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All Journal Jurnal Kedokteran Syiah Kuala Jurnal Anestesi Perioperatif Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Mutiara Medika: Jurnal Kedokteran dan Kesehatan Majalah Kedokteran Sriwijaya Jurnal Keperawatan Sriwijaya Biomedical Journal of Indonesia Syntax Literate : Jurnal Ilmiah Indonesia Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan SRIWIJAYA JOURNAL OF MEDICINE Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Aisyah : Jurnal Ilmu Kesehatan Sriwijaya Journal of Surgery Archives of The Medicine and Case Reports Bioscientia Medicina : Journal of Biomedicine and Translational Research
Legiran Legiran
Fakultas Kedokteran Universitas Sriwijaya
Humanities Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Polymorphism of CYP1A1 (Ile462Val) Gene Related to Uterine Myoma in Malays Ethnicity of South Sumatera Bella Ria Astuti; Ferry Yusrizal; Legiran Legiran
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 20, No 2 (2020): July
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mm.200249

Abstract

ABSTRACTASSOCIATION BETWEEN CYP1A1 (Ile462Val) GENE POLYMORPHISM AND OCCURANTE OF UTERINE MYOMA IN MALAYS POPULATION IN SOUTH SUMATERA.Bella Ria Astuti1, Ferry Yusrizal2 dan Legiran3Biomedical Science Program, Faculty of Medicine, University Sriwijaya          Background :  Uterine myoma is a tumor in the myometrium. Uterine myoma is a disease associated with interactions between genes, hormones, growth factors, cytokines, and the environment. Myoma has never been found before menarche, whereas after menopause only about 10% of myomas still grow. In general the incidence of uterine myoma is predicted to reach 20-30% in women over 35 years. In Indonesia myoma was found 2.39% - 11.7%. Uterine myomas can cause various symptoms including menometroragia, pelvic pain, spontaneous abortion and infertility. that the growth and development of uterine myomas depends on estrogen. Cytochrome CYP450 system is a group of enzymes involved in biosynthesis of steroid hormones and metabolic activation of carcinogens. CYP1A1 is one of three members of the CYP1 family that plays a role in the metabolism of large numbers of xenobiotics. The purpose of this study is to analyze the relationship of CYP1A1 (Ile462Val) gene polymorphism with the incidence of uterine myoma in ethnic Malays in South Sumatra.          Methods : This study is an observational analytic study with a case control. This research was conducted in February 2019 in the laboratory of molecular Biology, Faculty of Medicine, Sriwijaya University. Test the statistics using the chi square test. The study sample used blood samples taken in 70 samples consisting of 35 case samples and 35 control cases. CYP1A1 (Ile462Val) gene polymorphism using the method PCR-RFLP.          Results : There is a relationship between Polymorphism between genotypes and gene alleles CYP1A1 (Ile462Val) with the incidence of uterine myoma in ethnic Malays in South Sumatra. Key words      :  Polymorphism, Gene CYP1A1 (Ile462Val), Uterine leiomyoma.Citations          :  63 (2001-2015)          
HUBUNGAN POSISI DUDUK DAN KETIDAKSESUAIAN DESAIN TEMPAT DUDUK SEPEDA MOTOR DENGAN KEJADIAN NYERI PINGGANG PADA PENGENDARA OJEK DARING Ridho Surya Putra; Legiran Legiran; Mutiara Budi Azhar
Majalah Kedokteran Sriwijaya Vol 50, No 2 (2018): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36706/mks.v50i2.8551

Abstract

Hubungan Posisi Duduk dan Ketidaksesuaian Desain Tempat Duduk Sepeda Motor dengan Kejadian Nyeri Pinggang pada Pengendara Ojek Daring. Pengendara ojek daring merupakan profesi yang kesehariannya beraktivitas lebih banyak dilakukan dengan duduk.Posisi duduk di atas sepeda motor dapat dipengaruhi oleh desain tempat duduk sepeda motor. Berkendara di atas sepeda motor dengan posisi yang statis dan dalam waktu yang lama akan menimbulkan masalah pada tulang belakang. Salah satu efek samping dari posisi duduk statis dalam jangka waktu yang lama adalah dapat menimbulkan keluhan muskuloskeletal. Dampak dari keluhan muskuloskeletal yang paling sering dijumpai adalah Nyeri Punggung Bawah (NPB). Penelitian ini dilakukan untuk mengetahui hubungan posisi duduk dan ketidaksesuaian desain tempat duduk sepeda motor dengan NPB agar dapat dilakukan tindakan pencegahan sebelum timbulnya keluhan NPB pada pengendara ojek daring. Jenis penelitian yang digunakan adalah penelitian analitik observasional dengan desain cross-sectional (potong lintang) dengan teknik consecutive sampling. Populasi penelitian ini adalah semua pengendara ojek daring (Gojek) di Kota Palembang. Sampel penelitian adalah sebagian pengendara ojek daring yang ada di Kota Palembang yang berjumlah 108 orang. Data yang dikumpulkan adalah data primer dengan menggunakan kuisioner dan hasil ukur. Analisis data menggunakan analisis univariat dan bivariat menggunakan uji Chi-Square dan uji korelasi Rank Spearman. Dari penelitian ini ditemukan 80 pengendara (74.1%) yang menderita nyeri punggung bawah dari 108 pengendara. Pengendara dengan posisi duduk tegak sebanyak 27 orang (25.0%), posisi duduk duduk bungkuk sebanyak 8 orang (7.4%) dan posisi duduk menyandar sebanyak 73 orang (67.6%). Tidak terdapat hubungan bermakna antara posisi duduk dengan nyeri punggung bawah pada pengendara ojek daring (p>0.05, r=0.598). Dari uji korelasi menggunakan rank spearman, didapatkan hasil yang menunjukkan korelasi yang sangat lemah dan tidak signifikan antara intensitas nyeri dengan desain tempat duduk sepeda motor pada selang kepercayaan 95% (p>0.05). Tidak terdapat hubungan bermakna posisi duduk dan ketidaksesuaian desain tempat duduk sepeda motor dengan nyeri punggung bawah pada pengendara ojek daring
Factors Affecting Low Back Pain (LBP) among Public Transportation Drivers Muhammad Arma; Indri Seta Septadina; Legiran Legiran
Majalah Kedokteran Sriwijaya Vol 51, No 4 (2019): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36706/mks.v51i4.10240

Abstract

Low back pain (LBP) is one of the most common health problems among public transportation drivers. On the average, public transportation drivers has 12 hours working time per day with prolonged static sitting position so that it can cause problems such as muscle and spine pain in the lower back area. This study was conducted to analyze what factors affect LBP the most among public transportation drivers in Palembang. This analytic observational reasearch is using cross sectional design and incidental sampling technique. Subject of the research is 60 public transportation drivers in Palembang. LBP is measured with Nordic Questionnaire and the other factors is measured with self identity questionnaire, Perceived Stress Scale and anthropometric measurement. Data is analysed with Chi-Square method and logistic regression analysis. Thirty seven drivers (61,7%) of 60 drivers complained about LBP. There is significant association of LBP with age (p=0.044), BMI (p=0.006), working period (p=0.037), working time (p=0.040), and smoking (p=0.016), but no significant association with waist circumference (p=0.111), pelvis height (p=0.066), psychosocial stress (p=0.229), and family history(p=0.443). Multivariate analysis with logistic regression showed that BMI is associated with LBP (p=0.002). There is significant association between LBP with age, BMI, working period, working time, and smoking. BMI has a greater association with LBP. 
Pola Sidik Bibir pada Suku Palembang Berdasarkan Jenis Kelamin Nadya Aviodita; Legiran Legiran; Indri Seta Septadina
Majalah Kedokteran Sriwijaya Vol 49, No 4 (2017): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36706/mks.v49i4.8522

Abstract

Sumatera Selatan yang merupakan bagian dari Indonesia dikenal dengan keanekaragaman individu dengan ciri khas masing-masing yang unik pada setiap sukunya, diantaranya suku Palembang. Ciri khas tersebut salah satunya dapat dilihat dari pola sidik bibir. Tujuan penelitian ini adalah untuk mengidentifikasi perbedaan pola sidik bibir antara laki-laki dan perempuan pada suku Palembang. Penelitian yang dilakukan adalah penelitian observasional deskriptif potong lintang. Sebanyak 140 subjek penelitian yang berasal dari suku Palembang diwilayah kota Palembang diambil pola sidik bibirnya. Pengambilan dilakukakan dengan penggunaan pewarna bibir yang selanjutnya ditempelkan pada selotip transparan. Sidik bibir yang dianalisis pada bagian pertengahan bibir bawah dengan lebar 10 mm menggunakan klasifikasi Suzuki dan Tsuchihashi. Pola yang dianalisis berupa pola berpotongan, pola retikuler, garis vertikal, garis bercabang, dan bentuk lainnya. Pola sidik bibir tipe IV (23,6%) merupakan pola sidik bibir yang paling banyak muncul pada laki-laki dan tipe I’ (24,3%) paling banyak muncul pada perempuan. Pola tipe I (11,4%) paling sedikit ditemuakan pada perempuan dan pola tipe V (7,9%) paling jarang ditemukan pada laki-laki. Pola tipe vertikal sebagian lebih banyak ditemukan pada perempuan dan pola tipe retikuler lebih banyak ditemukan pada laki-laki.
Nyeri Pinggang dan Faktor-Faktor Risiko Yang Mempengaruhinya Indri Seta Septadina; Legiran Legiran
Jurnal Keperawatan Sriwijaya Vol 1, No 1 (2014)
Publisher : Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Tujuan: Keluhan nyeri punggung bawah atau pinggang (low back pain-LBP) masih tetap menjadi keluhan yang banyak dijumpai pada setiap orang. Keluhan ini juga banyak dijumpai di kalangan pekerja dari berbagai jenis pekerjaan. Akibat rasa nyerinya, pekerja terpaksa beristirahat dan mencari penyembuhan sehingga banyak kehilangan waktu kerja, menghabiskan banyak biaya untuk pengobatan, dan menurunkan produktivitas. Pada pekerja, ada beberapa faktor risiko utama yang diduga berperan dalam terjadinya LBP yaitu stres fisik, stres psikososial, karakter pribadi, dan karakter fisik. Tujuan penelitian ini adalah untuk mengkaji nyeri pinggang, faktor-faktor risiko dan hubungan antara nyeri pinggang dengan faktor-faktor risiko tersebut.   Metode: Metode penelitian yang digunakan adalah case control study. Populasi adalah pria atau wanita usia produktif. Sampel pada kelompok kasus ditentukan ahli penyakit dalam.   Hasil: Pada penelitian ini telah dilakukan pengukuran tinggi badan, berat badan, indeks massa tubuh, pemeriksaan radiologi rontgen foto lumbal antero-posterior dan lateral serta ditanyakan juga riwayat merokok, posisi kerja, dan beban pekerjaan. Tiap variabel dihubungkan dengan kejadian LBP dengan menggunakan uji hipotesis Chi-Square Test. Merokok dan IMT memiliki hubungan bermakna dengan terjadinya LBP (p<0,05), sedangkan posisi dan beban kerja tidak memiliki hubungan bermakna (p>0,05).   Simpulan: Tingkat risiko terbesar untuk terjadinya LBP diantara keempat variabel yang diteliti adalah merokok dengan nilai OR 2,813. Pada penelitian penentuan posisi kerja dan beban pekerjaan ditentukan atas dasar wawancara antara petugas dan responden sehingga masih menimbulkan bias.   Kata Kunci: Nyeri pinggang, merokok, posisi kerja, beban kerja, indeks massa tubuh
Cross-Sectional Study as Research Design in Medicine Puspa Zuleika; Legiran
Archives of The Medicine and Case Reports Vol. 3 No. 2 (2022): Archives of The Medicine and Case Reports
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/amcr.v3i2.193

Abstract

A cross-sectional study is an observational study that analyzes data from a population at one point in time. These studies are often used to measure prevalence in medicine, analyze health studies, and describe health characteristics. Unlike other types of observations, in a cross-sectional study, each research subject was only observed once, the measurement of research variables was carried out at the time of the observation, and no follow-up was carried out on the measurements made. These studies are less expensive and easier to perform and help establish preliminary evidence in planning further studies in the future. This article reviews essential characteristics, describes strengths and weaknesses, discusses methodological issues, and provides design recommendations and statistical analysis for cross-sectional studies.
Sleep and Bone Density: A Study on Postmenopausal Indonesian Women Shafira Irmayati; Muhammad Reagan; Legiran Legiran
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 3 No. 1 (2019): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v3i1.68

Abstract

Background: Low bone density has been known as one of the factors that increased fracture risk. Aging, estrogen deficiency, low BMI, and inadequate calcium intake are known factors that contribute to decreased bone density. Other than the known factors, some research show that sleep duration can also lower bone density. Sleep affects bone density in a way that it causes increased level of cortisol, proinflammatory cytokine, and decreased in physical activity. Method: This study is an observational analytic study with cross-sectional design. It is conducted on menopausal patients that has been examined with bone mineral densitometry at Poliklinik Reumatologi Penyakit Dalam RSUP Dr. Mohammad Hoesin Palembang in November 2017 to Oktober 2018. Samples are collected using total sampling technique. Results: From 93 subjects that participated in this study, 20,4% of them had osteopenia, and 51,6% had osteoporosis. Patients with low bone density, mainly slept for 6 to 8 hours at night per day, 30 minutes of nap per day, and has a total sleep duration for less than 8 hours each day. This study shows no significant association between night-time sleep, daytime napping, and total sleep duration with bone density (p value = 0,168, p value = 0,831, p value = 0,984). Analysis on other risk factors show significant association between body mass index and low bone density (p value = 0,002). Conclusion: There are no significant association between sleep duration and bone density in menopausal patients at Poliklinik Reumatologi RSUP Dr. Mohammad Hoesin Palembang.
Correlation between Lgr5 Expression and 5-FU based Chemotherapy Response in Stage IV Colorectal Cancer Patients Kgs. M. Rosyidi; Mediarty Syahrir; Suly Auline Rusminan; Legiran
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 10 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i10.358

Abstract

Background. Colorectal cancer is the third commonest malignancy and the second leading cause of cancer death in the world. 5-Fluorouracyl-based chemotherapy is the primary treatment modality for colorectal cancer. Cancer stem cells are known to be responsible for chemotherapy resistance. Lgr5 is a colorectal cancer stem cell marker that is the target gene for Wnt signaling. Lgr5 potentiates the Wnt signaling pathway through inhibition of a regulator that inhibits Wnt signaling. Lgr5 overexpression is associated with a worse prognosis and chemotherapy resistance. This study was aimed to investigate the correlation between Lgr5 expression and 5-FU-based chemotherapy response in stage IV colorectal cancer patients at Dr. Mohammad Hoesin Hospital Palembang.Methods. This study used a correlative analysis study with a retrospective design using secondary data from medical records and paraffin blocks of stage IV colorectal cancer patients who received 5-FU-based chemotherapy from September 2018 to September 2020. The number of samples was 30 subjects consisting of 22 cases of negative responses and eight positive responses. All samples were stained with Lgr5 immunohistochemistry. Data analysis used the contingency coefficient correlation test.Results. Of the 30 research subjects, 20 subjects (66.7%) had high Lgr5 expression and ten subjects (33.3%) with low Lgr5 expression. Correlation analysis using the contingency coefficient test showed a weak correlation between Lgr5 expression and 5-FU based chemotherapy response with a positive direction, which means the higher the Lgr5 expression, the less response to chemotherapy.Conclusion. There is a weak correlation between Lgr5 expression and 5-FU based chemotherapy response in stage IV colorectal cancer patients at dr.Mohammad Hoesin Hospital Palembang.
Sleep and Bone Density: A Study on Postmenopausal Indonesian Women Shafira Irmayati; Muhammad Reagan; Legiran Legiran
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 3 No. 1 (2019): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v3i1.68

Abstract

Background: Low bone density has been known as one of the factors that increased fracture risk. Aging, estrogen deficiency, low BMI, and inadequate calcium intake are known factors that contribute to decreased bone density. Other than the known factors, some research show that sleep duration can also lower bone density. Sleep affects bone density in a way that it causes increased level of cortisol, proinflammatory cytokine, and decreased in physical activity. Method: This study is an observational analytic study with cross-sectional design. It is conducted on menopausal patients that has been examined with bone mineral densitometry at Poliklinik Reumatologi Penyakit Dalam RSUP Dr. Mohammad Hoesin Palembang in November 2017 to Oktober 2018. Samples are collected using total sampling technique. Results: From 93 subjects that participated in this study, 20,4% of them had osteopenia, and 51,6% had osteoporosis. Patients with low bone density, mainly slept for 6 to 8 hours at night per day, 30 minutes of nap per day, and has a total sleep duration for less than 8 hours each day. This study shows no significant association between night-time sleep, daytime napping, and total sleep duration with bone density (p value = 0,168, p value = 0,831, p value = 0,984). Analysis on other risk factors show significant association between body mass index and low bone density (p value = 0,002). Conclusion: There are no significant association between sleep duration and bone density in menopausal patients at Poliklinik Reumatologi RSUP Dr. Mohammad Hoesin Palembang.
Correlation between Lgr5 Expression and 5-FU based Chemotherapy Response in Stage IV Colorectal Cancer Patients Kgs. M. Rosyidi; Mediarty Syahrir; Suly Auline Rusminan; Legiran
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 10 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i10.358

Abstract

Background. Colorectal cancer is the third commonest malignancy and the second leading cause of cancer death in the world. 5-Fluorouracyl-based chemotherapy is the primary treatment modality for colorectal cancer. Cancer stem cells are known to be responsible for chemotherapy resistance. Lgr5 is a colorectal cancer stem cell marker that is the target gene for Wnt signaling. Lgr5 potentiates the Wnt signaling pathway through inhibition of a regulator that inhibits Wnt signaling. Lgr5 overexpression is associated with a worse prognosis and chemotherapy resistance. This study was aimed to investigate the correlation between Lgr5 expression and 5-FU-based chemotherapy response in stage IV colorectal cancer patients at Dr. Mohammad Hoesin Hospital Palembang.Methods. This study used a correlative analysis study with a retrospective design using secondary data from medical records and paraffin blocks of stage IV colorectal cancer patients who received 5-FU-based chemotherapy from September 2018 to September 2020. The number of samples was 30 subjects consisting of 22 cases of negative responses and eight positive responses. All samples were stained with Lgr5 immunohistochemistry. Data analysis used the contingency coefficient correlation test.Results. Of the 30 research subjects, 20 subjects (66.7%) had high Lgr5 expression and ten subjects (33.3%) with low Lgr5 expression. Correlation analysis using the contingency coefficient test showed a weak correlation between Lgr5 expression and 5-FU based chemotherapy response with a positive direction, which means the higher the Lgr5 expression, the less response to chemotherapy.Conclusion. There is a weak correlation between Lgr5 expression and 5-FU based chemotherapy response in stage IV colorectal cancer patients at dr.Mohammad Hoesin Hospital Palembang.
Co-Authors Achmad Ridwan, Achmad Ade Dian Anggraini Ade Permana Bella Ria Astuti Benny Kusuma Bernhard Arianto Purba Chandra, Novy Rosalia Danny Amos Tarigan Diana Polania Efman EU Manawan Efrieni Yusuf Ferry Yusrizal Fitri Nurjanah Fredy Ferdinand Carol Hafid Komar Indah, Furqan Indrajaya, Taufik Indri Seta Septadina Kgs. M. Rosyidi Kms Yusuf Effendi M. Zalili Azis Martinova, Vera Mediarty Mega Sary Meirisa Rahma Pratiwi Mgs.Muhammad Irsan Saleh Muhammad Arma Muhammad David Riandy Muhammad Irsan Saleh Muhammad Reagan Mutiara Budi Azhar Nadya Aviodita Nedya Bellinawati Nur Qodir Nur Riviati, Nur Nurjanah, Fitri Precelia Fransiska Puspa Zuleika, Puspa Qodir, Nur Ridho Surya Putra Rizal Sanif Rizal Zainal Salni Sary, Mega Shafira Irmayati Sugiharto, Henry Suly Auline Rusminan Tri Suciati Wiria Aryanta Yusni Puspita