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All Journal Jurnal Surya Medika BIOEDUSCIENCE Al-Tamimi Kesmas: Jurnal Ilmu Kesehatan Masyarakat (Journal of Public Health Sciences) Jurnal Pengabdian Al-Ikhlas Journal of Engineering, Technology, and Applied Science (JETAS) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Dinamika Kesehatan: Jurnal Kebidanan dan Keperawatan Journal of Pharmaceutical Care and Sciences Bioscientiae, Jurnal ilmu ilmu Biologi Jurnal Rumpun Ilmu Kesehatan Innovative: Journal Of Social Science Research Sains Medisina Jurnal Farmasi SYIFA
Putri Vidiasari Darsono
Universitas Sari Mulia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : Jurnal Surya Medika

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Optimasi Formulasi Tablet Lepas Lambat Ekstrak Seledri (Apium graveolens L.) Menggunakan Polimer Xanthan Gum dan Lubrikan Magnesium Stearat dengan Metode Simplex Lattice Design (SLD): Optimization of Celery Extract (Apium graveolens L.) Sustained Release Tablet Formulation Using Xanthan Gum Polymer and Magnesium Stearate Lubricant with Simplex Lattice Design (SLD) Method Nur Azizah; Noval Noval; Putri Vidiasari Sudarsono
Jurnal Surya Medika (JSM) Vol. 9 No. 1 (2023): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v9i1.5165

Abstract

Antihypertensive drugs undergo first-pass metabolism and therefore have low oral bioavailability. It causes an increase in the frequency of drug use and concentration fluctuations that affect patient comfort. The sustained release tablet formulation was chosen because it can deliver the active substance with good bioavailability. An active antihypertensive substance that can be used is celery extract because it contains flavonoids, so a sustained release tablet formulation was made using xanthan gum and magnesium stearate to produce a constant and controlled release rate. This study aims to knowing the results of celery extract sustained release tablet evaluation using different concentrations of xanthan gum and magnesium stearate, and also obtains the optimal formulation. The manufacture of tablets uses the direct compression method. Powder evaluations include flow property through a funnel, angle of repose, compressibility index, and moisture content. Tablet evaluations include organoleptic, weight uniformity, size uniformity, hardness, friability, disintegration time, and dissolution tests. The evaluation results data were analyzed using Simplex Lattice Design. The powder evaluation result of all formulations meets the requirements of flow property through a funnel, angle of repose, compressibility index, and moisture content. Physical evaluation of the tablets shows all formulations meet the requirement of weight uniformity, hardness, and friability tests. On the size uniformity test, all formulations do not meet the requirement. The disintegration time test results show that F1 does not meet the requirement. Meanwhile, the dissolution test results show that F4 is the best formula because it shows constant and controlled release rate. Based on analyzed using Simplex Lattice Design, the F4 is the most optimal formula with xanthan gum 52 mg and magnesium stearate 3 mg.
Co-Authors Adriana Palimbo Alghafiqy Harya Evan Maulana Ali Rakhman Hakim Anggrita Sari Astuti Rizki Perdana Aulia Rahmah Triastanti Dede Mahdiyah Dede Mahdiyah Dewi Pusparani Sinambela Dewi Pusparani Sinambela Dyan Fitri Nugraha EKA RIA SAFITRI Estyqomah Estyqomah Fahrianti Fahrianti Fajriannor.TM, M. Fauzi Nurdin Hamidah Rasyida Hesty Wulandari I Ketut Purnama Putra Istiqamah Istiqamah Kunti Nastiti Lisnawati Lisnawati Mahdalena Mahdalena Mariatul Janah Melviani Melviani Melviani Melviani Mia Audina Mohamad Rafi Muti’ah Noval Noval Novalia Widiya Ningrum Novita Novita Nur Azizah Nur Syifa Rina Al Kahfi Rina Saputri Risky Amelia Rohama Rohama Rohama Rohama Romi Satria Saftia Aryzki Saftia Aryzki Sismeri Dona Siti Malahayati Siti Rahmawati Suwarni Suwarni Yulia Puteri Rahmida