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Karakteristik Fisik, Kimia, dan Biologi Tempat Perindukan Potensial Nyamuk Anopheles sp. di Wilayah Kerja Puskesmas Hanura Septilia Sugiarti; Riyan Wahyudo; Betta Kurniawan; Jhons Fatriyadi Suwandi
Medula Vol 10 No 2 (2020): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i2.66

Malaria is an infectious disease transmitted through mosquitoes and has become a health problem both in the world and Indonesia especially in Lampung. The population of the malaria vector is strongly influenced by the location of the breeding place. This study will examine the characteristics of breeding place of Anopheles sp as the malaria vector. This was an observational descriptive study conducted in the work area of Puskesmas Hanura Kabupaten Pesawaran. The physical characteristics has done by measuring temperature and water depth, the chemical characteristics by measuring pH and water salinity, and the biological characteristics by looking at organisms found at the sampling site. The breeding places are damaged boat, lagun, ditch, rice fields and abandoned ponds. The characteristics of the breeding palces are water temperature 29.5-32.4°C, water depth 10.1-28.6 cm, pH 5-6.6, salinity 0-9.3. Predators found in the breeding place are Aplocheilus panchax (tin head fish), Gambusia affinis (Cere Fish), Culex sp. (larvae stages), Aedes sp. (larvae stages), and water plants Ocsillatoria sp. (alga), Spirogyra (alga). Physical, chemical, and biological characteristics of Anopheles sp. breeding place in Puskesmas Hanura working area are optimum characteristics for Anopheles sp. breeding.

Kolaborasi Tuberculosis (TBC) dan Human Immunodeficiency Virus (HIV) Yona Arisena Magdalena Silitonga; Intanri Kurniati; Retno Ariza; Mukhlis Imanto; Jhond Fatriyadi S
Medula Vol 9 No 2 (2019): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v9i2.269

Tuberculosis (TBC) is becoming one of the highest causes of death in the world. Tuberculosis is caused by Mycobacterium tuberculosis that is transmitted via droplet originating from tuberculosis patients. It is estimated that one-third of people in the world have been infected by tuberculosis, but only 10-20% of people will show the symptoms. Symptoms that can arise in tuberculosis are such as bleeding cough, weight loss, night sweats, chest pain, shortness of breath and weakness. Meanwhile, human immunodeficiency virus (HIV) is a retrovirus-famili because of its ability to convert the RNA genome into DNA. HIV transmission occurs due to the entry of this virus into the body through body fluids of people who are already infected by HIV. Both of these infectious diseases alike because both of them can cause a decrease in immune system activities in the body of the sufferer. Collaboration of both diseases is common and is a deadly combination because it interacts with each other in all aspects of the disease, ranging from pathogenesis, epidemiology, clinical manifestations, treatment and prevention. Tuberculosis is also a leading cause of death in HIV-positive patients. In 2016 in Indonesia, there are found 360,565 cases of TBC, with 14% of them are also known to suffer from HIV-positive. The results of the study suggest that there is a mutual relationship between the two diseases in causing a clinical symptoms through decreased activity of the body's immune system.

Gen PfATP6 dan Resistensi Plasmodium falciparum Terhadap Golongan Artemisinin Jhons Fatriyadi Suwandi
JUKE Unila Vol 5, No 9 (2015)
Publisher : Fakultas Kedokteran Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (109.956 KB)

Resistensi P. falciparum terhadap antimalaria sangat bergantung pada kondisi genetik parasit tersebut. Gen yang saat ini dilaporkan bertanggung jawab terhadap timbulnya resistensi terhadap artemisinin adalah PfATP6. Hal ini sesuai dengan mekanisme kerja artemisinin yang menghambat sarcoendoplasmic reticulum calcium-dependent ATPase (SERCA) Ca2+-pump ATPase6. Posisi mutasi yang ditemukan pada berbagai codon menyebabkan sulitnya menentukan posisi codon yang berkaitan dengan timbulnya resistensi ini. Berdasarkan penelitian yang telah dipublikasikan ditemukan 4 posisi codon (263, 431, 623, dan 769) yang secara tunggal atau bersama-sama menurunkan suseptibilitas terhadap artemisinin. Tingginya variasi genetik gen PfATP6, menimbulkan keraguan mengenai kaitannya pada resistensi Plasmodium terhadap artemisinin. Hal ini menunjukkan kemungkinan adanya gen atau protein lain yang bertanggung jawab terhadap mekanisme resistensi ini. Berbagai penelitian untuk mengungkap marker molekuler ini terus dilakukan. Penelitian di Kamboja melaporkan adanya Mutant K13-propeller alleles pada isolat Plasmodium yang resisten terhadap artemisinin di Kamboja. Berdasarkan hasil penelitian ini, tampak bahwa mekanisme resistensi P. falciparum terhadap artemisinin tidak sepenuhnya berkaitan dengan gen PfATP6. [JuKe Unila 2015; 5(9):141-146]

Kejadian infeksi soil-transmitted helminth pada petani Fitria Saftarina; Maryatun Hasan; Jhons Fatriyadi Suwandi; Anisya Yulida Syani
Jurnal Kedokteran Syiah Kuala Vol 20, No 3 (2020): Volume 20 Nomor 3 Desember 2020
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v20i3.18732

Abstrak. Petani memiliki risiko terinfeksi Soil-Transmitted Helminth (STH) akibat sering berkontak langsung dengan tanah yang terkontaminasi oleh telur STH. Tingginya risiko terinfeksi STH pada petani berhubungan dengan perilaku personal hygiene dan pemakaian alat pelindung diri saat bekerja. Tujuan dilakukan penelitian untuk mengetahui angka kejadian infeksi STH dan faktor yang mempengaruhinya. Penelitian dilaksanakan di Kelurahan Pinang Jaya, Lampung. Populasi pada penelitian ini adalah 63 petani dan sampel dipilih sebanyak 55 petani dengan teknik purposive sampling. Data diperoleh dengan pemeriksaan feses, pengisian kuesioner, dan observasi. Data dianalisis dengan menggunakan α =5%. Hasil penelitian didapatkan prevalensi STH pada petani sebanyak 40% dengan jenis telur cacing A.lumbricoides (22,7%), cacing tambang (59,1%), dan terinfeksi keduanya (18,2%). Sebagian besar personal hygiene petani baik (63,6%) dan sebagian besar petani tidak lengkap menggunakan APD (69,1%). Hasil analisis menunjukkan bahwa personal hygiene dan penggunaan APD berhubungan terhadap kejadian STH (pα). Diperlukan edukasi kepada petani untuk dapat meningkatkan personal hygiene dan menggunakan alas kaki untuk melindungi diri dari risiko STH. Keyword: infeksi Soil Transmited Helminth, petani Abstract. Farmers have the risk of being infected with STH due to frequent direct contact with the soil which contaminated by STH eggs. The high risk of STH infection among farmers is related to personal hygiene behavior and the use of personal protective equipment while working. The purpose of this study is to determine the prevalence of STH and the factors that influence it. The study was conducted in Pinang Jaya Village, Lampung. The population in this study was 63 farmers and a sample of 55 farmers was selected by purposive sampling technique. Data obtained by stool examination, filling out questionnaires, and observing. Data were analyzed using α = 5%. The results showed that the prevalence of STH among farmers was 40% with A. lumbricoides eggs (22.7%), hookworms (59.1%), and both infected (18.2%). Most of the farmers' personal hygiene was good (63.6%) and most farmers did not completely use PPE (69.1%). The results of the analysis showed that personal hygiene and the use of PPE were related to the incidence of STH (p α. Education is needed for farmers to improve personal hygiene and use footwear to protect themselves from the risks of STH. Keywords: Soil Transmited Helminth infection, personal hygiene, farmers

PLASMODIUM KNOWLESI Betta Kurniawan; Jhons Fatriyadi Suwandi; Syazili Mustofa; Sri Janahtul Hayati
JURNAL KEDOKTERAN DAN KESEHATAN Vol 7, No 2 (2020)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/JKK.V7I1.9657

Malaria is a disease which caused by a parasite member of the species of genus Plasmodium. Plasmodium knowlesiis a parasite which found in long-tailed macaques and was firstdiscovered in 1930 from the Macaca fascicularisspeciment from Singapore. In 2004 there was a reported P. knowlesiinfection in humans in Sarawak, Borneo Malaysia and this finding made P. falciparumas the fifth malaria parasite which infect humans. Plasmodium knowlesican sustain its erytrocytic cycle within 24 hours so it can caused a higher infection proggressifity than another parasites. Plasmodium knowlesi’s switch transmission from macaques to human involve some factors, both demographically, environmentaly, and individual behavior.

Social Environment of Friends, Family, Communities, and HIV/AIDS Cases Indri Lestari; Dyah Wulan Sumekar Rengganis Wardani; Jhons Fatriyadi Suwandi; Samsul Bakri
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 22, No 1 (2022): January
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v22i1.12505

Control of HIV/AIDS infection can be done by screening at-risk groups in the social environment to prevent transmission. This study aims to determine the social environment of friends, family, and society’s influence on HIV/AIDS incidence. The study was conducted in December 2020–January 2021 at six Bandar Lampung health centers. The 111 respondents were divided into case/reactive and control/non-reactive groups, with a 1:2 ratio (37:74). Data were obtained by interview. The independent variables were the social environment of friends, family, and community, while the dependent variable was HIV/AIDS incidence. The data were analyzed bivariate and multivariate with the Binary Logistics Regression test utilizing Minitab 16 application, with CI 90% and α 0.1 significance level. The results showed that friends with HIV’s social environment had p 0.087; friend's education p 0.542; risky behavior from friends p 0.853; friends with risky behavior p 0,172; HIV family social environment p 0.999; family education p 0.999; risky behavior from family p 0.998; families with risky behavior p 0.999; HIV community social environment p 0.999; public education p 0.330; risk behavior from the community p 0.690; community with risky behavior p 0.862. Thus, only friends with HIV’s social environment affected HIV/AIDS incidence. Furthermore, having friends with HIV’s social environment will increase the risk of getting HIV/AIDS.

Identification of Plasmodium Falciparum Merozoit Surface Protein-1 (PFMSP-1) Gene From Malaria Patients in Hanura Area, Lampung, Indonesia Ade Triajayanti; Jhons Fatriyadi Suwandi; Betta Kurniawan; Nurul Utami
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 3 No. 4 (2019): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v3i4.97

Introduction: Malaria is a major health problem not only in Indonesia, but also the world. Incidence of anti malarial drug resistance has been found, and one of the possible cause is genetic factors. The changes that occur in the Plasmodium falciparum gene cause genetic variations that lead to resistance for treatment. There is a gene with high polymorphism that can be used as a gene marker of genetic variation in Plasmodium falciparum. Aim of Study: This study aim to identification of plasmodium falciparum merozoit surface protein-1 (PFMSP-1) gene from malaria patients in Puskesmas Hanura, Pesawaran, Lampung. Methods: Descriptive method with morbidity survey approach is used in this study. There are total 23 biological material stored that had been taken in 2016 from malaria patient in Puskesmas Hanura, Pesawaran, Lampung, by consecutive sampling. Identification of genetic variance of the Plasmodium falciparum gene was performed by nested PCR at Medical Faculty Biomolecular Laboratory of Lampung University. The results of this study were processed using a computer software. Results: There are 23 samples that amplified following nested PCR for Plasmodium falciparum Merozoit Surface Protein-1 (PFMSP-1) gene target. In all samples studied, there are PFMSP-1 gene with six variations base pair length range from 200 to 2000 bp. Conclusions: this study has successfully amplified PFMSP-1 gene from individualâ€™s blood sample infected by Malaria in Puskesmas Hanura work region, Pesawaran, Lampung.

Maturity Onset Diabetes of the Young (MODY) : Diagnosa dan Tatalaksana Jhons Fatriyadi Suwandi; Dian Isti Angraini; Syfa Dinia Putri
Jurnal Kedokteran Universitas Lampung Vol 3, No 1 (2019): JK Unila
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jk unila.v3i1.2232

Maturity Onset Diabetes of the Young (MODY), merupakan salah satu bentuk dari defek sel beta pankreas akibat mutasi genetik. Hingga saat ini terdapat lebih dari 10 mutasi fenotip gen yang mendasari terjadinya MODY. MODY mengenai seseorang di onset yang muda biasanya pada dekade dua dan berkaitan erat dengan riwayat diabetes yang kuat dalam keluarga. MODY dilaporkan sebagai bentuk paling umum dari diabetes monogenik dan mempengaruhi 1-2% dari semua pasien diabetes di Eropa. Penelitian terbaru telah melaporkan prevalensi MODY 21-45/1.000.000 anak dan 100/1.000.000 orang dewasa. Telah ditentukan bahwa 5% dari individu yang didiagnosis dengan diabetes sebelum usia 45 tahun memiliki MODY, dengan 80% dari individu salah didiagnosis memiliki tipe 1 (T1DM) atau tipe 2 diabetes mellitus (T2DM). Orang dengan MODY mungkin hanya memiliki gejala diabetes ringan atau tidak ada dan hiperglikemia ditemukan selama tes darah rutin. MODY sering sekali terlambat didiagnosis bahkan terjadi misdiagnosis karena sifatnya yang tidak khas sehinga dibutuhkan kehati-hatian dalam penegakkan diagnosis. Standar baku pemeriksaan MODY yaitu menggunakan analisis gen. Terapi yang dapat diberikan berdasarkan pada jenis MODY sangat spesifik, karena setiap tipe memiliki karakteristik klinis tersendiri. Pada MODY 2 dan 4 dapat dilakukan tatalaksana diet dibandingan MODY tipe lain yang membutuhkan obat anti diabetes atau insulin.Kata kunci: diagnosis, karakteristik klinis, maturity onset diabetes of the young (MODY), terapi

Mekanisme Ivabradine sebagai Terapi Gagal Jantung dengan Penurunan Fraksi Ejeksi Jhons Fatriyadi Suwandi; Giska Tri Putri; Puji Indah Permatasari
Jurnal Kedokteran Universitas Lampung Vol 3, No 1 (2019): JK Unila
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jk unila.v3i1.2227

Gagal jantun merupakan sindrom klinis yang kompleks dimana fungsi-fungsi jantung abnormal dengan gejala klinis dan tanda berupa berkurangnya curah jantung, paru, kongesti sistemik atau keduanya saat fase istirahat atau beraktivitas. Gagal jantung merupakan bagian akhir dari perjalanan penyakit jantung. Peningkatan prevalensi gagal jantung akan menambahkan beban sosio-ekonomi, dan akan terus bertambah akibat rehospitalisasi. Terapi pada gagal jantung ditujukan untuk meningkatkan kualitas hidup pasien, menurunkan gejala serta mengurangi angka rehospitalisasi. Pada pasien dengan gagal jantung dengan penurunan fraksi ejeksi dengan denyut jantung di atas 70 kali permenit, Ivabradine diindikasikan untuk mengoptimalkan terapi.Kata kunci: Gagal jantung, Ivabradine, Terapi

Identification of Plasmodium Falciparum Merozoit Surface Protein-1 (PFMSP-1) Gene From Malaria Patients in Hanura Area, Lampung, Indonesia Ade Triajayanti; Jhons Fatriyadi Suwandi; Betta Kurniawan; Nurul Utami
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 3 No. 4 (2019): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v3i4.97

Introduction: Malaria is a major health problem not only in Indonesia, but also the world. Incidence of anti malarial drug resistance has been found, and one of the possible cause is genetic factors. The changes that occur in the Plasmodium falciparum gene cause genetic variations that lead to resistance for treatment. There is a gene with high polymorphism that can be used as a gene marker of genetic variation in Plasmodium falciparum. Aim of Study: This study aim to identification of plasmodium falciparum merozoit surface protein-1 (PFMSP-1) gene from malaria patients in Puskesmas Hanura, Pesawaran, Lampung. Methods: Descriptive method with morbidity survey approach is used in this study. There are total 23 biological material stored that had been taken in 2016 from malaria patient in Puskesmas Hanura, Pesawaran, Lampung, by consecutive sampling. Identification of genetic variance of the Plasmodium falciparum gene was performed by nested PCR at Medical Faculty Biomolecular Laboratory of Lampung University. The results of this study were processed using a computer software. Results: There are 23 samples that amplified following nested PCR for Plasmodium falciparum Merozoit Surface Protein-1 (PFMSP-1) gene target. In all samples studied, there are PFMSP-1 gene with six variations base pair length range from 200 to 2000 bp. Conclusions: this study has successfully amplified PFMSP-1 gene from individualâ€™s blood sample infected by Malaria in Puskesmas Hanura work region, Pesawaran, Lampung.

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