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Media Farmasi Indonesia
Published by Sekolah Tinggi Ilmu Farmasi Yayasan Pharmasi Semarang
ISSN : 19788495     EISSN : 26551462     DOI : https://doi.org/10.53359/mfi.v17i1
Core Subject : Health, Science, Education,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Other
Media Farmasi Indonesia publishes original article in the all scopes of Pharmaceutical Science such as Pharmaceutics, Biopharmaceutics, Drug Delivery System, Chemical Pharmacy, Pharmaceutical Technology, Pharmaceutical Microbiology and Biotechnology, Pharmacology and Toxicology, Pharmacokinetics, Pharmaceutical Chemistry, Pharmaceutical Biology, Community and Clinical Pharmacy, Management Pharmacy, Alternative Medicines.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 10 Documents
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Search results for , issue "Vol. 8 No. 2 (2013): Media Farmasi Indonesia" : 10 Documents clear
UJI ANTI DIARE INFUSA DAUN MIMBA (Azadirachta indica Juss) TERHADAP MENCIT JANTAN GALUR SWISS Ika Puspitaningrum; Arsa Wahyu N.; Suwarmi -
Media Farmasi Indonesia Vol. 8 No. 2 (2013): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

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Abstract

ABSTRACT This study aims to determine the efficacy of neem leaf infusion antidiarrheal (Azadirachta indica Juss.) against male mice strain Swiss, and to determine the effective dose infusion of neem as antidiarrheal. Object of this study was the time of the occurrence, duration of diarrhea, and stool consistency and number of male mice strains Swiss. Samples of fresh neem leaves is used in the preparations made ​​by the infusion technique is random sampling . A 25 of mice was divided into 5 groups consisting of groups I- III were given neem leaf infusion dose of 68.12 mg/kgbw; 204.36 mg/kgbw and 613.08 mg/kgbw, group IV as a positive control group that were given loperamide HCl dose of 0.73 mg/kgbw, and group V as a negative control group that were given 0.75 ml of oleum ricini. All administration is done orally. Observations include the time of occurrence of diarrhea , duration of the course of diarrhea, stool consistency and number of each were evaluated statistically by Anova method and post- ANOVA test . The results showed that Infuse leaves of neem has antidiarrheal efficacy of male mice strain Swiss. Neem leaf infusion at a dose of 204.36 mg/kgbw and 613.08 mg/kgbw have antidiarrheal effects comparable to loperamide HCl dose of 0.73 mg / kgbw.
PERBANDINGAN KADAR Cu (Tembaga) PADA KERANG DARAH (Anadara granosa) SEGAR DAN REBUS YANG DIJUAL DI PASAR BANJARSARI PEKALONGAN Tri Minarsih
Media Farmasi Indonesia Vol. 8 No. 2 (2013): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

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Abstract

Protein is a nutrient needed by humans. Marine animals is a provider of high-protein, one of the much-loved marine animals is Shell Blood. In addition to have a high content of protein, shells also have disadvantages because heavy metals can accumulate in the body, such as Cu metal. Cooking such as boiling process is expected to eliminate the toxic effects of the Cu content in the Shell Blood. In this study, samples were taken from Anadara granosa sold in markets Banjarsari Pekalongan. The method used is the Tampak spectrophotometry method, by reacting Cu with Sodium diethyltricarbonate to form complex compounds. The results of this study are: the stability of the complex 15-minute period, the maximum wavelength of 440 nm, with a regression equation: y = 0.0987 x + 0.0756 and the correlation coefficient (r) was 0.9956, and obtained blood levels of Cu in the clam fresh is 8.75 ppm, 5.95 ppm and 19.36 ppm, and after boiling for 15 min levels down to 5.39 ppm, 4.47 ppm and 15.64 ppm. Boiling is effective in lowering levels of Cu by 16-45%.
MOLECULAR DOCKING, SINTESIS DAN UJI AKTIVITAS SITOTOKSIK SENYAWA 1-(3-KLOROBENZOIL)-1,3-DIMETILUREA Dian Agung Pangaribowo
Media Farmasi Indonesia Vol. 8 No. 2 (2013): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

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Abstract

A novel 1-(3-chlorobenzoyl)-1,3-dimethylurea has been designed, synthesized, structurally determined, and the in vitro cytotoxic activity was evaluated. Docking simulation was performed to the position of this compound into the Checkpoint kinase 1 (Chk1) active site to determine the probable binding model. Synthesis of 1-(3-chlorobenzoyl)-1,3-dimethylurea was completed by acylation reaction between 1,3-dimethylurea and 3-chlorobenzoyl chloride. The purity of synthesized product was determined by Thin Layer Chromatography and melting point measurement. Structure identification was performed by UV and FTIR spectrophotometer, NMR spectrometer. Antiproliferative assay result demonstrated that this compound possessed good cytotoxic activity against HeLa cells, which is comparable to the positive control. This compound with potent cytotoxic activity might be a potential anticancer agent.
PENGARUH JUS BUAH MANGGIS (Garcinia mangostana L.) TERHADAP PROFIL FARMAKOKINETIK PARASETAMOL TIKUS PUTIH JANTAN (Rattus norvegicus) GALUR WISTAR Emy OKTAVIANI; Mohamad ANDRIE; Bambang WIJIANTO
Media Farmasi Indonesia Vol. 8 No. 2 (2013): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

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Abstract

Drug interaction happens when drugs is given together with foods. This research was aimed to observe the effect of mangosteen juice to the paracetamol pharmacokinetic profile in Wistar male white rats. The study used Wistar rats weight of 200-350g. The animals were divided into three groups with the total of the male rats are 15. Group I (paracetamol) was given a single oral paracetamol 9 mg/200gBW. Group II (treatment 1) was given a single oral paracetamol 9 mg/200gBW together with mangosteen juice 2,88 g/200gBW. Group III(treatment 2) was given a single oral paracetamol 9 mg/200gBW together with mangosteen juice 0,66 g/200gBW. The serial blood was collected from tail vein for 9 hours and was analyzed using spectrophotometer UV for unchanged paracetamol. The pharmacokinetic parameters of paracetamol were calculated by recidual method and were analyzed by One Way ANOVA using 95% confidence interval. The difference between groups were analyzed using Post Hoc LSD-test. The results showed that the group II(paracetamol-mangosteen 1) and group III(paracetamol-mangosteen 2) increased of ka, Cpmaks, tmaks, t½ab, ke, t½el, CL, AUC and decreased of ka, ke, and CL. The research showed that mangosteen juice doses 2 give higher decreased metabolism and decreased elimination of paracetamol in rat.
PENGARUH JENIS PELARUT TERHADAP RENDEMEN DAN KUALITAS MINYAK BEKATUL YANG BERASAL DARI BEKATUL BERAS (Oryza sativa L.) Erlita Verdia Mutiara; A.A. Hesti Wulan S
Media Farmasi Indonesia Vol. 8 No. 2 (2013): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

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Abstract

Indonesia is an agricultural country with the paddy crop as main product. The process of paddy hulling rice will yield the main product, bekatul rice and lock up as the side product. The use of bekatul rice has not been optimum in Indonesia, as it is only used as the feed for livestock and poultry. Bekatul rice has the potency as the oil source which is much used in of pharmacy and food industry as salad oil, raw material for cosmetics, health supplement. Bekatul oil contains 80 % fatty acid (oleat acid and linoleat acid). The research has the target to know the difference of n-hexane solvent, ether petroleum and chloroform against the rendemen and the quality of bekatul rice oil, and to know the type of solvent which yields rendemen and the best quality of bekatul rice oil. Bekatul rice oil was made by way of soxhletacy with n-heksan solvent, ether petroleum, and chloroform; the filtrate obtained was evaporated to obtain rough bekatul rice oil. The rough bekatul rice oil was purified by gum removing process ( de-gumming) and wax separation. The bekatul rice oil obtained was measured to know the rendemen and the quality of bekatul rice oil, quality test of bekatul rice oil included the physical test of pH and bias index as well as chemical test that indicated peroxide number test and acid number test. The result of the rendemen and the bekatul rice quality (afractive index, peroxide number and acid number) showed a significant difference on the n-hexane solvent which produced rendemen and the best quality of bekatul rice oil. Based on the research, it can be concluaded that the difference in the type of solvent can influence the rendemen and the quality of bekatul rice oil on n-hexane solvent witch produced rendemen and the best quality of bekatul rice oil.
UJI AKTIVITAS PENGANGKAPAN RADIKAL 2,2-DIFENIL-1-PIKRILHIDRAZIL (DPPH) PIGMENT BAKTERIAL SIMBION DARI SARGASSUM POLYCYTRUM Lia Kusmita; Sri Achadi Nugraheni; Handung Nuryadi
Media Farmasi Indonesia Vol. 8 No. 2 (2013): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

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Abstract

Carotenoids are pigments that are found in plants, animals, microorganisms and humans. The pigment has many functions, one of which is as an antioxidant. There have been many studies of carotenoids in plants, but the types of carotenoids in bacteria is very rarely observed when the potential is not lost. The ability of marine bacteria is well known to produce carotenoids. Bacterial symbionts associated with Sargassum polycytrum can produce neoxanthin. This research will test the antioxidant activity by DPPH method on bacterial symbionts pigment extracts as compared with extracts of S. polycytrum. Based on the results obtained IC50 of 3.01 ± 2350 ppm was obtain for extract pigments S. polycytrum, 645 ± 2.11 ppm for pigment extract bacterial symbionts, and 564 ± 2.26 ppm for β-carotene as a comparison.
FAKTOR-FAKTOR YANG MEMPENGARUHI KEPATUHAN DOKTER TERHADAP PERESEPAN OBAT GENERIK DI INSTALASI FARMASI RSUD dr. R. GOETENG TAROENADIBRATA PURBALINGGA Gangga Harima; Soedarso -; Anjar Mahardian K
Media Farmasi Indonesia Vol. 8 No. 2 (2013): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

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Abstract

Permenkes RI No. HK.02.02/Menkes/068/2010 dispute that any mandatory to use generic drugs in public health facility. Recently, The Indonesian generic is have to using low, however the price is cheaper. The objective of this research to is determinate the pecentage of doctor’s obedience to generic prescription and know the influance of knowladge, trust, generic drugs avaluable and patient’s influance to the obedience of docter’s to prescribe generic drugs in Farmacy Instalation of RSUD dr. R. Goeteng Taroenadibrata Purbalingga. The research was observational research, used cross sectional approach and retrospective data. The instrument of research is quisioner. Validity test used to know validitas of quisioner. Statistic analysis are used bivariat analysis with chi square test and multivariat analysis used regresion logistic test. The result showed the percentage of doctor’ obedient was 58.3% and the unobedience 41.7%. Knowladge factor, trust, avaluability of drugs and patient influance each of them had significant influance to the level of doctor’s obedience to used generic drug’s. P value < 0.05. Factors of Knowladge, trust, avaluable of drugs and patient influance simultan had significant influance to the obedience of doctor. The conclution of this research is the persentage of doctor who obedience with generic prescribing were 58.3%. The other side the pertsentage of doctor who inobedience with generic prescribing were 41.7%. The higher of knowladge, trust, generic drugs avaluable and patient’s influance, so the higher of obedience of doctor in generic prescribe.
KRIM KULIT BUAH DURIAN (Durio zibethinus L.) SEBAGAI OBAT HERBAL PENGOBATAN INFEKSI JAMUR Candida albicans Hanny Setyowati; Hananun Zharfa Hanifah; Rr Putri Nugraheni; Wahyuning Setyani
Media Farmasi Indonesia Vol. 8 No. 2 (2013): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

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Abstract

Durian rind (Durio zibethinus L.) is a part of plant reported to have antifungal activity toward Candida albicans fungi. This research aimed to make extract rind of D. zibethinus L. formula cream and evaluated the physical characteristic toward C. albicans. The formulation of extract rind of D. zibethinus L. is made based on preliminary test with variety of extract concentration, which is 15%, 20%, and 25%. Negative control used basis cream consisting of emulgide, paraffinum liquidum, and aquadest, whereas positive control used Ketoconazole 2%. Cream produced was further tested for: organoleptic,homogeneity, adhesive power, dispersive power, and protection power. Antifungal activity tested is done by diffusion method. Antifungal activities data are analyzed by one way ANOVA. The result of this research showed that extract rind of D. zibethinus L. contains saponin, flavonoid, and tannin which is the formulation in cream had antifungal activities towards C. albicans with average resistibility zone diameter for 15% (0,62 cm) extract concentration, 20% (0,73 cm) extract concentration, and 25% (0,81 cm) extract concentration.
KARAKTERISASI MORFOLOGI SEL REKOMBINAN DAN PIGMEN HASIL FUSI PROTOPLAS INTERSPESIFIK Phaffia rhodozyma DAN Chlorella pyrenoidosaH Chick Indah Sulistyarini; Hermin Pancasakti Kusumaningrum; Endang Kusdiyantini
Media Farmasi Indonesia Vol. 8 No. 2 (2013): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

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Abstract

Protoplast fusion technique is a process offusion between protoplasts of theorganism to other organisms, so that the resulting recombinant cells with varying character derived from its parent. This study did Phaffia rhodozyma interspesies fusion and Chlorella pyrenoidosa. The purpose of this study was to analyze the morphological characteristics of cells results protoplast fusion recombinant yeast P. rhodozyma and microalgae C. pyrenoidosa. Protoplast fusion technique performed in 4 phases, namely the isolation of protoplasts, protoplast fusion, and analysis of recombinant cell morphological characters. The results showed that the recombinant cells have morphological characters derived from the parent P. rhodozyma and of the parent C. pyrenoidosa. But was character of the parent P. rhodozyma more dominant. Recombinant cells capable of producing pigment and lutein astaksanthin. Astaksanthin pigment levels in recombinant cell height in a shorter time than the parent P. rodozyma.
FORMULASI DAN EVALUASI STABILITAS FISIK SUSPENSI IBUPROFEN DENGAN MENGGUNAKAN NATROSOL HBr SEBAGAI BAHAN PENSUSPENSI Emilia -; Wintari TAURINA; Andhi FAHRURROJI
Media Farmasi Indonesia Vol. 8 No. 2 (2013): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

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Abstract

Ibuprofen it a non-steroidal anti-inflammatory drug which is practically insoluble in water it can be made in the form of suspension. Suspension requires suspending agent such as natrosol HBR for increasing the viscosity and reducing the rate of sedimentation that can produce stable suspension. The aimed of this research is to find the influence of natrosol HBR as the suspending agent toward physical stability of suspension. The method used in the manufacture of ibuprofen suspension is dispersion method. Ibuprofen suspensions were made with variation concentrations of 1%; 1.5%; 2% natrosol HBR respectively. In order to know the physical stability of suspension, it should be carried out organoleptic, density test, particle size distribution, viscosity test, sedimentation volume, redispersibility and pH test. The test result for three formulation suspensions for 30 days storage showed that the physical stablility changed in various showed concentration of natrosol. This research shown that the formulation with concentration of Natrosol Hbr 1% showed the best physical stability of the three formulas which indicated by the required results of the density test, sedimentation volume and redispersibility as well as the best particle size distribution and viscosity of the three formulas ibuprofen suspensions.

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