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All Journal Media Teknologi Hasil Perikanan JURNAL ILMIAH PLATAX Bioma : Berkala Ilmiah Biologi Jurnal Ilmiah Tindalung Jurnal Ilmiah Tatengkorang
Frans Gruber Ijong
Aquatic Product Processing And Storage, Department Of Fisheries And Marine, Politeknik Negeri Nusa Utara, Tahuna, Sangihe Islands, North Sulawesi 95812, Indonesia
Agriculture, Biological Sciences & Forestry Computer Science & IT Earth & Planetary Sciences Education Environmental Science Immunology & microbiology Languange, Linguistic, Communication & Media Public Health

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Journal : JURNAL ILMIAH PLATAX

 1 
Antifungal Potential Of The Sponge Styllisa Flabelliformis Against The Pathogenic And Resistant Aspergillus Fungi Aprelia Martina Tomasoa; Frets Jonas Rieuwpassa; Deidy Azhari; Frans Gruber Ijong; Revolson Alexius Mege; Wendy Alexander Tanod; Walter Balansa
Jurnal Ilmiah PLATAX Vol. 11 No. 1 (2023): ISSUE JANUARY-JUNE 2023
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35800/jip.v11i1.48603

Abstract

Together with bacterial and viral infection, fungal infection represents the world's top ten killer diseases, desperately requiring new antifungal drugs. This research aimed to evaluate the antifungal activity of the sponge Styllisa flabelliformis against the pathogenic fungi Aspergillus flavus and Aspergillus parasiticus by the standard agar diffusion technique. Three concentrations (1, 10, and 10 mg/mL) for the extract and 0.5 mg/mL for ketoconazole and fluconazole were prepared and evaluated in triplicate against the tested fungi. Whereas ketoconazole poorly inhibited A. parasiticus and fluconazole weakly inhibited A. flavus, the extract of S. flabelliformis exerted antifungal activity against A. parasiticus (6.8 ± 1.8; 8.3 ± 3.2; and 9.5 ± 2.1) mm and A. flavus (6.8 ± 1.1; 11.5 ± 1.4; and 14.3 ± 1.1) mm 1, 10 and 100 mg/mL respectively. PASS analysis showed jasplakinolide as a promising antifungal agent with potential activity (Pa) of 0.736. STITCH analysis further confirmed that jasplakinolide worked by inhibiting the expression of cytoskeleton genes that prevented fungi from synthesizing chitin and inhibiting the formation of the fungi’s cell walls and hyphae, different from the ergosterol synthesis inhibition in ketoconazole and fluconazole, implying the potential of jasplakinolide as an antifungal agent.
Co-Authors Agnes Triasih Agustin Aprelia Martina Tomasoa Ateta, Dessy Awom, Zakeus Costantein I. Sarapil Deidy Azhari Eko Cahyono Ely John Karimela Engel Victor Pandey, Engel Victor Fitria F. Lungari Frets Jonas Rieuwpassa Henny A Dien Inri ND Wagey Jaka Frianto Putra Palawe Joyce CV Palenewen Lohoo, Helen Jenny Natalia Prodiana Setiawati Novalina Maya Sari Ansar Obyn Imhart Pumpente Oksfriani J. Sumampow Oktavianus Alexander Poluakan, Oktavianus Alexander Revolson Mege Siegfried Berhimpon Stefiani Nofrida Asare Stevy Imelda M. Wodi Stevy Imelda Wodi Walter Balansa Wendy Alexander Tanod