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All Journal Research Journal of Life Science UNEJ e-Proceeding JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat JCRS (Journal of Community Research and Service) Jurnal Pengabdian Masyarakat Asia Pharmaceutical Sciences and Research (PSR)

Tutiek Purwanti

Department Of Pharmaceutical Sciences, Faculty Of Pharmacy, Universitas Airlangga, Surabaya, Indonesia

Author-ID : 406998

Agriculture, Biological Sciences & Forestry Arts Humanities Chemistry Computer Science & IT Economics, Econometrics & Finance Education Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Social Sciences Other

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Articles

PENDIDIKAN KOGNITIF DAN AFEKTIF DAGUSIBU UNTUK PENCEGAHAN RESISTENSI ANTIBIOTIK DI SMA SURABAYA Abhimata Paramanandana; Dini Retnowati; Andang Miatmoko; Dewi Isadiartuti; Sugiyartono1; Mohammad Agus Sjamsur Rijal; Dwi Setiawan; Esti Hendradi; Tutiek Purwanti; Noorma Rosita; Dewi Melani Hariyadi; Tristiana Erawati; Ardhani Dwi Lestari1; Helmy Yusuf; Retno Sari
ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat Vol. 4 No. 1 (2019): ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat
Publisher : Talenta Publisher

Antibiotics are not only used for humans, but also often used for cattle and livestock which are then been consumed by humans. This over prescribed and missed used of antibiotic is a major factor in antibiotic resistance. Antibiotic resistance is a condition where bacteria are unable to be treated with antibiotics. In fact, the use of antibiotics is the first response in curing infectious diseases (by bacteria) and preventing infectious diseases spreading. With antibiotic resistance, preventing infectious diseases by bacteria became harder. This community service activity came up with a slogan "Antibiotic Resistence Awareness Movement" was carried out in Surabaya 10 Public High Schools and Surabaya 17 Public High Schools with 60 students per school using several methods, namely: (a) giving lecture material using LCD projectors ) the implementation of poster making competitions, and (c) poster presentations that have been made that are accompanied by question and answer, and (d) evaluation activities in the form of written tests covering pre-test and post-test. Concerning the results of posters results, poster presentations and improving the results of this posttest can be concluded as a result of an increase in understanding and or knowledge of students of SMA 10 and SMA 17 Surabaya

EFFECT OF COMBINATION SODIUM ALGINATE-GELATIN 1% : 2% CONTENT IN CHARACTERISTIC AND ANTIMICROBIAL ACTIVITY OF PROBIOTIC MICROSPHERES Lactobacillus acidophilus Regia Nada Asshafa; Tutiek Purwanti; Dewi Melani Hariyadi
UNEJ e-Proceeding Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UPT Penerbitan Universitas Jember

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Probiotics is live micro-organisms which whenadministered in adequate amounts, confer ahealth benefit on the host (FAO / WHO, 2002).Probiotics may give therapeutic effect in minimalamounts 106-107cfu/g daily. Some reports in thelast decade have described that probiotic, such asLactobacillus acidophilus, is useful for treating skindisorder such as dermatitis, acne, cellulitis, andpsoriasis. This relates to the content of probioticsmetabolites that protect the skin from mostpathogenic bacteria, such as Staphylococcusaureus, and improve skin structure (Cinque et al.,2011).In topical application, the active ingredient shouldlast a long time on the skin and prolonged release.Meanwhile, Lactobacillus acidophilus unstable toenvirontment factors, such as the hightemperature, oxygen, and humidity (Al-Hurr,2011). Therefore, probiotics encapsulation isneeded. In addition, encapsulation also mayprovide prolonged release so that its effectivenessincreased as antimicrobial activity becomes longer.Encapsulation process that forms microparticles (1-1000 μm) called micro-encapsulation. Sphericalmicroparticles called microspheres (Sahil et al.,2011). The recommended size of microsphereswhich active ingredient site action is in epidermislayer is 5-300 μm (Chadawar and Shaji, 2007).Sodium alginate is widely used as a matrix ofmicroencapsulated probiotics. Microspheres madewith sodium alginate matrix may improve theviability of probiotics during storage. Gelatin alsooften used in microencapsulated probiotics(Solanki et al., 2013). Gelatin is biodegradable,non-toxic, and easy to experience a cross-linking sothat it can be used in the preparation of colloidaldelivery systems, such as microspheres andnanoparticles (Sailaja, et al., 2010).Type of matrix influence the characteristic ofmicrosphere. Microspheres are only made withsodium alginate tend to provide simultaneousrelease. Therefore for prolonged release, sodiumalginate should be combined with gelatin (Lee etal., 2014; Roy et al., 2009). Combination of sodiumalginate and gelatine in the ratio 1: 2 will providesmall particle size that not easily aggregate duringthe process of mixing and drying (Lee et al., 2014).In this study, microspheres were formed by crosslinking between combination of sodium alginateand gelatin (1% : 2%) with CaCl2 as cross linkerusing ionotropic gelation method.OBJECTIVEThe aim of this research was to investigaste theeffect of combination of sodium alginate andgelatin (1% : 2%) content in characteristics andantimicrobial activity of probiotic microspheresLactobacillus acidophilus.

Pengaruh Matriks Kombinasi Alginat:Gelatin (2%:1%) terhadap Karakteristik dan Aktivitas Antibakteri Mikrosfer Probiotik Lactobacillus acidophilus Tutiek Purwanti; Ria Puspita; Tristiana Erawati
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 6 No. 1 (2019): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Pendahuluan: Mikrosfer adalah salah satu sistem penghantaran obat yang dapat digunakan untuk menghantarkan obat pada pemakaian secara oral maupun topikal. Efektivitas mikrosfer sebagai sistem penghantar obat antara lain dipengaruhi oleh polimer penyusun matriknya. Tujuan: Tujuan dari penelitian ini untuk mengetahui pengaruh matrik natrium alginate 2% : gelatin 1% terhadap karakteristik mikrosfer probiotik yaitu ukuran, efisiensi penjebakan, dan aktivitas antibakteri yaitu diameter zona hambatnya. Metode: Dibuat mikrosfer probiotik dengan matriks berbeda yaitu kombinasi alginate:gelatin (2%:1%) (F-I), matriks alginat 3% (F-II) dan matriks gelatin 3% (F-III). Mikrosfer probiotik dibuat dengan teknik ekstrusi dan dikeringkan menggunakan oven. Hasil: Hasil pemeriksaan karakteristik menunjukkan bahwa rerata ukuran partikel F-I, F-II, dan F-III berturut-turut adalah 8,03 µm, 9,69 µm, dan 5,40 µm. Efisiensi penjebakan F-I, F-II, dan F-III berturut-turut adalah 77,48 %, 84,20 %, dan 87,93 %. Sedangkan hasil uji aktivitas antibakteri, diperoleh diameter zona hambat F-I, F-II, dan F-III berturut-turut adalah 11,72 ± 0,58 mm , 9,8 ± 0,57 mm, dan 9,27, ± 0,19 mm. Hasil uji statistik dengan metode ANOVA yang dilanjutkan uji HSD menunjukkan adanya perbedaan signifikan pada ukuran, efisiensi penjebakan maupun diameter zona hambat antara mikrosfer probiotik F-I, F-II, F-III. Kesimpulan: Disimpulkan bahwa mikrosfer probiotik F-I dengan matriks kombinasi alginat:gelatin (2%:1%) memiliki ukuran yang lebih kecil dari F-I (matriks alginat 3%) dan lebih besar dari F-III (matriks gelatin 3%). Mikrosfer probiotik F-I memiliki harga efisiensi penjebakan paling rendah, tetapi memiliki aktivitas antibakteri paling besar dibandingkan dengan mikrosfer probiotik F-II dan F-III.

The Effect of Niosomal System (Span 60-Cholesterol) on Diclofenac Sodium Preparation Characteristics and Diclofenac Sodium Preparation of Hydroxypropyl Cellulose Gel Base (HPC) Adeltrudis Adelsa Danimayostu; Esti Hendradi; Tutiek Purwanti
Research Journal of Life Science Vol 4, No 1 (2017)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat, Universitas Brawijaya

Diclofenac sodium is a lipophilic drug. That characteristic makes it difficult to disperse well in hydrophilic gel base. The niosome with its vesicle system could overcome that low dispersibility. It affects penetration by reducing water loss in trans-epidermal layer and change lipid bilayer conformation. The present study was designed to investigate the effect of niosomal system (Span 60–Cholesterol) on preparation characteristics and diclofenac sodium penetration of hydroxypropyl cellulose (HPC) gel base. We examined three different formulas in HPC gel base. Formula III was made in niosomal system. Preparation characteristics were evaluated with organoleptic and acidity tests. Drug penetration was checked using apparatus 5-paddle over disk and 0.45 μm Milipore membrane impregnated with isopropyl myristate. The solution is phosphate buffer saline pH 7.4±0.05 in temperature 37±0.5°C. All of the data were evaluated based on one way ANOVA and continued with HSD test. It was concluded that niosomal system (span 60-cholesterol) has an influence in increasing pH value and penetration (based on flux value and permeability) of diclofenac sodium in HPC gel base.

Stabilitas Fisik dan Efektivitas Sediaan Tabir Surya Kombinasi Oksibenson dan Oktil Metoksisinamat dalam Basis Gel Carbomer 940 dengan Penambahan Asam Glikolat Rosita, Noorma; Purwanti, Tutiek; Agustin, Agustin
Majalah Ilmu Kefarmasian Vol. 7, No. 2
Publisher : UI Scholars Hub

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To fulfill the consumer expectation, cosmetic industries mostly add glycolic acid as whitening agent to the sunscreen preparation. The aim of this research was to know the effect of glycolic acid addition with the concentration of 8, 10, and 12% w/w on physical stability and effectiveness of sunscreen product containing oxybenzone and octyl methoxycinnamate (2: 7% w/w) in carbomer 940 gel. The physical stability test was done by observing physical appearance, pH, and spreading ability during 60 day storages on zone IV condition (temperature 30±0.5° and RH 70±2%). The efficacy was determinated base on SPF (Sun Protection Factor) value by spectrophotometer. The result of the physical stability test showed that glycolic acid addition affects the physical appearance (consistency) of sunscreen product, but pH and spreading ability are relatively stable. The efficacy test result showed that the addition of glycolic acid has an effect on SPF value of sunscreen product. Product which combined with glycolic acid showed a significant increase of SPF value, compared to control formula. The addition of glycolic acid increased SPF value and alter the effectiveness category from extra protection to maximal protection.

Lecture Presentations Combined with Comic Story-Telling to Increase the Knowledge and Understanding of Elementary and Junior High School Students about Drugs Concerning Self-Medication Behavior Andang Miatmoko; Mufariha Mufariha; Dini Retnowati; Abhimata Paramanandana; Sugiyartono Sugiyartono; Retno Sari; Tutiek Purwanti; Dewi Isadiartuti; Esti Hendradi
Journal of Community Research and Service Vol 6, No 2: July 2022
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jcrs.v6i2.35665

Self-medication practice can result in medication errors due to limited public knowledge of pharmaceutical medicine, especially among school-aged adolescents, who are prohibited from doing self-medication. This study aimed to evaluate the students' knowledge and understanding of pharmaceutical medicine, pharmacists, and self-medication, and also the awareness to be wise and smart in responding to the use of pharmaceutical products for maintaining public health. The study was carried out by conducting the lecture on drugs and self-medication through a classical presentation and comic story to students of SDN Keputih 245 Elementary School and SMPN 19 Junior High School, Surabaya. Moreover, DAGUSIBU dance was also practiced. The students actively engaged in the class during the presentation. The results of the pre-and post-test evaluations showed that this lecture method had succeeded in increasing junior high school students' knowledge about medicine and DAGUSIBU. On the other hand, the pre-test scores of Elementary School students were better than the post-test, except for new knowledge related to the drug logo and classification. It suggests that the delivery methods were inappropriate for elementary school students. It can be concluded that school-age adolescents, especially in elementary and junior high schools, need assistance during self-medication. This community service activity by a presentation and comic telling methods successfully improved the knowledge of SMPN 19 Junior High School about drugs and DAGUSIBU; however, it needs a more straightforward explanation with attractive learning methods for delivering a lecture to Elementary School students.

Characteristic and Physical Stability of Anti-Aging Green Tea Extract (GTE) on NLC with Argan Oil as Liquid Lipid Anita Natalia Suryawijaya; Tutiek Purwanti; Djoko Agus Purwanto; Widji Soeratri
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 2 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i22022.115-124

Background: Green tea extract is a hydrophilic antioxidant that is difficult to penetrate. A nanostructured lipid carrier (NLC) delivers a system consisting of solid-liquid lipids that can improve penetration. Argan oil is a vegetable oil that can be used as a liquid lipid in NLC, reducing particle size and increasing penetration by hydrating the skin. Objective: To determine the formula of NLC green tea extract (NLC-GTE) with liquid lipid argan oil, which has good characteristics and is stable. Methods: Preparation of NLC-GTE used the High Shear Homogenization with solid lipids (cetyl palmitate-glyceryl stearate) - liquid lipids (argan oil) NLC-GTE1 (50:50), NLC-GTE2 (70:30), and NLC-GTE3 (90:10). Characteristic tests included organoleptic, pH, particle size (PS), and polydispersity index (PI). The physical stability test (organoleptic, pH, PS, and PI) used the thermal cycling method (3 cycles six days). Result: NLC-GTE1 – NLC-GTE2 has an odor of argan oil. NLC-GTE3 has odorless. NLC-GTE1 – NLC-GTE3 has a pH scale from 5.782-5.784; PS ranges from 359.73–432.56 nm; PI ranges from 0.175-0.257. The statistical analysis results showed no significant difference between NLC-GTE1 – NLC-GTE3 in pH and PI, there was a significant difference in PS NLC-GTE1; NLC-GTE2 against NLC-GTE3. Physical stability test NLC-GTE2 – NLC-GTE3 phase separation occurs. The statistical analysis results showed no significant difference in pH values NLC-GTE1 – NLC-GTE3 before and after storage; there was a significant difference in NLC-GTE3 before and after storage. Conclusion: NLC-GTE1 was a formula with good characteristics and stability.

Pelatihan Pembuatan Jamu pada Siswa SMA di Kabupaten Banyuwangi sebagai Upaya Pelestarian Budaya dan Menanamkan Enterprenuership Suciati Suciati; Wiwied Ekasari; Neny Purwitasari; Rice Disi Oktarina; Lidya Tumewu; Yanu Andhiarto; Hanifa Rahma Putri; Tutiek Purwanti; Sudjarwo Sudjarwo
Jurnal Pengabdian Masyarakat Vol 4 No 1 (2023): Jurnal Pengabdian Masyarakat
Publisher : LP2M Institut Teknologi dan Bisnis Asia Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32815/jpm.v4i1.1333

Siswa SMA sebagai generasi penerus bangsa berperan penting dalam upaya kesehatan masyarakat. Jamu merupakan warisan budaya bangsa yang harus terus dikenalkan kepada generasi muda supaya dapat dijaga kelestariannya. Peran jamu dalam upaya pemeliharaan kesehatan masyarakat sudah tidak diragukan lagi. Tujuan dari kegiatan ini adalah untuk memberikan pelatihan pembuatan jamu kepada siswa SMA di Kabupaten Banyuwangi. Sebanyak 39 orang siswa SMA sebagai peserta mendapatkan materi tentang cara pembuatan jamu yang baik dan benar serta keamanan produk jamu yang beredar di masyarakat. Selain itu peserta juga melakukan praktek pembuatan jamu kunyit asam dan masker wajah. Kegiatan ini diharapkan untuk meningkatkan pengetahuan dan keterampilan siswa SMA dalam pembuatan jamu serta meningkatkan jiwa kewirausahaan siswa SMA yang secara tidak langsung dapat meningkatkan perekonomian keluarga. Hasil yang diperoleh menunjukkan antusiasme peserta dalam mengikuti kegiatan ini serta hasil pretest dan postest menunjukkan peningkatan pengetahuan yang signifikan.

Co-Authors Abhimata Paramanandana Abhimata Paramanandana Adeltrudis Adelsa Danimayostu Agustin Agustin Agustin Agustin Andang Miatmoko Anita Natalia Suryawijaya Ardhani Dwi Lestari1 Dewi Isadiartuti Dewi Melani Hariyadi Dini Retnowati Djoko Agus Purwanto Dwi Setiawan Esti Hendradi Hanifa Rahma Putri Lidya Tumewu Mohammad Agus Sjamsur Rijal Mufariha Mufariha Noorma Rosita Purwitasari, Neny Regia Nada Asshafa Retno Sari Retno Sari Ria Puspita Rice Disi Oktarina Suciati Suciati Sudjarwo Sudjarwo Sugiyartono Sugiyartono Sugiyartono1 Tristiana Erawati Widji Soeratri Wiwied Ekasari Yanu Andhiarto Yusuf, Helmy

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