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All Journal Jurnal Kedokteran Brawijaya JAM : Jurnal Aplikasi Manajemen JMMR (Jurnal Medicoeticolegal dan Manajemen Rumah Sakit) MNJ (Malang Neurology Journal) Majalah Kesehatan FKUB Perspektif : Jurnal Ekonomi dan Manajemen Universitas Bina Sarana Informatika Jurnal Respirologi Indonesia Respiratory Science BKM Public Health and Community Medicine JMMR (Jurnal Medicoeticolegal dan Manajemen Rumah Sakit)

Harun Al Rasyid

Faculty Of Medicine, University Of Brawijaya, Malang, East Java

Author-ID : 358171

Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Environmental Science Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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EKSPRESI BCL-2 PADA NEOPLASMA EPITELIAL OVARIUM JINAK, BORDERLINE, DAN GANAS SERTA KORELASINYA DENGAN DERAJAT HISTOPATOLOGIK Dewi, Rose Khasana; Hardika, Arif Satria; Retnani, Diah Prabawati; Rasyid, Harun Al
Majalah Kesehatan FKUB Vol 7, No 1 (2020): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Neoplasma epitelial ovarium diklasifikasikan menjadi 3 kategori yaitu jinak, borderline, dan ganas. Neoplasma ganas ovarium termasuk dalam sepuluh besar penyebab kematian tersering akibat kanker pada perempuan di dunia. Penentuan kategori neoplasma ovarium kadang masih menjadi masalah karena dipengaruhi oleh beberapa faktor, termasuk proliferasi dan apoptosis sel serta invasi stroma. Bcl-2 (B-cell lymphoma 2) merupakan salah satu protein prosurvival yang berfungsi sebagai antiapoptosis dan cukup berperan dalam perkembangan neoplasma. Tujuan penelitian ini adalah untuk mengetahui perbedaan eks-presi Bcl-2 pada neoplasma epitelial ovarium jinak, borderline, ganas serta untuk mengungkap hubungan ekspresi Bcl-2 dengan derajat histopatologik pada neoplasma ganas. Penelitian ini merupakan penelitian analitik cross-sectional. Sampel penelitian berupa 35 blok parafin kasus neoplasma ovarium serosum dan musinosum (13 jinak, 8 borderline, 14 ganas) di RSUD Dr. Saiful Anwar Malang periode 2016-2017. Kelompok neoplasma ganas terdiri dari masing-masing 5 kasus derajat 1 dan 3 (35,7%) serta 4 kasus derajat 2 (28,6%). Perbedaan ekspresi pulasan imunohistokimia Bcl-2 antara neoplasma jinak, borderline, dan ganas dianalisis menggunakan uji Kruskal-Wallis, sedangkan korelasinya dengan derajat histopatologik dianalisis menggunakan uji korelasi Spearman. Hasil penelitian menunjukkan ekspresi Bcl-2 tidak berbeda signifikan antara neoplasma jinak, borderline, dan ganas (p = 0,159). Bcl-2 pada neoplasma ganas menunjukkan eks-presi yang semakin rendah dengan meningkatnya derajat histopatologik (p = 0,021 dan r = -0,608). Ke-simpulannya, tidak terdapat perbedaan ekspresi Bcl-2 yang signifikan antara neoplasma epitelial ovarium jinak, borderline, dan ganas. Ekspresi Bcl-2 berkorelasi negatif yang kuat dengan derajat histopatologik pada neoplasma ganas.Â

PERBEDAAN EKSPRESI PROTEIN CYCLIN D1 ANTARA ADENOMA DAN ADENOKARSINOMA KOLOREKTAL, SERTA KORELASINYA DENGAN GRADING DAN STADIUM TUMOR Rosidah, Aris; Norahmawati, Eviana; Anita, Kenty Wantri; Rasyid, Harun Al
Majalah Kesehatan FKUB Vol 7, No 3 (2020): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.majalahkesehatan.2020.007.03.1

Sebagian besar karsinoma kolorektal adalah adenokarsinoma, dan lebih dari 95% karsinoma kolorektal diawali oleh lesi prekursor yaitu adenoma. Risiko suatu adenoma berubah menjadi suatu karsinoma akan lebih tinggi pada adenoma dengan ukuran lebih dari 1 cm, tipe villous, dan disertai displasia high grade. Telah diketahui bahwa grading dan stadium merupakan faktor prognostik penting baik pada adenoma maupun adenokarsinoma. Perkembangan adenoma menjadi adenokarsinoma melibatkan peran banyak gen dan protein, salah satunya cyclin D1 yang berperan meningkatkan proliferasi sel, angiogenesis dan invasi sel. Penelitian ini bertujuan untuk mengetahui perbedaan ekspresi cyclin D1 antara adenoma dan adenokarsinoma kolorektal, serta hubungannya dengan grading dan stadium tumor. Lalu, ditentukan 30 sampel untuk masing-masing adenoma dan adenokarsinoma yang diambil dari Instalasi Patologi Anatomi RS. dr. Saiful Anwar Malang. Keseluruhan sampel dilakukan pulasan imunohistokimia dengan antibodi cyclin D1 kemudian dihitung persentase ekspresinya, dan dianalisis hubungan antara cyclin D1 tersebut dengan grading pada adenoma dan grading serta stadium pada adenokarsinoma. Hasil penelitian menunjukkan terdapat perbedaan ekspresi cyclin D1 yang bermaknaÂ antara kelompok adenoma dan adenokarsinoma dengan p < 0,01. Tidak terdapat hubungan yang bermakna antara ekspresi cyclin D1 dengan grading adenoma serta grading dan stadium adenokarsinoma (p > 0,05). Kesimpulan penelitian ini adalah ekspresi cyclin D1 dapat digunakan untuk membedakan antara adenoma dan adenokarsinoma, tetapi ekspresi tersebut tidak berhubungan dengan grading dan stadium tumor.Â

HUBUNGAN EKSPRESI HER2 DENGAN UKURAN TUMOR DAN INVASI KAPSULAR PAPILLARY THYROID CARCINOMA (PTC) Pinahayu, Griesinta Trianty Andria; Retnani, Diah Prabawati; Anita, Kenty Wantri; Rasyid, Harun Al; Susilo, Hery
Majalah Kesehatan FKUB Vol 8, No 1 (2021): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.majalahkesehatan.2021.008.01.3

Papillary thyroid carcinoma (PTC) merupakan karsinoma tersering pada tiroid yang secara klinis dapat menyerupai lesi jinak. PTC subtipe ocult tidak jarang ditemukan bermetastase pada kelenjar getah beningÂ (KGB) atau organ lain. Faktor prognosis pada pasien PTC ditentukan oleh subtipe histologi, ukuran tumor, usia, jenis kelamin, metastase dan invasi kapsular, dengan angka kekambuhan cukup tinggi, yaitu 20%.Â Human Epidermal Growth Factor Receptor 2 (HER2) adalah anggota Epithelial Growth Factor Receptor (EGFR), yang menunjukkan ekspresi kuat pada keganasan sel epitel manusia. Penelitian ini bertujuan untuk melihat hubungan ekspresi HER2 dengan ukuran tumor dan invasi kapsular PTC. Pemeriksaan histopatologi dan imunohistokimia HER2 dilakukan pada 54 sampel, 27 dengan invasi kapsular dan 27 tanpa invasi kapsular, kemudian diukur besar tumor, interpretasi ekspresi HER2, lalu ditabulasi dan dianalisis hubungan ekspresi HER2 dengan ukuran tumor dan invasi kapsular PTC. Ekspresi HER2 pada penelitian ini didapatkan pada 10 sampel HER2 skor 3+,Â 22 sampel skor 2+, 14 sampel skor 1+, danÂ 8 sampel skor 0. Hubungan antara ekspresi HER2 dengan invasi kapsular PTC, dianalisis dengan Mann Whitney test, didapatkan hasil bermakna (p = 0,002). Dengan uji korelasi Spearman, didapatkan korelasi lemah terbalik (koefisien korelasi -.299) tapi bermakna (p = 0,028) antara ekspresi HER2 dengan ukuran tumor PTC. Terdapat hubungan ekspresi HER2 dengan invasi kapsular, dan hubungan lemah berbanding terbalik antara ekspresi HER2 dengan ukuran tumor yaitu semakin besar ukuran tumor semakin rendah skor HER2 dan sebaliknya.Â

BRAND AWARENESS INFLUENCES BEHAVIOR TEJA MEMBERS MEMBER CLUB (TMC) ON THE SELECTION OF MEDICAL SERVICES IN HOSPITALS Fahmy Rezkiah; Tita Hariyanti; Harun Al Rasyid
Jurnal Aplikasi Manajemen Vol 15, No 1 (2017)
Publisher : Jurusan Manajemen Fakultas Ekonomi dan Bisnis Universitas Brawijaya

Marketing is an effort of the hospital to get and keep the customers. This study aimed to know the influence of brand (brand image and brand awareness), social factors and personal factors to the behavior of Teja Member Club (TMC) on choosing the health services in Teja Husada Hospital. This research categorized as explanatory research with cross sectional approach. This research involved 62 members of TMC. Questionnaires about brand image, brand awareness, social factors and personal factors as well as the behavior of members of TMC on choosing the health services in Teja Husada Hospital were used. The data analysis used linear regression test with White’s Robust Standard Error. The results found all independent variables influence simultaneously to the behavior of members of TMC on choosing the health services in Teja Husada Hospital and brand awareness is the dominant variable. Partial test results indicate that only brand awareness that has an influence on the behavior of respondents on choosing the health services in Teja Husada Hospital.

CONSUMER’S CONSIDERATION IN CHOOSING A HOSPITAL sri retnaningtyas; Tita Hariyanti; Harun Al Rasyid
Jurnal Aplikasi Manajemen Vol 15, No 3 (2017)
Publisher : Jurusan Manajemen Fakultas Ekonomi dan Bisnis Universitas Brawijaya

The purpose of the research is to find out the consumers’ consideration in choosing a hospital. The researcher utilizes the approach by measuring the impact of motivation, reference group, and marketing mix toward consumers’ decision to choose An-Nisaa’ hospital. The research is a quantitative by applying cross sectional study. Then, the researcher needs for about two months to take 70 respondents, which are taken from outpatients of polyclinic and An-Nisaa’ Hospital by utilizing questionnaire as a research instrument. By the research, the researcher applies independent and dependent variables. The independent variable consists of motivation, reference group, and marketing mix. The dependent variable consists of consumers’ decision to choose An Nisaa Hospital. The data analysis applies doubled linear analysis by using SPSS program. The result of the research shows that there is a simultaneous effect of motivation, reference group, and marketing mixed toward consumers’ decision in choosing An-Nisaa’ Hospital. Marketing mixed has a dominant influence. However, motivation partially has no effect toward consumers’ decision in choosing An-Nisaa’ Hospital.

Pengaruh Motivasi Kerja terhadap Kinerja Dokter dalam Kelengkapan Pengisian Rekam Medis dengan di Moderasi Karakteristik Individu (Studi di Rumah Sakit Islam Unisma Malang) Cicilia Lihawa; . Noermijati; Harun Al Rasyid
Jurnal Aplikasi Manajemen Vol 14, No 2 (2016)
Publisher : Jurusan Manajemen Fakultas Ekonomi dan Bisnis Universitas Brawijaya

Abstract: One of the parameters for determining the quality of health services in hospitals is the information documented in a good and complete medical record (MR). Medical record completion by a physician within 24 hours is a standard quality of care in UNISMA Islamic Hospital Malang. One of these indicators that has not yet been achieved is the 24 hours postadmission MR completion rate of 50% from the 100% standard. This study aims todetermine the impact of work motivation on physician performance in completing MR, moderated by the individual characteristics (gender, age and tenure). This study is an observational researchusing cross sectional approach, involving 45 physicians as respondents. Data were collected using questionnaires and MR completion checklists, with five medical records assigned to each respondent, and were analyzed using linear regression test. The results showedthat gender, age, and years of service do not moderate the impact of work motivation on physician performance in completing MR (p ≥ 0,05). This suggests that the management team does not need to consider individual characteristics in an effort to improve the physi- cian performance in completing MR through increased motivation.

Pemberian Media Photonovela Meningkatkan Pemahaman Isi Informed Consent Pada Pasien Sectio Caesaria di RSIA HST Trenggalek Dewangga Primananda Susanto; Harun Al Rasyid; Lukman Hakim
JMMR (Jurnal Medicoeticolegal dan Manajemen Rumah Sakit) Vol 6, No 2 (2017): August
Publisher : Universitas Muhammadiyah Yogyakarta in Clollaboration with ADMMIRASI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jmmr.6132

The aim of this research is to know the effect of traditional comic strip photo novella media on the level of informed understanding of patient of Sectio Caesarea (SC). This research is a quasi-experimental research by dividing the research subjects into two groups namely the treatment group (given photo novella) and control (not given photo novella) each of 30 people in RSIA HST Trenggalek hospital. This study found that group understanding received significantly higher media in terms of explanation of indications, procedures, objectives, alternatives, risks, complications and SC costs compared to patients without photo novella media. There were no significant differences in terms of explanation of action names and SC prognosis in both groups

Differences in the Expression of miRNA-126 and Interleukin (IL)-13 in Fully Controlled and Not Fully Controlled Asthma Patients Yulia Kartina; Susanthy Djajalaksana; Iin Noor Chozin; Harun Al Rasyid
Jurnal Respirologi Indonesia Vol 40, No 1 (2020)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i2.99

Backgrounds: Important finding in the last decades in the field of biology and medicine are micro-RNA (miRNA), including miRNA-126 that are involved in the regulation of interleukin-13 (IL-13) and the T helper 2 cell (Th2) response, the key components of the asthmatic response. The aim of this study is to find the difference in the expression of miRNA-126 and IL-13 serum in fully controlled and not fully controlled groups of stable asthma patients and analyze the relationship between them. Methods: Case-control studies was conducted in 36 stable asthma patients who visited pulmonary outpatient clinic Saiful Anwar Hospital from September 2018 to March 2019. Subjects were divided into 2 groups, each group consisted of 18 fully controlled asthma and 18 not fully controlled asthma patients. The expression of miRNA-126 was measured by the quantitative polymerase chain reaction (q-PCR) and IL-13 using the enzyme-linked immunosorbent assay (ELISA) method. Results: The expression of miRNA-126 was higher in the control group (3.499±2.99) than case group (2.719±2.73), but the difference was not significant (P=0.273). The IL-13 levels were higher in the case group (17.285±9.37) than control group (11.681±5.22), and the difference was significant (P=0.009). However, there was no relationship between the expression of miRNA-126 and IL-13 levels in both groups. Conclusions: There were differences in IL-13 levels, but there were no differences in the expression of miRNA-126 in the two groups. There was no relationship between miRNA-126 expression and IL-13 levels in both groups. (J Respir Indo. 2020; 40(1): 24-32)

The Effect of Pulmonary Rehabilitation on The Duration of Antibiotic Switches, IL-10 Levels and PEFR Values in Hospitalized Community Pneumonia Patients Mariyatul Khiptiyah; Iin Noor Chozin; Suryanti Dwi Pratiwi; Rahmad Rahmad; Harun Al Rasyid
Jurnal Respirologi Indonesia Vol 40, No 4 (2020)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i4.129

Background: Pneumonia is an acute inflammation of the lung parenchyma and ranked third of 30 causes of death in the world. WHO estimates the death caused by pneumonia is 1.6 million per year. Long duration of antibiotic switches is associated with increased morbidity, nosocomial infections and costs of healthcare. This study aims to assess the effect of pulmonary rehabilitation with the duration of antibiotic switches and interleukin-10 (IL-10) levels of pneumonia patients in non-intensive care thus pulmonary rehabilitation can be routinely use as adjuvant therapy. Methods: The study was conducted in May-November 2019 at Saiful Anwar Hospital Malang, with 40 pneumonia patients in the non-intensive care and divided in two groups which contains of 20 patients. This study uses consecutive simple random sampling. In treatment group, pulmonary rehabilitation consists of breathing exercise, effective cough techniques, clapping, postural drainage and breathing muscle exercises with spirometry incentive tools. The pulmonary rehabilitation treatment was done by Medical Rehabilitation Department of Saiful Anwar Malang Hospital. IL-10 levels and PEFR values on the zero and fifth days of treatment were measured. Results: The duration of antibiotic switches received pulmonary rehabilitation was shorter 5.05 days (P

The Effect of Ophiocephalus Striatus Extract on suPAR, Neutrophil Levels and Lung Diffusion Capacity (DLCO) in Stable Chronic Obstructive Pulmonary Disease (COPD) Patients with Muscle Wasting Sasongko Adhi Nugroho; Teguh Rahayu Sartono; Susanthy Djajalaksana; Harun Al Rasyid
Jurnal Respirologi Indonesia Vol 39, No 2 (2019)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v39i2.56

Background: Muscle wasting is one of the extrapulmonary manifestation which influence quality of life in Chronic Obstructive Pulmonary Disease (COPD) patients. It caused by imbalance of protein metabolism in skeletal muscle. This study aimed to evaluate the effect of Ophiocephalus striatus extract on neutrophil count, soluble urokinase-type plasminogen activator (suPAR) level, diffusion capacity of lung for carbon monoxide (DLCO) and quality of life in stable COPD patients with muscle wasting. Methods: Clinical pre and post quasi experimental study was conducted to 32 stable muscle-wasted COPD patients from Pulmonary Outpatient Clinic Saiful Anwar Hospital Malang, determined by The Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2016, Bioelectrical impedance analysis (BIA) dengan fat-free mass (FFM)

Co-Authors . Noermijati agus tri indah, agus tri Anisa Ramadhani Kusumastiti Annisa Nurul Arofah, Annisa Nurul Aris Rosidah Armanu Thoyib Asih Trimurtini Badrul Munir, Badrul Cicilia Lihawa Dewangga Primananda Susanto Dewi, Rose Khasana Eky Indyanty Wuryaning Lestari Eviana Norahmawati Fahmy Rezkiah Fiella Rachmatika Gede Sasmika Suwandi Hakim, Lukman Hardika, Arif Satria Iin Noor Chozin Indah K, Agus Tri Kenty Wantri Anita, Kenty Wantri Kusumastiti, Anisa Ramadhani Lilik Zuhriyah Lukman Hakim lumban gaol, andy Machlusil Husna, Machlusil Mariyatul Khiptiyah Masruroh Rahayu, Masruroh Nadiya Elfira Bilqis, Nadiya Elfira Ngakan Putu Parsama Putra Pinahayu, Griesinta Trianty Andria Prabowo, Edwin Damar Pratiwi, Suryanti Dwi Putra, Ngakan Putu Rahmad Rahmad Retnani, Diah Prabawati Riskawati, Yhusi Karina Rizky Rosita, Rizky Santony Santony Sasongko Adhi Nugroho Shahdevi Nandar Kurniawan, Shahdevi Nandar Siahaan, Sylvia Sagita Sri Budhi Rianawati, Sri Budhi sri retnaningtyas Sugiri, Yani Jane Suryanti Dwi Pratiwi Susanthy Djajalaksana Susanthy Djajalaksana Susanto, Dewangga Primananda Susilo, Hery Tae, Vidria Handayani Teguh Rahayu Sartono Teguh Rahayu Sartono Tita Hariyanti Tita Hariyanti Tita Hariyanti Tita Hariyanti Tri Wahju Astuti Yani Jane Sugiri Yulia Kartina

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