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All Journal Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Jurnal Kimia Riset Jurnal Penelitian Pendidikan IPA (JPPIPA) Acta Pharmaciae Indonesia : Acta Pharm Indo Jurnal Biologi Tropis Jurnal Penelitian Farmasi Indonesia Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Jurnal Pengabdian Magister Pendidikan IPA Indonesia Natural Research Pharmaceutical Journal (INRPJ) Jurnal Kefarmasian Indonesia Lumbung Farmasi : Jurnal Ilmu Kefarmasian Sasambo Journal of Pharmacy INDRA: Jurnal Pengabdian kepada Masyarakat Jurnal Sains dan Kesehatan Jurnal Pijar MIPA Jurnal Katalisator
Windah Anugrah Subaidah
Universitas Mataram
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics

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Journal : Jurnal Biologi Tropis

 1 
Nanoparticle Formula Optimization of Juwet Seeds Extract (Syzygium cumini) using Simplex Lattice Design Method Yohanes Juliantoni; Wahida Hajrin; Windah Anugrah Subaidah
Jurnal Biologi Tropis Vol. 20 No. 3 (2020): September - Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v20i3.2124

Abstract

Diabetes is a degenerative disease whose numbers continue to increase from year to year. Treatment with oral antidiabetic drugs can cause harmful side effects for patients. One of the plants that can be used for diabetes therapy is juwet (Syzygium cumini L.). Flavonoid compounds of juwet seed is easily oxidized and hydrolyzed in intestinal fluids with low absorption. This problem can be overcome by forming nanoparticle of juwet seed extract. The aims of this study was to obtain the formula for juwet seed nanoparticles. Nanoparticle of juwet seed extract made by ionic gelation method with chitosan and Na-TPP polymers which are varied. The formula optimization design in this study was determined using a simplex lattice design by 3 variations of materials based on the parameters %entrapment efficiency, %transmittant, particle size, polydisperse index, and zeta potential. The results showed that the yield of duwet seed extract was 7,44%. Juwet seed ethanolic extract contains 3.33 mg of quercetin per 1 g of extract. Based on the desirability value approach, the optimum formula was produced with an extract composition of 1.650 mL; chitosan 0.500 mL; and Na-TPP 0.010 mL can give optimal results with a desirability value of 0.772 which results in the criteria of 63.66% entrapment efficiency; 50.56% transmittant; 615,833nm particle size; 0.620 PDI; and zeta potential of +13.89 mV. Juwet seeds extract can be formulated into the form of nanoparticles. To get better parameters, it is advisable to optimize the mixing time and mixing speed in the ionic gelation method.
Application of Simplex Lattice Design Method on The Optimisation of Deodorant Roll-on Formula of Ashitaba (Angelica keiskei) Wahida Hajrin; Windah Anugrah Subaidah; Yohanes Juliantoni; Dyke Gita Wirasisya
Jurnal Biologi Tropis Vol. 21 No. 2 (2021): Mei - Agustus
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v21i2.2717

Abstract

Ashitaba is known to have antioxidant activity and gram-positive antibacterial activity that causes body odor. This is the potential activity for an active substance to be developed as deodorant. The appropriate formula is needed, so it is necessary to optimize the formula using the right method. This study aimed was to determine the application of the simplex lattice design method on the optimization of a deodorant roll-on formula of ashitaba extract. Ashitaba was extracted by the maceration method. The formula optimization design was determined using the simplex lattice design method by Design Expert®7.5.1. The components for optimization were the concentration of carbopol and concentration of TEA, and the optimization parameters were the spreadability test, sticky power, and pH test. The optimum formula of deodorant consists of 0.45% carbopol and 2.05% TEA. The responses of optimum formula obtained spreadability test 6.32 ± 0.33 cm, sticky power 44.67 ± 3.94 seconds, and pH 7.73 ± 0.17. These results meet the criteria for good preparation but need further testing related to the effectiveness of the preparation and the level of acceptance of the preparation by the user.
Co-Authors Afrah Baitunnisyah Agus Dwi Ananto Agus Dwi Ananto Ali Al-Mokaram Almira Amini Ananto, Agus Dwi Candra Dwipayana Hamdin Dewa Ayu Puspaning Kumaradewi Dewa Ayu Puspaning Kumaradewi Diva Almira Dyke Gita Wirasisya Dyke Gita Wirasisya Eskarani Tri Pratiwi Handa Muliasari Handa Muliasari Hardiyanti Dewi Azmi Hidayati, Agriana Rosmalina I Komang Ary Werdhi Widnyana Lalu Mukhlis Maqbul Sani M. Elyadi Muliasari, Handa Murniyati Murniyati Murniyati, Murniyati Nana Mardiana Nisa Isneni Hanifa Novita Eliya Wardani Novita Eliya Wardani Putri Nuryana Regita Pramesti Risa Dwi Sosalia Rizqa Fersiyana Deccati Sosalia, Risa Dwi Sucilawaty Ridwan Wahida Hajrin Wahida Hajrin Wahida Hajrin Wahida Hajrin Wahida Hajrin Wahida Hajrin Wahida Hajrin Wayan Cintya Ganes Budastra Wirasisya, Dyke Gita Yayuk Andayani Yayuk Andayani Yayuk Andayani Yohanes Juliantoni Yohanes Juliantoni Yohanes Juliantoni Yohanes Juliantoni Yohanes Juliantoni Yohanes Juliantoni Yohanes Juliantoni, Yohanes