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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Media Kesehatan Masyarakat Indonesia Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Kesehatan Masyarakat Indonesian Journal of Cancer Chemoprevention Journal of Biomedicine and Translational Research Universa Medicina Biosaintifika: Journal of Biology & Biology Education YARSI Medical Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Medica Hospitalia Journal of Telenursing (JOTING) Diponegoro International Medical Journal (DIMJ) Bioscientia Medicina : Journal of Biomedicine and Translational Research Life Science JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Neni Susilaningsih
Anatomy Histology Department, Faculty Of Medicine, Diponegoro University, Semarang, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : Sainsmedika

 1 
Acute Toxicity Test of Soursop Leaves (Annona muricata) on Liver and Kidney of Switzerland Mice Utomo, Astika Widy; Susilaningsih, Neni; Armalina, Desy
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 6, No 2 (2015): July-December 2015
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (682.764 KB) | DOI: 10.30659/sainsmed.v6i2.600

Abstract

Introduction: The soursoup leaves extract (Annona muricata) has widely been used as traditional medicine for cancer. No studies have been conduct to investigate the safety of the extract. Objectives: The purpose of the study was to investigate the acute oral toxicity test of soursoup leaves extract (Annona muricata) on Swiss mice’s liver and kidney.Methods: Twenty four mice were divided into 4 groups. Group I was control group, while group II-IV was given soursoup leaves extract as single dose orally via sonde. The mice were obsereved until day 7 to determine the LD50 and at the end were terminated to collect the liver and kidney. The organs later were made into histopathology slides. The slides read with light microscope. The data analyzed with ANOVA and was considered significant at p<0.05.Results: All mice were alive during the 7 days observation and no mice showing the toxic spectrum after the dosing. Microscopically, no damage on the liver and kidney organ among the groups.Conclusion: The LD50 of soursoup leaves extract is more than 2000 mg/kgBW. This result indicate that the extract is practically non toxic and do not damage the liver and kidney.
The Effect of Honey in Second Degree Burn Healing on Wistar Rats (Overview of Angiogenesis and the Number of Fibroblasts) Almaz, Ayyasi Izaz; Purnawati, Ratna Dama; Istiadi, Hermawan; susilaningsih, Neni
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 11, No 1 (2020): January - June 2020
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1120.434 KB) | DOI: 10.30659/sainsmed.v11i1.7614

Abstract

Introduction: Burn therapy is generally done using a burn ointment. However, honey can also be used as an alternative treatment for burns. Honey contains active flavonoid as an antioxidant and hydrogen peroxide which can stimulate fibroblasts proliferation also angiogenesis on burn healing phase.Objective: to determine the effect of honey in second degree burn healing from angiogenesis and the number of fibroblasts on Wistar rats. Methods: This research used a posttest only controlled group design on 15 rats with random selection and divided into 3 groups: H-G was given honey, B-G was given Bioplacenton®, N-G without any treatment after burn was induced. Rats were given a second degree burn in a size of 2 cm x 2cm on the back area and were treated twice a day for 14 days. Burn healing was measured by calculating the observation results of microscopic VEGF expression, the number of neovascularization, and the number of fibroblasts. Hypothesis analysis used Annova post hoc LSD and Mann-Whitney.Results: The highest mean in VEGF expression and the number of neovascularization was obtained from group B-G followed by group H-G and group N-G. Significant differences in the number of neovascularization between group B-G with group N-G, p<0.05.Conclusion: Honey can provide a healing effect on the second degree of burns in Wistar rats in terms of the number of neovascularization as well as Bioplacenton®
Co-Authors Abu Azhar Aditya Purnama Agnes Stella Valentina Akhmad Ismail Almaz, Ayyasi Izaz Asri, Hairul Astika Widy Utomo, Astika Widy Awal Prasetyo Bambang Joni Karjono Bambang Witjahjo Bambang Witjahjo Bernadus Parish Budiono Catharina Suharti Damma Purnawati, Ratna Desy Armalina Dimarti, Safira Chairani Dwi Marliyawati Elvira Yunita Eriawan Agung Nugroho Eriawan Agung Nugroho Eva Annisa Fahmi Syarif Fanti Saktini Fidela Hanan Zivana Hardian Hardian Hermawan Istiadi Ignatius Riwanto, Ignatius Indah Saraswati Joni Karjono, Bambang Kanti Yunika Maria Eka Patri Yulianti Mario Sadar Bernitho Hutagalung Meiny Suzery Najatullah Najatullah Nani Maharani Nauval Marta Kusuma Parish Budiono Purnawati, Ratna Dama Putri, Ajeng Kurniasari Rahajeng, Herera Ratna Damma Purnamawati Ratna Damma Purnawati Renni Yuniati Sigit Adi Prasetyo Sri Susilowati Susilowati Suhartono, Suhartono Supandi Andy Trilaksana Nugroho Udadi Sadhana, Udadi Wahyu Haris Prabowo Yan Wisnu Prajoko Yuriz Bakhtiar Zhafran Hafizhki