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All Journal Jurnal Kedokteran Brawijaya Molecular and Cellular Biomedical Sciences (MCBS) Pendas mahakam : jurnal pendidikan dan pembelajaran Sekolah Dasar Jurnal Keperawatan Padjadjaran Journal of Tropical Pharmacy and Chemistry JIMR - Journal of Islamic Medicine Research Kumawula: Jurnal Pengabdian Kepada Masyarakat Jurnal Kebidanan Mutiara Mahakam Jurnal Kesehatan Pasak Bumi Kalimantan Indonesian Journal of Pharmacology and Therapy Jurnal Sains dan Kesehatan Jurnal Pengabdian Kreativitas Pendidikan Mahakam (JPKPM)
Fikriah, Ika
Department Of Pharmacology, Faculty Of Medicine, Mulawarman University, Samarinda, Indonesia.
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : Jurnal Kedokteran Brawijaya

 1 
PENGARUH CURCUMIN TERHADAP KADAR KOLESTEROL TOTAL, LDL-KOLESTEROL, JUMLAH F2 -ISOPROSTAN, DAN SEL BUSA (FOAM CELL) DINDING AORTA PADA TIKUS DENGAN DIET ATEROGENIK Fikriah, Ika; Kalim, Handono; Dradjat, Respati Suryanto
Jurnal Kedokteran Brawijaya Vol 21, No 2 (2005)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (151.016 KB) | DOI: 10.21776/ub.jkb.2005.021.02.1

Abstract

ABSTRACT Death  caused  by  cardiovascular  and  cerebrovascular diseases  are  still  the  highest.  Atherosclerosis  due  to hypercholesterolemia is a predispositioning factor of both diseases. Curcumin has an antioxidant character that can inhibit lipid peroxidase to atherogenesis process. The aim of this study was to observe the effect of curcumin in decreasing total cholesterol level, LDL-cholesterol, the number of  F2-isoprostan and foam cell of aorta’s wall of white rats strain wistar after giving atherogenic diet for 10 weeks. There were 6 groups in this study (n=24): atherogenic diet group (group I as positive control), atherogenic diet group + curcumin 50 mg/kg b.w. per day (group II), atherogenic diet group + curcumin 100 mg/kg b.w. per day (group III), atherogenic diet group + curcumin 200 mg/kg b.w. per day (group IV), atherogenic diet group + curcumin 400 mg/kg b.w. per day (group V), normal diet group (group VI as negative control). After 10th, the level of total cholesterol and LDL-cholesterol were measured by spectrofotometri. Staining F2-isoprostan was done with Avidin Biotin Complex imunohystochemistry method, and staining foam cell with HE-oil Red O. The number of  F2-isoprostan and foam cells were counting semi quantitatively using  light microscope. The highest total cholesterol level was found in group I (275,15 ± 10,01; Mean ± SD), the highest LDL-cholesterol level was found in group I (158,15 ± 12,19). Statistically total cholesterol level and LDL-cholesterol level in group I were significantly higher (p ≤ 0,05) than other
Co-Authors Adheya Putrindashafa Agustina Rahayu Magdalena Agustina Rahayu Magdaleni Almira Fahrinda Anik Puji Rahayu Annin Dya Maina Arfian Deny Prakoso Bilqis Faiqotun Nabilah Dilan Cicih Bhakti Purnamasari Crissty Magglin Denny J. Rotinsulu Ediyar Miharja Endang Sawitri Evi Fitriany Hadi Kuncoro Handono Kalim Handy Wiradharma Imran Irsal Imran Irsyal Iwan Samsugito Jaya Mualimin Khemasili Kosala Khemasili Kosala Krispinus Duma Meiliati Aminyoto Meilinda Meilinda Miftahul Jannah Naina Nataniel Tandirogang Novia Fransisca Novia Fransiska Ngo Nursaci Mardania Pipi Surianti Rahmat Bakhtiar Regina Anastasia Sanjaya Respati Suryanto Dradjat Rifqiya Faiza, Mita Maulida Rochimah Thul Ulyah Rudi Saputra Sapta Rahayuning Ratri Sholichin Sholichin Siti Khotimah Siti Rahmadhani Sjarif Ismail Sulistiawati Sudarso Sulistiawati Sudarso Sulistiyawati Sulistiyawati Yadi Yadi Yuliana Kartika Ningrum Yuniati Yuniati