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ANALISA PELAKSANAAN INVESTIGASI KONTAK DAN PEMBERIAN TERAPI PENCEGAHAN TUBERKULOSIS PADA ANAK DI KOTA PARIAMAN TAHUN 2020 Muhammad Hendri; Finny Fitry Yani; Edison edison
HUMAN CARE JOURNAL Vol 6, No 2 (2021): Human Care Journal
Publisher : Universitas Fort De Kock

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32883/hcj.v6i2.1255

Tuberkulosis (TB) anak merupakan penyakit yang menjadi permasalahan kesehatan baik ditingkat Global, Nasional, sampai ketingkat kabupaten/kota. Dampak tidak dilakukannya penemuan kasus TB pada anak terutama balita yaitu beresiko tertular kuman TB yang menyebabkan balita menjadi sakit TB. Jika tidak diobati maka balita akan mengalami TB berat hingga terjadinya kematian. Masih rendahnya penemuan kasus TB pada balita disebabkan penemuan kasus masih bersifat pasif, yaitu menunggu di Puskesmas. Kebijakan Kementerian Kesehatan RI dalam penemuan kasus yaitu menggunakan pelaksanaan investigasi kontak TB. Penemuan kasus TB anak di Kota Pariaman 3 (tiga) tahun terakhir mengalami penurunan dan pemberian terapi pencegahan pada balita di Kota Pariaman belum pernah dilaksanakan dalam 3 (tiga) tahun tarakhir ini. Tujuan penelitian ini untuk melihat gambaran pelaksanaan investigasi kontak dan pemberian terapi pencegahan di Kota Pariaman Tahun 2020. Metode yang dipakai pada penelitian ini yaitu menggunakan mix methode. Hasil penelitian pelaksanaan investigasi kontak TB belum berjalan optimal yang disebabkan karena masih lemahnya pernecanaan program TB sehingga tidak adanya anggaran khusus dalam pelaksanaan investigasi kontak. Selain perencanaan yang lemah, penyebab belum optimalnya pelaksanaan investigasi kontak adalah masih kurangnya koordinasi serta monitoring dan evaluasi baik dari tingkat Dinas Kesehatan maupun dari pihak Puskesmas.Kata kunci: TB balita, investigasi kontak TB, Terapi Pencegahan TB

Status Vitamin D pada Anak dengan Leukemia Akut Shinta Ayudhia; Amirah Zatil Izzah; Firman Arbi; Finny Fitry Yani
Sari Pediatri Vol 24, No 1 (2022)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp24.1.2022.51-5

Latar belakang. Vitamin D adalah kelompok prohormon yang berperan dalam pencegahan dan pertumbuhan sel kanker sebagai antiproliferatif, pro apoptosis dan anti inflamasi. Hal ini disebabkan karena reseptor vitamin D juga terdapat pada sel hematopoesis normal dan abnormal. Namun, penelitian tentang vitamin D pada anak dengan leukemia masih sedikit. Dari beberapa penelitian yang telah ada menunjukkan kadar vitamin D pada pasien leukemia berada pada level defisiensi dan insufisiensi.Tujuan. Mengetahui status vitamin D pada pasien leukemia akut di Rumah Sakit Umum Pusat M. Djamil, Padang.Metode. Penelitian potong lintang dilakukan pada 53 pasien anak yang baru terdiagnosis leukemia akut dari bulan Mei 2018 hingga Mei 2019. Dilakukan pemeriksaan kadar vitamin D di laboratorium dan pengumpulan data karakteristik pasien.Hasil. Didapatkan 30 (56,6%) pasien berjenis kelamin laki-laki, rentang umur paling banyak usia 1-10 tahun. Status gizi kurang terdapat pada 47 (88,7%) pasien. Diagnosis leukemia limfoblastik akut didapatkan 47 (88,7%) pasien. Gejala klinis terbanyak adalah demam (96,2%), pucat (96,2%), hepatomegali (92,5%). Pasien mendapatkan paparan matahari > 30 menit sebanyak 86,8%. Rerata kadar vitamin D pada pasien leukemia akut adalah 24,01±7,91 ng/ml. Status vitamin D pada pasien leukemia akut 50,9% berada pada rentang insufisiensi.Kesimpulan. Status vitamin D pada pasien leukemia akut di RSUP M. Djamil berada pada rentang insufisiensi.

Gene Polymorphisms Vitamin D Receptor Against Dengue Infection In Children Ahmad Kurniawan Akbar; Nur Indrawaty Lipoeto; Arni Amir; Finny Fitry Yani
Majalah Kedokteran Andalas Vol 45, No 3 (2022): Online July 2022
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v45.i3.p417-422.2022

BACKGROUND: Dengue infection is a vector-born disease associated with endemic areas in the tropics and subtropics. Genetic factors that play a role such as mutations and polymorphisms that influence a person's susceptibility to dengue fever. AIM: This study aims to determine gene polymorphisms of vitamin D against dengue infection in children. MATERIAL AND METHODS: This study was an observational study with a cross-sectional design, where the dependent and independent variables were examined at the same time in pediatric patients who were hospitalized with clinical symptoms of dengue infection at Raden Mattaher Hospital Jambi and Baiturrahim Jambi Hospital who met the inclusion criteria with positive anti-dengue IgM. and or positive anti-dengue IgG in children aged less than two years to eighteen years. RESULT: The results showed that the relationship between patients who have polymorphisms in one of the vitamin D receptor genes will experience heavier dengue infection than those who do not have polymorphisms in the vitamin D receptor gene and this difference is statistically significan (p= 0.005). CONCLUSION: This study concluded that there was a relationship between vitamin D receptor gene polymorphisms and the degree of dengue virus infection. Keywords: Dengue infection in children, Vitamin D receptor gene polymorphisms, vitamin D level

SARS-CoV-2 Serology Antibody in Children with MIS-C (Multiple Inflammatory Syndrome in Children) Suspected Finny Fitry Yani; Indra Ihsan; Efrida
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 10 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i10.572

Background: Multiple inflammatory syndromes in children (MIS-C) relate to COVID-19 severity in children. SARS-CoV-2 serology antibody is one of the diagnostic tools of MIS-C. The study aimed to describe the yield of serology antibodies of MIS-C and some characteristics found in hospitalized children with MIS-C suspects. Methods: This research was an analytic observational study. The data were collected retrospectively from some children who were hospitalized in Dr. M. Djamil General Hospital, Padang, West Sumatra, Indonesia, from April - June 2021. The inclusion criteria were children aged 1 month to 18 years, with or without contact history with the person who probable or confirmed COVID-19 and have signs and symptoms as MIS-C base on WHO criteria. Results: About eight out of 44 children showed positive serology antibodies and were diagnosed as MISC (18,2%). Based on demographic characteristics, children aged 11-15 years (27.3%) and boys were more affected (52.3%) as MIS-C suspected. Most of them were referred from a 2nd-level hospital outside Padang City (70.4%), but only 13.6% had a history of contact with COVID-19 confirmation patients. There was a significant difference in cardiovascular signs and symptoms between positive and negative serology antibody SARS-CoV-2 among children with MIS-C suspected (p<0.05), but not in fever, respiratory distress, gastrointestinal, neurology symptoms, either in laboratory results such as leukocytes, CRP and D-dimmer. Intravenous immunoglobulin, steroid, and PICU admitted showed no significant differences between the 2 groups, but more death prevalence in positive than negative. However, no significant differences (12.5% vs. 11.1%, p>0.05). Conclusion: Cardiovascular signs and symptoms could be proposed to be one of the significant differences in clinical conditions to differentiated children with MIS-C suspected and MIS-C due to serology antibody results.

Kajian Terkini CoronaVirus Disease 2019 (COVID-19) Chicy Widya Morfi; Ahmad Junaidi; Elsesmita Elsesmita; Diana Nur Asrini; Dya Mulya Lestari; Irvan Medison; Russilawati Russilawati; Fauzar Fauzar; Roza Kurniati; Finny Fitry Yani
Jurnal Ilmu Kesehatan Indonesia Vol 1 No 1 (2020): Maret 2020
Publisher : Fakultas Kedokteran, Universitas Andalas

The COVID-19 outbreak in Wuhan, Hubei Province, China, caused by a newly known coronavirus strain, SARS-CoV-2, up to March 3th, 2020, has caused 90.870 confirmed cases to be reported from 72 countries (including Indonesia) with 3.112 deaths (CFR 3,4%). Upper airway swab and lower airway aspirate specimens from suspected patients are required for examination by the RT-PCR microbiological method for establishing COVID-19. There are no specific antivirals for the management of COVID-19. On January, 30th, 2020 WHO has established Covid-19 as the Public Health Emergency of International Concern (PHEIC), but the increase in the number of cases is fast enough so that on March,11th 2020, WHO has established Covid-19 as a pandemic.

Neonatus dari Ibu Tuberkulosis Aktif Revi Riliani; Finny Fitry Yani
Jurnal Ilmu Kesehatan Indonesia Vol 1 No 1 (2020): Maret 2020
Publisher : Fakultas Kedokteran, Universitas Andalas

TB merupakan salah satu penyakit menular terbanyak di dunia dan mengalami perubahan dalam epidemiologi dimana terjadi peningkatan proporsi wanita usia subur yang tertular TB dan selanjutnya berkemungkinan akan berdampak pada kejadian TB perinatal. Diperkirakan insiden transmisi vertikal TB dari ibu ke bayi sebesar 16%, dengan angka kematian yang tinggi yaitu 50-60%. Kesulitan dalam diagnosis berkontribusi pada tingginya angka kematian ini. Indeks kecurigaan yang tinggi disertai penelusuran infeksi dapat menurunkan angka kematian akibat TB kongenital, serta pemberian pengobatan profilaksis yang optimal dapat mencegah kejadian TB perinatal pada bayi yang terpapar dengan penderita. Penulisan kasus ini bertujuan untuk melihat luaran pada bayi yang terpapar tuberkulosis dan mendapatkan pengobatan profilaksis. Penelusuran literatur dilakukan oleh dua orang melalui PubMed dan DOAJ untuk mencari penelitian yang relevan. Kata teks digunakan dalam pencarian studi. Dari penelusuran didapatkan empat studi memenuhi kriteria eligibilitas. Dari keempat studi, pada dua studi ditemukan hanya satu subjek yang mendapat pengobatan profilaksis yang berkembang menjadi infeksi tuberkulosis. Dengan demikian dapat disimpulkan bahwa pemberian profilaksis pada bayi yang terpapar tuberkulosis berpengaruh pada luaran dan efektif menjegah progresivitas penyakit.

Hubungan ASI Eksklusif dan Riwayat ISPA Terhadap Kolonisasi Streptococcus pneumoniae pada Swab Nasofaring Anak Bawah Dua Tahun Indri Permata Rani; Finny Fitry Yani
Jurnal Ilmu Kesehatan Indonesia Vol 1 No 2 (2020): Juli 2020
Publisher : Fakultas Kedokteran, Universitas Andalas

Pneumonia merupakan penyebab kematian utama pada anak di dunia. Streptococcus pneumoniae (S. pneumoniae) sebagai bakteri terbanyak penyebab pneumonia dapat membentuk kolonisasi di nasofaring anak. Faktor yang mempengaruhi kolonisasi S. pneumoniae ini diantaranya adalah pemberian air susu ibu (ASI) ekslusif dan infeksi saluran pernafasan akut (ISPA) pada anak. Penelitian ini bertujuan untuk mengetahui hubungan pemberian ASI ekslusif dan riwayat ISPA terhadap kolonisasi S. pneumoniae pada swab nasofaring anak usia bawah dua tahun. Penelitian ini merupakan studi analitik dengan metode cross sectional pada 30 orang anak usia bawah dua tahun. Data mengenai pemberian ASI eksklusif dan riwayat ISPA didapatkan dari hasil wawancara langsung pada saat pengambilan swab nasofaring anak. Analisis data menggunakan uji chi square. Hasil yang didapatkan pada penelitian ini sebanyak 63,3% dari anak usia bawah dua tahun ditemukan adanya kolonisasi S. pneumoniae dari hasil swab nasofaring. Hasil analisis data menggunakan chi square diperoleh nilai p=0,637 untuk hubungan pemberian ASI eksklusif terhadap kolonisasi S. pneumoniae, dan hubungan riwayat ISPA terhadap kolonisasi S. pneumoniae nilai p=0,245. Kesimpulan dari penelitian ini tidak terdapat hubungan yang bermakna antara pemberian ASI eksklusif dan riwayat ISPA terhadap kolonisasi S. pnuemoniae pada swab nasofaring anak usia bawah dua tahun

Penggunaan Kortikosteroid pada Pasien Anak dengan Perikarditis Tuberkulosis. Novi Violona Edwar; Abi Andayu; Finny Fitry Yani
Jurnal Ilmu Kesehatan Indonesia Vol 1 No 3 (2020): November 2020
Publisher : Fakultas Kedokteran, Universitas Andalas

Tuberculous pericarditis (TB pericarditis) is a disease that still frequently occurs in developing countries. The mortality rate due to TB pericarditis is still quite high, reaching 17-40%. Death due to tuberculous pericarditis is influenced by adequate or not treatment. The use of additional corticosteroid therapy is still a matter of debate in the treatment of tuberculous pericarditis. Writing this case aims to see the outcome of the use of corticosteroids in patients with tuberculous pericarditis. Literature searches were carried out through Pubmed and Google Scholar. From the results of literature search, two meta-analyzes were obtained that discussed the use of corticosteroids in tuberculous pericarditis. In children with tuberculous pericarditis, the use of corticosteroids does not reduce mortality, but can reduce complications due to tuberculous pericarditis. Keywords: corticosteroids, tuberculous pericarditis, outcome.

Successful Long-Term Monitoring of Children with Scrofuloderma, Malnutrition, and HIV Destri Linjani; Finny Fitry Yani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 8 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i8.550

Background: Scrofuloderma is a skin TB that occurs percontinuitatum from tissues underneath, such as lymph nodes, muscles, and bones. It often affects children and young adults. The incidence of TB disease is estimated to increase 20-fold in children with HIV infection. Poor nutrition can affect the mortality rate of children with HIV infection. This case report presents long-term monitoring of boys aged 1 year 5 months with scrofuloderma, malnutrition, and HIV infection. The case report aims to assist children and caregivers in undergoing treatment to prevent drug withdrawal and nutritional procedures and monitor the growth and development of children. Case presentation: A 1-year and 5-month-old boy with a complaint of ulcers on his right neck since 12 months ago. He also complained of diarrhea 12 months ago, accompanied by recurrent stomatitis and progressive weight loss since 3 months ago. He looked pale 1 month ago. Blood laboratory examination with hemoglobin 5.1 gr/dl, leukocytes 5280 / mm3, platelets 323,000 / mm3, hematocrit 20%, reactive anti-HIV test, CD4 examination with a value of 178 cells / L, negative tuberculin test, a chest x-ray showed infiltrate in both lung fields, and bajah examination of the nodules in the Colli dextra region, with the impression of granulomatous inflammation that can be caused by mycobacterial infection. Conclusion: Tuberculosis is the most common opportunistic infection found in children with HIV infection and increases the mortality rate. There is a relationship between nutritional status and the incidence of mortality in HIV/AIDS children, so it is necessary to monitor children for adherence to treatment, improve nutritional status and reduce morbidity and mortality rates.

SARS-CoV-2 Serology Antibody in Children with MIS-C (Multiple Inflammatory Syndrome in Children) Suspected Finny Fitry Yani; Indra Ihsan; Efrida
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 10 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i10.572

Background: Multiple inflammatory syndromes in children (MIS-C) relate to COVID-19 severity in children. SARS-CoV-2 serology antibody is one of the diagnostic tools of MIS-C. The study aimed to describe the yield of serology antibodies of MIS-C and some characteristics found in hospitalized children with MIS-C suspects. Methods: This research was an analytic observational study. The data were collected retrospectively from some children who were hospitalized in Dr. M. Djamil General Hospital, Padang, West Sumatra, Indonesia, from April - June 2021. The inclusion criteria were children aged 1 month to 18 years, with or without contact history with the person who probable or confirmed COVID-19 and have signs and symptoms as MIS-C base on WHO criteria. Results: About eight out of 44 children showed positive serology antibodies and were diagnosed as MISC (18,2%). Based on demographic characteristics, children aged 11-15 years (27.3%) and boys were more affected (52.3%) as MIS-C suspected. Most of them were referred from a 2nd-level hospital outside Padang City (70.4%), but only 13.6% had a history of contact with COVID-19 confirmation patients. There was a significant difference in cardiovascular signs and symptoms between positive and negative serology antibody SARS-CoV-2 among children with MIS-C suspected (p<0.05), but not in fever, respiratory distress, gastrointestinal, neurology symptoms, either in laboratory results such as leukocytes, CRP and D-dimmer. Intravenous immunoglobulin, steroid, and PICU admitted showed no significant differences between the 2 groups, but more death prevalence in positive than negative. However, no significant differences (12.5% vs. 11.1%, p>0.05). Conclusion: Cardiovascular signs and symptoms could be proposed to be one of the significant differences in clinical conditions to differentiated children with MIS-C suspected and MIS-C due to serology antibody results.

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