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Jurnal Ilmiah Manuntung

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Published by SEKOLAH TINGGI ILMU KESEHATAN SAMARINDA

ISSN : 2443115X EISSN : 24771821 DOI : -

Core Subject : Agriculture,

Agriculture, Biological Sciences & Forestry

Jurnal Media Pertanian dipublikasikan dalam Bahasa Indonesia dan diterbitkan dua kali dalam setahun. Jurnal ini mempublikasikan artikel hasil penelitian dan artikel review bidang ilmu Agronomi secara luas. Semua tulisan yang masuk hendaknya bukanlah hasil plagiat dan belum dipublikasikan. Artikel akan di review oleh editor dan hasilnya akan di komunikasikan dengan penulis.

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Articles 169 Documents

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OPTIMASI POLIVINILPIROLIDON DAN CARBOPOL PADA SEDIAAN PATCH DISPERSI PADAT PIROKSIKAM Nurahmanto, Dwi; Sabrina, Friska Wira; Ameliana, Lidya
Jurnal Ilmiah Manuntung Vol 3 No 2 (2017): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

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Piroxicam, a non steroidal anti inflammatory drugs (NSAID), is an oxicam derivative which can be used for treatment of various rheumatic diseases, such as rheumatoid arthritis and osteoarthritis. Piroxicam patch is an affective approach evading piroxicam?s side effect such as peptic ulcer and first pass metabolism. One of the patch components is polymer that the function is to control the speed of drug release from the patch. The aims of this study were to determine the optimum formula of a combination of polyvinylpyrolidone (PVP) and Carbopol to % moisture content (MC) and the flux release in solid dispersion piroxicam patch using Simplex Lattice Design. Piroxicam was prepared in the form of a solid dispersion in PEG 4000 to increase its solubility. The design formula of solid dispersion piroxicam patch made with the ratio PVP : Carbopol, that were 1 : 0; 0.5 : 0.5; 0 : 1. The optimum formula was chosen with the ratio PVP : Carbopol, 1: 0, which gave the best result of % MC and flux release. The result of % MC was 6.91% and the result of flux release was 35.543 µg/cm2.menit1/2.

EFEK EKSTRAK ETANOL DAUN SINGKONG (Manihot Utilissima Pohl) SEBAGAI OBAT ALTERNATIF ANTI REMATIK TERHADAP RASA SAKIT PADA MENCIT Rikomah, Setya Enti; Elmitra, Elmitra; Yunita, Diana Gustina
Jurnal Ilmiah Manuntung Vol 3 No 2 (2017): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

Medicinal plants used for generations one of which is crop cassava leaves. Cassava leaves is believed to cure rheumatism, gout, anemia, constipation, and to increase endurance. This study aims to determine the Effects Of Ethanol Leaf Extract Singkong (Manihot Utilissima Pohl) As Drug Alternatif Antirheumatic Of Pain On Mice. This study was an experimental study using 25 mice. These animals were divided into five groups where each group consisted of 5 mice. Cassava leaf extracts as a control test, flamar gel as a positive control, and distilled water as a negative control. Observations were made for 45 minutes using a hot excitatory response in the form of a decrease in a lick or jump after the treatments. The results showed a decline in the response of mice to lick the feet or jump to the heat stimuli were administered after administration of cassava leaf extract. Cassava leaf extract has an effect antirheumatic to pain in mice. Based on the analysis of SPSS best dose in this study is the first dose (0.65mg / 20gr mice BB).

IDENTIFIKASI DAN PENETAPAN KADAR RHODAMIN B DALAM KERUPUK BERWARNA MERAH YANG BEREDAR DI PASAR ANTASARI KOTA BANJARMASIN Kumalasari, Eka
Jurnal Ilmiah Manuntung Vol 1 No 1 (2015): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

Crackers are madeÂ from tapioca flour batter mixed with flavorings and colorings, still many outstanding crackers that contain ingredients banned dye Rhodamine B. Rhodamine B is a chemical used for red dye in the textile industry and plastic. Rhodamine B can cause cancer, poisoning, lung irritation, sore eyes, and sore throat. This study aims to identify and determination the levels of Rhodamine B in circulating red crackers Antasari market Banjarmasin.The population is that sold in the red crackers that sold in Antasari market Banjarmasin.. The sampling is technique incidental sampling , that is based on chance, so any population by chance met with researchers can be used as a sample. Identification of Rhodamine B was done by Thin Layer Chromatography (TLC) by using the stationary phase silica GF 254 and mobile phase is elution solvent is n-butanol, ethyl acetate, ammonia (10:4:5). Then detected with a UV lamp 254 nm and 366 nm. While for the determination of levels using Vis spectrophotometry at a wavelength of 544 nm.The results showed that the samples of 6 found one sample containing Rhodamine B, namely samples 5 (cassava crackers matches) and obtained valuesÂ of 7,25 Â± 3,8640 levels mg / kg. Based on these results, Rhodamine B still found in crackers that sold in the market Antasari Banjarmasin.

UJI MUTU FISIK GRANUL EKSTRAK ETANOL DAUN KEMANGI (Ocimum americanum L.) DENGAN VARIASI KONSENTRASI EXPLOTABÂ® Soemarie, Yulistia Budianti; Sa'adah, Hayatus; Fatimah, Nurul; Ningsih, Tri Marga
Jurnal Ilmiah Manuntung Vol 3 No 1 (2017): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

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Bad breath is usually caused by bacteria and food debris left in the mouth. Development of preparations using herbal ingredients, to overcome the problem of bad breath one of them is with utilization basil leaves (Ocimum americanum L.) which have anti bacterial activity. The method of wet granulation is a single method for use in granulation of large doses of active substances because if using direct induced method will require again the addition of a large number of fillers to make it easier forging, but cause the tablet to be not feasible as it will resulting in an increase in tablet size. The type of research conducted is an experimental study. Object the study was basil leaf extract formulated. This formulation was prepared by wet granulation method with variation Explotab® ss crusher ie 2%, 4%, 6% and 8%. Performed wet granulation on each formulation. Granul evaluated the flow time, mass density test, silent angle and fixed assay test. Based on research result the physical quality of ethanol extract granule of basil leaves (Ocimum americanum L.) with explotab® concentration variation it can be concluded that all the formula fulfill the good quality of granule characteristic, because it meets the requirements of parameters of time flow, rest angle, compressibility and density mass

KADAR ASAM URAT PADA PASIEN TUBERKULOSIS DENGAN TERAPI OBAT ANTI TUBERKULOSIS (OAT) DI PUSKESMAS CEMPAKA MARET 2017 Nafila, Nafila; Haqiqi, Rizqia Nurul; Wahyunita, Sari
Jurnal Ilmiah Manuntung Vol 3 No 2 (2017): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

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Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis that mostly attacks the lungs. Uric acid is the result of purine metabolism in the body. Actually, uric acid is a natural substance in the body but it becomes unnatural in the body when uric acid becomes up and beyond normal limits. The purpose of this study was to detemmine the description of uric acid levels in tuberculosis patients with anti tuberculosis drug therapy (OAT) at Puskesmas Cempaka. The population in this study was 22 patients with TB patiens who received OAT treatment. The sample of this research is 15 people with purposive sampling method. Examination was done in area of cempaka with capillary blood using rapid test method. Of the 15 patient studied with pulmonary tuberculosis who consumed OAT in Cempaka Puskesmas work area, obtained uric acid levels increased (26,67%) and normal levels uric acid (73,33%) in male gender (75%) and female gender (25%). Characteristics of age in the age group 41-50 years (25%), age 51-60 years (25%) In female gender. Should be monitored specifically for the symptoms of side effects of Anti Tuberculosis (OAT) by looking at clinical symptoms, such as nausea, vomiting, etc.

FORMULASI SEDIAAN GEL DISPERSI PADAT IBUPROFEN : STUDI GELLING AGENT DAN SENYAWA PENINGKAT PENETRASI Nurahmanto, Dwi; Mahrifah, Ifa Rosi; Azis, Rani Firda Nur Imaniah; Rosyidi, Viddy Agustian
Jurnal Ilmiah Manuntung Vol 3 No 1 (2017): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

ABSTRACT This study aims to determine the effect of using gelling agent and chemical penetration enhancer on the solid dispersion Ibuprofen gel in increasing the transdermal drug penetration. Inhibition of the COX-1 enzyme caused by ibuprofen in oral administration can cause side effects of gastrointestinal disorders, dyspepsia, diarrhea, upper gastrointestinal infections, nausea and bloating, resulting in a topical route to reduce side effects. The gel is prepared using hydroxy propyl methyl cellulose (HPMC) and carbopolÂ® as gelling agents, and also propylene glycol and glycerin as chemical penetration enhancer compounds. The gel evaluation are viscosity, pH, spreadability and penetration flux rate. The value of the formula 3 penetration flux is 1.5383 Â± 0.029 ug / cm2.minute, the formula 1 is 1.403 Â± 0.055 ug / cm2. minute, the formula 2 is 0.756 Â± 0.071 ug / cm2 minute, while the formula 4 is 0.5404 Â± 0.106 ug / Cm2. minute. The amount of gelling agent concentration and chemical penetration enhancer compound effect on the value of the flux penetration

OPTIMASI HYDROXYPROPYL METHYLCELLULOSE DAN CHITOSAN PADA TABLET FLOATING-MUCOADHESIVE SIMETIDIN DENGAN METODE DESAIN FAKTORIAL A., Mohammad Zulfikhar; Nurahmanto, Dwi; R.K.S., Lusia Oktora
Jurnal Ilmiah Manuntung Vol 5 No 2 (2019): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

Cimetidine is an H2 receptor antagonist which can be used to reduce acid secretion in the stomach by inhibiting selective binding of histamine to H2 receptors so that it can reduce the concentration of cyclic-adenosine monophosphate (c-AMP) which plays a role in the proton pump mechanism. The combination of floating and mucoadhesive systems is used to increase drug retention in the stomach so that it can reduce the drug interval and increase bioavailability of the drug. The purpose of this study was to make floating-mucoadhesive cimetidine tablets using Hydroxypropyl Methylcellulose (HPMC) as a floating polymer and chitosan as a mucoadhesive polymer. Tablets are expected to have the ability to maintain the dosage form in the stomach for approximately 12 hours. The evaluations carried out included the flow characteristics and the angle repose of the powder mixture, tablet weight uniformity, tablet hardness, tablet friability, floating lag time, floating duration time and tablet mucoadhesive strength. The responses observed were the ability to float and the mucoadhesive strength of tablets. The tablet release test (dissolution) for the optimum formula was performed to determine the character of tablet release. The optimum amount for HPMC is 146,686 mg and chitosan are 50 mg. The combination of polymers with this amount produces a floating lag time of 43,458 seconds, floating duration time >12 hours and the strength of mucoadhesive is 100 grams. The release of the optimum formula in the 720th minute is about 73,180% following the Higuchi release model with dissolution efficiency (DE720) about 67,855%.

KONSENTRASI HAMBAT MINIMUM (KHM) KADAR EKSTRAK ETANOL BATANG BAJAKAH TAMPALA (Spatholobus littoralis Hassk) TERHADAP BAKTERI ESCHERICHIA COLI MELALUI METODE SUMURAN Saputera, Mochammad Maulidie Alfiannor; Marpaung, Tio Widia Astuti; Ayuchecaria, Noverda
Jurnal Ilmiah Manuntung Vol 5 No 2 (2019): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

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Empirically, one of the plants that are widely used by the Dayak tribe as a medicine is the bajakah tampala (Spatholobus littoralis Hassk.) This plant is claimed to be able to treat several diseases such as abdominal pain, diarrhea and dysentery. But until now studies on the antibacterial activity of bajakah tampala have never been done. This study studied the antibacterial activity of bajakah ethanol extract against the growth of Escherichia coli bacteria and minimum inhibitory value (MIC). This type of research is experimental research. The stem bajakah Tampala looks like it wastaken from the inland forest in Garung Village, Jabiren District, Pulang Pisau Regency, Central Kalimantan. The sample of this study was 70% ethanol extract of bajakah tampala stems obtained by maceration. Extract payment of antibacterial activity using a concentration of 3.12%; 6.25%; 12.5%; 25% and 50%. The positive control used is ampicillin 0.01 mg/ml and negative control using distilled water. Tests are carried out by the well method. The tested data were analyzed statistically by the One-Way ANOVA test method. The results of the study showed that the ethanol extract bajakah tampala could inhibit the growth of E. coli bacteria. The biggest inhibition of E. coli bacteria at a concentration of 50% with an average inhibition diameter of 20.32 mm. included in the category of very strong. The minimum inhibitory concentration of extract batang bajakah tampala is 6.25%

PENGARUH VARIASI KONDISI FERMENTASI TERHADAP PRODUKSI METABOLIT ANTIBAKTERI EKSTRAK ISOLAT I5 FUNGI ENDOFIT Anredera cordifolia (Ten.) Steenis Ismail, Ismail; Megawati, Megawati; Ali, Alimuddin; Ningsih, Fuji Asmiati
Jurnal Ilmiah Manuntung Vol 5 No 2 (2019): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

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Endophytic fungi are one of the microorganisms that live in plants and symbiotic with their host plant produce secondary metabolites. This study aims to determine the optimum growth profile of endophytic fungus isolated from the leaf of Anredera cordifolia (Ten.) Steenis namely isolate I5 as antibacterial. The fungus growth profile optimization analyzed by a correlation between fermentation time and mycelium weight, which collected every 24 hours for 15 days. The media were varied at pH conditions of 4, 7, and 8 in each PDYB medium (glucose and fructose substrates). The results showed that isolate I5 grew optimally on the 13th day on the PDYB medium pH 8. Ethyl acetate extract 5% of isolate I5 could inhibit bacteria growth with the largest inhibition zone diameter against Staphylococcus aureus of 9.96 mm (± 0.60) and Escherichia coli of 9.03 mm (± 0.46).

UJI EFEKTIVITAS ANTIBAKTERI ESKTRAK ETIL ASETAT BAWANG DAYAK (Eleutherine palmifolia Merr) TERHADAP STAPHYLOCOCCUS AUREUS DENGAN METODE SUMURAN Fitriyanti, Fitriyanti; Abdurrazaq, Abdurrazaq; Nazarudin, Muhammad
Jurnal Ilmiah Manuntung Vol 5 No 2 (2019): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

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Dayak onion (Eleutherine palmifolia Merr.) is a multifunctional medicinal plant for various diseases, one of which is an antibacterial. Dayak Onions (E. palmifolia Merr.) contains an alkaloid, flavonoid, triterpenoid, and saponin compound which has antibacterial properties. This study aims to determine the effect of the ethyl acetate extract of Dayak Onion tubers inhibits the growth of Staphylococcus aureus bacteria. Dayak onion tuber was extracted using ethyl acetate solvent by the maceration method until thick extract was obtained. The concentration extract used were 30 mg/ml;15 mg/ml;7,5 mg/ml;3,75 mg/ml; 1,875 mg/ml; and 0,9375 mg/ml tested for antibacterial effectivity against Staphylococcus aureus using Mueller Hinton Agar (MHA) with the wells method. The result showed that the ethyl acetate of Dayak onion with MEC (Minimum effective concentration) 3,75 mg/ml obtained inhibition zone of 10,367 mm while at the highest concentration of 30 mg/ml had the best antibacterial effectiveness. The effective concentration of ethyl acetate onion of Dayak tuber which is 30 mg/ml obtained inhibition zone of 18,404 mm even in the moderate category.

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