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Jurnal Kedokteran Diponegoro
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ISSN : -     EISSN : 25408844     DOI : -
Core Subject : Health,
JKD : JURNAL KEDOKTERAN DIPONEGORO ( ISSN : 2540-8844 ) adalah jurnal yang berisi tentang artikel bidang kedokteran dan kesehatan karya civitas akademika dari Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang dan peneliti dari luar yang membutuhkan publikasi . JURNAL KEDOKTERAN DIPONEGORO terbit empat kali per tahun. JURNAL KEDOKTERAN DIPONEGORO diterbitkan oleh Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang.
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Search results for , issue "Vol 10, No 2 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)" : 15 Documents clear
THE EFFECT OF ANTLIONS EXTRACT TOWARDS BLOOD GLUCOSE LEVEL OF MALE SWISS MICE INDUCED BY STREPTOZOTOCIN Rizky Indra Puspito; Santoso Jaeri; Y.L Aryoko Widodo; Andrew Johan
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 2 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i2.29681

Abstract

ABSTRACTBackground: Diabetes mellitus is a disease that is included in the group of metabolic diseases, characterized by hyperglycemia that occurs due to abnormal insulin secretion. Generally, treatment of diabetes mellitus uses insulin injection and Oral Hypoglycemic Drugs (OHD). In addition there are also animals are trusted by public in healing diabetes mellitus. Antlions (Myrmeleon sp)  is a useful animal to treat diabetes mellitus. The body of antlions contains sulfonylureas which is a substance that stimulates insulin secretion in pancreatic beta cells. Aim: The objective of this research was to analyze the effect of antlions extract on blood glucose level of male swiss mice induced by streptozotocin Methods: This research was a pure experimental laboratory study and the design used is the Pre Test and Post Test Control Group Design, which is done by comparing the results of observations in the control and treatment groups after the action was done. Sampling was done using the simple random sampling technique. The sample size used in this study amounted to 30 mice. The data obtained were analyzed using ANOVA test with a confidence level of 95%. Results: The administration of antlions extract could lower (p<0.05) blood glucose levels in male Swiss mice after 28 days of treatment. The administration of antlions extract with doses of 14 mg/kgBW and 56 mg/kgBW significantly lowered blood glucose levels in male Swiss mice as evidenced by p=<0.001 and p=0.034. Whereas the administration of antlions extract with a dose of 28 mg/kgBW was less significant in lowering blood glucose levels in male Swiss mice (p=0.210). Conclusion: The administration of antlions extract (Myrmeleon sp.) with a dose of 14 mg/kgBW had the best effect on lowering blood glucose levels in male Swiss mice after 28 days of treatment. Keywords: diabetes mellitus, blood glucose, antlions
Difference in Profiles of Oxidative Stress Marker (MDA) in STEMI and NSTEMI Kaninta Nuga Sekunda; Ariosta Ariosta; Charles Limantoro; Andreas Arie Setiawan
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 2 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i2.29673

Abstract

ABSTRACT Introduction: Acute Myocardial Infarction (AMI) results in necrosis of the myocardium due to blockage in the coronary artery. AMI is classified into two categories, STEMI and NSTEMI. AMI is a multifactorial condition closely related to the increase in production of reactive oxygen species (ROS). As the end product of lipid peroxidase, Malondialdehyde (MDA) is often used as a biomarker for oxidative stress. Purpose: To prove the difference between profiles of oxidative stress marker (MDA) in STEMI and NSTEMI. Methods: An observational analytic study with a cross-sectional study approach done in Dr. Kariadi Central Public Hospital and Diponegoro National Hospital, Semarang, Central Java, between April and September 2020. Subjects were diagnosed by the presence of chest pains and an increase in CKMB and troponin levels. The study was conducted on 47 subjects consisting of 20 STEMI samples and 27 NSTEMI samples. Serum MDA was examined using the TBARS method. Data were analyzed by a computer program. Results: Mean serum MDA in STEMI and NSTEMI was 0,22 ± 0,12 μmol/L and 0,82 ± 0,92 μmol/L respectively. From the statistical analysis, results showed that the difference in serum MDA concentrations between STEMI and NSTEMI were significant (p = 0,007). Conclusion: Malondialdehyde concentration in NSTEMI was significantly higher than in STEMI. It is suggested that further research be done to know which type of MDA is more accurate, to understand the effect of lipid profile towards STEMI and NSTEMI, and to put patient’s medical history into consideration. Key Words: Acute Myocardial Infarction, Reactive Oxygen Species, Oxidative Stress, Malondialdehyde
THE DIFFERENCE OF MEAN PLATELET VOLUME AND PLATELET COUNT IN CORONARY HEART DISEASE PATIENTS WITH ACUTE CORONARY SYNDROME AND NON ACUTE CORONARY SYNDROME Aditya Paelo Rizki Sikumbang; Indranila Kustarini Samsuria; Novi Anggriyani; Charles Limantoro
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 2 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i2.29460

Abstract

Background: Coronary Heart Disease (CHD) is currently one of main causes and the first death in developed and developing countries, including Indonesia. CHD appeared with the clinical appearance of asymptomatic, stable angina pectoris until acute coronary syndrome. ACS is a progressively CHD and takes parameters that describe the process pathogenesis. MPV and platelet count are two parameters in the complete blood count which reflect the activity of platelets in CHD.Objective: This study is to investigate the differences Mean Platelet Volume and Platelet Count in CHD with ACS compared to non ACS.Methods: A cross-sectional study was conducted with collecting data from the medical records of patients with CHD who underwent treatment in the dr. Kariadi General Hospital Medical Center Semarang, the period of January - December 2019. Eighty subjects of 20 non-ACS patients and 60 ACS patients were included in this study which is Mean Platelet Volume and Platelet Count in hematology laboratory were analyzed. The Independent T-test were used for comparing the group means.Results: MPV was found to be higher significantly among ACS patients as compared to non ACS, 9,43 ± 0,3868 fl vs 9,43 ± 0,3868 fl (p-value<0.01) while Platelet Count was lower significantly among ACS patients as compared to non ACS, 282,63 ± 75,084 109/L  vs 322,30 ± 41,980 109/L.Conclusion: There were significantly differences in Mean Platelet Volume and Platelet count between patients with ACS and non ACS.
BREAST CANCER IN PREGNANCY AT DR. KARIADI GENERAL HOSPITAL: A SERIAL CASE Ireneus Vanessa Martono; M. Besari Adi Pramono; Herman Kristanto; Albertus Ari Adrianto
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 2 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i2.29172

Abstract

Background Each year 2.1 million women were diagnosed with breast cancer, being the most common type of cancer found and cancer-related cause of death in women worldwide. In Indonesia, especially in Middle Java, more than 80% women diagnosed were already in the late stage. Physiological changes in pregnancy contributes to the delay in diagnosis in pregnant women and pregnancy also resulted in a more complicated approach of therapy. Regarding only few studies were done involving pregnancy with breast cancer, the aim of the study is to provide further knowledge associated with it.Methods Medical records of pregnant women with breast cancer in year 2014-2018 at Dr. Kariadi General Hospital were studied.Results Based on the 3 cases be studied, patients were referred from class B and C hospitals outside of Semarang city showing stage III (33.33%) and IV (66.67%) breast cancers. Two-third of the patients underwent mastectomy previously and one of them also underwent chemotherapy program prior her pregnancy. Comorbidities varied between patients and therapies were adjusted individually and multidisciplinary. Two of the cases went through transperitoneal caesarean section for delivery and one patient with twin pregnancy died by complications and intrauterine foetal death was also determined.Conclusion Overall, all patients were > 35 years old and the breast cancers were diagnosed at late stage. Complications by comorbidities such as anaemia, severe malnutrition, and infection, were found. Two pregnancies which were already in third trimester was terminated and a case of maternal mortality was found.Keywords Breast cancer, pregnancy
Comparison of Intraocular Pressure (IOP) Value Before and After Vitrectomy in Diabetic Retinopatic Patients Arnila Novitasari Saubig; Fifin Luthfia Rahmi; Hesti Triwahyu Hutami
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 2 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i2.29943

Abstract

Background: Diabetic retinopathy is one of the second highest complications of microangiopathy in Indonesia due to diabetes mellitus in the form of damage to retina of the eye and can cause blindness in adults. The management of diabetic retinopathy is done by operative measure, one of which vitrectomy. However, this procedure can lead to an increase in the value of intraocular pressure after surgery. In this study, analysis of differences in intraocular pressure values before and after vitrectomy was carried out in patients with diabetic retinopathy.Research Purpose: To know, compare, and analyze the intraocular pressure values before and after vitrectomy in patients with diabetic retinopathy.Method: The study design was an analytic observation with a study design cross-sectional. Sampling using method consecutive sampling obtained from medical record of 45 diabetic retinopathy patients who underwent vitrectomy at the RSND for the period July-December 2019. After the data was collected, the data were analyzed using the difference Wilcoxon rank test.Result: A total of 45 diabetic retinopathy patients underwent vitrectomy from medical records were dominated by 24 people aged >69 years and 26 female patients. The mean values of intraocular pressure before and one week after vitrectomy were 20.32 + 2.57 mmHg and 23.89 + 9.24 mmHg. The results showed that there was a higher intraocular pressure value after vitrectomy than before vitrectomy in diabetic retinopathy patients (p=0.021) or p,0.05
The Effect of Educational Video About Maternal Health Related to COVID-19 to Knowledge Level of Medical Student Aulika Alya Paramesti; Putri Sekar Wiyati; Diah Rahayu Wulandari
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 2 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i2.29498

Abstract

Background : There have not been many cases of COVID-19 infection in pregnant women before, during and after gavebirth, so knowledge about COVID-19 infection in pregnancy and the fetus is still limited. This research is expected to provide basic data for further studies and provide new knowledge, especially regarding maternal health related to COVID-19, considering that currently COVID-19 is a new type of virus and is currently a pandemic.Objectives : This study aimed to to determine the effect of educational videos about maternal health related to COVID-19 on the level of knowledge of Medical Students.Methods : This research was a pre-experimental research design design using the form of a "One Group Pretest-Postest only" design (without a control group). Statistical analysis using the Wilcoxon Test.Results: The results shows that from 38 respondents after being given education through video media, it was found that 36 (95%) of respondents had increased knowledge, 2 (5%) had fixed knowledge, and there were no respondents whose knowledge had decreased, so there was a significant difference in knowledge before and after being given education through video.Conclusion: The study result showed that there is a significant difference in knowledge about maternal related to COVID19 before and after being given education via video and it can be concluded that there is an effect of educational videos on Maternal Health related to COVID19. Keywords :  Educational Video, Maternal, COVID-19, Knowledge.
THE ASSOCIATION BETWEEN KNOWLEDGE AND THE READINESS OF HEALTH WORKERS IN IMPLEMENTING WIFI TB PROGRAM Kumala Aulia Rizfi; Fathur Nur Kholis; Hari Peni Julianti; Dea Amarilisa Adespin
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 2 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i2.29459

Abstract

Background: Semarang city contributes to reducing the number of missing TB cases by using Wajib Notifikasi TB (WiFi TB) application program, which began to be used simultaneously in 2018. WiFi TB application is an application to record and report every TB case found by health facilities, and it is part of Directly Observed Treatment Short-course (DOTS) strategy in monitoring, recording, and reporting component. Aim: Knowing the association between knowledge and the readiness of health workers in implementing WiFi TB program. Methods: The research design used in this study was analytic observational with a cross sectional approach. The qualitative method was also used in this study to know the evaluation about the implementation of WiFi TB program from the subjects. The sample size of this study were 27 subjects using purposive sampling method from each of the 10 Primary Clinics in Semarang city that included inclusion criteria. Data were collected by recording the results of answers to questionnaires and interviews. Fisher exact was used to test the hypothesis. Results: Most of the health workers from each of the 10 Primary Clinics in Semarang city had good readiness in implementing WiFi TB program. The results of this study showed a significant association between knowledge (p = 0,030) and the readiness of health workers in implementing WiFi TB program. Conclusion: There was an association between knowledge and the readiness of health workers in implementing WiFi TB program.Key Words: Tuberculosis, WiFi TB, readiness, knowledge
CORRELATION OF INTERLEUKIN-23 SERUM LEVELS IN MEN WITH ACNE VULGARIS: A PRELIMINARY STUDY Maria Hotmaida Carolina Munthe; Novi Kusumaningrum; Amallia Nuggetsiana Setyawati; Astika Widy Utomo; Santoso Santoso
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 2 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i2.29955

Abstract

Background: Acne vulgaris (AV) is an inflammatory condition of pilosebaceous unit that is common in adolescents and young adults. The pathogenesis of AV is multifactorial, one of which is inflammation. Interleukin-23 (IL-23) has an important role in the activity of T helper 17 (Th17) cells that produce IL-17 in chronic inflammation.Objective: To determine the correlation between serum IL-23 levels and AV severity in men.Methods: This is an analytical observational preliminary study with a cross-sectional design involving 15 male subjects with AV who were divided into groups of AV severity based on Lehmann’s criteria. The subjects were examined for serum IL-23 levels. Data were analyzed using Spearman’s Rho non-parametric correlation test to determine the correlation between variables.Results: Mean IL-23 serum levels in men with AV was 111,05 ± 115,27 pg/ml, with mild AV was 210,57 ± 122,038 pg/ml, moderate AV was 103,65 ± 91,15 pg/ml and severe AV was 18,94 ± 15,76 pg/ml. There is a significant correlation between IL-23 serum levels and AV severity in men. (p = 0,001). Serum IL-23 levels decreased with increasing AV severity (r = -0,756).Conclusion: There is a strong negative correlation between IL-23 serum levels and AV severity in men.
THE EFFECT OF “PERMATA-KU” EXERCISES ON THE IMPROVEMENT OF COMPUTER VISION SYNDROME SCORE Made Ayu Kusuma Dewi; Fifin Luthfia Rahmi; Arnila Novitasari Saubig; Hari Peni Julianti
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 2 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i2.29524

Abstract

Background : Most human activities cannot be separated from the use of computers. Long-term and uncontrolled use of computers can lead to Computer Vision Syndrome (CVS). According to the Ministry of Health of the Republic of Indonesia (KEMENKES) CVS can be handled with ergonomics use of computers resultantly reducing the impact of computer exposure. Education on ergonomics use of computer and PERMATA-KU exercise is expected to improve CVS scores.Research Purpose : Proving the effect of PERMATA-KU exercises toward CVS score improvementMethod : Research subjects are divided into treatment group and control group, each group consists of 15 people. The treatment group received education about the ergonomics use of computer and PERMATA-KU exercises while the control group received education on the ergonomics use of computers. The measurement’s instrument is the CVS questionnaire. The dependent variable of the study was the CVS score and the independent variable of the study was the type of treatment. Statistical test with Wilcoxon, paired t test, unpaired t test, Mann whitney and chi square. Meaning value p <0.05.Result : There was a significant difference in CVS scores before and after the intervention in the treatment group (p = 0.001) and the control group (p = 0.006). There was a significant difference in delta CVS scores between the treatment group and the control group (p=0,008). There was a significant difference in CVS scores after the intervention in the treatment group and the control group (p=0,017). There was no significant difference in the incidence of CVS after the intervention between the treatment group and the control group (p = 0.259).Conclusion : There is an effect of "PERMATA-KU" exercise on the improvement of CVS scores.
Comparison Of Plyometrics And Aerobic Exercises On Attention Levels In Young Adults Kinanti Maura Sandradewi; Endang Kumaidah; Yosef Purwoko; Marijo Marijo
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 2 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i2.29286

Abstract

Background. Plyometrics and aerobic training is a form of exercise that is easily applicable to all people. Plyometrics and aerobic trainings are proven to improve attention level in previous study.Objective. The aim of this study is to compare the effect of plyometrics training and aerobic training on attention level of young adults.Methods. A quasi-experimental study with pre and post test&control group design. The subjects were 54 male, with age range from 18 to 23 years old. Subjects were divided into 3 groups: C (control), EP1 (plyometrics training), and EP2 (aerobic training; with of 20meters multistage shuttle test design) . Both EP groups was given training for 6 weeks, twice a week. The attention level was measured using Attention Networks Test.Results. After 6-weeks of training, attention score in both of experimental groups were better than the control group. In EP1, all of the attention level component which was alerting, orienting, and executive increases significantly (p<0,01). In EP2, only alerting (p<0,01) and executive (p=0,01) increase significantly. Plyometrics training is proven to increase the attention level better than aerobic training, with significant increase in alerting (p=0,012), orienting (p=0,016), and executive (p=0,02)Conclusion. Plyometrics training is proven to increase attention level better than aerobic training in young adults.

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