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All Journal JURNAL KIMIA SAINS DAN APLIKASI Jurnal Natur Indonesia Jurnal Ilmu Lingkungan Jurnal Penelitian Farmasi Indonesia Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Jurnal Riset Kimia JURNAL PHOTON
Adel Zamri
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Engineering Environmental Science Mathematics Medicine & Pharmacology Nursing Physics

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Sintesis dan Uji Antiinflamasi Senyawa (R)-3-(4-Florofenil)-1-fenil-5-(tiofen-2-il)-4,5-dihidro-1H-pyrazol Serta Pengaruhnya terhadap Kerusakan Lambung Rullah, Kamal; Hasti, Syilfia; Hariani, Destawira; Utama, Putri Bela; Teruna, Hilwan Yuda; Zamri, Adel
Jurnal Penelitian Farmasi Indonesia Vol 1, No 01 (2013)
Publisher : Jurnal Penelitian Farmasi Indonesia

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Abstract

An in-vivo anti-inflammatory study of pyrazoline compound synthesized from chalcone has been carried out using Paw Edema method.Compound (R)-3-(4-florofenil)-1-fenil-5-(tiofen-2-il)-4, 5-dihidro-1H-pyrazole was synthesized by milling method in alkaline condition,with no solvent addition and was conducted under room temperature. Characterization of the synthesized compound was determined using1H-NMR and HR-MS spectrometer. As for anti-inflammatory study, suspension of compound (R)-3-(4-florofenil)-1-fenil-5-(tiofen-2-il)-4,5-dihidro-1H-pyrazol was administrated orally to white female mice (Rattus novergicus) with doses 20, 40, 80 mg/kg bw, respectively. Theresult showed that the compound with doses 40 and 80 mg/kg bw exhibited insignificant difference compared with standard drugs Celecoxiband Piroksikam (p>0,05). Futhermore, all doses of compound did not cause any damage of stomach organ of mice, which is given the same“ulcer index” (Iu) with negative control (Iu 2,00). Meanwhile, ulcer index for Celecoxib of Iu 35,99 and Piroksikam of Iu 70,01.
SINTESIS ANALOG 2-PIRAZOLIN DARI KALKON INTI NAFTALEN DAN UJI AKTIVITASNYA SEBAGAI ANTIBAKTERI Hayati, Fitrah; Zamri, Adel
Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Vol 1, No 2 (2014): Wisuda Oktober 2014
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam

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Abstract

Pyrazolines have been reported to possess many of interesting biological activities suchas antibacterial, antitumor, antioxidant, anti-inflammatory, antimalarial, anticancer, andanticonvulsant activity. In this research, an analog pyrazoline 5-(4-chlorophenyl)-3-(naphthalene-1-yl)-4,5-dihydro-1H-pirazol was synthesized by the reaction between 1-naphthyl chalcones and hydrazine hydrate using glacial acetic acid as catalyst undermicrowave irradiation. The compound showed a good yield, and then was characterizedby UV, IR and 1 H-NMR spectroscopy. The antibacterial activity of this compound wasdetermined using agar diffusion method against the bacteria Escherichia coli,Salmonella typi, Bacillus subtilis and Staphylococcus aureus. The antibacterial activitywere classified as very weak at concentrations of 10, 30 and 50 μg/disk with a diameterof inhibition produced of 6,2 – 8,1 mm.
SINTESIS DAN UJI TOKSISITAS SENYAWA METOKSI FLAVANON TURUNAN 2’-HIDROKSIKALKON Rizal, Syamsul; Zamri, Adel
Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Vol 1, No 2 (2014): Wisuda Oktober 2014
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam

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Abstract

Flavanone is one of secondary metabolities included into flavonoid group that has biological activities such as anticancer, antitumor, antiproliferative, and antimicrobe. Moreover, flavanone is the biosynthesis main precursor for other types of flavonoids. In this research, 4’-methoxyflavanone has been synthesized from cyclization of 2’-hydroxychalcones derivatives by microwave irradiation using sodium acetate in ethanoland water as a catalyst. The yield obtained was 68,5 %. The purity of compound has been tested using TLC, melting point test, and HPLC. The compound was characterized by UV, IR,1 H-NMR, and MS. Toxicity activity was determined using Brine Shrimp Lethality Test (BSLT) against larvae of Arthemia salina Leach and with value LC50 = 3,29 µg/ mL. Accordings to the primary test, the flavanone compound is potentially as anticancer which was proven by LC 50 values <200 μg/mL.
PERBANDINGAN ISOLASI MINYAK ATSIRI BIJI PALA (Myristica fragrans Houtt) CARA HIDRODISTILASI MICROWAVE DAN KONVENSIONAL SERTA UJI AKTIVITAS ANTIBAKTERI DAN ANTIOKSIDAN Rachmi, Widya; Zamri, Adel
Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Vol 1, No 2 (2014): Wisuda Oktober 2014
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam

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Abstract

Essential oil of nutmeg (Myristica fragrans Houtt) has been successfully obtained by distillation using conventional and microwave hydrodistillation methods. The essential oil produced by microwave method is more advantageous in yield of oil andcomponents of resulted compounds. The yield of extracted essential oil using microwave method is about 7,07% for 60 minutes higher than that of conventional method which is about 4,30% for 4 hours. Based on the result of  GC-MS analysis,microwave hydrodistillation components obtained 55 compounds more than conventional hydrodistillation as many as 43 compounds in essential oil. The results of antibacterial and antioxidant activity showed that essential oil could inhibit Bacillussubtilis of bacteria and had weak antioxidant activity than of ascorbic acid againtsDPPH radical that is >1000 ug/mL.
PERBANDINGAN ISOLASI MINYAK ATSIRI DAUN NILAM (Pogostemon cablin Benth.) METODE HIDRODISTILASI KONVENSIONAL DAN HIDRODISTILASI OVEN MICROWAVE DISERTAI UJI AKTIVITAS ANTIMIKROBA Jannah, Rahmi Miftahul; Zamri, Adel
Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Vol 1, No 2 (2014): Wisuda Oktober 2014
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam

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Abstract

Microwave assisted hydrodistillation (MAHD) is the improvement of hydrodistillation (HD) technics which uses microwave energy as source in its refining process. The purpose of this research was to determine the best method of two extraction methods forpatchouli leaves (Pogostemon cablin Benth.). MAHD and HD methods have been compared and evaluated for its effectiveness to isolate the essential oil of fresh patchouli leaves. The results showed MAHD method offered a very important advantage exceeded HD within energy storage and isolation term. MAHD method took time for 1.5 hours whereas HD for 6 hours. The essential oil composition of extraction that determined by GC-MS. The main compounds of essential oil of  Patchouli leaves were patchouli alcohol with levels 53.00% HD and 53.10% MAHD. The density was 0.959 g/mL of HD and 0.963 g/mL of MAHD. Antimicrobial test showed te HD essential oil effectiveness was better than those of MAHD and te  effectiveness on E.coli bacteria. However, the MAHD method was to be considered enviromental friendly.
SINTESIS DAN UJI TOKSISITAS ANALOG FLAVANON TERSUBSTITUSI HALOGEN Rush, Ibnu; Teruna, Hilwan Yuda; Zamri, Adel
Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Vol 1, No 2 (2014): Wisuda Oktober 2014
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam

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Abstract

Flavanones have been reported to possess many of interesting biological  activities  such as antimicrobe, antitumor, antioxidance, antiinflammatory, antimalaria, anticancer, and anti-HIV. In this research, a  halogenated flavanone 2-(3 -bromophenyl)chroman-4-one was synthesized by cyclization of  (E)-3-(3-bromophenyl)-1-(2-hydroxyphenyl)-2-propen-1-one  using  sodium  acetate as catalyst  under microwave  irradiation. The compound showed a good yield, and then was characterized by UV, IR and 1 H-NMR spectroscopy. The toxicity activity of this  compound was determined using Brine Shrimp Lethality Test (BSLT) method against larvae Artemia salina  Leach and showed a good activity with LC50  = 0,457 µg/mL. The result indicated that this compound  was potential  as anticancer.
Sintesis dan Uji Antibakteri Senyawa Bromo Kalkon Piridin Jasril, Jasril; Teruna, Hilwan Yuda; Zamri, Adel; Alfatos, Darian; Yuslinda, Elka; Nurulita, Yuana
Jurnal Natur Indonesia Vol 14, No 3 (2012)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (95.23 KB) | DOI: 10.31258/jnat.14.3.172-175

Abstract

Three pyridine chalcones including (Z)-1-(4-bromophenyl)-3-(pyridin-2-yl)prop-2-en-1-one (1), (Z)-1-(4-bromophenyl)-3- (pyridin- 3-yl)prop-2-en-1-one (2) and (Z)-1-(4-bromophenyl)-3-(pyridin-4-yl)prop-2-en-1-one (3) were synthesized by aldol condensation reactions from pyridinecarbaldehyde with 4-bromoacetophenone. In antibacterial assay, compound 3 exhibited strong activity against Staphylococcus aureus, Bacillus subtilis and Escherichia coli with the inhibition zone of 19.9; 19.5, and 17.5 mm, respectively.
Studi Sintesis Analog Piokelin III: Sintesis Asam 3-Asetil-2-(2-(2-Hidroksifenil)- 4,5-Dihidrotiazol-4-Il)Tiazolidine-4-Karboksilat Zamri, Adel
Jurnal Natur Indonesia Vol 10, No 1 (2007)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (191.292 KB) | DOI: 10.31258/jnat.10.1.49-52

Abstract

The total syntheses of 3-acetyl-2-(2-(2-hydroxyphenyl)-4,5-dihydrothiazole-4-yl) thiazolidine-4-carboxylic acid, a new pyochelin analog is described. The molecule intermediate 4’-(2-hydroxy-phenyl)-2,3,4,5,2’,5,-hexahydro- [2,2’]bithiazolil-4-carboxylic acid was obtained in 4 steps reaction from 2-hydroxybenzonitrile in good yields. The Nacetylation of molecule intermediate was carried out by acetic anhydride to produce pyochelin analog in moderate yields.
Synthesis, Characterization and Anti Mcf-7 Proliferative Acitivity of Flavonol Derivatives of 2'-Hydroxyacetophenon and 3,4,5-Dimethoxy Benzaldehid Rokim, Muhamad; Zamri, Adel; Teruna, Hilwan Yuda
Jurnal Natur Indonesia Vol 17, No 2 (2019)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (475.257 KB) | DOI: 10.31258/jnat.17.2.16-24

Abstract

Flavonols a derivatives of 2'-hydroxyacetophenon and 3,4,5-dimethoxy benzaldehid has been synthesized under basic condition (KOH). The structure of the compound was characterized based on the interpretation of spectroscopic data, including UV, FTIR, NMR and HRMS. Anticancer activity was evaluated using the MTS assay against MCF-7 cells, which showed that the flavonol 2'-hydroxycalone derivative was potentially active as an anticancer substance with IC50 values <1000 µg / mL.
Sintesis Turunan 2’-hidroksi Kalkon melalui Kondensasi Claisen-Schmidt dan Uji Aktivitasnya sebagai Antimikroba Eryanti, Yum; Zamri, Adel; Jasril, Jasril; Rahmita, Rahmita
Jurnal Natur Indonesia Vol 12, No 2 (2010)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (73.717 KB) | DOI: 10.31258/jnat.12.2.223-227

Abstract

Tiga senyawa turunan kalkon telah berhasil disintesis dari suatu keton aromatik dan aldehida aromatik melaluireaksi kondensasi Claisen-Schmidt dalam suasana basa. Turunan kalkon tersebut adalah 2’-hidroksi kalkon,(2Z,4Z)-1-(2-hidroksifenil)-5-fenilpenta-5-2-4-dien-1-on dan 2’-hidroksi-4-dimetilamino kalkon. Senyawa yangdihasilkan relatif murni, dilihat dari uji KLT yang menunjukkan satu noda dan titik leleh ketiganya berada padarange kecil. Elusidasi struktur didasarkan pada data spektra UV, IR, 1H-NMR dan 13C-NMR. Uji antimikroba terhadapketiga senyawa, hanya satu senyawa yang memberikan hasil positif yaitu senyawa 2’-hidroksi-4-dimetilaminokalkon pada konsentrasi 60 ìg terhadap bakteri B.subtilis.
Co-Authors -, Lelani Darian Alfatos David Aprianto, David Destawira Hariani Elka Yuslinda Fitrah Hayati Gasella, Raja Mutya Helmi Putra Herfindo, Noval Hilwan Yuda Teruna Ibnu Rush Ikhtiarudin, Ihsan Jasril Jasril Kamal Rullah Karsana, Elsaria Kurniati, - Lusrianti, - Neni Frimayanti, Neni Nur Balatif Oktavia, Denaria Oscifiani, Nelly Putri Bela Utama Rahayu Rahayu Rahma Dona, Rahma Rahmi Miftahul Jannah Rahmita, Rahmita Riki Setiawan Rokim, Muhamad Siti Aisyah Syamsul Rizal Syilfia Hasti Veza Azteria Widya Rachmi Yuana Nurulita Yuharmen - Yuharmen, - Yum Eryanti Yusni Ikhwan Siregar