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All Journal Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Jurnal Kimia Riset Jurnal Penelitian Pendidikan IPA (JPPIPA) Acta Pharmaciae Indonesia : Acta Pharm Indo Jurnal Biologi Tropis Jurnal Penelitian Farmasi Indonesia Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Jurnal Pengabdian Magister Pendidikan IPA Indonesia Natural Research Pharmaceutical Journal (INRPJ) Jurnal Kefarmasian Indonesia Lumbung Farmasi : Jurnal Ilmu Kefarmasian Sasambo Journal of Pharmacy INDRA: Jurnal Pengabdian kepada Masyarakat Jurnal Sains dan Kesehatan Jurnal Pijar MIPA Jurnal Katalisator
Windah Anugrah Subaidah
Universitas Mataram
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics

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Formulasi Dan Uji Aktivitas Antioksidan Sediaan Masker Peel Off Ekstrak Daun Jambu Biji ( Psidium guajava L.) Sosalia, Risa Dwi; Subaidah, Windah Anugrah; Muliasari, Handa
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 2, No 2 (2021): JULI
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v2i2.5068

Abstract

ABSTRAKRadikal bebas merupakan substansi yang bersifat karsinogenik, dapat menghilangkan elastisitas kulit serta menyebabkan penuaan dini. Keadaan ini dapat dicegah dengan senyawa antioksidan salah satunya yaitu daun jambu biji (Psidium guajava L.) yang mengandung senyawa metabolit sekunder sehingga memiliki potensi sebagai penangkal radikal bebas. Penggunaan daun jambu biji akan lebih mudah dalam bentuk sediaan seperti masker peel off. Tujuan dari penelitian ini yaitu mengetahui aktivitas antioksidan ekstrak daun jambu biji dan formulasinya sebagai sediaan masker peel off. Penelitian yang dilakukan meliputi ekstraksi daun jambu biji dengan metode maserasi menggunakan pelarut etanol 70%, lalu dilakukan skrining fitokimia dan uji aktivitas antioksidan pada ekstrak dengan metode DPPH. Kemudian ekstrak diformulasi menjadi sediaan masker peel off  dan diuji sifat fisiknya yang meliputi uji organoleptis, pH, homogenitas, viskositas, daya sebar, daya lekat, dan waktu sediaan kering serta diuji  aktivitas antioksidan sediaan dengan metode DPPH. Hasil diperoleh menunjukan bahwa ekstrak daun jambu biji  positif mengandung flavonoid, tanin dan fenolik serta  memiliki aktivitas antioksidan yang sangat kuat dengan nilai IC50 sebesar 23,29 μg/mL. Uji sifat  fisik sediaan masker peel off ekstrak daun jambu biji F0 dan F1 telah memenuhi syarat pH, homogenitas, viskositas, daya sebar,waktu sediaan kering dan daya lekat yang baik. Aktivitas antioksidan sediaan masker peel off ekstrak dan jambu biji F0 dan F1 dalam bentuk nilai IC50 diperoleh hasil berturut-turut yaitu 2692,92 μg/mL dan 157,53 μg/mL. Kata kunci: Radikal bebas; Antioksidan; DPPH; Daun Jambu Biji; Masker Peel OffABSTRACTFree radicals are carcinogenic substances, can reduce skin elasticity and cause premature aging. This situation can be prevented with antioxidant compounds, one of which is guava leaf (Psidium guajava L.) which contains secondary metabolites so that it has the potential as an antidote to free radicals. The use of guava leaves will be easier in dosage forms such as peel off masks. The purpose of this study was to determine the antioxidant activity of guava leaf extract and its formulation as a peel off mask preparation. The research carried out included the extraction of guava leaves by maceration method using 70% ethanol solvent, then carried out phytochemical screen and antioxidant activity tests on the extract using the DPPH method. Then the extract was formulated into a peel off mask preparation and tested for its physical properties which included organoleptic tests, pH, homogeneity, viscosity, dispersion, adhesion, and dry preparation time as well as the antioxidant activity of the preparation using the DPPH method. The results showed that guava leaf extract was positive for flavonoids, tannins and phenolics and had very strong antioxidant activity with an IC50 value of 23.29 g/mL. Physical properties test of guava leaf extract peel off mask preparations F0 and F1 met the requirements for pH, homogeneity, viscosity, dispersion, dry preparation time and good adhesion. The antioxidant activity of peel-off mask preparations and guava extract F0 and F1 in the form of IC50 values preserved results, respectively, namely 2692.92 g/mL and 157.53 g/mL.Keywords: Free radicals; Antioxidants; DPPH; Guava leaves; Peel Off Mask 
Formulasi Dan Uji Aktivitas Antiradikal Bebas Sediaan Gel Ekstrak Etanol Daun Bidara (Ziziphus mauritiana Lamk) Menggunakan Metode DPPH Murniyati, Murniyati; Subaidah, Windah Anugrah; Ananto, Agus Dwi
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 2, No 2 (2021): JULI
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v2i2.5167

Abstract

ASBTRAKEkstrak daun bidara memiliki IC50 sebesar 4,9379 ppm dan daun bidara mengandung senyawa fenolik sehingga dapat digunakan sebagai antioksidan alami penangkal radikal bebas serta memiliki potensi yang dapat dikembangkan sebagai kosmetik salah satunya adalah sediaan gel. Tujuan penelitian ini adalah memformulasi sediaan gel ekstrak etanol daun bidara dan menguji aktivitas antiradikal bebas menggunakan metode DPPH. Daun bidara diekstraksi menggunakan metode maserasi dengan pelarut etanol 70%. Gel dibuat dengan konsentrasi ekstrak 4%, 5% dan 6%, selanjutnya dilakukan evaluasi sifat fisik meliputi organoleptis, homogenitas, uji pH, uji daya sebar, dan uji daya lekat. Aktivitas antioksidan diuji dengan metode DPPH. Hasil menunjukkan ekstrak etanol daun bidara dapat diformulasikan menjadi sediaan gel antioksidan dengan variasi konsentrasi ekstrak 4%, 5% dan 6%, dimana sediaannya memenuhi persyaratan sifat fisik yang baik. Gel ekstrak etanol daun bidara memiliki aktivitas antioksidan yang berbeda-beda berdasarkan variasi konsentrasi ekstrak. Peningkatan konsentrasi ekstrak menyebabkan perbedaan kemampuan pelepasan zat aktif yang ditunjukkan dengan nilai IC50 yang berbeda untuk sediaan 4%, 5% dan 6% yaitu masing-masing sebesar 1679,874 ppm, 1203,636 ppm dan 998,736 ppm. Berdasarkan nilai IC50, intensitas aktivitas penghambatan radikal bebas pada sediaan gel ekstrak etanol daun bidara tergolong lemah.Kata kunci : Aktivitas Antiradikal Bebas; Daun Bidara; Gel; DPPH. ABSTRACTBidara leaf extract has an IC50 of 4.9379 ppm and bidara leaves contain phenolic compounds so that they can be used as natural antioxidants to ward off free radicals and have the potential to be developed as a cosmetic, one of which is a gel preparation. The purpose of this study was to formulate a gel preparation of bidara leaf ethanol extract and to test its anti-free radical activity using the DPPH method. Bidara leaves were extracted using maceration method with 70% ethanol as solvent. Gels were made with extract concentrations of 4%, 5% and 6%, then evaluated for physical properties including organoleptic, homogeneity, pH test, spreadability test, and adhesion test. Antioxidant activity was tested by DPPH method. The results show that the ethanol extract of bidara leaves can be formulated into an antioxidant gel preparation with variations in extract concentrations of 4%, 5% and 6%, where the preparation meets the requirements of good physical properties. The ethanol extract gel of bidara leaves has different antioxidant activities based on variations in the concentration of the extract. Increasing the concentration of the extract caused differences in the ability to release the active substance as indicated by different IC50 values for 4%, 5% and 6% preparations, which were 1679,874 ppm, 1203,636 ppm and 998,636 ppm, respectively. Based on the IC50 value, the intensity of free radical inhibitory activity in the ethanol extract gel preparation of bidara leaves is classified as weak.Keywords : Free Antiradical Activity; Bidara Leaf; Gel; DPPH.
Formulasi Pasta Gigi Ekstrak Etanolik Herba Ashitaba (Angelica keiskei) Juliantoni, Yohanes; Subaidah, Windah Anugrah; Wirasisya, Dyke Gita
Jurnal Farmasi Sains dan Terapan Vol 7, No 2 (2020): Oktober
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v7i2.2365

Abstract

Ashitaba (Angelica keiskei) memiliki khasiat sebagai antibakteri Streptococcus aureus mutans yang merupakan penyebab karies gigi. Pasta gigi merupakan salah satu bentuk sediaan untuk pembersih gigi. Penelitian ini dilakukan untuk membuat formulasi ekstrak herba ashitaba dalam bentuk pasta gigi. Metode maserasi digunakan untuk mengekstraksi ashitaba dengan larutan penyari etanol 96%. Pasta gigi dibuat dengan tiga variasi konsentrasi dari karbopol 940 secara berurutan yaitu 1% (formulasi I), 2% (formulasi II), dan 3% (formulasi III). Parameter uji formula pasta gigi meliputi pH, homogenitas, tinggi busa, dan uji hedonik. Rendemen ekstrak etanol ashitaba diperoleh sebesar 18,13%. Hasil uji sifat fisik tiga sediaan pasta gigi menunjukkan bahwa ketiga formula homogen, memenuhi syarat pH, dan Formula II memiliki nilai respon kesukaan yang paling baik.
Uji Kestabilan Fisik Krim Tabir Surya Ekstrak Etanol Biji Jintan Hitam (Nigella sativa L.) Subaidah, Windah Anugrah
Jurnal Farmasi Sains dan Terapan Vol 7, No 2 (2020): Oktober
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v7i2.2363

Abstract

Jintan hitam (Nigella sativa L.) diketahui memiliki kandungan flavanoid yang dapat menangkal radikal bebas karena adanya gugus kromofor (ikatan rangkap terkonjugasi). Gugus kromofor pada falavonoid dalam jintan hitam (Nigella sativa L.) mampu menyerap radiasi sinar UVA dan UVB. Penelitian ini bertujuan untuk mengetahui kestabilan fisik krim tabir surya ekstrak etanol biji jintan hitam (Nigella sativa L) dengan variasi emulgator polisorbat 60 dan sorbitan 60 setelah penyimpanan dipercepat. Ekstrak biji jintan hitam (Nigella sativa L) yang diperoleh dengan metode maserasi menggunakan pelarut etanol 70%. Aktivitas tabir surya ekstrak biji jintan hitam (Nigella sativa L) ditentukan dengan mengukur nilai persen transmisi eritema (%Te) dan nilai persen transmisi pigmentasi (%Tp) menggunakan spektrofotometer UV. Ekstrak biji jintan hitam (Nigella sativa L) diformulasikan kedalam sediaan krim kemudian di evaluasi sifat fisik sebelum dan sesudah penyimpanan dipercepat. Hasil penelitian menunjukkan Ekstrak biji jintan hitam (Nigella sativa L.) masuk kedalam kategori sunblock dengan nilai transmisi eritema sebesar 0,5707% dan nilai transmisi pigmentasi sebesar 0,7074%. Ekstrak biji jintan hitam (Nigella sativa L.) yang diformulasikan kedalam sediaan krim dengan variasi emulgator polisorbat 60 dan sorbitan 60 setelah penyimpanan dipercepat tidak mengalami perubahan organoleptis, homogenitas dan tipe emulsi. Perubahan terjadi pada viskositas dan pH sediaan krim.
Formulasi dan Evaluasi Sifat Fisik Lotion Ekstrak Etanol Daun Kemuning (Murraya paniculata (L) Jack) dan Daun Lidah Buaya (Aloe vera Linn) Windah Anugrah Subaidah; Yohanes Juliantoni; Wahida Hajrin
Sasambo Journal of Pharmacy Vol. 1 No. 1 (2020): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (196.65 KB) | DOI: 10.29303/sjp.v1i1.6

Abstract

The ultraviolet radiation and skin water loss could damage the skin. Kemuning leaves (Murraya paniculata (L) Jack) as a source of anti-oxidants and Aloe vera leaves (Aloe vera Linn) can prevent this action. This study aims to formulate and evaluate lotion containing the Kemuning leaves and Aloe vera extract. The extract of Kemuning leaves was obtained by sonication using 70% ethanol solvent. Aloe vera juice was obtained by smoothing the aloe vera gel then filtered using clean gauze.  The kemuning leaves extract and aloe vera extract had formulated into lotion preparation. The physical properties of the lotion (homogeneity, type of emulsion, pH, spreadability, and adhesion) were determined. The organoleptic test showed that the color of the lotion was pale yellow with a smooth texture and had extract scent. The lotion was showed good homogeneity, spreadability 7.31 cm, pH 7, type oil in water and adhesion 45 seconds. The physical properties parameters of lotion preparations showed that the lotion preparations had fulfilled the requirements of good preparations.
Formulasi Sediaan Gel Sari Buah Duwet (Syzygium cumini) dengan Basis Karbopol 940 Sebagai Gelling Agent Yohanes Juliantoni; Wahida Hajrin; Windah Anugrah Subaidah
Sasambo Journal of Pharmacy Vol. 1 No. 2 (2020): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (185.863 KB) | DOI: 10.29303/sjp.v1i2.14

Abstract

Duwet fruit (Syzygium cumini) is a local Indonesian fruit that has many benefits. Duwet juice contains antioxidants that have DPPH free radical activity. But the use of duwet fruit is not practical for modern society. This research was conducted to formulate duwet juice into a gel-based carbopol 940 with the physical quality test of the gel. Duwet fruit extraction was tested for phytochemical screening qualitatively. The gel is made in 5 formulas namely I (100% aquadest: 0% ethanol 70%); II (75% aquadest: 25% ethanol 70%); III (50% aquadest: 50% ethanol 70%); IV (25% aquadest: 75% ethanol 70%); and V (0% aquadest: 100% ethanol 70%). The results showed that Duwet juice contained of flavonoid, polyphenols, and anthocyanins based on phytochemical screening tests. The formula of gel I, II, and III has fulfilled the pH requirements of 4.5-6.5, homogeneity, and spread capacity of 5-7 cm. Increasing the concentration of 70% ethanol in the gel formula will increase the pH value and spread capacity.
Formulasi dan evaluasi karakter fisik sediaan gel ekstrak etanol daun salam (Syzygium polyanthum) Lalu Mukhlis Maqbul Sani; Windah Anugrah Subaidah; Yayuk Andayani
Sasambo Journal of Pharmacy Vol. 2 No. 1 (2021): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (314.884 KB) | DOI: 10.29303/sjp.v2i1.57

Abstract

Abstrak: Bay leaves (Syzygium polyanthum) are known to have antioxidant effects that can neutralize free radicals found in the skin. The objectives of this research are to formulate the ethanol extract of bay leaves into gel formulation and evaluate the physical properties of gel formulation. Ethanol extract of bay leaves was obtained through the maceration method with 70 % ethanol as a solvent. The thick ethanol extract of bay leaves was formulated into gel formulation with CMC – Na as a gelling agent, glycerin as a humectant, methyl paraben as a preservative, and aquadest as a solvent. After the freeze-thaw test was done, there was no change found in organoleptic but there were changes in pH, spreadability, and adhesion. The pH of gel preparation before being in storage was 5 and after being in storage was 6. In the spreadability, gel formulation spread 5,5 cm before being in the storage, and 5,1 cm after being in the storage. Gel adhesion has a sticky time of 8.35 seconds before in being storage and 8.45 seconds after being in storage.
Edukasi penyakit malaria dan pengobatan menggunakan obat herbal pasca gempa di Lombok Windah Anugrah Subaidah; Yohanes Juliantoni; Wahida Hajrin
INDRA: Jurnal Pengabdian kepada Masyarakat Vol. 2 No. 2 (2021): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (647.665 KB) | DOI: 10.29303/indra.v2i2.127

Abstract

In September 2018 malaria was identified as an extraordinary event in NTB. Malaria plague spread in West Lombok. According to data from the West Lombok health service there were 184 cases. This includes pregnant women, children, and babies. Severe impact on vulnerable groups such as pregnant women and children. Pregnant women infected with malaria will experience severe anemia and have a higher risk of fetal death. In children, it affects the growth and intelligence disorders caused by anemia. The purpose of this community service was to increase the knowledge about malaria disease and ways to prevent it. The method is done by presenting the method, then followed by an interactive discussion and giving evaluation through post-test and pre-test. The service was carried out at the Senggigi village office in Batu Layar District, West Lombok Regency, West Nusa Tenggara Province. The contents of the presentation were what is malaria, how to prevent malaria, and how to use herbal medicine to cure malaria. Afterward, the committee distributed leaflets and abate powders to participants. The evaluation showed there was an increase in the knowledge of participants after education was given. The increase of knowledge about malaria would decrease the number of malaria cases at Senggigi village
In vitro concentration optimization of ethanol extract from Makasar fruit seeds (Brucea javanica L. Merr) as an anti-inflammatory agent Diva Almira; Windah Anugrah Subaidah; Agus Dwi Ananto; Rizqa Fersiyana Deccati; Handa Muliasari
Jurnal Pijar Mipa Vol. 16 No. 5 (2021): November 2021
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (302.503 KB) | DOI: 10.29303/jpm.v16i5.2655

Abstract

Anti-inflammatory medications are necessary to treat excessive inflammation reactions due to injury, infection, or irritation. The emergence of several adverse effects associated with synthetic anti-inflammatory drugs has prompted the continued use of anti-inflammatory agents derived from natural products with low side effects and a high therapeutic effect. While it is well established that the seeds of the Makassar fruit (Brucea javanica (L.) Merr.)  have anti-inflammatory activity, the optimal concentration of Makasar fruit seed extract for anti-inflammatory activity is unknown. This study aims to determine the optimal Makassar fruit seed extract concentration as an in vitro anti-inflammatory. The seeds of the Makasar fruit were extracted using the sonication method (3 x 35 minutes) in 96% ethanol and then concentrated using a rotary evaporator. The secondary metabolites of Makasar fruit seed extract were then identified in the test tubes, and the anti-inflammatory activity was determined using the protein denaturation inhibition method. The results indicated that the extract produced had a yield of 10.03%. The Makassar fruit seed extract contains secondary metabolites of phenolics, flavonoids, and terpenoids. Makasar fruit seed extract exhibited the optimum anti-inflammatory activity at a concentration of 1%, with a 55.47% inhibition of protein denaturation.
Efektivitas Formula Krim Tabir Surya Berbahan Aktif Ekstrak Etanol Biji Wali (Brucea javanica L. Merr) Almira Amini; Candra Dwipayana Hamdin; Handa Muliasari; Windah Anugrah Subaidah
Jurnal Kefarmasian Indonesia VOLUME 10, NOMOR 1, FEBRUARI 2020
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (378.285 KB) | DOI: 10.22435/jki.v10i1.2066

Abstract

High intensity of ultraviolet (UV) radiation causes several adverse effect such as erythema, sunburn, pigmentation, early senescence, and skin cancer. These effects can be prevented by using sun protection product. Wali (Brucea javanica L. Merr) is one of natural plants that contain phenol and flavonoid. These compounds are proven to have sunscreen effect. The purposes of this studies are to formulate and evaluate the effectivity of oil-in-water-type sunscreen cream using 1% ethanol extract of Wali seed. The sunscreen cream is developed by using a fusion method and the evaluation of the effectivity is conducted in vivo on the skin of mice (Mus musculus). The formulated sunscreen cream is then tested for its physical properties, including homogenity, pH, spreadability, adhesion, and stability. The effectivity of the formulated cream is also tested by observing the formation of erytema on the skin of mice (Mus musculus). Erythema appearing on the mouse skin is analyzed with ImageJ and SPSS v23 using the one way anova method. The results showed that the ethanol extract of Wali seeds could be formulated into sunscreen cream. Furthermore, the formulated cream was also able to protect the mice skin against the formation of erythema significantly compared to negative controls (p
Co-Authors Afrah Baitunnisyah Agus Dwi Ananto Agus Dwi Ananto Ali Al-Mokaram Almira Amini Ananto, Agus Dwi Candra Dwipayana Hamdin Dewa Ayu Puspaning Kumaradewi Dewa Ayu Puspaning Kumaradewi Diva Almira Dyke Gita Wirasisya Dyke Gita Wirasisya Eskarani Tri Pratiwi Handa Muliasari Handa Muliasari Hardiyanti Dewi Azmi Hidayati, Agriana Rosmalina I Komang Ary Werdhi Widnyana Lalu Mukhlis Maqbul Sani M. Elyadi Muliasari, Handa Murniyati Murniyati Murniyati, Murniyati Nana Mardiana Nisa Isneni Hanifa Novita Eliya Wardani Novita Eliya Wardani Putri Nuryana Regita Pramesti Risa Dwi Sosalia Rizqa Fersiyana Deccati Sosalia, Risa Dwi Sucilawaty Ridwan Wahida Hajrin Wahida Hajrin Wahida Hajrin Wahida Hajrin Wahida Hajrin Wahida Hajrin Wahida Hajrin Wayan Cintya Ganes Budastra Wirasisya, Dyke Gita Yayuk Andayani Yayuk Andayani Yayuk Andayani Yohanes Juliantoni Yohanes Juliantoni Yohanes Juliantoni Yohanes Juliantoni Yohanes Juliantoni Yohanes Juliantoni Yohanes Juliantoni, Yohanes