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All Journal HAYATI Journal of Biosciences Jurnal Tumbuhan Obat Indonesia Jurnal Penelitian Farmasi Indonesia Journal of Mathematical and Fundamental Sciences Jurnal Riset Kimia Indonesian Journal of Chemistry JSFK (Jurnal Sains Farmasi & Klinis) JFIOnline ASEAN Journal on Science and Technology for Development
DAYAR ARBAIN
Faculty Of Pharmacy, University 17 Agustus 1945, Jl. Sunter Raya Permai, Jakarta, 14350
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Physics Public Health

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Isolasi Senyawa dan Uji Aktivitas Anti-inflammasi Ekstrak Metanol Daun Puwar Kincung (Nicolaia speciosa Horan) Fernando, Armon; Suryani, Fitri; Ahmad, Farediah; Sirat, Hasnah M.; Arbain, Dayar
Jurnal Penelitian Farmasi Indonesia Vol 1, No 01 (2013)
Publisher : Jurnal Penelitian Farmasi Indonesia

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Abstract

The study of anti-inflammatory activity and isolation of the methanolic extract, hexane and ethyl acetate fractions of the leaves of puwarkincung (Nicolaia speciosa Horan) have been done. Isolation was carried out by extraction, fractionation and multiple column chromatographicmethod, followed by recrystallization technique. Two compounds were isolated and labeled as F4 and S3. F4 was derived from n-hexanefraction as yellowish-white crystals (20 mg) with mp. 55–57 oC and S3 from the ethyl acetate fraction (15 mg) as yellow crystals with mp.68–69 oC. Anti-inflammatory activity of methanolic extract using Paw Edema method showed that the dose 250 and 1000mg/kgbw wereactive as anti inflammatory agents.
ISOLASI SENYAWA ALKALOID DARI KULIT BATANG Dehaasia lancifolia BL. Ridl Hasnirwan, Hasnirwan; Arbain, Dayar; Effendy, Harry Abrir
Jurnal Riset Kimia Vol 3, No 2 (2010): March
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v3i2.39

Abstract

  ABSTRACT Dehaasia lancifolia plant from family of Lauraceae and base on the phytochemical survey in Malaysia and West Sumatera containing alkaloid compounds. The alkaloid compounds containing in Dehaasia lancifolia BL. Ridl has not been isolated and from chemotaxonomy aproximation gave an indication that alkaloid structure not quite difference with one of Phoebe genus of the same family wich has been isolated. The isolated alkaloid compound was obtained in amorf solid phase and yellowish colored in relatively high concentration. The bromide salt of this compound melt at 261°-264°C. UV spectrum indicated the maximum absorbtion band at wavelength 282 and 204 nm wich indicated the chromophoric group of tetrahydroquinoline. IR spectrum shown an absorbtion band at: 3550 cm-1 (stretching C-N), 3030 cm-1 (C-H aromatic), 2930 cm-1 (-CH2- stretching), 2860 (CH aliphatic stretching), 1660-1600 cm-1 (C=C aromatic), 1530 cm-1 (C=N aromatic), 1070 cm-1 (C-O-C stretching) and brommide salt shown an absorbtion band at 2680 cm-1 (>N+-H stretching) and without OH group in this molecule Keywords: dehaasia lancifolia BL. Ridl, alkaloid, spectrophotometer UV and IR
CHEMICAL CONSTITUENTS AND ANTIBACTERIAL ACTIVITIES OF LEAVES OF SUMATRAN KING FERN (Angiopteris evecta G. Forst HOFFM.) Anggia, Vivi -; Bakhtiar, Amri; Arbain, Dayar -
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 7, No 4 (2015)
Publisher : Indonesian Research Gateway

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Abstract

ABSTRACT : 4,5-dihydro-4-hydroxy-5-methyl-1H-pyran-1-one (2), angiopteroside (3) and well known stigmast-5-en-3--ol (1) have been isolated from the leaves of  Sumatran King fern Angiopteris evecta G. Forst HOFFM. and investigated for their antimicrobial activities towards some human pathogenic bacteria. Angiopteroside (3) showed potential activities to inhibit the growth of Bacillus subtilis. Keywords: Angiopteris evecta, 4,5-dihydro-4-hydroxy-5-methyl-1H-pyran-1-one,  Angiopteroside, antibacterial. ABSTRAK : 4,5-dihidro-4-hidroksi-5-metil-1H-piran-1-one (2), angiopteroside (3) dan senyawa yang umum stigmast-5-en-3--ol (1) berhasil diisolasi dari daun tumbuhan paku gajah Angiopteris evecta G. Forst HOFFM. dan diuji aktivitas antibakterinya terhadap beberapa bakteri patogen manusia. Angiopteroside (3) menunjukan aktivitas daya hambat terhadap pertumbuhan bakteri Bacillus subtilis. Kata kunci: Angiopteris evecta, 4,5-dihidro-4-hidroksi-5-metil-1H-piran-1-one, angiopteroside, antibakteri
CHEMICAL CONSTITUENTS AND ANTIBACTERIAL ACTIVITIES OF LEAVES OF SUMATRAN KING FERN (Angiopteris evecta G. Forst HOFFM.) Anggia, Vivi -; Bakhtiar, Amri; Arbain, Dayar -
Jurnal Farmasi Indonesia Vol 7, No 4 (2015)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (676.668 KB) | DOI: 10.35617/jfi.v7i4.193

Abstract

ABSTRACT : 4,5-dihydro-4-hydroxy-5-methyl-1H-pyran-1-one (2), angiopteroside (3) and well known stigmast-5-en-3--ol (1) have been isolated from the leaves of  Sumatran King fern Angiopteris evecta G. Forst HOFFM. and investigated for their antimicrobial activities towards some human pathogenic bacteria. Angiopteroside (3) showed potential activities to inhibit the growth of Bacillus subtilis. Keywords: Angiopteris evecta, 4,5-dihydro-4-hydroxy-5-methyl-1H-pyran-1-one,  Angiopteroside, antibacterial. ABSTRAK : 4,5-dihidro-4-hidroksi-5-metil-1H-piran-1-one (2), angiopteroside (3) dan senyawa yang umum stigmast-5-en-3--ol (1) berhasil diisolasi dari daun tumbuhan paku gajah Angiopteris evecta G. Forst HOFFM. dan diuji aktivitas antibakterinya terhadap beberapa bakteri patogen manusia. Angiopteroside (3) menunjukan aktivitas daya hambat terhadap pertumbuhan bakteri Bacillus subtilis. Kata kunci: Angiopteris evecta, 4,5-dihidro-4-hidroksi-5-metil-1H-piran-1-one, angiopteroside, antibakteri
Antimicrobial Activity of Endemic Herbs from Tangkahan Conservation Forest North Sumatera to Bacteria and Yeast KIKI NURTJAHJA; TATA BINTARA KELANA; DWI SURYANTO; NUNUK PRIYANI; GINTA RIO; DEDI PRIMA PUTRA; DAYAR ARBAIN
HAYATI Journal of Biosciences Vol. 20 No. 4 (2013): December 2013
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (341.705 KB) | DOI: 10.4308/hjb.20.4.177-181

Abstract

Tangkahan Conservation Forest in Karo County, North Sumatera has high biodiversity of endemic herbs. Many species of the wild herbs are well known used as traditional medicine not only by local people but also by people out of the area. The methanol extract of the medicinal wild herbs in Tangkahan Conservation Forest, Karo County to relief skin diseases caused by bacteria and fungi never been studied medically. The antimicrobial activity leave extract of the medicinal herbs to pathogenic  microorganisms are studied. The leaves extract of kembu-kembu (Callicarpa candicans), rintih bulung (Piper muricatum), cep-cepan (Castanopsis costata), and sereh kayu (Eugenia grandis), has antimicrobial to bacteria (Bacillus sp., Escherichia coli, Serratia marcescens, Staphylococcus aureus) and yeast (Candida albicans). Toxicity assay of these plants by brine shrimp method using Artemia salina indicates that cep-cepan dan sereh kayu have lethal concentration higher than kembu-kembu and rintih bulung.
ISOLASI SENYAWA ALKALOID DARI KULIT BATANG Dehaasia lancifolia BL. Ridl Hasnirwan Hasnirwan; Dayar Arbain; Harry Abrir Effendy
Jurnal Riset Kimia Vol. 3 No. 2 (2010): March
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v3i2.39

Abstract

  ABSTRACT Dehaasia lancifolia plant from family of Lauraceae and base on the phytochemical survey in Malaysia and West Sumatera containing alkaloid compounds. The alkaloid compounds containing in Dehaasia lancifolia BL. Ridl has not been isolated and from chemotaxonomy aproximation gave an indication that alkaloid structure not quite difference with one of Phoebe genus of the same family wich has been isolated. The isolated alkaloid compound was obtained in amorf solid phase and yellowish colored in relatively high concentration. The bromide salt of this compound melt at 261°-264°C. UV spectrum indicated the maximum absorbtion band at wavelength 282 and 204 nm wich indicated the chromophoric group of tetrahydroquinoline. IR spectrum shown an absorbtion band at: 3550 cm-1 (stretching C-N), 3030 cm-1 (C-H aromatic), 2930 cm-1 (-CH2- stretching), 2860 (CH aliphatic stretching), 1660-1600 cm-1 (C=C aromatic), 1530 cm-1 (C=N aromatic), 1070 cm-1 (C-O-C stretching) and brommide salt shown an absorbtion band at 2680 cm-1 (>N+-H stretching) and without OH group in this molecule Keywords: dehaasia lancifolia BL. Ridl, alkaloid, spectrophotometer UV and IR
KAJIAN ETNOFARMASI DAN FITOKIMIA TUMBUHAN OBAT KAMPUNG ADAT URUG, KECAMATAN SUKAJAYA, KABUPATEN BOGOR, JAWA BARAT Ghalib Syukrilah Syahputra; Mutiara Ayudia Astuti; Piter Piter; Dayar Arbain
Jurnal Tumbuhan Obat Indonesia Vol 14 No 1 (2021): Jurnal Tumbuhan Obat Indonesia
Publisher : Balai Besar Penelitian dan Pengembangan Tanaman Obat dan Obat Tradisional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jtoi.v14i1.3016

Abstract

ABSTRACT Knowledge and arts of the traditionally use of medicinal plant are valuable assets of Indonesian culture, which should be documented and preserved. Simultaneously, the plant that are traditionally used for health care should be investigated, particularly regarding their chemical constituents, biological activities and their safety, as well. This study aimed to inventory of medicinal plants used by people from Kampung Adat Urug, a Sundanese traditional village. This community still practices their traditional way of life, including how to maintain health and to treat illness. This study began with an ethnobotanical survey using Participation Observatory Method (POM) and interviewing the selected traditional healers. Data analysis was carried out by calculating Use Value (UV), Relative Frequency of Citation (RFC), and Relative Importance (RI) of plant species. The study revealed 29 medicinal plants used by Kampung Urug community. Five medicinal plants (Ixora salicifolia, Scleria levis, Hippobroma longiflora; Pterocarpus indicus and Pothos junghuhnii) showed high level of UV, RFC, and RI. Those species were found to be potential in treating various neglected diseases, women health care during pregnancy, postpartum illness, and maintaining health care in general. Besides, there were four plants extracts, each from Barringtonia acutangula; Pterocarpus indicus; Selaginella cf. lana and Pothos junghuhnii which showed potent inhibition against Staphylococcus aureus. The phytochemical screening of the above extracts showed various major constituents, particularly phenolics and flavonoids. Keywords: Ethnopharmacy, Kampung Urug, Phytochemistry ABSTRAK Pengetahuan dan seni tentang penggunaan tumbuhan obat merupakan salah satu kekayaan budaya bangsa Indonesia yang harus didokumentasikan dan dilestarikan. Secara bersamaan tumbuhan obat yang digunakan untuk pemeliharaan kesehatan dan obat itu juga harus diteliti, khususnya kandungan kimia dan bioaktifitasnya serta divalidasi khasiat dan keamanan penggunaannya. Adapun tujuan dari penelitian ini adalah untuk menginventarisasi penggunaan tumbuhan obat oleh salah satu masyarakat adat Suku Sunda yang tinggal tidak jauh dari kota Bogor yang dikenal dengan nama Kampung Adat Urug. Mereka hidup secara tradisional termasuk bagaimana memelihara kesehatan dan mengobati penyakit. Kajian ini dimulai dengan melakukan survei etnobotani menggunakan metode Participation Observatory Method (POM) dan mewawancarai beberapa dukun terpilih menggunakan analisis Use Value (UV), Relative Frequency of Citation (RFC), dan Relative Importance (RI). Pada kegiatan ini telah terkumpul 29 jenis tumbuhan obat, dibuat spesimen herbariumnya dan disiapkan juga ekstrak metanol dari tumbuhan obat yang dikoleksi tersebut. Berdasarkan metode POM dan wawancara beberapa dukun terpilih menggunakan analisis UV, RFC, dan RI, terpilih lima jenis tumbuhan obat, yaitu: Ixora salicifolia, Scleria levis, Hippobroma longiflora, Pterocarpus indicus dan Pothos junghuhnii, yang potential digunakan untuk berbagai penyakit terabaikan, perawatan wanita hamil dan setelah melahirkan serta untuk pemeliharaan kesehatan secara umum. Berdasarkan studi pustaka terdapat empat ekstrak tumbuhan; Barringtonia acutangula, P. indicus, Selaginella cf. plana, dan P. junghuhnii yang menghambat kuat pertumbuhan bakteri Staphylococcus aureus yang sering menyebabkan infeksi secara umum. Hasil penapisan fitokimia terlihat bahwa ekstrak-ekstrak yang aktif antimikroba di atas memperlihatkan adanya kandungan senyawa kimia khususnya senyawa fenolik dan flavonoid yang diperlukan untuk perencanaan kajian-kajian isolasi dan karakterisasi kandungan senyawa aktif yang ada. Kata kunci: Etnofarmasi, Fitokimia, Kampung Urug
Cytotoxic Activities of Extracts and Isolated Compounds of Some Potential Sumatran Medicinal Plants against MCF-7 and HSC-3 Cell Lines Meiridha Mutiara Andania; Friardi Ismed; Muhammad Taher; Solachuddin Jauhari Arief Ichwan; Amri Bakhtiar; Dayar Arbain
Journal of Mathematical and Fundamental Sciences Vol. 51 No. 3 (2019)
Publisher : Institute for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2019.51.3.2

Abstract

In continuation of our study of Sumatran plants and the bioactivity of their constituents, Stereocaulon halei Lamb (Stereocaulaceae) was extracted and isolated to obtain atranorin (1), lobaric acid (6), and methyl-β-orcinol carboxylate (9). We also prepared methanolic extracts of some Sumatran medicinal plants, i.e. Alpinia denticulata, Alpinia malaccensis, Alpinia submutica, Curcuma zedoaria, Centella asiatia, Mangifera indica, Piper crocatum, Mussaenda frondosa, together with previously isolated compounds, i.e. crocatin A (2) and crocatin B (3) from P. crocatum, curcumin (4) from Curcuma longa, demethoxymatteucinol (5) from Sphaerostephanos polycarpus, mangiferin (7) from M. indica, methyl caffeate (8) from Balanophora elongata, tiliroside (10) from Guazuma ulmifolia, and usnic acid from Usnea sp (11). These extracts and compounds were tested for their cytotoxicity against MCF-7 and HSC-3 cell lines by MTT assay (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide). It was found that the IC50 value of atranorin (1), lobaric acid (6), methyl-β-orcinol carboxylate (9), and methanolic extract of A. submutica towards the MCF-7 cell line was 208.20 µM, 172.05 µM, 382.60 µM and 70.95 µg/mL, respectively. The IC50 value of lobaric acid (6) and methyl-β-orcinol carboxylate (9) against the HSC-3 cell line was 88.92 µM and 260.09 µM, respectively. The other extracts did not show significant cytotoxicity.
Isolation and Antibacterial Properties of Phenyl Acrylic Acid Derivatives from Balanophora elongata Blume Nanda Putra; Goldha Faroliu; Nova Syafni; Nofrizal; Amri Bakhtiar; Dayar Arbain
Journal of Mathematical and Fundamental Sciences Vol. 53 No. 2 (2021)
Publisher : Institute for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2021.53.2.5

Abstract

Balanophora elongata (Balanophoraceae) is a tropical parasitic flowering plant 9 cm in height. Four known phenyl acrylic acid derivatives, methyl caffeate (1), caffeic acid (2), 1,6-di-O-caffeoyl-β-D-glucopyranose (3), and coniferin (4), were isolated from this plant. Structural elucidation of the isolated compounds was determined by IR, LC-ESI-MS, 1D and 2D NMR.  Extracts and isolated compounds were tested toward some standard human pathogenic bacteria using the agar disk diffusion method. Their inhibition zones were compared to that of chloramphenicol as positive control. Compound 1 showed inhibition toward Streptococcus mutans, while compound 3 and 4 inhibited Staphylococcus aureus.
A Preliminary Investigation of The Alkaloid of Phoebe Lanceolata Dayar Arbain; Melvyn V. Sargent
ASEAN Journal on Science and Technology for Development Vol. 4 No. 1 (1987): ASEAN Journal on Science and Technology for Development (AJSTD)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (191.191 KB) | DOI: 10.29037/ajstd.141

Abstract

A Preliminary Investigation of The Alkaloid of Phoebe Lanceolata
Co-Authors Amri Bakhtiar Amri Bakhtiar Amri Bakhtiar Amri Bakhtiar Armon Fernando Deddi Prima Putra DEDI PRIMA PUTRA DWI SURYANTO Farediah Ahmad Faroliu, Goldha Fitri Suryani Friardi Ismed Ghalib Syukrilah Syahputra GINTA RIO Harry Abrir Effendy Hasnah M. Sirat Hasnirwan Hasnirwan KIKI NURTJAHJA Meiridha Mutiara Andania Melvyn V. Sargent Muhammad Taher Mutiara Ayudia Astuti Nanda Putra Nofrizal Nova Syafni NUNUK PRIYANI Piter Piter Solachuddin Jauhari Arief Ichwan Sri Hainil TATA BINTARA KELANA Vivi Anggia Vivi Anggia, Vivi