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All Journal HAYATI Journal of Biosciences Jurnal Tumbuhan Obat Indonesia Jurnal Penelitian Farmasi Indonesia Journal of Mathematical and Fundamental Sciences Jurnal Riset Kimia Indonesian Journal of Chemistry JSFK (Jurnal Sains Farmasi & Klinis) JFIOnline ASEAN Journal on Science and Technology for Development
DAYAR ARBAIN
Faculty Of Pharmacy, University 17 Agustus 1945, Jl. Sunter Raya Permai, Jakarta, 14350
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Physics Public Health

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Journal : Journal of Mathematical and Fundamental Sciences

 1 
Cytotoxic Activities of Extracts and Isolated Compounds of Some Potential Sumatran Medicinal Plants against MCF-7 and HSC-3 Cell Lines Meiridha Mutiara Andania; Friardi Ismed; Muhammad Taher; Solachuddin Jauhari Arief Ichwan; Amri Bakhtiar; Dayar Arbain
Journal of Mathematical and Fundamental Sciences Vol. 51 No. 3 (2019)
Publisher : Institute for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2019.51.3.2

Abstract

In continuation of our study of Sumatran plants and the bioactivity of their constituents, Stereocaulon halei Lamb (Stereocaulaceae) was extracted and isolated to obtain atranorin (1), lobaric acid (6), and methyl-β-orcinol carboxylate (9). We also prepared methanolic extracts of some Sumatran medicinal plants, i.e. Alpinia denticulata, Alpinia malaccensis, Alpinia submutica, Curcuma zedoaria, Centella asiatia, Mangifera indica, Piper crocatum, Mussaenda frondosa, together with previously isolated compounds, i.e. crocatin A (2) and crocatin B (3) from P. crocatum, curcumin (4) from Curcuma longa, demethoxymatteucinol (5) from Sphaerostephanos polycarpus, mangiferin (7) from M. indica, methyl caffeate (8) from Balanophora elongata, tiliroside (10) from Guazuma ulmifolia, and usnic acid from Usnea sp (11). These extracts and compounds were tested for their cytotoxicity against MCF-7 and HSC-3 cell lines by MTT assay (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide). It was found that the IC50 value of atranorin (1), lobaric acid (6), methyl-β-orcinol carboxylate (9), and methanolic extract of A. submutica towards the MCF-7 cell line was 208.20 µM, 172.05 µM, 382.60 µM and 70.95 µg/mL, respectively. The IC50 value of lobaric acid (6) and methyl-β-orcinol carboxylate (9) against the HSC-3 cell line was 88.92 µM and 260.09 µM, respectively. The other extracts did not show significant cytotoxicity.
Isolation and Antibacterial Properties of Phenyl Acrylic Acid Derivatives from Balanophora elongata Blume Nanda Putra; Goldha Faroliu; Nova Syafni; Nofrizal; Amri Bakhtiar; Dayar Arbain
Journal of Mathematical and Fundamental Sciences Vol. 53 No. 2 (2021)
Publisher : Institute for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2021.53.2.5

Abstract

Balanophora elongata (Balanophoraceae) is a tropical parasitic flowering plant 9 cm in height. Four known phenyl acrylic acid derivatives, methyl caffeate (1), caffeic acid (2), 1,6-di-O-caffeoyl-β-D-glucopyranose (3), and coniferin (4), were isolated from this plant. Structural elucidation of the isolated compounds was determined by IR, LC-ESI-MS, 1D and 2D NMR.  Extracts and isolated compounds were tested toward some standard human pathogenic bacteria using the agar disk diffusion method. Their inhibition zones were compared to that of chloramphenicol as positive control. Compound 1 showed inhibition toward Streptococcus mutans, while compound 3 and 4 inhibited Staphylococcus aureus.
Co-Authors Amri Bakhtiar Amri Bakhtiar Amri Bakhtiar Amri Bakhtiar Armon Fernando Deddi Prima Putra DEDI PRIMA PUTRA DWI SURYANTO Farediah Ahmad Faroliu, Goldha Fitri Suryani Friardi Ismed Ghalib Syukrilah Syahputra GINTA RIO Harry Abrir Effendy Hasnah M. Sirat Hasnirwan Hasnirwan KIKI NURTJAHJA Meiridha Mutiara Andania Melvyn V. Sargent Muhammad Taher Mutiara Ayudia Astuti Nanda Putra Nofrizal Nova Syafni NUNUK PRIYANI Piter Piter Solachuddin Jauhari Arief Ichwan Sri Hainil TATA BINTARA KELANA Vivi Anggia Vivi Anggia, Vivi