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All Journal Jurnal Natur Indonesia Jurnal Ilmu Lingkungan Jurnal Penelitian Farmasi Indonesia Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Jurnal Riset Kimia Jurnal Penelitian Farmasi Indonesia JURNAL PHOTON Makara Journal of Science
Adel Zamri
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Environmental Science Mathematics Medicine & Pharmacology Nursing Physics

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Sintesis dan Uji Antiinflamasi Senyawa (R)-3-(4-Florofenil)-1-fenil-5-(tiofen-2-il)-4,5-dihidro-1H-pyrazol Serta Pengaruhnya terhadap Kerusakan Lambung Rullah, Kamal; Hasti, Syilfia; Hariani, Destawira; Utama, Putri Bela; Teruna, Hilwan Yuda; Zamri, Adel
Jurnal Penelitian Farmasi Indonesia Vol 1, No 01 (2013)
Publisher : Jurnal Penelitian Farmasi Indonesia

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Abstract

An in-vivo anti-inflammatory study of pyrazoline compound synthesized from chalcone has been carried out using Paw Edema method.Compound (R)-3-(4-florofenil)-1-fenil-5-(tiofen-2-il)-4, 5-dihidro-1H-pyrazole was synthesized by milling method in alkaline condition,with no solvent addition and was conducted under room temperature. Characterization of the synthesized compound was determined using1H-NMR and HR-MS spectrometer. As for anti-inflammatory study, suspension of compound (R)-3-(4-florofenil)-1-fenil-5-(tiofen-2-il)-4,5-dihidro-1H-pyrazol was administrated orally to white female mice (Rattus novergicus) with doses 20, 40, 80 mg/kg bw, respectively. Theresult showed that the compound with doses 40 and 80 mg/kg bw exhibited insignificant difference compared with standard drugs Celecoxiband Piroksikam (p>0,05). Futhermore, all doses of compound did not cause any damage of stomach organ of mice, which is given the same“ulcer index” (Iu) with negative control (Iu 2,00). Meanwhile, ulcer index for Celecoxib of Iu 35,99 and Piroksikam of Iu 70,01.
SINTESIS ANALOG 2-PIRAZOLIN DARI KALKON INTI NAFTALEN DAN UJI AKTIVITASNYA SEBAGAI ANTIBAKTERI Hayati, Fitrah; Zamri, Adel
Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Vol 1, No 2 (2014): Wisuda Oktober 2014
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam

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Pyrazolines have been reported to possess many of interesting biological activities suchas antibacterial, antitumor, antioxidant, anti-inflammatory, antimalarial, anticancer, andanticonvulsant activity. In this research, an analog pyrazoline 5-(4-chlorophenyl)-3-(naphthalene-1-yl)-4,5-dihydro-1H-pirazol was synthesized by the reaction between 1-naphthyl chalcones and hydrazine hydrate using glacial acetic acid as catalyst undermicrowave irradiation. The compound showed a good yield, and then was characterizedby UV, IR and 1 H-NMR spectroscopy. The antibacterial activity of this compound wasdetermined using agar diffusion method against the bacteria Escherichia coli,Salmonella typi, Bacillus subtilis and Staphylococcus aureus. The antibacterial activitywere classified as very weak at concentrations of 10, 30 and 50 μg/disk with a diameterof inhibition produced of 6,2 – 8,1 mm.
SINTESIS DAN UJI TOKSISITAS ANALOG FLAVANON TERSUBSTITUSI HALOGEN Rush, Ibnu; Teruna, Hilwan Yuda; Zamri, Adel
Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Vol 1, No 2 (2014): Wisuda Oktober 2014
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam

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Flavanones have been reported to possess many of interesting biological  activities  such as antimicrobe, antitumor, antioxidance, antiinflammatory, antimalaria, anticancer, and anti-HIV. In this research, a  halogenated flavanone 2-(3 -bromophenyl)chroman-4-one was synthesized by cyclization of  (E)-3-(3-bromophenyl)-1-(2-hydroxyphenyl)-2-propen-1-one  using  sodium  acetate as catalyst  under microwave  irradiation. The compound showed a good yield, and then was characterized by UV, IR and 1 H-NMR spectroscopy. The toxicity activity of this  compound was determined using Brine Shrimp Lethality Test (BSLT) method against larvae Artemia salina  Leach and showed a good activity with LC50  = 0,457 µg/mL. The result indicated that this compound  was potential  as anticancer.
SINTESIS DAN UJI TOKSISITAS SENYAWA METOKSI FLAVANON TURUNAN 2’-HIDROKSIKALKON Rizal, Syamsul; Zamri, Adel
Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Vol 1, No 2 (2014): Wisuda Oktober 2014
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam

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Abstract

Flavanone is one of secondary metabolities included into flavonoid group that has biological activities such as anticancer, antitumor, antiproliferative, and antimicrobe. Moreover, flavanone is the biosynthesis main precursor for other types of flavonoids. In this research, 4’-methoxyflavanone has been synthesized from cyclization of 2’-hydroxychalcones derivatives by microwave irradiation using sodium acetate in ethanoland water as a catalyst. The yield obtained was 68,5 %. The purity of compound has been tested using TLC, melting point test, and HPLC. The compound was characterized by UV, IR,1 H-NMR, and MS. Toxicity activity was determined using Brine Shrimp Lethality Test (BSLT) against larvae of Arthemia salina Leach and with value LC50 = 3,29 µg/ mL. Accordings to the primary test, the flavanone compound is potentially as anticancer which was proven by LC 50 values <200 μg/mL.
PERBANDINGAN ISOLASI MINYAK ATSIRI DAUN NILAM (Pogostemon cablin Benth.) METODE HIDRODISTILASI KONVENSIONAL DAN HIDRODISTILASI OVEN MICROWAVE DISERTAI UJI AKTIVITAS ANTIMIKROBA Jannah, Rahmi Miftahul; Zamri, Adel
Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Vol 1, No 2 (2014): Wisuda Oktober 2014
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam

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Abstract

Microwave assisted hydrodistillation (MAHD) is the improvement of hydrodistillation (HD) technics which uses microwave energy as source in its refining process. The purpose of this research was to determine the best method of two extraction methods forpatchouli leaves (Pogostemon cablin Benth.). MAHD and HD methods have been compared and evaluated for its effectiveness to isolate the essential oil of fresh patchouli leaves. The results showed MAHD method offered a very important advantage exceeded HD within energy storage and isolation term. MAHD method took time for 1.5 hours whereas HD for 6 hours. The essential oil composition of extraction that determined by GC-MS. The main compounds of essential oil of  Patchouli leaves were patchouli alcohol with levels 53.00% HD and 53.10% MAHD. The density was 0.959 g/mL of HD and 0.963 g/mL of MAHD. Antimicrobial test showed te HD essential oil effectiveness was better than those of MAHD and te  effectiveness on E.coli bacteria. However, the MAHD method was to be considered enviromental friendly.
PERBANDINGAN ISOLASI MINYAK ATSIRI BIJI PALA (Myristica fragrans Houtt) CARA HIDRODISTILASI MICROWAVE DAN KONVENSIONAL SERTA UJI AKTIVITAS ANTIBAKTERI DAN ANTIOKSIDAN Rachmi, Widya; Zamri, Adel
Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Vol 1, No 2 (2014): Wisuda Oktober 2014
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam

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Abstract

Essential oil of nutmeg (Myristica fragrans Houtt) has been successfully obtained by distillation using conventional and microwave hydrodistillation methods. The essential oil produced by microwave method is more advantageous in yield of oil andcomponents of resulted compounds. The yield of extracted essential oil using microwave method is about 7,07% for 60 minutes higher than that of conventional method which is about 4,30% for 4 hours. Based on the result of  GC-MS analysis,microwave hydrodistillation components obtained 55 compounds more than conventional hydrodistillation as many as 43 compounds in essential oil. The results of antibacterial and antioxidant activity showed that essential oil could inhibit Bacillussubtilis of bacteria and had weak antioxidant activity than of ascorbic acid againtsDPPH radical that is >1000 ug/mL.
SINTESIS DAN UJI TOKSISITAS SENYAWA ANALOG KALKON DARI 4’- HIDROKSIASETOFENON DENGAN DIMETOKSIBENZALDEHID Lusrianti, -; Balatif, Nur; Zamri, Adel
Sistem Informasi Vol 6 No 01 (2015): Jurnal Photon
Publisher : Fakultas MIPA dan Kesehatan Universitas Muhammadiyah Riau

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Abstract

Senyawa kalkon terdiri dari dua cincin aromatik yang dihubungkan oleh tiga atom karbon dengan sistem karbonil α, β tak jenuh. Senyawa kalkon dilaporkan memiliki bioaktivitas yang beragam dan menarik, diantaranya sebagai antioksidan, antikanker, anti-inflamasi, antialzheimer dan antimikroba. Senyawa (E)-3-(2,3-dimetoksifenil)-1-(4’-hidroksifenil)prop-2-en-1-on disintesis melalui iradiasi gelombang mikro dengan katalis KOH dan pelarut etanol absolut. Analisis struktur senyawa ini dilakukan menggunakan spektroskopi UV, FTIR, HRMS dan 1H-NMR. Rendemen yang diperoleh yaitu 74,6%. Berdasarkan uji toksisitasnya, senyawa ini tidak berpotensi sebagai antikanker karena memiliki nilai LC50 = 291,789 μg/mL.
SINTESIS DAN UJI TOKSISITAS SENYAWA ANALOG KALKON TURUNAN 2’-HIDROKSIASETOFENON DAN HALOBENZALDEHID Ikhtiarudin, Ihsan; -, Lelani; Zamri, Adel; Teruna, Hilwan Yuda; -, Yuharmen
Sistem Informasi Vol 5 No 1 (2014): Jurnal Photon
Publisher : Fakultas MIPA dan Kesehatan Universitas Muhammadiyah Riau

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Abstract

Kalkon merupakan senyawa metabolit sekunder golongan flavonoid yang terdapat pada beberapa jenis tumbuhan. Senyawa ini dikenal memiliki berbagai bioaktivitas yang menarik. Dalam bidang sintesis, senyawa ini digunakan untuk mensintesis berbagai macam senyawa heterosiklik seperti benzodiazepin, pirazolin, flavanon, flavonol, dan senyawa turunan kalkon lainnya yang juga memiliki bioaktivitas yang menarik. Oleh karena itu, senyawa ini banyak dijadikan sebagai molekul target untuk keperluan pencarian senyawa-senyawa aktif sebagai kandidat obat, salah satunya adalah sebagai obat antikanker. Pada penelitian ini, tiga analog kalkon turunan 2’-hidroksiasetofenon dan halobenzaldehid telah disintesis menggunakan metode stirer dengan katalis KOH dan pelarut PEG-400. Struktur setiap produk dikarakterisasi dengan spektroskopi UV-Vis, FTIR, 1H NMR, 13C NMR, dan HRMS. Uji toksisitas dilakukan menggunakan metode Brine Shrimp Lethality Test (BSLT). Berdasarkan hasil uji BSLT, ketiga senyawa tersebut berpotensi sebagai senyawa antikanker dengan nilai LC50<200 μg/mL.
SINTESIS SENYAWA KALKON TURUNAN 4’-METOKSIASETOFENON DAN UJI TOKSISITAS DENGAN METODE BRINE SHRIMP LETHALITY TEST (BSLT) Gasella, Raja Mutya; Eryanti, Yum; Zamri, Adel
Sistem Informasi Vol 6 No 01 (2015): Jurnal Photon
Publisher : Fakultas MIPA dan Kesehatan Universitas Muhammadiyah Riau

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Abstract

Senyawa kalkonturunan 4’-metoksiasetofenon (E)-1-(4’-metoksifenil)-3-(2-hidroksifenil)prop-2-en-1-on (RMG1) telah disintesis dari senyawa 4’-metoksiasetofenon dan 2-hidroksibenzaldehid dibawah iradiasi gelombang mikromenggunakan kalium hidroksida sebagai katalis. Struktur senyawa kalkon dikonfirmasi berdasarkan interpretasi data spektroskopi UV, IR, 1H-NMR, dan MS. Aktivitas toksisitas senyawa kalkon ditentukan dengan metoda Brine Shrimp Lethality Test terhadap larva Artemiasalina Leach dan menunjukkan aktivitas dengan nilai LC50 = 1,58 x 1029 μg/mLdanmenunjukkanbahwa senyawa kalkon RMG2 tidak memiliki aktivitastoksisitas dengan nilai LC50 diatas 200 μg/mL.
SINTESIS DAN UJI TOKSISITAS SENYAWA ANALOG KALKON 3’-METOKSIASETOFENON DENGAN 2-HIDROKSIBENZALDEHID Aprianto, David; Balatif, Nur; Zamri, Adel
Sistem Informasi Vol 6 No 01 (2015): Jurnal Photon
Publisher : Fakultas MIPA dan Kesehatan Universitas Muhammadiyah Riau

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Abstract

Kalkon merupakan salah satu metabolit sekunder golongan flavonoid yang sangat berpotensi untuk dikembangkan. Kalkon telah dilaporkan memiliki aktivitas biologis seperti antimikroba, antitumor, antioksidan, antiinflamasi, antimalaria, dan antikanker. Senyawa (E)-3-(2-hidroksifenil)-1-(3’-metoksifenil)prop-2-en-1-on disintesis dengan metode iradiasi gelombang mikro dan menggunakan katalis basa KOH. Struktur senyawa kalkon dikarakterisasi berdasarkan interpretasi data spektroskopi UV, IR, 1H-NMR, dan MS. Uji toksisitas senyawa kalkon ditentukan dengan metode Brine Shrimp Lethality Test dan menunjukkan aktivitas dengan nilai LC50 yaitu 186,48 μg/mL. Senyawa ini menunjukkan aktivitas toksisitas yang baik karena nilai LC50 < 200 μg/mL.
Co-Authors -, Lelani Abdi Wira Septama Darian Alfatos David Aprianto, David Destawira Hariani Elka Yuslinda Fitrah Hayati Gasella, Raja Mutya Haiyul Fadhli Helmi Putra Hendra, Rudi Herfindo, Noval Hilwan Yuda Teruna Ibnu Rush Ikhtiarudin, Ihsan Jasril Jasril Jufrizal Syahri Kamal Rullah Karsana, Elsaria Kurniati, - Lusrianti, - Neni Frimayanti, Neni Nur Balatif Oktavia, Denaria Oscifiani, Nelly Putri Bela Utama Rahayu Rahayu Rahma Dona Rahma Dona, Rahma Rahmi Miftahul Jannah Rahmita, Rahmita Riki Setiawan Rokim, Muhamad Siti Aisyah Syamsul Rizal Syilfia Hasti Widya Rachmi Winda Tria Safitri Yuana Nurulita Yuharmen - Yuharmen, - Yuharmen, Yuharmen Yum Eryanti Yusni Ikhwan Siregar