Article Per Year (5 Year)
p-Index From 2019 - 2024
1.048
P-Index
This Author published in this journals
All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Majalah Kedokteran Bandung e-Journal Pustaka Kesehatan Journal of Agromedicine and Medical Sciences Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Jurnal Ilmiah Kesehatan Jember Medical Journal (JMJ)
M. Ihwan Narwanto
Fakultas Kedokteran Universitas Jember
Health Professions Immunology & microbiology Library & Information Science Medicine & Pharmacology Public Health

Published : 11 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 11 Documents
Search

 1   2 
Efek Pemberian Vitamin E (d-α-tocopherol) terhadap Memori Kerja Spasial Tikus (Rattus novergicus) Remaja yang Diinduksi Etanol Shera Nadhila Setyo Bisono; M. Ihwan Narwanto; Kristianningrum Dian Sofiana
Pustaka Kesehatan Vol 2 No 2 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

During neurogenesis process, nerve cells especially hippocampus susceptible to damage when exposed to ethanol. Vitamin E is an antioxidant and capable to protect nerve cells damage. This study aimed to determine the effect of vitamin E (d-α-tocopherol) on spatial working memory of adolescent rats induced with ethanol. The study used 30 days-old rats (Rattus novergicus), weight between 50-100 grams. Total of 25 rats were divided into 5 groups: 2 control groups and 3 treatment groups. K1/K(-) was normal group without ethanol and vitamin E, and K2/K(+) were induced with ethanol. The treatment groups were given ethanol and vitamin E at a dose of 100mg/kgBW; 200 mg/kgBW; 400 mg/kgBBW respectively for P1, P2 and P3. After treatment for 14 days, the rats were tested for spatial working memory using the Radial Arm Maze (RAM) for 10 consecutive days. Spatial working memory was observed by the total number of right arm option which were entered by rats. The average number of right arm maze option for 10 days, were; K (-): (7 ± 0.52), K (+): (3.98 ± 0.66), P1: (4 , 56 ± 0.41), P2: (6.76 ± 1.01) and P3 (6.38 ± 0.63). In conclusion, there was an effect of vitamin E at a dose of 200 mg/kgBW and 400 mg KgBW on spatial working memory of ethanol-induced adolescent rats.   Keywords: ethanol, vitamin E, spatial memory, Radial Arm Maze
Pengaruh Minuman Kopi Minim Kafein terhadap VO2max dan Pemulihan Denyut Nadi setelah Melakukan Treadmill (The Effect of Decaffeinated Coffee Drink on VO2max and Pulse Recovery Rate after Treadmill Test) Chikita R Hanifati; Cholis Abrori; M Ihwan Narwanto
Pustaka Kesehatan Vol 4 No 3 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Coffee can be classified as a psicostimulant agent cause awakening, due to its content, such as caffeine. For intolerant person caffeine can be harmful, so nowadays created decaffeinated coffee. The purpose of this study was to determine the effect of decaffeinated coffee drink consumption on VO2max and pulse recovery rate after treadmill test. This was a quasi experimental study with Randomized Clinical Trial (RCT) methods. There were 20 volunteers, divided into two groups that swapping roles after 4 days washing out. The control group was given an instant coffee drink while the treatment group was given a decaffeinated coffee drink. All volunteers were asked to perform Modified Bruce Treadmill Test procedure until exhausted then VO2max were examined. The results showed the average value of VO2max in treatment group was +45,22 ml/kg/min and in control group +46,96 ml/kg/min from the previous study the value of VO2max using placebo was 25,98 ml/kg/min. Duration of pulse recovery rate in treatment group was 52 minutes faster than control group, 57 minutes. Analyses by T-test obtained p=0,23 mean there was no significant difference. In conclusion, decaffeinated coffee drinks could increased VO2max as the instant coffee did, but it still could accelerate pulse recovery rate. Keywords: Modified Bruce Treadmill, pulse recovery rate, VO2max, decaffeinated coffee
Pengaruh Minuman Kopi terhadap VO2max dan Pemulihan Denyut Nadi pasca Melakukan Treadmill (The Influence of a Coffee Drinks to VO2max and Pulse Recovery after Doing Treadmill) Natasha Amelia; Cholis Abrori; M Ihwan Narwanto
Pustaka Kesehatan Vol 3 No 2 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Coffee can be classified as a psicostimulant which cause person stay awake. Coffee contains any ingredients such as caffeine.Caffeine could improve the performance of athletes. VO2max is a highest ratio of oxygen consumed during intense physical activity. The purpose of this study was to determine the effect of caffeine consumption on VO2max and exercise recovery pulse. The study used experimental research with Randomized Clinical Trial (RCT) methods. There were 20 volunteers, who were divided into two groups. The control group was given a drink that contains no caffeine while the treatment group was given a drink containing caffeine. Then all volunteers were asked to perform Modified Bruce Treadmill Test procedure until exhaustion occurred then VO2max.The next 4 days were washing out period where the control and treatment groups swap the roles. The results showed the average value of VO2max in the treatment group was 30.69 ml/ kg/min higher than in the control group 25.98 ml/ kg/min, but the duration of pulse recovery in the treatment group was 127 minutes slower than the control group, 121 minutes, indicating to its effects as a stimulant. In conclusion, administration of caffeine increased VO2max, but delayed time of pulse recovery.   Keywords: Modified Bruce Treadmill Test, pulse recovery, caffeine,VO2max
Efek Ekstrak Teh Hijau (Camellia sinensis) terhadap Memori Kerja Spasial Tikus Wistar (Rattus novergicus) Remaja yang Diinduksi Etanol Prasetia Aji Ramadhan; Muhamad Ihwan Narwanto; K Dian Sofiana
Pustaka Kesehatan Vol 2 No 1 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Ethanol is a well-known agent causing organ damage including hippocampus. Hippocampus damage will reduce spatial memory. This study aimed to determine the effects of green tea extract on spatial memory function in adolescent rats following ethanol administration. One of cathecin derivates in green tea is EGCG which is believed to prevent hippocampal damage due to ethanol. The research was conducted on 25 rats, divided into 5 groups with 2 control groups and 3 experimental groups. A control group 1 (K1) was given 20 % ethanol with a dose of 2g/kgBW, while a control group 2 (K2) was only given with distilled water. All experimental groups (P1,P2 and P3) were given ethanol 2gr/kgBW and green tea extract with a dose of 108mg/200gBW, 216mg/200gBW, and 432mg/200gBW, respectively for P1, P2, and P3. Administration of ethanol and green tea extracts were performed for 14 days. The rats' spatial memory were tested by observation using the Radial Arm Maze ( RAM ) for 10 days. The number of the right arm in K1 was fewer than K2, P1, P2 and P3, but in K2 the right arm similar with P2 and higher than P1 and P2. In conclusion, the green tea extract influence the spatial memory of ethanol-induced adolescent rat. Keywords: Ethanol, green tea extract, Radial Arm Maze, spatial memory
Identification and In Silico Analysis of Anti Inflammation and Anti Oxidant Potentials of Polyphenol Compounds in Methanol Extract of Tamarindus indica Seeds Muhammad Ihwan Narwanto; Masruroh Rahayu; Setyawati Soeharto; Nurdiana Nurdiana; Moch. Aris Widodo
Journal of Agromedicine and Medical Sciences Vol 4 No 1 (2018)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v4i1.6735

Abstract

ABSTRACT Indonesia has abundant stock of Tamarindus indica seeds, but it is not yet utilized maximally, especially in medical field. Tamarindus indica seeds have high content of polyphenols compound. No reseacrh is supported by in silico data on polyphenol compound in Tamarindus indica seeds extract. Polyphenols compound can be utilized as a neuroprotective agent. This research aims to measure polyphenols concentration in methanol Tamarindus indica seeds extract and determine the anti inflammation and antioxidant potential of each polyphenol compound in methanol Tamarindus indica seeds extract by in silico method. The extraction of Tamarindus seeds used maceration method and methanol as solvent. Identification and measurement of polyphenols compound applied HLPC-MS. PyMol and Pyrx tools were used for in silico analysis. Extract recidu was obtained from methanol Tamarindus indica seeds as much as 12%w/v. HPLC-MS anaysis mentioned that levels of procyanidin B2, myricentin and caffeic acid were respectively 38.850 mg/kg, 5.845 mg/kg and 260 mg/kg. The highest anti inflammatory potential was owned by myricentin than caffeic acid, while the lowest potential in procyanidin B2. Furthermore, the highest antioxidant potential was sequentially in myricentin, procyanidin B2 and caffeic acid. It is very possible to utilize methanol Tamarindus indica seeds extract for preventing neurodegenerative diseases since its pathogenesis involves inflammatory and stress oxidative process. Keywords : Tamarindus indica, myricetin, procyanidin B2, caffeic acid, anti inflammatory, antioxidant
Hubungan Aktivitas Fisik dan Indeks Massa Tubuh dengan Gangguan Muskuloskeletal pada Mahasiswa Kedokteran Universitas Jember di Masa Pandemi Covid-19 Muhammad Ihwan Narwanto; Syadza Salsabila; Pipiet Wulandari
Jurnal Ilmiah Kesehatan Vol 21 No 1 (2022): Jurnal Ilmiah Kesehatan terbitan Maret Volume 21 Nomor 01 Tahun 2022
Publisher : STIKIM Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33221/jikes.v21i1.1557

Abstract

Pandemi COVID-19 mengakibatkan terjadinya perubahan gaya hidup, terjadi penurunan tingkat aktivitas fisik dan peningkatan indeks massa tubuh. Diketahui bahwa aktivitas fisik dan indeks massa tubuh merupakan faktor resiko terjadinya gangguan muskuloskeletal. Perkuliahan daring menurunkan aktifitas fisik dan meningkatkan waktu duduk. Tujuan penelitian ini untuk mengetahui hubungan antara aktivitas fisik dan indeks massa tubuh dengan gangguan muskuloskeletal pada mahasiswa kedokteran Universitas Jember di masa pandemi COVID-19. Penelitian dengan metode cross sectional yang diikuti oleh 248 mahasiswa Fakultas Kedokteran Universitas Jember. Kuisiouner digunakan untuk menilai perubahan aktifitas fisik sebelum dan saat pandemi, aktifitas fisik dan indeks massa tubuh saat pandemi. Kuesioner dibagikan secara online pada 27 Maret - 12 April 2021. Data dianalisis menggunakan uji deskriptif dan uji chi square. Perubahan aktivitas fisik mahasiswa sebelum dan saat pandemi, yaitu 69,4% mengalami penurunan aktivitas fisik, 19,4% tetap, dan 11,3% mengalami kenaikan aktivitas fisik. Tingkat aktivitas fisik mahasiswa saat pandemi, yaitu 40,3% aktifitas fisik sedang, 33,9% aktifitas fisik rendah, dan 25,8% aktifitas fisik tinggi. Indeks massa tubuh mahasiswa, 61,7% normal, 14,5% gemuk berat, 10,5% kurus ringan, 9,7% gemuk ringan dan 3,6% kurus berat. Sebanyak 67,3% mahasiswa mengalami gangguan muskuloskeletal dengan lokasi terbanyak di pinggang (66,5%), punggung (60,5%), dan leher atas (58,7%). Dari uji chi-square diketahui bahwa terdapat hubungan signifikan antara tingkat aktivitas fisik dan perubahan aktivitas fisik sebelum dan saat pandemi dengan gangguan muskuloskeletal dengan nilai p=0,034 dan p=0,047, sedangkan hubungan antara indeks massa tubuh dengan gangguan muskuloskeletal tidak signifikan (p=0,766). Kesimpulan penelitian adalah aktivitas fisik mahasiswa kedokteran Universitas Jember di masa Pandemi Covid-19 berhubungan dengan terjadinya gangguan musculoskeletal, sedangkan tidak demikian untuk indeks massa tubuh.
Neurotoxicity of Chlorpyrifos, Carbofuran, and Cypermethrin in Adolescent Rats’ Brain Muhammad Ihwan Narwanto; Azham Purwandhono; Kristianningrum Sofiana; Zahrah Febianti; Elvia Rahmi Marga putri; Muhammad Afiful Jauhani
Majalah Kedokteran Bandung Vol 54, No 4 (2022)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v54n4.2749

Abstract

Chronic exposure to insecticides, even at low levels, has led to chronic neurotoxicity. Adolescent brain is still undergoing important developments, including in the hippocampus. This study investigated neurotoxicity effects of subacute exposure to chlorpyrifos, carbofuran and cypermethrin in the brain of adolescent rats. This study was performed at the Histology, Biochemistry, and Animal House Laboratory of Jember University from November to December 2021. Subjects were divided into five groups: normal, control, chlorpyrifos, carbofuran, and cypermethrin. Short-term memory was evaluated by Y maze test and tissue damage was evaluated by histological examination. Brain MDA levels were determined by thiobarbituric acid reactive substance method to evaluate the oxidative stress effect on the organ. This study showed spontaneous alternation in the Y maze test and the number of pyramidal neurons in hippocampus decreased in the cypermethrin group. There was a significant elevation of brain MDA level in carbofuran and cypermethrin groups. Thus, cypermethrin causes more severe neurotoxicity than carbofuran and chlorpyrifos. Improvements in the insecticide application management are urgently needed to prevent neurotoxicity.
Subchronic exposure to Chlorpyrifos, Carbofuran, and Cypermethrin increase sciatic nerve damage and degeneration in adolescent rats Muhammad Ihwan Narwanto; Muhammad Haikal Supriyadi; Desie Dwi Wisudanti
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 7, No 1 (2023): Qanun Medika Vol 07 No 01 January 2023
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v7i1.13666

Abstract

Several types of pesticides that are often used are chlorpyrifos (organophosphate), carbofuran (carbamate), and cypermethrin (pyrethroid).  Pesticides can kill pests but also can cause toxic effects on humans when exposed.  One of the adverse effects of pesticide exposure is a disturbance in the peripheral nervous system.  Age is an essential factor in peripheral nerve damage.  Nerve injury is one of the most common injuries in children and adolescents and is estimated at 10% to 15% of all exceptional unit cases.  However, the outcome of peripheral nerve injury is known better in subjects who sustain the injury at a younger age.  This study aims to determine the subchronic exposure effect of chlorpyrifos, carbofuran, and cypermethrin to sciatic nerve histopathology in juvenile rats.  This study used 30 male Wistar rats (Rattus norvegicus) which were divided into 5 groups, normal group (N), control group (K), chlorpyrifos group (P1), carbofuran group (P2) and cypermethrin group (P3).  Subcutaneous injection of pesticides was carried out for 21 days.  Rats were sacrificed using the cervical dislocation method, and the right sciatic nerve was taken for histopathological observation.  Assessment of the degree of ischiatic nerve histopathological damage is using the Jensen et al., (2018) method.  Data were analyzed using the Kruskal-Wallis test and continued with the Mann-Whitney test.  This study showed a significantly increased degree of histopathological damage in the chlorpyrifos group, carbofuran group, and cypermethrin group compared to the control group and the normal group (p<0.05).  It can be concluded that exposure to chlorpyrifos, carbofuran, and cypermethrin pesticides increased damage and degeneration of the ischiadicus nerve in juvenile rats.
Aluminum chloride impaired spatial memory, but not senile plaques formation in the rat model of Alzheimer’s disease Narwanto, Muhammad Ihwan; Rahayu, Masruroh; Soeharto, Setyawati; Nurdiana, Nurdiana
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 13, No 1 (2022)
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (366.4 KB) | DOI: 10.30659/sainsmed.v13i1.18102

Abstract

Aluminum compounds can be easily found in the environment. Aluminum contamination is the environmental factor as one of the risk factors for Alzheimer's disease (AD). In the animal model, aluminum chloride (AlCl3) induces inflammation and oxidative stress. Inflammation and oxidative stress are important pathogenesis pathways in the AD. This study was conducted to determine whether AlCl3 can impair spatial memory and induce senile plaques formation. A total of 24 young adult Wistar rats were used in this study. The rats were divided into four groups; one control group and three AlCl3 treated groups with doses of 150 mg/kg, 300 mg/kg, and 600 mg/kg, respectively for 8 weeks. The spatial memory test was measured using Morris water maze and the histopathology was done by identification of senile plaques formation in the hippocampal tissue. Statistical analysis was performed using one-way analysis of variance (ANOVA) followed by Tukey's test for multiple comparisons. The level of statistical significance was set at a p value < 0.05. This study showed that there are significant differences (p<0,05) between the control group and all the AlCl3 treatment groups in the memory test, however, there is no change in the senile plaque’s expression in all groups. Administration of AlCl3 for 8 weeks can cause the impaired of spatial memory without senile plaques formation.
Lokasi Lesi Sistem Saraf Pusat pada Pemeriksaan Magnetic Resonance Imaging Pasien Covid-19 dengan Stroke: Tinjauan Naratif Moh. Nur Indra Caesar; Muhammad Ihwan Narwanto; Jauhar Firdaus
Jember Medical Journal Vol. 1 No. 1 (2022)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (565.169 KB) | DOI: 10.19184/jmj.v1i1.198

Abstract

Stroke dengan infeksi SARS-CoV-2 merupakan komplikasi penyakit yang serius. Fakta menunjukkan bahwa stroke memiliki persentase kematian sebesar 49%, sehingga stroke dengan infeksi SARS-CoV-2 memiliki risiko kematian yang lebih tinggi dengan manifestasi penyakit yang lebih parah. Tujuan dari penelitian ini adalah untuk mengetahui lokasi pemeriksaan lesi pasien stroke dengan COVID-19 menggunakan Magnitude Resonance Imaging (MRI). Metode penelitian yang digunakan adalah penelitian deskriptif analitik dengan menggunakan tinjauan literatur. Sumber data pada penelitian tinjauan literatur ini diambil dari artikel penelitian nasional dan internasional dengan menggunakan basis data PubMed, Science Direct, Cochrane Library, dan Portal Garuda. Hasil dari penelitian ini didapatkan 24 artikel yang memenuhi kriteria inklusi sebagai sampel. Data yang diekstraksi menunjukkan bahwa lokasi anatomi lesi sistem saraf pusat pada pasien stroke dengan infeksi SARS-CoV-2 yaitu pada cerebrum, cerebellum dan ganglia basalis. Lokasi lesi pada otak besar paling sering ditemukan di lobus frontal dan parietal, diikuti oleh lobus temporal. Dari penelitian ini dengan menggunakan metode tinjauan literatur didapatkan gambaran lesi hiperintensitas melalui pemeriksaan MRI dengan berbagai lokasi lesi mulai dari lobus frontalis, parietalis, temporalis, occipitalis, insula, dan basal ganglia, serta cerebellum. Munculnya lesi pada pasien stroke dengan COVID diduga akibat hiperkoagulabilitas yang menyebabkan tromboemboli dan pada pemeriksaan MRI tampak adanya gambaran lesi hiperintensitas.
Co-Authors Azham Purwandhono Chikita R Hanifati Cholis Abrori, Cholis Desie Dwi Wisudanti Elvia Rahmi Marga putri Jauhar Firdaus K Dian Sofiana Kristianningrum Dian Sofiana Kristianningrum Sofiana Masruroh Rahayu Masruroh Rahayu, Masruroh Moch. Aris Widodo Moh. Nur Indra Caesar Muhammad Afiful Jauhani Muhammad Haikal Supriyadi Natasha Amelia Nurdiana Nurdiana Nurdiana Nurdiana Pipiet Wulandari Prasetia Aji Ramadhan Setyawati Soeharto Setyawati Soeharto, Setyawati Shera Nadhila Setyo Bisono Siti Jamalia Syadza Salsabila Yuli Hermansyah Zahrah Febianti