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All Journal International Journal of Integrated Health Sciences Althea Medical Journal Jurnal Kesehatan Andalas Indonesian Journal of Obstetrics & Gynecology Science JKM (Jurnal Kebidanan Malahayati)
Akhmad Yogi Pramatirta, Akhmad Yogi
Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran RSUP Dr. Hasan Sadikin Bandung
Health Professions Medicine & Pharmacology Public Health

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Journal : International Journal of Integrated Health Sciences

 1 
Correlation between fms-Like Tyrosine Kinase-1 (sFlt-1) Cell-Free Messenger RNA Expression and fms-Like Tyrosine Kinase-1 (sFlt-1) Protein Level in Severe Preeclampsia and Normal Pregnancy Jeffry Iman Gurnadi; Johanes Cornelius Mose; Budi Handono; Prima Nanda Fauziah; Akhmad Yogi Pramatirta
International Journal of Integrated Health Sciences Vol 3, No 2 (2015)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Objective: Preeclampsia is still a problem in Indonesia due to the high maternal and neonatal morbidity and mortality. Placental soluble fms-like tyrosine kinase-1 (sFlt-1), an antagonist of vascular endothelial growth factor (VEGF), and placental growth factor (PIGF), is considered as one of the etiology factors that cause endothelial damage in preeclampsia due to increased sFlt-1 level modulating vascular endothelial integrity. This study aims to analyze sFlt-1 and sFlt-1 mRNA levels in severe preeclampsia and normal pregnancy, and the correlation between both in occurrence of severe preeclampsia.Methods: This is a cross-sectional analytic observational study involving 18 subjects with severe preeclampsia and 19 subjects with normal pregnancy as controls who met inclusion and exclusion criteria. Levels of sFlt-1 and sFlt-1 mRNA were measured with ELISA and RT PCR. Statistical analysis was performed with Chi square test, Fisher’s exact test, T-test, Mann-Whitney test, and Spearman’s rank correlation test.Results: This study showed no significant difference (p>0.05) in characteristics of maternal age, gestational age, and parity in both study groups. Mean level of sFlt-1 mRNA in severe preeclampsia was higher (6.3404 pg/mL) compared to its level in normal pregnancy (5.9701 pg/mL). There is a not significant (p>0.05) positive correlation between sFlt-1 mRNA with sFlt-1 level in normal pregnancy, and a not significant (p>0.05) negative correlation between both level in severe preeclampsia.Conclusions: sFlt-1 mRNA levels in severe preeclampsia are higher than its level in normal pregnancy. There is no correlation between sFlt-1 mRNA level and sFLt-1 protein level in severe preeclampsia. There is a not significant positive correlation between sFlt-1 mRNA with sFlt-1 level in normal pregnancy, and a not significant negative correlation between both in severe preeclampsia.Keywords: Normal pregnancy, severe preeclampsia, sFlt-1 mRNA DOI: 10.15850/ijihs.v3n2.586
Co-Authors Adhi Pribadi Adhi Pribadi Akbar Rahmat Alamsyah Aziz Ali Budi Harsono Amillia Siddiq, Amillia Amran Amrullah Budi Handono Budi Handono Devi Nurlaelasari Dini Hidayat Fadil Oenzil FM. Dicky Fitraendi Galih Apriadi Hanom Husni Syam Herman Susanto Jeffry Iman Gurnadi Johanes C. Mose Jusuf S. Effendi Jusuf Sulaeman Effendi Jusuf Sulaeman Effendi Lani Gumilang Lucky Saputra M. Rizkar Arev Sukarsa Meita Dhamayanti Neneng Martini Pradistya Syifa Yudiasari Prima Nanda Fauziah R. M. Sonny Sasotya Raden Tina Dewi Judistiani Rizna Tyrani Rumanti Rizna Tyrani Rumanti Sharon Gondodiputro Sharon Gondodiputro Sofie R. Krisnadi Tita Husnitawati Madjid Udin Sabarudin Vaulinne Basyir Yanwirasti Yanwirasti Yoga Paripurna Yudiasari, Pradistya Syifa