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All Journal Jurnal Biologi Tropis JIMKI : Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Cut Warnaini
Universitas Mataram
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Faktor – Faktor Terkait Tingkat Keparahan Infeksi Coronavirus Disease 2019 (COVID-19): Sebuah Kajian Literatur Abiyyu Didar Haq; Adli Putra Nugraha; I Komang Gede Andhika Wibisana; Febbi Anggy; Fiana Damayanti; R.R. Ditya Mutiara Syifa; Ni Putu Visty Widhiani; Cut Warnaini
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 1 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.1 Edisi Maret - Juli
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i1.338

Abstract

Background: COVID-19 pandemic that started in the early 2020 triggers the declaration of Public Health Emergency of International Concern (PHEIC) by WHO. Caused by SARS-CoV-2 virus, COVID-19 mainly infects the respiratory tract by binding to the ACE2 receptor. COVID-19 infection can cause many clinical manifestation from no symptom to severe life-threatening symptom depending on many factors. Factors that can determine the severity of clinical manifestation is urgently needed to be recognized by our clinician in order to be able to anticipate patient’s condition before the severe clinical manifestation even begins. This literature review is aimed to summarize and discuss some factors that are most often showed up and determined the severity of COVID-19 infection. Methods: This literature review uses journal article that are sourced from online databases such as PubMed and Google Scholar. The type of article that will be chosen are research article, systematic review and meta-analysis, narrative review, and literature review with the topic of transmission, clinical manifestasion, pathogenesis, immune response, and severity risk factor of COVID-19. Discussion: From our literature search, it is concluded that the factors that are most likely to determine the severity of COVID-19 infection is age, comorbid disease, vitamin D deficiency, and obesity. These four factors are not four independent factors but rather overlapping and interconnecting factors that determines the severity of COVID-19 infection. Conclusion: Most of the factors that determined the severity of COVID-19 mainly are easily preventable factors. Therefore, the knowledge and awareness of our clinician about these factors will really helps anticipating the severe clinical manifestation among COVID-19 patients before the manifestation even starts to appear.
HIPERTENSI, DIABETES MELLITUS, DAN OBESITAS SEBAGAI FAKTOR KOMORBIDITAS UTAMA TERHADAP MORTALITAS PASIEN COVID-19: SEBUAH STUDI LITERATUR Luh Ade Dita Rahayu; Jannatul Cahya Admiyanti; Yumna Iftinan Khalda; Fatikha Rudia Ahda; Nur Feby Febiana Agistany; Sastraningsih Setiawati; Nabila Indah Shofiyanti; Cut Warnaini
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 1 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.1 Edisi Maret - Juli
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i1.342

Abstract

Background: COVID-19 patients with comorbid diseases have a higher mortality rate than patients without congenital diseases. The most common comorbids found in COVID-19 patients are diabetes mellitus, hypertension, and obesity. The prevalence of COVID-19 patients with diabetes mellitus reached 41.7%, hypertension reached 56.6%, and obesity reached 41.7%. Methods: The method used in this paper is literature review from various references and focused on the correlation of comorbid with the risk of death in COVID-19 patients. The references are being retrieved from NCBI and Google Scholar. Overall, 21 sources were used which were obtained from various data bases including PubMed, ScienceDirect, Researchgate, and WHO. Discussion: There is an increase in ACE-2 expression which causes a high susceptibility to SARS-CoV-2 infection on COVID-19 patient with hypertension. Impaired T-cell function and increased levels of interleukin-6 (IL-6) also play an important role in increasing the severity on COVID-19 patient with diabetes. Obesity can cause abnormalities in the secretion of cytokines, adipokines, and inferferon which will disrupt the immune system in the human body. Conclusion: The complex pathophysiological mechanisms of hypertension, diabetes mellitus, and obesity as comorbid in COVID-19 patients increase the severity and mortality risk.
The Effect of Food on the Incident of Hypertension Restia; Yusra Pintaningrum; Cut Warnaini
Jurnal Biologi Tropis Vol. 23 No. 1 (2023): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v23i4b.5814

Abstract

Hypertension is the condition of a person whose blood pressure is above the normal limit according to medical regulations, namely greater than 140/90 mmHg. Hypertension is a major risk factor for cardiovascular disease, stroke, kidney failure and the main cause of death throughout the world. Consuming foods that are high in fat, carbohydrates, fiber and sodium can increase the occurrence of hypertension. This study aims to determine the effect of food on the incidence of hypertension. This research uses several relevant literature from various references and focuses on risk factors for hypertension, one of which is food. The references used came from searches on NCBI, Pubmed, Google Scholar, and Science Direct and 25 data-based sources were obtained. The results of this research are that there is an influence between food sources such as carbohydrates, fat and sodium which can increase the occurrence of hypertension and high fiber consumption which helps to reduce the occurrence of hypertension. Excessive sodium consumption causes the sodium concentration in the extracellular fluid to increase. And consuming excess carbohydrates can cause triglyceride levels in the blood to increase, causing carbohydrates to be converted into fat. High fat levels can cause atherosclerosis which will ultimately lead to hypertension. The conclusion is that consuming foods high in carbohydrates, fat and sodium can cause hypertension and high fiber consumption can help minimize the occurrence of hypertension.
Co-Authors Abiyyu Didar Haq Adli Putra Nugraha Fatikha Rudia Ahda Febbi Anggy Fiana Damayanti I Komang Gede Andhika Wibisana Jannatul Cahya Admiyanti Luh Ade Dita Rahayu Nabila Indah Shofiyanti Ni Putu Visty Widhiani Nur Feby Febiana Agistany R.R. Ditya Mutiara Syifa Restia Sastraningsih Setiawati Yumna Iftinan Khalda Yusra Pintaningrum