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Pharmaciana: Jurnal Kefarmasian

PHARMACIANA
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Published by Universitas Ahmad Dahlan

ISSN : 20884559 EISSN : 24770256 DOI : 10.12928

Core Subject : Health,

Medicine & Pharmacology

Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 38 Documents

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Search results for , issue "Vol 8, No 2 (2018): Pharmaciana" : 38 Documents clear

Evaluation of Adherence, Distress and Quality of Life For Type 2 Diabetes Melitus Patients In Puskesmas Wedarijaksa I and Puskesmas Trangkil Kabupaten Pati Perwitasari, Dyah Aryani; Urbayatun, Siti; Wilisa, Oni Yulianta
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Diabetes mellitus is chronic disease that needs the complex and a long term medical treatment. Patient adherence and level Â of distress canÂ affect patient quality of life.Â The purposes of this study is to examine patients adherence, distress, and quality of life patients type 2 diabetes mellitus in KabupatenPati.This study used cross sectional design and data patients collection techniques were conducted prospective data. The subjects of research were patients with Type 2 diabetes amounted to 126 people. Instruments used in this research is Medication Adherence Respon Scale (MARS) questionnaire to measure patients adherence, Diabetes Distress Scale (DDS) to measure distress, and EQ-5D-5L questionnaire to measure quality of life. Data analysis statistic used Mann Whiney test, and regresi linier.Â Â Â Â This study was dominated by female patients 78.6%. The mean age of DMT2 patients was 54.49 Â± 6.19 years. The average value of adherence (MARS) was 21.33 Â± 2.90 including in moderate adherence. The mean total ofÂ DDS score was 1,56Â±0,42Â including not distress level and the highest is the emotional burden domain. The mean value ofÂ EQ5D5L index was 0.729 Â± 0.161. The results showed a significant association (p <0.05) between patient characteristics age and duration of sick with adherence. There wereÂ significant association (p <0.05) between age to physician distress, gender with emotional, marital status with emotional and interpersonal distress, duration of sick to physician distress and management teraphy distress. Marital status and income hadÂ significant relationshipÂ to quality of life. Emotional burden domain had significant relationship to quality of life. Multivariate analysis showed that the relationship of adherence and distress by the emotional burden to quality of life. This study concluded Â the significant relationship between adherence, distress and quality of life.

The Effect of Concentration Variation of Ethanolic Extract from Potato Peels (Solanum tuberosum L.) on the Physical Properties and Antibacterial Activity of Gels against Propionibacterium acnes Rashati, Dewi; Eryani, Mikhania Cristiningtyas
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

This research was aimed to know the effect of ptotato skins ethanolic extract variation concentration to physical properties of gel and antibacterial effect to Propionibacterium acnes. Gel were formulated in 3 formulas with potato skins concentration 50%, 60% and 705 respectivelly. The phisical properties of gel which obeserved include organoleptic, homogenity, pH, and spreadability. The results show that variation concentration of potato skins ethanolic extract has an effect to gel colour and viscosity but has not effect to form, smell, pH, and spreadability of gel. All formulas show strong inhibition power to Propionibacterium acnes.Â

REDUCED ULCEROGENECITY FROM SELF-NANO EMULSIFYING DRUG DELIVERY SYSTEM OF PIROXICAM Wahyuningsih,M.Si., Apt, Iis; Widyaningsih, Wahyu; Wulandari, Silviana
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Piroxicam is antiinflammatory non-steroidal (AINS) drug group that has anti-inflammatory, analgesic and antipyretic effects. Like most other AINS drugs, piroxicam has low solubility and has gastrointestinal (ulcerogenic) side effects on long-term use. The nano-emulsifying drug delivery system (SNEDDS) is one of the technologies that can be used to overcome it. This study aims to determine the effect of ulcerogenic SNEDDS piroxicam compared with piroxicam formulas instead of SNEDDS. This study uses white rats male strain SD age 2-3 months and weight 100-200 grams of 40 rats. Rats divided into 5 groups. Group I was a normal control group, the test animals were given only water. Group II was a suspending control group treated with a 1% polyvinylpyrrolidone (PVP) solution, group III is a carrier control group treated with SNEDDS carrier which is a mixture of tween 80, virgin coconut oil (VCO) and polyethylene glycol (PEG) 400, group IV was a group of piroxicam drugs suspended with piroxicam 1.08 mg/kg in 1% PVP, group V was treated with SNEDDS piroxicam.Treatment was done for 28 days. After treatment, the gastric of rats were taken to be observed for ulcerogenic effects. Observations were made macroscopically by looking at ulcer scores followed by histopathological observations of tissue. The ulcer score data from each group were analyzed using one-way ANOVAand LSD test. The results showed that the normal control group, 1% PVP suspension and carrier group had a ulcer index of 0.0, 0.0 and 0.0, while the piroxicam suspension group and the SNEDDS group had an ulcer index of 0.88 and 0.0. These results were confirmed by histopathologic results of SNEDDS piroxicam to decrease the effect of pyroxicam ulcerogenic with results in the piroxicam suspension group has ulcer with necrosis by neutrophil infiltration, lymphocytes and mast cells in the mucosal tunica to submucosa. In the SNEDDS piroxicam group there is erosion with necrosis of the mucosal tunica epithelium with infiltration of lymphocytes and mast cells in submucosal tunica. It can be concluded the SNEDDS piroxicam can decrease the ulcerogenic effect.

The potentiation effect of Bawang Dayak (Sisyrinchium palmifolium L.) extract on T47D cell growth inhibition after 5-fluorouracil treatment Yuniarti, Azizah; Sundhani, Elza; Nurulita, Nunuk Aries
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

5-Fluorouracil (5-FU) is chemotherapy agents that used in breast cancer treatment that has toxic effects such as myelotoxicity. its effectiveness relatively low. Bawang Dayak has been widely empirically used as a breast cancer treatment. This studys aims were to determine the sensitivity of 5-FU against T47D cells, as single and its combination with EBD, to determine apoptotic induction, and the inhibitory effect of T47D cell cycle. The cytotoxic assay was using the MTT method with the concetration of 5-FU (0-600Î¼g / mL) and EBD (0-250Î¼g / mL). Apoptotic induction analysis were determined by PI/annexin V. Both of apoptotic and cell cycle analysis was performed by flowcytometry. The results of the 5-FU and EBD cytotoxic test on T47D cells obtained IC50 274Î¼g/mL and 75Î¼g/mL, respectively. The combination of 5-FU and EBD has a mild to strong synergistic effect (CI 0.829 and 0.779). its ombined treatment induced apoptosis in T47D cells by 21.33%. Combination of these combinations caused cell accumulation in G0-G1 phase of 57.11%, greater than control (41.20%). Provision of 5-FU and EBD combination treatments causes disturbance and damage to cells that cause cell cycle arrest in the G0-G1 phase and can not proceed to the next phase. The combination of 5-fluorouracil and EBD has a synergistic effect as breast cancer co-chemotherapy is able to induce apoptosis against T47D cells by triggering cell accumulation in G0-G1 phase. The extract of Bawang Dayak has a high potential to be developed as co-chemotherapy in breast cancer.

Inhibition of HMG CoA Reductase and Lipid Peroxidation in The Rats Liver by Selected Zingiberaceae Hasimun, Patonah; Sulaeman, Agus; Putra, Hendra Mahakam; Lindasari, Heni
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Cardiovascular disease is the leading cause of death worldwide. One of the major risk factors for cardiovascular disease is hyperlipidemia. This study aimed to determine the potential of Zingiberaceae (10 species) as inhibitor of HMG-CoA reductase enzyme activity and lipid peroxidation. This study was conducted by 2 methods including assay of HMG CoA reductase inhibition and lipid peroxidation test. The study was performed by in vitro method, using 20% rat liver homogenate. The inhibition of HMG CoA reductase enzyme was done by reacting liver homogenate, HMG CoA substrate, which added the Zingiberaceae extract compared with simvastatin as standard drug. The absorbance of the mixture was measured by a Microlab 300 spectrophotometer at a 340 nm wavelength. Lipid peroxidation assay was induced by the FeSO4.7H2O solution. The absorbance value measured using a spectrophotometer at a 532 nm wavelength. Lipid peroxidation inhibition was characterized by absorbance of the test extract, compared with the control group. The obtained data was calculated as percent of inhibition and was used to calculate IC50 extract test. The results showed that the 10 ethanolic extracts of Zingiberaceae rhizomes have activity as enzyme inhibitor HMG-CoA reductase with IC50 value range 65.8Â±4.1 â 203.3Â±15.2 ppm, and inhibition of lipid peroxidation with IC50 value range 13.5Â±5.0 â 219.6Â±4.3 ppm. This study can be concluded that the Zingiberaceae rhizomes have potential role as antihyperlipidemic agents through inhibition of HMG CoA reductase enzyme activity and preventing lipid peroxidation.

Effect of the ethanolic extract of red roselle calyx (Hibiscus sabdariffa L.) on hematocrit, platelets, and erythrocytes in healthy volunteers Setianingsih, Siti; Nurani, Laela Hayu; Rohman, Abdul
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Kelopak bunga rosella (Hibiscus sabdariffaÂ L.) memiliki kandungan flavonoid terutama antosianin dan quersetin yang berpotensi sebagai antioksidan, hepatoprotektor, diuretik, antikolesterol serta imunostimulator. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian serta keamanan ekstrak etanol kelopak bunga rosella merah selama 30 hari dan selama 15 hari setelah tidak mengkonsumsi rosella terhadap nilai hematokrit, trombosit dan eritrosit. Penelitian ini menggunakan rancangan pre-post treatment design study. Dua puluh satu sukarelawan sehat digunakan dalam penelitian yang telah memenuhi kriteria inklusi dan eksklusi serta bersedia mengisi informed consent. Sukarelawan diberikan kapsul dengan dosis 500 mg sebanyak 1 kali sehari, 10-15 menit setelah makan pada malam hari selama 30 hari. Pemeriksaan hematologi dilakukan pada hari ke-0; 31; dan 45 yang meliputi parameter hematokrit, trombosit, dan eritrosit menggunakan hematology analyzer. Hasil yang diperoleh dibandingkan secara statistik menggunakan paired t testÂ dan wilcoxonÂ test. Hasil rerata hematokrit, trombosit, dan eritrosit pada sukarelawan laki-laki dan perempuan hari ke-0, hari ke-31 dan hari ke-45 masuk dalam rentang normal. Hasil penelitian menunjukkan tidak terdapat perbedaan bermakna (p>0,05) nilai hematokrit, trombosit dan eritrosit perbandingan hari ke-0 dengan hari ke-31, hari ke-31 dan hari ke-45, serta hari ke-0 dan hari ke-45. Pemberian kapsul ekstrak etanol rosella merah 500 mg selama 30 hari dan setelah 30 hari tidak mengkonsumsi kapsul ekstrak etanol rosella tidak mempengaruhi semua parameter hematologi pada sukarelawan sehat.

Evaluasi terapi erytropoetin pada pasien hemodialisa di rumah sakit PKU Muhammadiyah Yogyakarta Adnan, Adnan; Dania, Haafizah; Supadmi, Woro
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Most of the patients with end-stage renal disease who undergoing hemodialysis received erythropoietin (EPO) therapy for the anemia treatment. Deficiency anemia erythropoietin is a common complication of chronic kidney disease (CKD). EPO therapy is expected to improve the anemia and can improve the quality of life of patients.This study was conducted in an analytic observational with Cross Secsional design. The purpose of this study was to know there was a difference of red blood cell profile involve hemoglobin (Hb), Mean Corpusculair Volume (MCV), Mean Corpusculair Haemoglobin (MCH), Mean Corpusculair Haemoglobin Concentration (MCHC) and quality of life of CKD patients who received EPO and non EPO therapy in PKU Muhammadiyah Yogyakarta Hospital. Inclusion criteria in this study were PGK ICD N18.9 patients who were undergoing hemodialysis therapy at RS PKU Muhammadiyah Yogyakarta, outpatient, can read and understand the questionnaire, and accept to be a respondent.The results of this study showed no significant difference (p>0,05) in red blood cell (Hb, MCV, MCH, MCHC) between EPO and non EPO therapy groups. The associated of EPO with the quality of life of patients in all of KDQOL domains was p> 0.05.The conclusions of this study showed that there was no significant difference between EPO and Non EPO therapy and there was no correlation between EPO and non EPO therapy with quality of life of hemodialysis patients.

In silico toxicity prediction of 1-phenyl-1-(quinazolin-4-yl) ethanol compounds by using Toxtree, pkCSM and preADMET Yeni, Yeni; Supandi, Supandi; Merdekawati, Fajar
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The 1-phenyl-1-(quinazolin-4-yl) ethanol compounds are alkaloids of quinozoline class found in many Hydrangeaceae families. A survey revealed that most of the identified quinazolin derivatives have anticancer activity. Toxicity prediction of 1-phenyl-1-(quinazolin-4-yl) ethanols were performed to obtain the best three compounds with high activity and the lowest toxicity. Toxicity prediction was conducted using Toxtree, pkCSM and PreADMET. 2D structure of compounds were formed using ChemDraw. The decision tree approach was used in Toxtree application with endpoints including Cramer rules, Kroes TTC, carcinogenicity (genotoxic and non genotoxic) and in vitro mutagenicity. Graph based signature was used in pkCSM application with endpoints including mutagenicity, maximum daily dose, LD50 and hepatotoxicity. In PreADMET application, a method based on drugs similarity and ADMET properties was used with endpoints including mutagenicity, carcinogenicity to rat and mice. The results of data analysis showed that the best three anticancer compounds that have high activity and the lowest toxicity are compounds 14, 16 and 19.

The physical properties and stability of purple yam (Ipomoea batatas (L.) Lam ) lipstick susmiatun, susmiatun; kusuma, Anjar mahardian; Budiman, Arif; Hapsari, Indri
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Ubi jalar ungu memiliki antosianin yang bermanfaat sebagai pewarna alami yang lebih aman dari pewarna sintesis. Antosianin mempunyai daya antioksidan yang dapat menangkap radikal bebas. Tujuan dari penelitian ini adalah untuk menilai pengaruh penggunaan konsentrasi ekstrak ubi ungu terhadap sifat fisik dan stabilitas fisik lipstik.. Lipstik dibuat dalam 3 macam formula yaitu L01, L02, L03. Untuk evaluasi kualitas produk tersebut maka dilakukan uji sifat fisik dan uji stabilitas terhadap lipstik ubi ungu. Uji sifat fisik terdiri atas uji organoleptik, uji titik leleh, uji kekerasan, uji homogenitas, uji daya oles, uji pH lipstik dan pengujian stabilitas lipstik dilakukan dengan menyimpan lipstik selama 30 hari dalam suhu ruang 25Â°C kemudian dilakukan pengamatan terhadap adanya perubahan bentuk, warna dan aroma selama penyimpanan. Sebagai pembanding digunakanÂ lipstick top leader market di Indonesia yaitu merk âWâ. Data pengamatan titik leleh, kekuatan dan pH lipstik dianalisis dengan menggunakan One Way Anova dan dilanjutkan dengan Turkey serta data organoleptik, homogenitas, daya oles dan stabilitas lipstik dijelaskan secara deskriptif. Hasil penelitian menunjukan tidak ada perbedaan bermakna antara lipstik L01, L02, L03 pada organoleptik lipstik, titik leleh, kekerasan lipstik, homogenitas, daya oles lipstik, pH serta stabilitas fisik lipstik. Â Namun apabila dibandingkan dengan lipstik merk âWâ terdapat perbedaan bermakna pada titik leleh, kekerasan dan daya oles antara lipstik L01, L02, L03 dengan lipstik merk âWâ. Kesimpulannya penggunaan ekstrak ubi ungu dengan bermacam konsentrasi tidak berpengaruh terhadap sifat fisik lipstik ubi ungu dan stabilitas lipstik ubi ungu yang dihasilkan.Â Kata kunci : Lipstik, Ubi ungu, Sifat fisik, StabilitasÂ

Anti Inflammatory And Anti Bacterial Activity Of Sumbawa Oil Sugara, Taufan Hari; Nurbaety, Baiq
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v8i2.8010

Sumbawa oil is a traditional ingredient that known as local wisdom of the island society of Sumbawa. It is believed to treat wounds, sprains, rheumatism, thrush and toothache. This study aims to determine the the effectiveness of anti-inflammatory and antibacterial activity of sumbawa oil products based on the types of raw materials and its phytochemical compounds. There are 3 stages in this research, consists of collecting various trademark of sumbawa oil product, determining type of raw material and analysis of phytochemical compound, followed by pharmacological activity test (Anti-inflammatory and antibacterial). Anti-inflammatory test was performed by observing the decrease of percentage inflammation of 21 white rats in 7 groups of egg white injection treatment. Antibacterial test using TSA method by observing the inhibition zone against S. aureus and E. coli bacteria. The results showed that Sumbawa oil products are known to contain secondary metabolite compounds of saponins, Triterpenoids, steroids and Flavonoids. All samples of Sumbawa oil products showed anti-inflammatory activity based on a decrease in the percentage of inflammation in the white rats leg for 6 hours of observation. Sumbawa oil also shows antibacterial activity in the strong category and has a wide spectrum because it can inhibit the growth of gram positive and negative bacteria each of 11,83-14,67 mm and 10,67-12,33 mm.Â This study concluded that Sumbawa oil was shown to have antiinflamatory and antibacterial activity even though its value was still lower than standard drug.

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Muhammad Syahrir

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Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

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Contact Name Muhammad Syahrir

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Journal Mail Official nurkhasanah@pharm.uad.ac.id

Editorial Address Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location Kota yogyakarta, Daerah istimewa yogyakarta INDONESIA

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Contact Name
Muhammad Syahrir

Contact Email
m.syahrir7406@unm.ac.id

Phone
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Journal Mail Official
nurkhasanah@pharm.uad.ac.id

Editorial Address
Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location
Kota yogyakarta,

Daerah istimewa yogyakarta

INDONESIA