 1 (2023): January-June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cdj.v13i1.2023.24-28

Abstract

Background: Deep caries, cavity preparation and use of burs or other dental instruments often result in pulpal perforation. In the case of an exposed pulp, regenerative pulp tissue treatment aims to regenerate normal tissue and maintain pulp vitality by inducing pulp regeneration using the right material, so that a good percentage and size of material porosity is needed to help cell regeneration by supporting cell proliferation and attachment, stimulating remineralization and differentiation of odontoblast-like cells. Nano-HA has the ability to produce dentine bridges continuously, has porous properties that allow cell growth, improves mechanical properties, but is not anti-inflammatory so that EGCG is added which has the advantage of being an antioxidant, anti-inflammatory which can optimize pulp tissue regeneration and also acts as an antimicrobial by reduce the growth of bacteria in the oral cavity and can trigger the proliferation and differentiation of human dental pulp cells. Purpose: This study aims to prove the difference in surface porosity of nano hydroxyapatite added with EGCG compared to nano hydroxyapatite and aquadest. Methods: This study used a laboratory experimental study with a posttest-only control group design. The research sample consisted of 32 samples which were divided into 2 groups, the treatment group (nano HA - EGCG) and the control group (nano HA - aquadest). Each research group was subjected to freeze drying and SEM tests. Results: There was a significant difference in the percentage of surface porosity between the nano hydroxyapatite added with EGCG compared to nano hydroxyapatite and aquadest.on the results of the Independent T-test (p<0.05). Conclusion: The addition of EGCG to nano hydroxyapatite has a higher porosity percentage compared to nano hydroxyapatite with aquadest.
Co-Authors Adecha Ekalipta Primazafira Adioro Soetojo Ahmad Afif Dzulfikar Ahmad Afif Dzulfiqar Anuj Bhardwaj Ari Subiyanto Bagus Aji Wibowo Caeleb Fabrizio Sudarsono Cinitra Anindya Dea Arshila Dede Ghozali Pangestu Devi Eka Juniarti Dian Dwi Pratiwi Djoko Agus Purwanto Febriastuti Cahyani Galih Sampoerno Hendri Eko Wahyudi Hendy Jaya Kurniawan Ika Tangdan Indira Moza Azzaria Ira Widjiastuti Karina Erda Saninggar Latief Mooduto Leidy Herlin Rumbiak Michelle Suhartono Nadya Ayusandra Larasati Nanik Zubaidah Nanik Zubaidah Nindhira Puspita Sari Olivia Vivian Widjaja Olivia Vivian Widjaja Olivia Vivian Widjaya Paramita Tanjung Sari Pramita Tanjung Sari Putri Dea Amani Faadhilah Rahmi Nawawi Rara Amorita Miranda Reinold C. Lina Ria Puspita Sari Ria Puspita Sari Rizky Ernawati Salicha, Ramadhani Putri Sandra Kartika Sari Sandra Kartika Sari Setyabudi Setyabudi Singgih Harseno Singgih Harseno Sri Kunarti Syarifah Nadhira Assyafira Al-Habsyi Sylvia Tiara Sukmawati Virdah Dwi Dewaantari Widjaja, Olivia Vivian Widya Saraswati Widya Saraswati